TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Fokialakis, N.
AU  - Dobrić, Silva
AU  - Pratsinis, H
AU  - Kletsas, D
AU  - Kovačević, Nada
AU  - Chinou, I
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/849
AB  - The root extracts of Onosma leptanhtha were evaluated for their anti-iflammatory and cytotoxic activities. The cyclohexane extract, which appeared as the most active in both assays, has been further subjected to bioassay-directed fractionation to afford the naphthazarine derivatives: beta,beta-dimethylacrylshikonin (1), isovalerylshikonin (2) and acetylshikonin (3). The evaluation of the anti-inflammatory activity was performed on carrageenan-induced rat paw edema test. All the tested compounds proved to be active, while compound 3 showed the best anti-inflammatory effect. In addition, the cytotoxic activity of the extracts and isolated compounds, was also assayed against L1210 murine lymphoblastic leukemia cell line, and human fibrosarcoma HT-1080 cells. Compound I exhibited remarkable cytotoxic activity (390nM for L1210 cells), which is superior to that of shikonin, which was used as control.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Phytomedicine
T1  - Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha
VL  - 13
IS  - 4
SP  - 290
EP  - 294
DO  - 10.1016/j.phymed.2004.10.009
ER  - 

@article{
author = "Kundaković, Tatjana and Fokialakis, N. and Dobrić, Silva and Pratsinis, H and Kletsas, D and Kovačević, Nada and Chinou, I",
year = "2006",
abstract = "The root extracts of Onosma leptanhtha were evaluated for their anti-iflammatory and cytotoxic activities. The cyclohexane extract, which appeared as the most active in both assays, has been further subjected to bioassay-directed fractionation to afford the naphthazarine derivatives: beta,beta-dimethylacrylshikonin (1), isovalerylshikonin (2) and acetylshikonin (3). The evaluation of the anti-inflammatory activity was performed on carrageenan-induced rat paw edema test. All the tested compounds proved to be active, while compound 3 showed the best anti-inflammatory effect. In addition, the cytotoxic activity of the extracts and isolated compounds, was also assayed against L1210 murine lymphoblastic leukemia cell line, and human fibrosarcoma HT-1080 cells. Compound I exhibited remarkable cytotoxic activity (390nM for L1210 cells), which is superior to that of shikonin, which was used as control.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Phytomedicine",
title = "Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha",
volume = "13",
number = "4",
pages = "290-294",
doi = "10.1016/j.phymed.2004.10.009"
}

Kundaković, T., Fokialakis, N., Dobrić, S., Pratsinis, H., Kletsas, D., Kovačević, N.,& Chinou, I.. (2006). Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha. in Phytomedicine
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 13(4), 290-294.
https://doi.org/10.1016/j.phymed.2004.10.009

Kundaković T, Fokialakis N, Dobrić S, Pratsinis H, Kletsas D, Kovačević N, Chinou I. Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha. in Phytomedicine. 2006;13(4):290-294.
doi:10.1016/j.phymed.2004.10.009 .

Kundaković, Tatjana, Fokialakis, N., Dobrić, Silva, Pratsinis, H, Kletsas, D, Kovačević, Nada, Chinou, I, "Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma lentantha" in Phytomedicine, 13, no. 4 (2006):290-294,
https://doi.org/10.1016/j.phymed.2004.10.009 . .