TY  - JOUR
AU  - Dmitrasinović, Gordana
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2748
AB  - Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation
VL  - 35
IS  - 4
SP  - 375
EP  - 384
DO  - 10.1515/jomb-2016-0021
ER  - 

@article{
author = "Dmitrasinović, Gordana and Pešić, Vesna and Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Dajak, Marijana and Ignjatović, Svetlana",
year = "2016",
abstract = "Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation",
volume = "35",
number = "4",
pages = "375-384",
doi = "10.1515/jomb-2016-0021"
}

Dmitrasinović, G., Pešić, V., Stanić, D., Plećaš-Solarović, B., Dajak, M.,& Ignjatović, S.. (2016). ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 375-384.
https://doi.org/10.1515/jomb-2016-0021

Dmitrasinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry. 2016;35(4):375-384.
doi:10.1515/jomb-2016-0021 .

Dmitrasinović, Gordana, Pešić, Vesna, Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Dajak, Marijana, Ignjatović, Svetlana, "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation" in Journal of Medical Biochemistry, 35, no. 4 (2016):375-384,
https://doi.org/10.1515/jomb-2016-0021 . .

TY  - JOUR
AU  - Zogović, Dušanka
AU  - Pešić, Vesna
AU  - Dmitrasinović, Gordana
AU  - Dajak, Marijana
AU  - Plećaš, Bosiljka
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Ignjatović, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2237
AB  - Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students
VL  - 33
IS  - 3
SP  - 291
EP  - 298
DO  - 10.2478/jomb-2014-0016
ER  - 

@article{
author = "Zogović, Dušanka and Pešić, Vesna and Dmitrasinović, Gordana and Dajak, Marijana and Plećaš, Bosiljka and Batinić, Bojan and Popović, Dejana and Ignjatović, Svetlana",
year = "2014",
abstract = "Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students",
volume = "33",
number = "3",
pages = "291-298",
doi = "10.2478/jomb-2014-0016"
}

Zogović, D., Pešić, V., Dmitrasinović, G., Dajak, M., Plećaš, B., Batinić, B., Popović, D.,& Ignjatović, S.. (2014). Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(3), 291-298.
https://doi.org/10.2478/jomb-2014-0016

Zogović D, Pešić V, Dmitrasinović G, Dajak M, Plećaš B, Batinić B, Popović D, Ignjatović S. Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry. 2014;33(3):291-298.
doi:10.2478/jomb-2014-0016 .

Zogović, Dušanka, Pešić, Vesna, Dmitrasinović, Gordana, Dajak, Marijana, Plećaš, Bosiljka, Batinić, Bojan, Popović, Dejana, Ignjatović, Svetlana, "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students" in Journal of Medical Biochemistry, 33, no. 3 (2014):291-298,
https://doi.org/10.2478/jomb-2014-0016 . .