Buha-Đorđević, Aleksandra

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Authority KeyName Variants
orcid::0000-0002-6942-7040
  • Buha-Đorđević, Aleksandra (120)
  • Buha, Aleksandra (57)
Projects
Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200161 (University of Belgrade, Faculty of Pharmacy)
DecodExpo - Decoding the Role of Exposome in Endocrine Health Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča)
Special Research Account of University of Crete (ELKE No 4920), the University of Crete spin-off ToxPlus S.A. Agence Nationale de la Recherche ANR-13-CESA-008-Cadmidia
Grants from the National Institute of Environmental Health Sciences (NIEHS)—R01ES10563 and NIEHS R01ES07331 “Improving anti-cancer immunotherapy efficacy of CAR-T cells or PD-1/PD-L1 inhibitors by combining immune modulators”, funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia, in the framework of scientific cooperation with the People’s Republic of China (451-03-1203/2021-09)
Biomarkers of organ damage and dysfunction Palinspastika tektonostratigrafskih jedinica između Jadranske i Mezijske ploče
Innlandet Hospital Trust, Norway, and by the Oklahoma State University Center for Health Sciences Seed/Pilot Grant Program, grant number 154357. Innovation Sciences and Technologies (PON RI 2014-2020) at the University of Cagliari.
Medical Research Council of UK (award reference number MR/R005699/1 ) Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije kroz međunarodni projekat između Republike Srbije i NR Kine: „Povećanje efikasnosti terapije karcinoma kombinacijom CAR-T ćelija ili PD-1/PD-L1 inhibitora pomoću imunomodulatora” (451-03-1203/2021-09).
Ministry of Research and Innovation in Romania: Program 1—The Improvement of the National System of Research and Development, Subprogram 1.2—Institutional Excellence—Projects of Excellence Funding in RDI, Contract No. 7PFE/16.10.2018 Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers “Digital biodesign and personalized healthcare” No075-15-2020-92
National Institutes of Health and the OSU-CHS 355 Office of the Vice President for Research Seed Grant (#1-54333; DRW) NIEHSR01ES07331
Oklahoma IDeA Network of Biomedical Research Excellence (OK-INBRE; P20GM103447; DRW) Oklahoma State University Center for Health Science Pilot Grant Program (#1-54333)
Oklahoma State University Center for Health Sciences (OVPR) Pilot/Seed Grant (AG154391) and Presidential Fellowship (to KM, LY, and LV) D.R.W.; Oklahoma State UniversityCenter for Health Sciences Pilot/Seed Grant (1-54357; D.W.)
Oklahoma State University grant #154357 OSU - 154333-7
OSUCHS 154357 (to D.R.W.) OSU intramural funding [#154333 & #154357]
Pod pokroviteljstvom Ministarstva zdravlja Republike Srbije, Projekat „Hitan odgovor Republike Srbije na COVID-19” R01ES10563
Sardegna for the financial support of the project RASSR79857. Serbia-China project: 451- 03-1203/2021-09

Author's Bibliography

Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds

Umićević, Nina; Kotur-Stevuljević, Jelena; Baralić, Katarina; Đukić-Ćosić, Danijela; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Ćurčić, Marijana; Bulat, Zorica; Antonijević, Biljana

(Sciendo, 2024)

TY  - JOUR
AU  - Umićević, Nina
AU  - Kotur-Stevuljević, Jelena
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5592
AB  - This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O2•-), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (PAB), oxidative stress index (OSI), superoxide dismutase (SOD) and paraoxonase-1 (PON1) enzyme activity, total SH group content (SHG), and total antioxidant status (TAS). Trace metal levels (copper, zinc, iron, magnesium, and manganese) were analysed in whole blood. All oxidative stress and antioxidative defence parameters were higher in the exposed workers than controls, except for PON1 activity. Higher Fe, Mg, and Zn, and lower Cu were observed in the exposed vs control men, while the exposed women had higher Fe and lower Mg, Zn, and Cu than their controls. Our findings confirm that combined exposure to a mixture of VOCs, even at permitted levels, may result in additive or synergistic adverse health effects and related disorders. This raises concern about current risk assessments, which mainly rely on the effects of individual chemicals, and calls for risk assessment approaches that can explain combined exposure to multiple chemicals.
AB  - Cilj istraživanja bio je procijeniti redoks status i koncentracije metala u tragovima kod 49 radnika (11 muškaraca i 38 žena) zaposlenih u
industriji obuće, izloženih mješavini hlapljivih organskih spojeva (engl. volatile organic compounds, krat. VOC) koju su činili alifatski i aromatični
ugljikovodici, ketoni, esteri, eteri i karboksilne kiseline. Sve izmjerene razine VOC bile su ispod dozvoljenih granica profesionalne izloženosti.
U kontrolnoj je skupini bilo 50 neizloženih ispitanika (25 muškaraca i 25 žena). U plazmi obućarskih radnika analizirani su sljedeći parametri:
superoksid anion radikal (O2
•-
), uznapredovali produkti oksidacije proteina (AOPP), totalni oksidacijski status (TOS), prooksidacijsko-
antioksidacijski balans (PAB), indeks oksidacijskoga stresa (OSI), aktivnost superoksid-dismutaze (SOD), aktivnost enzima paraoksonaze-1
(PON1), ukupni sadržaj sulfhidrilnih grupa (SHG) i totalni antioksidacijski status (TAS). Koncentracije metala u tragovima (bakar, cink,
željezo, magnezij i mangan) analizirane su u punoj krvi. U usporedbi s kontrolnom skupinom, svi parametri oksidacijskoga stresa i
antioksidacijske obrane u izloženih radnika bili su povišeni, osim aktivnosti PON1. Povećana koncentracija Fe, Mg i Zn te smanjena
koncentracija Cu uočene su u izloženih muškaraca u usporedbi s kontrolnima, a u žena je primijećena povišena koncentracija Fe, a niža
koncentracija Mg, Zn i Cu u odnosu na kontrolnu skupinu. Naši nalazi potvrđuju da kombinirano izlaganje mješavini VOC, čak i pri
dozvoljenim koncentracijama, može dovesti do aditivnih ili sinergističkih štetnih učinaka na zdravlje i popratnih poremećaja. Trenutna
procjena rizika, koja se uglavnom oslanja na učinke pojedinačnih kemikalija, izaziva zabrinutost i upućuje na potrebu za novim pristupima
koji će objasniti kombiniranu izloženost većem broju kemikalija.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju
T1  - Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds
T1  - Povećani oksidacijski stres u obućarskih radnika izloženih mješavini niskih razina hlapljivih organskih spojeva
VL  - 75
IS  - 1
SP  - 51
EP  - 60
DO  - 10.2478/aiht-2024-75-3804
ER  - 
@article{
author = "Umićević, Nina and Kotur-Stevuljević, Jelena and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2024",
abstract = "This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O2•-), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (PAB), oxidative stress index (OSI), superoxide dismutase (SOD) and paraoxonase-1 (PON1) enzyme activity, total SH group content (SHG), and total antioxidant status (TAS). Trace metal levels (copper, zinc, iron, magnesium, and manganese) were analysed in whole blood. All oxidative stress and antioxidative defence parameters were higher in the exposed workers than controls, except for PON1 activity. Higher Fe, Mg, and Zn, and lower Cu were observed in the exposed vs control men, while the exposed women had higher Fe and lower Mg, Zn, and Cu than their controls. Our findings confirm that combined exposure to a mixture of VOCs, even at permitted levels, may result in additive or synergistic adverse health effects and related disorders. This raises concern about current risk assessments, which mainly rely on the effects of individual chemicals, and calls for risk assessment approaches that can explain combined exposure to multiple chemicals., Cilj istraživanja bio je procijeniti redoks status i koncentracije metala u tragovima kod 49 radnika (11 muškaraca i 38 žena) zaposlenih u
industriji obuće, izloženih mješavini hlapljivih organskih spojeva (engl. volatile organic compounds, krat. VOC) koju su činili alifatski i aromatični
ugljikovodici, ketoni, esteri, eteri i karboksilne kiseline. Sve izmjerene razine VOC bile su ispod dozvoljenih granica profesionalne izloženosti.
U kontrolnoj je skupini bilo 50 neizloženih ispitanika (25 muškaraca i 25 žena). U plazmi obućarskih radnika analizirani su sljedeći parametri:
superoksid anion radikal (O2
•-
), uznapredovali produkti oksidacije proteina (AOPP), totalni oksidacijski status (TOS), prooksidacijsko-
antioksidacijski balans (PAB), indeks oksidacijskoga stresa (OSI), aktivnost superoksid-dismutaze (SOD), aktivnost enzima paraoksonaze-1
(PON1), ukupni sadržaj sulfhidrilnih grupa (SHG) i totalni antioksidacijski status (TAS). Koncentracije metala u tragovima (bakar, cink,
željezo, magnezij i mangan) analizirane su u punoj krvi. U usporedbi s kontrolnom skupinom, svi parametri oksidacijskoga stresa i
antioksidacijske obrane u izloženih radnika bili su povišeni, osim aktivnosti PON1. Povećana koncentracija Fe, Mg i Zn te smanjena
koncentracija Cu uočene su u izloženih muškaraca u usporedbi s kontrolnima, a u žena je primijećena povišena koncentracija Fe, a niža
koncentracija Mg, Zn i Cu u odnosu na kontrolnu skupinu. Naši nalazi potvrđuju da kombinirano izlaganje mješavini VOC, čak i pri
dozvoljenim koncentracijama, može dovesti do aditivnih ili sinergističkih štetnih učinaka na zdravlje i popratnih poremećaja. Trenutna
procjena rizika, koja se uglavnom oslanja na učinke pojedinačnih kemikalija, izaziva zabrinutost i upućuje na potrebu za novim pristupima
koji će objasniti kombiniranu izloženost većem broju kemikalija.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju",
title = "Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds, Povećani oksidacijski stres u obućarskih radnika izloženih mješavini niskih razina hlapljivih organskih spojeva",
volume = "75",
number = "1",
pages = "51-60",
doi = "10.2478/aiht-2024-75-3804"
}
Umićević, N., Kotur-Stevuljević, J., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2024). Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds. in Arhiv za higijenu rada i toksikologiju
Sciendo., 75(1), 51-60.
https://doi.org/10.2478/aiht-2024-75-3804
Umićević N, Kotur-Stevuljević J, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds. in Arhiv za higijenu rada i toksikologiju. 2024;75(1):51-60.
doi:10.2478/aiht-2024-75-3804 .
Umićević, Nina, Kotur-Stevuljević, Jelena, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds" in Arhiv za higijenu rada i toksikologiju, 75, no. 1 (2024):51-60,
https://doi.org/10.2478/aiht-2024-75-3804 . .

Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies

Baralić, Katarina; Živanović, Jovana; Marić, Đurđica; Božić, Dragica; Grahovac, Lazar; Antonijević-Miljaković, Evica; Ćurčić, Marijana; Buha-Đorđević, Aleksandra; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(MDPI, 2024)

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živanović, Jovana
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Grahovac, Lazar
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5516
AB  - Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.
PB  - MDPI
T2  - Antioxidants
T1  - Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies
VL  - 13
IS  - 2
DO  - 10.3390/antiox13020147
ER  - 
@article{
author = "Baralić, Katarina and Živanović, Jovana and Marić, Đurđica and Božić, Dragica and Grahovac, Lazar and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies",
volume = "13",
number = "2",
doi = "10.3390/antiox13020147"
}
Baralić, K., Živanović, J., Marić, Đ., Božić, D., Grahovac, L., Antonijević-Miljaković, E., Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants
MDPI., 13(2).
https://doi.org/10.3390/antiox13020147
Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević-Miljaković E, Ćurčić M, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies. in Antioxidants. 2024;13(2).
doi:10.3390/antiox13020147 .
Baralić, Katarina, Živanović, Jovana, Marić, Đurđica, Božić, Dragica, Grahovac, Lazar, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies" in Antioxidants, 13, no. 2 (2024),
https://doi.org/10.3390/antiox13020147 . .
1

Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms

Radović, Biljana; Baralić, Katarina; Ćurčić, Marijana; Marić, Đurđica; Živanović, Jovana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Đukić-Ćosić, Danijela; Bulat, Zorica; Antonijević, Biljana

(Elsevier V. B., 2024)

TY  - JOUR
AU  - Radović, Biljana
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Marić, Đurđica
AU  - Živanović, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5530
AB  - The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.
PB  - Elsevier V. B.
T2  - Science of the Total Environment
T1  - Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms
VL  - 917
SP  - 170437
DO  - 10.1016/j.scitotenv.2024.170437
ER  - 
@article{
author = "Radović, Biljana and Baralić, Katarina and Ćurčić, Marijana and Marić, Đurđica and Živanović, Jovana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2024",
abstract = "The constant exposure of humans to a mixture of low doses of toxic substances, emerging from the daily emission of toxic dust containing various metals and organic compounds in electrical and electronic waste (e-waste) recycling areas, poses potential harmful effects on health and the environment. While individually recognized as endocrine disruptors affecting hormonal balance, the combined impact of these toxic substances in a mixture remains insufficiently explored, particularly in relation to reproductive health. Thus, the aim of this in silico analysis was to: (i) assess the relationship between the exposure to a mixture of DBDE, DBDPE, TBBPA, Pb, Cd and Ni and development of male and female reproductive system disorders; and (ii) demonstrate the ability of in silico toxicogenomic tools in revealing the potential molecular mechanisms involved in the mixture toxicity. As the main data-mining tool, Comparative Toxicogenomics Database (CTD) was used, along with the ToppGene Suite portal and GeneMANIA online server. Our analysis identified 5 genes common to all the investigated substances and linked to reproductive system disorders. Notably, the most prominent interactions among these genes were physical interactions (77.64 %). Pathway enrichment analysis identified oxidative stress response as the central disrupted molecular pathway linked to reproductive pathology in the investigated mixture, while our chemical-phenotype CTD analysis uncovered additional affected pathways – apoptosis, hormonal regulation, and developmental functions. These findings highlight an increased risk of reproductive system disorders associated with the exposure to the investigated mixture of toxic substances in electronic waste recycling areas, emphasizing the urgent need for attention to address this environmental health concern. Hence, future laboratory studies should prioritize investigating the specific genes and common mechanisms identified in this study.",
publisher = "Elsevier V. B.",
journal = "Science of the Total Environment",
title = "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms",
volume = "917",
pages = "170437",
doi = "10.1016/j.scitotenv.2024.170437"
}
Radović, B., Baralić, K., Ćurčić, M., Marić, Đ., Živanović, J., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2024). Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment
Elsevier V. B.., 917, 170437.
https://doi.org/10.1016/j.scitotenv.2024.170437
Radović B, Baralić K, Ćurčić M, Marić Đ, Živanović J, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Bulat Z, Antonijević B. Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms. in Science of the Total Environment. 2024;917:170437.
doi:10.1016/j.scitotenv.2024.170437 .
Radović, Biljana, Baralić, Katarina, Ćurčić, Marijana, Marić, Đurđica, Živanović, Jovana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Endocrine disruptors in e-waste dismantling dust: In silico prediction of mixture-induced reproductive toxicity mechanisms" in Science of the Total Environment, 917 (2024):170437,
https://doi.org/10.1016/j.scitotenv.2024.170437 . .
1

Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions

Bjørklund, Geir; Buha-Đorđević, Aleksandra; Hamdan, Halla; Wallace, David R.; Peana, Massimiliano

(Elsevier B.V., 2024)

TY  - JOUR
AU  - Bjørklund, Geir
AU  - Buha-Đorđević, Aleksandra
AU  - Hamdan, Halla
AU  - Wallace, David R.
AU  - Peana, Massimiliano
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5443
AB  - Autoimmunity is a multifaceted disorder influenced by both genetic and environmental factors, and metal exposure has been implicated as a potential catalyst, especially in autoimmune diseases affecting the central nervous system. Notably, metals like mercury, lead, and aluminum exhibit well-established neurotoxic effects, yet the precise mechanisms by which they elicit autoimmune responses in susceptible individuals remain unclear. Recent studies propose that metal-induced autoimmunity may arise from direct toxic effects on immune cells and tissues, coupled with indirect impacts on the gut microbiome and the blood-brain barrier. These effects can activate self-reactive T cells, prompting the production of autoantibodies, inflammatory responses, and tissue damage. Diagnosing metal-induced autoimmunity proves challenging due to nonspecific symptoms and a lack of reliable biomarkers. Treatment typically involves chelation therapy to eliminate excess metals and immunomodulatory agents to suppress autoimmune responses. Prevention strategies include lifestyle adjustments to reduce metal exposure and avoiding occupational and environmental risks. Prognosis is generally favorable with proper treatment; however, untreated cases may lead to autoimmune disorder progression and irreversible organ damage, particularly in the brain. Future research aims to identify genetic and environmental risk factors, enhance diagnostic precision, and explore novel treatment approaches for improved prevention and management of this intricate and debilitating disease.
PB  - Elsevier B.V.
T2  - Autoimmunity Reviews
T1  - Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions
VL  - 23
IS  - 3
DO  - 10.1016/j.autrev.2023.103509
DO  - 2-s2.0-85181822086
ER  - 
@article{
author = "Bjørklund, Geir and Buha-Đorđević, Aleksandra and Hamdan, Halla and Wallace, David R. and Peana, Massimiliano",
year = "2024",
abstract = "Autoimmunity is a multifaceted disorder influenced by both genetic and environmental factors, and metal exposure has been implicated as a potential catalyst, especially in autoimmune diseases affecting the central nervous system. Notably, metals like mercury, lead, and aluminum exhibit well-established neurotoxic effects, yet the precise mechanisms by which they elicit autoimmune responses in susceptible individuals remain unclear. Recent studies propose that metal-induced autoimmunity may arise from direct toxic effects on immune cells and tissues, coupled with indirect impacts on the gut microbiome and the blood-brain barrier. These effects can activate self-reactive T cells, prompting the production of autoantibodies, inflammatory responses, and tissue damage. Diagnosing metal-induced autoimmunity proves challenging due to nonspecific symptoms and a lack of reliable biomarkers. Treatment typically involves chelation therapy to eliminate excess metals and immunomodulatory agents to suppress autoimmune responses. Prevention strategies include lifestyle adjustments to reduce metal exposure and avoiding occupational and environmental risks. Prognosis is generally favorable with proper treatment; however, untreated cases may lead to autoimmune disorder progression and irreversible organ damage, particularly in the brain. Future research aims to identify genetic and environmental risk factors, enhance diagnostic precision, and explore novel treatment approaches for improved prevention and management of this intricate and debilitating disease.",
publisher = "Elsevier B.V.",
journal = "Autoimmunity Reviews",
title = "Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions",
volume = "23",
number = "3",
doi = "10.1016/j.autrev.2023.103509, 2-s2.0-85181822086"
}
Bjørklund, G., Buha-Đorđević, A., Hamdan, H., Wallace, D. R.,& Peana, M.. (2024). Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions. in Autoimmunity Reviews
Elsevier B.V.., 23(3).
https://doi.org/10.1016/j.autrev.2023.103509
Bjørklund G, Buha-Đorđević A, Hamdan H, Wallace DR, Peana M. Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions. in Autoimmunity Reviews. 2024;23(3).
doi:10.1016/j.autrev.2023.103509 .
Bjørklund, Geir, Buha-Đorđević, Aleksandra, Hamdan, Halla, Wallace, David R., Peana, Massimiliano, "Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions" in Autoimmunity Reviews, 23, no. 3 (2024),
https://doi.org/10.1016/j.autrev.2023.103509 . .
5

Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status

Vukelić, Dragana; Baralić, Katarina; Marić, Đurđica; Đukić-Ćosić, Danijela; Bulat, Zorica; Panieri, Emiliano; Saso, Luciano; Buha-Đorđević, Aleksandra

(Elsevier B.V., 2024)

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Panieri, Emiliano
AU  - Saso, Luciano
AU  - Buha-Đorđević, Aleksandra
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5313
AB  - The understanding that humans are exposed to a low level of toxic metals and metalloids in their lifetime has resulted in a shift in scientific and regulatory perspectives from the traditional evaluation of single metal toxicity to complex mixtures, relevant to real-life exposure. Therefore, the aim of this study was to examine the impact of real-life, 90-days exposure to mixture of toxic metal(oid)s, Cd, Pb, Ni, Cr, As and Hg, on the nuclear factor erythroid 2–related factor 2 and hemoxygenase-1 (Nrf2/HO-1) signalling and redox status by assessing total sulfhydryl groups (SH), glutathione (GSH), superoxide dismutase activity (SOD), malondialdehyde (MDA), and ischemia modified albumin (IMA) in the liver and kidney of Wistar rats. Animals (20 males and 20 females) were randomized in 2 control and 6 treated groups that received by oral gavage mixture of metal(oid)s solutions in doses that reflect blood metal(oid) levels determined in previous human biomonitoring study as benchmark dose (F/M _BMD), median (F/M _MED), and 95th percentile (F/M _95). Our results have shown that metal(oid)s mixture impaired the activation of the Nrf2/HO-1 pathway in the kidney and liver of male rats and kidney of female rats, followed by depletion of GSH levels in males. Additionally, in males elevated levels of IMA in the liver were observed, while in both genders increased MDA levels were observed in the kidney. Interestingly, the effects were more pronounced in male than in female rats. This study is among the first that examined hepato-renal toxic mechanisms of real-life metal mixture exposure, while our results might be of immense importance for assessing the risk of exposure to mixtures of toxic substances.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status
VL  - 908
DO  - 10.1016/j.scitotenv.2023.168352
ER  - 
@article{
author = "Vukelić, Dragana and Baralić, Katarina and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Panieri, Emiliano and Saso, Luciano and Buha-Đorđević, Aleksandra",
year = "2024",
abstract = "The understanding that humans are exposed to a low level of toxic metals and metalloids in their lifetime has resulted in a shift in scientific and regulatory perspectives from the traditional evaluation of single metal toxicity to complex mixtures, relevant to real-life exposure. Therefore, the aim of this study was to examine the impact of real-life, 90-days exposure to mixture of toxic metal(oid)s, Cd, Pb, Ni, Cr, As and Hg, on the nuclear factor erythroid 2–related factor 2 and hemoxygenase-1 (Nrf2/HO-1) signalling and redox status by assessing total sulfhydryl groups (SH), glutathione (GSH), superoxide dismutase activity (SOD), malondialdehyde (MDA), and ischemia modified albumin (IMA) in the liver and kidney of Wistar rats. Animals (20 males and 20 females) were randomized in 2 control and 6 treated groups that received by oral gavage mixture of metal(oid)s solutions in doses that reflect blood metal(oid) levels determined in previous human biomonitoring study as benchmark dose (F/M _BMD), median (F/M _MED), and 95th percentile (F/M _95). Our results have shown that metal(oid)s mixture impaired the activation of the Nrf2/HO-1 pathway in the kidney and liver of male rats and kidney of female rats, followed by depletion of GSH levels in males. Additionally, in males elevated levels of IMA in the liver were observed, while in both genders increased MDA levels were observed in the kidney. Interestingly, the effects were more pronounced in male than in female rats. This study is among the first that examined hepato-renal toxic mechanisms of real-life metal mixture exposure, while our results might be of immense importance for assessing the risk of exposure to mixtures of toxic substances.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status",
volume = "908",
doi = "10.1016/j.scitotenv.2023.168352"
}
Vukelić, D., Baralić, K., Marić, Đ., Đukić-Ćosić, D., Bulat, Z., Panieri, E., Saso, L.,& Buha-Đorđević, A.. (2024). Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status. in Science of the Total Environment
Elsevier B.V.., 908.
https://doi.org/10.1016/j.scitotenv.2023.168352
Vukelić D, Baralić K, Marić Đ, Đukić-Ćosić D, Bulat Z, Panieri E, Saso L, Buha-Đorđević A. Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status. in Science of the Total Environment. 2024;908.
doi:10.1016/j.scitotenv.2023.168352 .
Vukelić, Dragana, Baralić, Katarina, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Panieri, Emiliano, Saso, Luciano, Buha-Đorđević, Aleksandra, "Hepato-renal toxicity of low dose metal(oid)s mixture in real-life risk simulation in rats: Effects on Nrf2/HO-1 signalling and redox status" in Science of the Total Environment, 908 (2024),
https://doi.org/10.1016/j.scitotenv.2023.168352 . .

Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača

Umićević, Nina; Kotur-Stevuljević, Jelena; Baralić, Katarina; Đukić-Ćosić, Danijela; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Ćurčić, Marijana; Bulat, Zorica; Antonijević, Biljana

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Umićević, Nina
AU  - Kotur-Stevuljević, Jelena
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5430
AB  - Zaposleni u industriji obuće su potencijalno izloženi smješi organskih rastvarača, što predstavlja povećan rizik od hepatotoksičnosti, neurotoksičnosti i hematotoksičnosti. Toksičnost smješe se često može previdjeti, a još uvek nema dovoljno podataka o mehanizmima koji se aktiviraju u ljudskom organizmu uslijed profesionalne izloženosti niskim koncentracijama rastvarača. ...
AB  - Employees in the shoe industry are potentially exposed to a mixture of organic solvents, which poses an increased risk of hepatotoxicity, neurotoxicity and hematotoxicity. The toxicity of the mixture can often be overlooked, and there are still uncertainties in occupational exposure to low concentrations of solvents regarding the mechanisms triggered in the human body. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača
T1  - Oxidative stress parameters in workers exposed to a mixture of low-level organic solvents
SP  - 69
EP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5430
ER  - 
@conference{
author = "Umićević, Nina and Kotur-Stevuljević, Jelena and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Zaposleni u industriji obuće su potencijalno izloženi smješi organskih rastvarača, što predstavlja povećan rizik od hepatotoksičnosti, neurotoksičnosti i hematotoksičnosti. Toksičnost smješe se često može previdjeti, a još uvek nema dovoljno podataka o mehanizmima koji se aktiviraju u ljudskom organizmu uslijed profesionalne izloženosti niskim koncentracijama rastvarača. ..., Employees in the shoe industry are potentially exposed to a mixture of organic solvents, which poses an increased risk of hepatotoxicity, neurotoxicity and hematotoxicity. The toxicity of the mixture can often be overlooked, and there are still uncertainties in occupational exposure to low concentrations of solvents regarding the mechanisms triggered in the human body. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača, Oxidative stress parameters in workers exposed to a mixture of low-level organic solvents",
pages = "69-70",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5430"
}
Umićević, N., Kotur-Stevuljević, J., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2023). Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 69-70.
https://hdl.handle.net/21.15107/rcub_farfar_5430
Umićević N, Kotur-Stevuljević J, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:69-70.
https://hdl.handle.net/21.15107/rcub_farfar_5430 .
Umićević, Nina, Kotur-Stevuljević, Jelena, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "Parametri oksidativog stresa kod radnika izloženih smješi niskih koncentracija organskih rastvarača" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):69-70,
https://hdl.handle.net/21.15107/rcub_farfar_5430 .

Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji

Živanović, Jovana; Baralić, Katarina; Božić, Dragica; Živančević, Katarina; Vukelić, Dragana; Marić, Đurđica; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5552
AB  - Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ...
AB  - Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji
T1  - Possibilities and challenges of applying artificial intelligence in toxicology
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5552
ER  - 
@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Veštačka inteligencija predstavlja upotrebu mašina i softvera za konstrukciju modela koji oponašaju kognitivne sposobnosti ljudi u rešavanju problema iz realnog sveta. S obzirom na njenu sve veću primenu u različitim oblastima biomedicinskih nauka, cilj ovog rada je da se predstave mogućnosti i izazovi primene modela zasnovanih na veštačkoj inteligenciji u toksikologiji. ..., Artificial intelligence involves the use of machines and software to create models that mimic the cognitive abilities of humans in solving real-world problems. Given their increasing application in various fields of biomedical sciences, this work aimed to present the possibilities of applying artificial intelligence-based models in toxicology. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji, Possibilities and challenges of applying artificial intelligence in toxicology",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5552"
}
Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552
Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5552 .
Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Mogućnosti i izazovi primene veštačke inteligencije u toksikologiji" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5552 .

Komparativna toksikogenomska baza podataka: Nove mogućnosti

Živanović, Jovana; Baralić, Katarina; Božić, Dragica; Živančević, Katarina; Vukelić, Dragana; Marić, Đurđica; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5514
AB  - Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ...
AB  - In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Komparativna toksikogenomska baza podataka: Nove mogućnosti
T1  - The Comparative Toxicogenomic Database: New possibilities
SP  - 157
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5514
ER  - 
@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Poslednje dve decenije intenzivno se razvija toksikogenomika sa ciljem da prikupi, objedini i analizira podatke o uticaju toksičnih supstanci na nivou gena i da ih integriše u baze podataka, poput Komparativne toksikogenomske baze podataka (engl. Comparative Toxicogenomic Database, CTD; http:// ctdbase.org/). ..., In the last two decades, toxicogenomics has been intensively developed with the aim of collecting, standardizing, and analyzing data on toxic substances that affect genes and integrating them into databases, such as the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/). ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Komparativna toksikogenomska baza podataka: Nove mogućnosti, The Comparative Toxicogenomic Database: New possibilities",
pages = "157-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5514"
}
Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514
Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. Komparativna toksikogenomska baza podataka: Nove mogućnosti. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:157-158.
https://hdl.handle.net/21.15107/rcub_farfar_5514 .
Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Komparativna toksikogenomska baza podataka: Nove mogućnosti" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):157-158,
https://hdl.handle.net/21.15107/rcub_farfar_5514 .

Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?

Manić, Luka; Đorđević, Vladimir; Grubor, Nikica; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela; Uysal-Onganer, Pinar; Mortoglou, Maria; Wallace, David; Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Manić, Luka
AU  - Đorđević, Vladimir
AU  - Grubor, Nikica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5512
AB  - Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ...
AB  - There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?
T1  - A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?
SP  - 143
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5512
ER  - 
@conference{
author = "Manić, Luka and Đorđević, Vladimir and Grubor, Nikica and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Istraživanje u oblasti karcinoma pankreasa i zagađivača iz životne sredine sve je intenzivnije. Za neke od ovih zagađivača pretpostavlja se da su povezani sa nastankom ili progresijom karcinoma pankreasa. Nijedna meta-analiza o povezanosti navedenog nije sprovedena, dok bi rezultati iste mogli pomoći u tumačenju dostupnih podataka i usmeravanju budućeg istraživanja. ..., There is a rise in research on the connection between pancreatic cancer and environmental pollutants. Some of these pollutants are assumed to be associated with the onset or progression of pancreatic cancer. No meta-analyses summarizing the association between these two have been conducted yet, while the results of such an analysis could help interpret current and guide future research.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?, A meta-analysis excerpt: Is exposure to environmental pollutants associated with pancreatic cancer?",
pages = "143-146",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5512"
}
Manić, L., Đorđević, V., Grubor, N., Bulat, Z., Antonijević, B., Đukić-Ćosić, D., Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512
Manić L, Đorđević V, Grubor N, Bulat Z, Antonijević B, Đukić-Ćosić D, Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:143-146.
https://hdl.handle.net/21.15107/rcub_farfar_5512 .
Manić, Luka, Đorđević, Vladimir, Grubor, Nikica, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Odlomak iz meta-analize: Da li je izloženost zagađivačima iz životne sredine povezana sa karcinomom pankreasa?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):143-146,
https://hdl.handle.net/21.15107/rcub_farfar_5512 .

Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova

Marić, Đurđica; Vukelić, Dragana; Milovanović, Vesna; Bulat, Zorica; Ćurčić, Marijana; Đukić-Ćosić, Danijela; Lukić, Vera; Antonijević, Biljana; Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Milovanović, Vesna
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Lukić, Vera
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5508
AB  - Endokrini ometači, u koje se između ostalih ubrajaju i toksični metali poput kadmijuma (Cd), se dovode u vezu sa sve češćom pojavom neplodnosti i poremećajima reproduktivnog zdravlja. Kako je jedan od najznačajnijih mehanizama toksičnosti Cd njegova interakcija sa bioelementima, dalje ispitivanje ovog mehanizma moglo bi da doprinese rasvetljavanju mehanizama toksičnosti ovog metala u testisima, kao i uloge izloženosti ovom metalu u reproduktivnom zdravlju.
AB  - Endocrine disruptors, which include, but are not limited to, toxic metals such as Cd, have been linked to the increasing incidence of infertility and reproductive health disorders. As one of the most important mechanisms of Cd toxicity is its interaction with bioelements, further investigation of this mechanism could contribute to a better understanding of mechanisms of endocrine-disrupting Cd activities in testes and its role in human reproductive health.
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova
T1  - Effect of cadmium intoxication on the bioelements levels in testicular tissue of rats
SP  - 103
EP  - 104
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5508
ER  - 
@conference{
author = "Marić, Đurđica and Vukelić, Dragana and Milovanović, Vesna and Bulat, Zorica and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Lukić, Vera and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Endokrini ometači, u koje se između ostalih ubrajaju i toksični metali poput kadmijuma (Cd), se dovode u vezu sa sve češćom pojavom neplodnosti i poremećajima reproduktivnog zdravlja. Kako je jedan od najznačajnijih mehanizama toksičnosti Cd njegova interakcija sa bioelementima, dalje ispitivanje ovog mehanizma moglo bi da doprinese rasvetljavanju mehanizama toksičnosti ovog metala u testisima, kao i uloge izloženosti ovom metalu u reproduktivnom zdravlju., Endocrine disruptors, which include, but are not limited to, toxic metals such as Cd, have been linked to the increasing incidence of infertility and reproductive health disorders. As one of the most important mechanisms of Cd toxicity is its interaction with bioelements, further investigation of this mechanism could contribute to a better understanding of mechanisms of endocrine-disrupting Cd activities in testes and its role in human reproductive health.",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova, Effect of cadmium intoxication on the bioelements levels in testicular tissue of rats",
pages = "103-104",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5508"
}
Marić, Đ., Vukelić, D., Milovanović, V., Bulat, Z., Ćurčić, M., Đukić-Ćosić, D., Lukić, V., Antonijević, B.,& Buha-Đorđević, A.. (2023). Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 103-104.
https://hdl.handle.net/21.15107/rcub_farfar_5508
Marić Đ, Vukelić D, Milovanović V, Bulat Z, Ćurčić M, Đukić-Ćosić D, Lukić V, Antonijević B, Buha-Đorđević A. Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:103-104.
https://hdl.handle.net/21.15107/rcub_farfar_5508 .
Marić, Đurđica, Vukelić, Dragana, Milovanović, Vesna, Bulat, Zorica, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Lukić, Vera, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Efekat intoksikacije kadmijumom na nivoe bielemenata u tkivu testisa pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):103-104,
https://hdl.handle.net/21.15107/rcub_farfar_5508 .

Hematotoxicity of lead, cadmium, mercury and arsenic low dosed mixtures relevant to environmental exposure: the Adverse Outcome Pathway framewor

Živančević, Katarina; Živanović, Jovana; Baralić, Katarina; Božić, Dragica; Marić, Đurđica; Vukelić, Dragana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Ćurčić, Marijana; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(Elsevier, 2023)

TY  - CONF
AU  - Živančević, Katarina
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Marić, Đurđica
AU  - Vukelić, Dragana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5170
AB  - Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...
PB  - Elsevier
C3  - Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
T1  - Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor
VL  - 384
IS  - S1
SP  - S78
EP  - S78
DO  - 10.1016/S0378-4274(23)00454-X
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5170
ER  - 
@conference{
author = "Živančević, Katarina and Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Marić, Đurđica and Vukelić, Dragana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Prostate cancer is a major cause of death in men. Traditional therapies have limited efficacy, leading to the increased interest in phytochemicals like sulforaphane (SFN), found in cruciferous vegetables. ...",
publisher = "Elsevier",
journal = "Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia",
title = "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor",
volume = "384",
number = "S1",
pages = "S78-S78",
doi = "10.1016/S0378-4274(23)00454-X",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5170"
}
Živančević, K., Živanović, J., Baralić, K., Božić, D., Marić, Đ., Vukelić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia
Elsevier., 384(S1), S78-S78.
https://doi.org/10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170
Živančević K, Živanović J, Baralić K, Božić D, Marić Đ, Vukelić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor. in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia. 2023;384(S1):S78-S78.
doi:10.1016/S0378-4274(23)00454-X
https://hdl.handle.net/21.15107/rcub_farfar_5170 .
Živančević, Katarina, Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Marić, Đurđica, Vukelić, Dragana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Hematotoxicity of lead, cadmium, mercury and arsenic  low dosed mixtures relevant to environmental exposure:  the Adverse Outcome Pathway framewor" in Toxicology Letters, 57th Congress of the European Toxicologists and European Societies of Toxicology, EUROTOX Congress 2023 “Toxicology – multidisciplinary science leading to safer and sustainable life”, 10 - 13 September 2023, Ljubljana, Slovenia, 384, no. S1 (2023):S78-S78,
https://doi.org/10.1016/S0378-4274(23)00454-X .,
https://hdl.handle.net/21.15107/rcub_farfar_5170 .

From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles

Aschner, Michael; Skalny, Anatoly; Santamaria, Abel; Buha-Đorđević, Aleksandra; Tizabi, Yousef; Jiang, Yueming; Lu, Rongzhu; Virgolini, Miriam B.; Tinkov, Alexey A.

(IMR Press Limited, 2023)

TY  - JOUR
AU  - Aschner, Michael
AU  - Skalny, Anatoly
AU  - Santamaria, Abel
AU  - Buha-Đorđević, Aleksandra
AU  - Tizabi, Yousef
AU  - Jiang, Yueming
AU  - Lu, Rongzhu
AU  - Virgolini, Miriam B.
AU  - Tinkov, Alexey A.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5081
AB  - Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
PB  - IMR Press Limited
T2  - Frontiers in Bioscience - Landmark
T1  - From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
VL  - 28
IS  - 9
SP  - 1
EP  - 21
DO  - 10.31083/j.fbl2809204
ER  - 
@article{
author = "Aschner, Michael and Skalny, Anatoly and Santamaria, Abel and Buha-Đorđević, Aleksandra and Tizabi, Yousef and Jiang, Yueming and Lu, Rongzhu and Virgolini, Miriam B. and Tinkov, Alexey A.",
year = "2023",
abstract = "Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.",
publisher = "IMR Press Limited",
journal = "Frontiers in Bioscience - Landmark",
title = "From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles",
volume = "28",
number = "9",
pages = "1-21",
doi = "10.31083/j.fbl2809204"
}
Aschner, M., Skalny, A., Santamaria, A., Buha-Đorđević, A., Tizabi, Y., Jiang, Y., Lu, R., Virgolini, M. B.,& Tinkov, A. A.. (2023). From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles. in Frontiers in Bioscience - Landmark
IMR Press Limited., 28(9), 1-21.
https://doi.org/10.31083/j.fbl2809204
Aschner M, Skalny A, Santamaria A, Buha-Đorđević A, Tizabi Y, Jiang Y, Lu R, Virgolini MB, Tinkov AA. From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles. in Frontiers in Bioscience - Landmark. 2023;28(9):1-21.
doi:10.31083/j.fbl2809204 .
Aschner, Michael, Skalny, Anatoly, Santamaria, Abel, Buha-Đorđević, Aleksandra, Tizabi, Yousef, Jiang, Yueming, Lu, Rongzhu, Virgolini, Miriam B., Tinkov, Alexey A., "From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles" in Frontiers in Bioscience - Landmark, 28, no. 9 (2023):1-21,
https://doi.org/10.31083/j.fbl2809204 . .
7

Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans

Javorac, Dragana; Baralić, Katarina; Marić, Đurđica; Mandić-Rajčević, Stefan; Đukić-Ćosić, Danijela; Bulat, Zorica; Buha-Đorđević, Aleksandra

(Elsevier Ltd, 2023)

TY  - JOUR
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Mandić-Rajčević, Stefan
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4299
AB  - Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.
PB  - Elsevier Ltd
T2  - Environmental Pollution
T1  - Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans
VL  - 316
DO  - 10.1016/j.envpol.2022.120428
ER  - 
@article{
author = "Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Mandić-Rajčević, Stefan and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.",
publisher = "Elsevier Ltd",
journal = "Environmental Pollution",
title = "Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans",
volume = "316",
doi = "10.1016/j.envpol.2022.120428"
}
Javorac, D., Baralić, K., Marić, Đ., Mandić-Rajčević, S., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans. in Environmental Pollution
Elsevier Ltd., 316.
https://doi.org/10.1016/j.envpol.2022.120428
Javorac D, Baralić K, Marić Đ, Mandić-Rajčević S, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans. in Environmental Pollution. 2023;316.
doi:10.1016/j.envpol.2022.120428 .
Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Mandić-Rajčević, Stefan, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Exploring the endocrine disrupting potential of lead through benchmark
modelling – Study in humans" in Environmental Pollution, 316 (2023),
https://doi.org/10.1016/j.envpol.2022.120428 . .
2
13
11

Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma

Uysal-Onganer, Pinar; Mortoglou, Maria; Wallace, David; Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Uysal-Onganer, Pinar
AU  - Mortoglou, Maria
AU  - Wallace, David
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5500
AB  - Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, with a 5-year overall survival of less than 8%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma
SP  - 10
EP  - 10
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5500
ER  - 
@conference{
author = "Uysal-Onganer, Pinar and Mortoglou, Maria and Wallace, David and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, with a 5-year overall survival of less than 8%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma",
pages = "10-10",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5500"
}
Uysal-Onganer, P., Mortoglou, M., Wallace, D.,& Buha-Đorđević, A.. (2023). Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 10-10.
https://hdl.handle.net/21.15107/rcub_farfar_5500
Uysal-Onganer P, Mortoglou M, Wallace D, Buha-Đorđević A. Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:10-10.
https://hdl.handle.net/21.15107/rcub_farfar_5500 .
Uysal-Onganer, Pinar, Mortoglou, Maria, Wallace, David, Buha-Đorđević, Aleksandra, "Role of cadmium and nickel on selected microrna expression in pancreatic ductal adenocarcinoma" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):10-10,
https://hdl.handle.net/21.15107/rcub_farfar_5500 .

Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta

Buha-Đorđević, Aleksandra

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5419
AB  - Ekspozom predstavlja sredinski ekvivalent ljudskom genomu. Istražujući ulogu toksičnih metala u različitim endokrinim poremećajima, projekat DecodExpo je nastojao da istraži kompleksne uticaje poreklom iz životne sredine na ljudsko endokrino zdravlje. Prvi deo projekta sastojao se iz studije hu- manog biomonitoringa (HBM), koja je nastojala da utvrdi nivoe odabranih šest toksičnih meta(oid)a (Pb, Cd, Hg, As, Cr i Ni), kojima su ljudi izloženi u svakodnevnom životu, kao i da ispita vezu između metala i različitih nivoa hormona u organizmu. ...
AB  - The exposome represents the environmental equivalent of the human genome. The DecodExpo project
aimed to explore the relationship between toxic metals present in the environment and various
endocrine disorders. The first part of the project involved a human biomonitoring (HBM) study, which
measured the levels of six toxic metal(oid)s (Pb, Cd, Hg, As, Cr, and Ni) in the general population and
examined their connection to hormone levels in the body.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta
T1  - Investing the role of exposome in human endocrine health: DecodExpo project results
SP  - 11
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5419
ER  - 
@conference{
author = "Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Ekspozom predstavlja sredinski ekvivalent ljudskom genomu. Istražujući ulogu toksičnih metala u različitim endokrinim poremećajima, projekat DecodExpo je nastojao da istraži kompleksne uticaje poreklom iz životne sredine na ljudsko endokrino zdravlje. Prvi deo projekta sastojao se iz studije hu- manog biomonitoringa (HBM), koja je nastojala da utvrdi nivoe odabranih šest toksičnih meta(oid)a (Pb, Cd, Hg, As, Cr i Ni), kojima su ljudi izloženi u svakodnevnom životu, kao i da ispita vezu između metala i različitih nivoa hormona u organizmu. ..., The exposome represents the environmental equivalent of the human genome. The DecodExpo project
aimed to explore the relationship between toxic metals present in the environment and various
endocrine disorders. The first part of the project involved a human biomonitoring (HBM) study, which
measured the levels of six toxic metal(oid)s (Pb, Cd, Hg, As, Cr, and Ni) in the general population and
examined their connection to hormone levels in the body.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta, Investing the role of exposome in human endocrine health: DecodExpo project results",
pages = "11-12",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5419"
}
Buha-Đorđević, A.. (2023). Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 11-12.
https://hdl.handle.net/21.15107/rcub_farfar_5419
Buha-Đorđević A. Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:11-12.
https://hdl.handle.net/21.15107/rcub_farfar_5419 .
Buha-Đorđević, Aleksandra, "Ispitivanje uloge ekspozoma u endokrinom zdravlju ljudi: rezultati DecodExpo projekta" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):11-12,
https://hdl.handle.net/21.15107/rcub_farfar_5419 .

Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?

Vukelić, Dragana; Petrović, Bojana; Marić, Đurđica; Baralić, Katarina; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Đukić-Ćosić, Danijela; Ćurčić, Marijana; Antonijević, Biljana; Bulat, Zorica

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Vukelić, Dragana
AU  - Petrović, Bojana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5486
AB  - Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ...
AB  - Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?
T1  - Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?
SP  - 59
EP  - 60
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5486
ER  - 
@conference{
author = "Vukelić, Dragana and Petrović, Bojana and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Zagađenje vazduha predstavlja ekološki faktor rizika koji je povezan sa 1% svih slučajeva razvoja karcinoma i 2% svih smrtnih slučajeva usled razvoja karcinoma u Evropi. Postoji veliki broj podataka koji ukazuju na vezu između zagađenja vazduha, posebno suspendovanih čestica (PM), i pojave karcinoma pluća. ..., Air pollution represents environmental risk factor linked to 1% of all cancer incidences and 2% of all cancer deaths in Europe. There is a strong body of data linking outdoor (ambient) air pollution, particularly particulate matter (PM), with lung cancer incidence.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?, Exposure to outdoor air pollution and cancer development: Is air pollution responsible for more than lung cancer?",
pages = "59-60",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5486"
}
Vukelić, D., Petrović, B., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486
Vukelić D, Petrović B, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:59-60.
https://hdl.handle.net/21.15107/rcub_farfar_5486 .
Vukelić, Dragana, Petrović, Bojana, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Uticaj zagađenja vazduha na pojavu i razvoj karcinoma: Da li su ugrožena samo pluća?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):59-60,
https://hdl.handle.net/21.15107/rcub_farfar_5486 .

Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda

Repić, Aleksandra; Lukić, Vera; Ždrale, Branislava; Vukelić, Dragana; Buha-Đorđević, Aleksandra; Bulat, Petar; Bulat, Zorica

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Repić, Aleksandra
AU  - Lukić, Vera
AU  - Ždrale, Branislava
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Petar
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5484
AB  - Olovo (Pb) i kadmijum (Cd) su toksični metali kojima je stanovništvo primarno izloženo iz životne i/
ili radne sredine. Dugotrajna izloženost čak i niskim koncentracijama Pb i Cd može doprineti razvoju
različitih bolesti. Cilj istraživanja je određivanje nivoa Pb i Cd u punoj krvi stanovnika Beograda dobrovoljnih
davaoca krvi i identifikovanje faktora koji utiču na njihove koncentracije. ...
AB  - Lead (Pb) and cadmium (Cd) are toxic metals whose primary exposure is through the living and/or working environment. Even long-term exposure to low concentrations can affect the development of some disorders. The aim of this study was to determine the levels of Pb and Cd in the whole blood of the residents of Belgrade, voluntary blood donors, and to identify factors that most influence their concentrations. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda
T1  - The influence of individual factors and lifestyle on the level of lead and cadmium in the blood of Belgrade residents
SP  - 46
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5484
ER  - 
@conference{
author = "Repić, Aleksandra and Lukić, Vera and Ždrale, Branislava and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Bulat, Petar and Bulat, Zorica",
year = "2023",
abstract = "Olovo (Pb) i kadmijum (Cd) su toksični metali kojima je stanovništvo primarno izloženo iz životne i/
ili radne sredine. Dugotrajna izloženost čak i niskim koncentracijama Pb i Cd može doprineti razvoju
različitih bolesti. Cilj istraživanja je određivanje nivoa Pb i Cd u punoj krvi stanovnika Beograda dobrovoljnih
davaoca krvi i identifikovanje faktora koji utiču na njihove koncentracije. ..., Lead (Pb) and cadmium (Cd) are toxic metals whose primary exposure is through the living and/or working environment. Even long-term exposure to low concentrations can affect the development of some disorders. The aim of this study was to determine the levels of Pb and Cd in the whole blood of the residents of Belgrade, voluntary blood donors, and to identify factors that most influence their concentrations. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda, The influence of individual factors and lifestyle on the level of lead and cadmium in the blood of Belgrade residents",
pages = "46-47",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5484"
}
Repić, A., Lukić, V., Ždrale, B., Vukelić, D., Buha-Đorđević, A., Bulat, P.,& Bulat, Z.. (2023). Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 46-47.
https://hdl.handle.net/21.15107/rcub_farfar_5484
Repić A, Lukić V, Ždrale B, Vukelić D, Buha-Đorđević A, Bulat P, Bulat Z. Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:46-47.
https://hdl.handle.net/21.15107/rcub_farfar_5484 .
Repić, Aleksandra, Lukić, Vera, Ždrale, Branislava, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Bulat, Petar, Bulat, Zorica, "Uticaj individualnih faktora i stila života na nivoe olova i kadmijuma u krvi stanovnika Beograda" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):46-47,
https://hdl.handle.net/21.15107/rcub_farfar_5484 .

Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?

Ćurčić, Marijana; Buha-Đorđević, Aleksandra; Milovanović, Vesna; Antonijević-Miljaković, Evica; Đukić-Ćosić, Danijela; Bulat, Zorica; Antonijević, Biljana

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5440
AB  - Dekabromovani difenil etar (BDE-209) je široko rasprostranjena toksična supstanca u životnoj sredini,
posebno na mestima odlaganja električnog i elektronskog otpada. Sa deponija se BDE-209 može oslo-
boditi u životnu sredini i dospeti do organizma čoveka, i eventualno uzrokovati štetne efekte. ...
AB  - Deca brominated diphenyl ether (BDE-209) is a widely present toxic substance in the environment,
particularly in electrical and electronic waste sites. From landfill sites, BDE-209 can be released into the
environment, reach humans and possibly induce adverse effects. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?
T1  - Are the zinc and copper involved in toxic effects induced by BDE-209 in the brain of Wistar rats?
SP  - 25
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5440
ER  - 
@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Dekabromovani difenil etar (BDE-209) je široko rasprostranjena toksična supstanca u životnoj sredini,
posebno na mestima odlaganja električnog i elektronskog otpada. Sa deponija se BDE-209 može oslo-
boditi u životnu sredini i dospeti do organizma čoveka, i eventualno uzrokovati štetne efekte. ..., Deca brominated diphenyl ether (BDE-209) is a widely present toxic substance in the environment,
particularly in electrical and electronic waste sites. From landfill sites, BDE-209 can be released into the
environment, reach humans and possibly induce adverse effects. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?, Are the zinc and copper involved in toxic effects induced by BDE-209 in the brain of Wistar rats?",
pages = "25-26",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5440"
}
Ćurčić, M., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 25-26.
https://hdl.handle.net/21.15107/rcub_farfar_5440
Ćurčić M, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Bulat Z, Antonijević B. Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:25-26.
https://hdl.handle.net/21.15107/rcub_farfar_5440 .
Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "Da li su cink i bakar uključeni u toksične efekte u mozgu Wistar pacova indukovane primenom BDE-209?" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):25-26,
https://hdl.handle.net/21.15107/rcub_farfar_5440 .

Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza

Božić, Dragica; Baralić, Katarina; Živančević, Katarina; Buha-Đorđević, Aleksandra; Antonijević-Miljaković, Evica; Ćurčić, Marijana; Bulat, Zorica; Antonijević, Biljana; Zhang, Yi; Yang, Li; Đukić-Ćosić, Danijela

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Božić, Dragica
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Zhang, Yi
AU  - Yang, Li
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5425
AB  - Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ...
AB  - Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza
T1  - Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis
SP  - 61
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5425
ER  - 
@conference{
author = "Božić, Dragica and Baralić, Katarina and Živančević, Katarina and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Zhang, Yi and Yang, Li and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforafan (SFN) je imunomodulator poreklom iz kupusastog povrća čija su antioksidativna i antikancerogena svojstva prepoznata sredinom prošlog veka. Međutim, njegov toksikološki profil i potencijal da izazove štetne efekte su nedovoljno razjašnjeni. Cilj ove studije bio je predviđanje toksičnog potencijala SFN kombinovanjem bioinformatičkih analiza. ..., Sulforaphane (SFN) is an immunomodulator from cruciferous vegetables whose anti-oxidative and anti-carcinogenic properties were recognized in the middle of the last century. However, its toxicological profile remains insufficiently elucidated. The aim of the study was to predict the toxicity of SFN by combining bioinformatic analyses. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza, Predicting toxic effects of an immunomodulator, sulforaphane: Bioinformatic analsis",
pages = "61-62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5425"
}
Božić, D., Baralić, K., Živančević, K., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B., Zhang, Y., Yang, L.,& Đukić-Ćosić, D.. (2023). Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425
Božić D, Baralić K, Živančević K, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Zhang Y, Yang L, Đukić-Ćosić D. Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:61-62.
https://hdl.handle.net/21.15107/rcub_farfar_5425 .
Božić, Dragica, Baralić, Katarina, Živančević, Katarina, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Zhang, Yi, Yang, Li, Đukić-Ćosić, Danijela, "Predviđanje toksičnih efekata imunomodulatora sulforafana: Bioinformatička analiza" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):61-62,
https://hdl.handle.net/21.15107/rcub_farfar_5425 .

Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje

Vukelić, Dragana; Anđelković, Milena; Repić, Aleksandra; Marić, Đurđica; Baralić, Katarina; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Kotur-Stevuljević, Jelena; Đukić-Ćosić, Danijela; Ćurčić, Marijana; Antonijević, Biljana; Bulat, Zorica

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Vukelić, Dragana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5423
AB  - Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ...
AB  - Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje
T1  - Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling
SP  - 57
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5423
ER  - 
@conference{
author = "Vukelić, Dragana and Anđelković, Milena and Repić, Aleksandra and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "Novija saznanja ukazuju da niska izloženost olovu (Pb), koja se u današnje vreme sreće, predstavlja rizik
po zdravlje ljudi. Jedan od najznačajnijih mehanizama toksičnosti Pb je oksidativni stres koji nastaje
usled osobine Pb da indukuje stvaranje slobodnih kiseoničnih i azotovih radikala i suprimira antioksidativnu zaštitu. ..., Recent findings indicate that low-dose lead (Pb) exposure, which is encountered today, represents a
risk to human health. One of the most important mechanisms of Pb toxicity is oxidative stress, which
occurs due to Pb ability to induce the formation of free oxygen and nitrogen radicals and suppress
antioxidant protection. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje, Oxidative stress induced by low doses of lead: a Subacute toxicity study in Wistar rats and Benchmark modeling",
pages = "57-58",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5423"
}
Vukelić, D., Anđelković, M., Repić, A., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2023). Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423
Vukelić D, Anđelković M, Repić A, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:57-58.
https://hdl.handle.net/21.15107/rcub_farfar_5423 .
Vukelić, Dragana, Anđelković, Milena, Repić, Aleksandra, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Oksidativni stres izazvan niskim dozama olova: Subakutna studija toksičnosti na Wistar pacovima i Benchmark modelovanje" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):57-58,
https://hdl.handle.net/21.15107/rcub_farfar_5423 .

Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova

Stojilković, Nikola; Stojković, Miodrag; Ćurčić, Marijana; Vukelić, Dragana; Buha-Đorđević, Aleksandra; Stojanović, Aleksandra; Zdravković, Aleksandra; Stojadinović, Tina; Marić, Đurđica; Baralić, Katarina; Antonijević, Biljana

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Stojilković, Nikola
AU  - Stojković, Miodrag
AU  - Ćurčić, Marijana
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Stojanović, Aleksandra
AU  - Zdravković, Aleksandra
AU  - Stojadinović, Tina
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5428
AB  - Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ...
AB  - One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova
T1  - Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats
SP  - 65
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5428
ER  - 
@conference{
author = "Stojilković, Nikola and Stojković, Miodrag and Ćurčić, Marijana and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Stojanović, Aleksandra and Zdravković, Aleksandra and Stojadinović, Tina and Marić, Đurđica and Baralić, Katarina and Antonijević, Biljana",
year = "2023",
abstract = "Jedan od najvećih izazova u toksikologiji je procena toksičnosti hemijskim smešama, odnosno procena
rizika po zdravlje ljudi usled celoživotnog izlaganja složenim smešama različitih supstanci. Studije bio-
monitoringa su nesumnjivo pokazale prisustvo preko stotinu hemikalija u ljudskom telu. ..., One of the biggest challenges in toxicology is the evaluation of the toxicity of chemical mixtures, as
well as the risk to human health due to lifelong exposure to complex mixtures of different substances.
Biomonitoring studies have undoubtedly shown the presence of over a hundred chemicals in the
human body. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova, Effect of lead and polychlorinated-biphenyls mixture on sperm cells and serum level of testosterone in rats",
pages = "65-66",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5428"
}
Stojilković, N., Stojković, M., Ćurčić, M., Vukelić, D., Buha-Đorđević, A., Stojanović, A., Zdravković, A., Stojadinović, T., Marić, Đ., Baralić, K.,& Antonijević, B.. (2023). Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428
Stojilković N, Stojković M, Ćurčić M, Vukelić D, Buha-Đorđević A, Stojanović A, Zdravković A, Stojadinović T, Marić Đ, Baralić K, Antonijević B. Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:65-66.
https://hdl.handle.net/21.15107/rcub_farfar_5428 .
Stojilković, Nikola, Stojković, Miodrag, Ćurčić, Marijana, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Stojanović, Aleksandra, Zdravković, Aleksandra, Stojadinović, Tina, Marić, Đurđica, Baralić, Katarina, Antonijević, Biljana, "Efekti smeše olova i polihlorovanih-bifenila na spermatozoide i nivo testosterona kod pacova" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):65-66,
https://hdl.handle.net/21.15107/rcub_farfar_5428 .

In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19

Živanović, Jovana; Baralić, Katarina; Božić, Dragica; Živančević, Katarina; Vukelić, Dragana; Marić, Đurđica; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Bulat, Zorica; Antonijević, Biljana; Đukić-Ćosić, Danijela

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Živanović, Jovana
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5168
AB  - Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ...
AB  - Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19
T1  - In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease
SP  - 37
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5168
ER  - 
@conference{
author = "Živanović, Jovana and Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Vukelić, Dragana and Marić, Đurđica and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Izloženost ljudi na radnom mestu ili iz životne sredine toksičnim metalima može da izazove štetne efekte na plućima, bubrezima, jetri, itd. Sa pojavom infektivnog oboljenja, COVID-19, koje izaziva novi korona virus 2 (SARS-CoV-2), nametnulo se pitanje da li izloženost toksičnim metalima može da doprinese razvoju komplikacija ove bolesti, budući da virus dominantno deluje na pluća. ..., Exposure of people to toxic metals in workplace or environment can have harmful effects on the lungs, kidneys, liver, etc. With the emergence of an infectious disease, COVID-19, caused by the new coronavirus 2 (SARS-CoV-2), the question arose whether exposure to toxic metals contributes to the development of complications of this disease, since this virus mainly affects lungs.  ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19, In silico analysis of toxicogenomic data on the influence of toxic metals on the complications of COVID-19 disease",
pages = "37-38",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5168"
}
Živanović, J., Baralić, K., Božić, D., Živančević, K., Vukelić, D., Marić, Đ., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168
Živanović J, Baralić K, Božić D, Živančević K, Vukelić D, Marić Đ, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Bulat Z, Antonijević B, Đukić-Ćosić D. In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:37-38.
https://hdl.handle.net/21.15107/rcub_farfar_5168 .
Živanović, Jovana, Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Vukelić, Dragana, Marić, Đurđica, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "In silico analiza toksikogenomskih podataka o uticaju toksičnih metala na komplikacije bolesti COVID-19" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):37-38,
https://hdl.handle.net/21.15107/rcub_farfar_5168 .

Nickel as a potential disruptor of thyroid function: benchmark modelling of human data

Marić, Đurđica; Baralić, Katarina; Javorac, Dragana; Mandić-Rajčević, Stefan; Žarković, Miloš; Antonijević, Biljana; Đukić-Ćosić, Danijela; Bulat, Zorica; Buha-Đorđević, Aleksandra

(Frontiers Media SA, 2023)

TY  - JOUR
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Mandić-Rajčević, Stefan
AU  - Žarković, Miloš
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5144
AB  - Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni to disrupt thyroid function by exploring the relationship between blood Ni concentration and serum hormone levels (TSH, T4, T3, fT4 and fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using correlation analysis and Benchmark (BMD) concept. Methods: Ni concentration was measured by ICP-MS method, while CLIA was used for serum hormone determination. SPINA Thyr software was used to calculate SPINA-GT and SPINA-GD parameters. BMD analysis was performed by PROAST software (70.1). The limitations of this study are the small sample size and the uneven distribution of healthy and unhealthy subjects, limited confounding factors, as well as the age of the subjects that could have influenced the obtained results. Results and discussion: The highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was established between Ni and all the measured parameters of thyroid functions in entire population and in both sexes. However, the narrowest BMD intervals were obtained only in men, for Ni - SPINA-GT pair (1.36-60.9 µg/L) and Ni - fT3 pair (0.397-66.8 µg/L), indicating that even 78.68 and 83.25% of men in our study might be in 10% higher risk of Ni-induced SPINA-GT and fT3 alterations, respectively. Due to the relationship established between Ni and the SPINA-GT parameter, it can be concluded that Ni has an influence on the secretory function of the thyroid gland in men. Although the further research is required, these findings suggest possible role of Ni in thyroid function disturbances. Copyright
PB  - Frontiers Media SA
T2  - Frontiers in Endocrinology
T1  - Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
VL  - 14
DO  - 10.3389/fendo.2023.1145153
ER  - 
@article{
author = "Marić, Đurđica and Baralić, Katarina and Javorac, Dragana and Mandić-Rajčević, Stefan and Žarković, Miloš and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni to disrupt thyroid function by exploring the relationship between blood Ni concentration and serum hormone levels (TSH, T4, T3, fT4 and fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using correlation analysis and Benchmark (BMD) concept. Methods: Ni concentration was measured by ICP-MS method, while CLIA was used for serum hormone determination. SPINA Thyr software was used to calculate SPINA-GT and SPINA-GD parameters. BMD analysis was performed by PROAST software (70.1). The limitations of this study are the small sample size and the uneven distribution of healthy and unhealthy subjects, limited confounding factors, as well as the age of the subjects that could have influenced the obtained results. Results and discussion: The highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was established between Ni and all the measured parameters of thyroid functions in entire population and in both sexes. However, the narrowest BMD intervals were obtained only in men, for Ni - SPINA-GT pair (1.36-60.9 µg/L) and Ni - fT3 pair (0.397-66.8 µg/L), indicating that even 78.68 and 83.25% of men in our study might be in 10% higher risk of Ni-induced SPINA-GT and fT3 alterations, respectively. Due to the relationship established between Ni and the SPINA-GT parameter, it can be concluded that Ni has an influence on the secretory function of the thyroid gland in men. Although the further research is required, these findings suggest possible role of Ni in thyroid function disturbances. Copyright",
publisher = "Frontiers Media SA",
journal = "Frontiers in Endocrinology",
title = "Nickel as a potential disruptor of thyroid function: benchmark modelling of human data",
volume = "14",
doi = "10.3389/fendo.2023.1145153"
}
Marić, Đ., Baralić, K., Javorac, D., Mandić-Rajčević, S., Žarković, M., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Nickel as a potential disruptor of thyroid function: benchmark modelling of human data. in Frontiers in Endocrinology
Frontiers Media SA., 14.
https://doi.org/10.3389/fendo.2023.1145153
Marić Đ, Baralić K, Javorac D, Mandić-Rajčević S, Žarković M, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Nickel as a potential disruptor of thyroid function: benchmark modelling of human data. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1145153 .
Marić, Đurđica, Baralić, Katarina, Javorac, Dragana, Mandić-Rajčević, Stefan, Žarković, Miloš, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Nickel as a potential disruptor of thyroid function: benchmark modelling of human data" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1145153 . .
6

Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats

Radović, Biljana; Stojilković, Nikola; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Buha-Đorđević, Aleksandra; Baralić, Katarina; Vukelić, Dragana; Đukić-Ćosić, Danijela; Marić, Đurđica; Bulat, Zorica; Antonijević, Biljana

(Elsevier, 2023)

TY  - CONF
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Đukić-Ćosić, Danijela
AU  - Marić, Đurđica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5175
AB  - Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats
VL  - 384
IS  - S1
SP  - S223
EP  - S223
DO  - 10.1016/S0378-4274(23)00790-7
ER  - 
@conference{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Baralić, Katarina and Vukelić, Dragana and Đukić-Ćosić, Danijela and Marić, Đurđica and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "Considering that combined exposure to toxic metals and organic pollutants may induce various adverse effects on human health, it is important to elucidate the mechanisms of toxicity that occur after lowdose exposure to these chemicals in a real-life scenario. ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats",
volume = "384",
number = "S1",
pages = "S223-S223",
doi = "10.1016/S0378-4274(23)00790-7"
}
Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Baralić, K., Vukelić, D., Đukić-Ćosić, D., Marić, Đ., Bulat, Z.,& Antonijević, B.. (2023). Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters
Elsevier., 384(S1), S223-S223.
https://doi.org/10.1016/S0378-4274(23)00790-7
Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Baralić K, Vukelić D, Đukić-Ćosić D, Marić Đ, Bulat Z, Antonijević B. Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats. in Toxicology Letters. 2023;384(S1):S223-S223.
doi:10.1016/S0378-4274(23)00790-7 .
Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Baralić, Katarina, Vukelić, Dragana, Đukić-Ćosić, Danijela, Marić, Đurđica, Bulat, Zorica, Antonijević, Biljana, "Oxidative damage in liver tissue induced by low doses exposure to a mixture of lead and polychlorinated biphenyls: Subacute toxicity study in rats" in Toxicology Letters, 384, no. S1 (2023):S223-S223,
https://doi.org/10.1016/S0378-4274(23)00790-7 . .

Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data

Baralić, Katarina; Vukelić, Dragana; Marić, Đurđica; Antonijević, Biljana; Đukić-Ćosić, Danijela; Bulat, Zorica; Buha-Đorđević, Aleksandra

(Elsevier, 2023)

TY  - CONF
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5174
AB  - Toxic metal(oid)s are being frequently referred to as endocrine-disrupting chemicals (EDCs), and as they are prevalent in nature, they may be linked to the current reproductive issues confronting the female population. [1,2]  ...
PB  - Elsevier
C3  - Toxicology Letters
T1  - Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data
VL  - 384
IS  - S1
SP  - S145
EP  - S145
DO  - 10.1016/S0378-4274(23)00609-4
ER  - 
@conference{
author = "Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Antonijević, Biljana and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2023",
abstract = "Toxic metal(oid)s are being frequently referred to as endocrine-disrupting chemicals (EDCs), and as they are prevalent in nature, they may be linked to the current reproductive issues confronting the female population. [1,2]  ...",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data",
volume = "384",
number = "S1",
pages = "S145-S145",
doi = "10.1016/S0378-4274(23)00609-4"
}
Baralić, K., Vukelić, D., Marić, Đ., Antonijević, B., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data. in Toxicology Letters
Elsevier., 384(S1), S145-S145.
https://doi.org/10.1016/S0378-4274(23)00609-4
Baralić K, Vukelić D, Marić Đ, Antonijević B, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data. in Toxicology Letters. 2023;384(S1):S145-S145.
doi:10.1016/S0378-4274(23)00609-4 .
Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Antonijević, Biljana, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Metals in the Mix: Uncovering the Link Between Real-Life Environmental Exposures, Hormone Disruption, and Female Reproductive Health using Human and Animal Data" in Toxicology Letters, 384, no. S1 (2023):S145-S145,
https://doi.org/10.1016/S0378-4274(23)00609-4 . .