TY  - JOUR
AU  - Ramsay, Rona R.
AU  - Popović-Nikolić, Marija
AU  - Nikolić, Katarina
AU  - Uliassi, Elisa
AU  - Bolognesi, Maria Laura
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3148
AB  - Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.
PB  - Springeropen, London
T2  - Clinical and Translational Medicine
T1  - A perspective on multi-target drug discovery and design for complex diseases
VL  - 7
DO  - 10.1186/s40169-017-0181-2
ER  - 

@article{
author = "Ramsay, Rona R. and Popović-Nikolić, Marija and Nikolić, Katarina and Uliassi, Elisa and Bolognesi, Maria Laura",
year = "2018",
abstract = "Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.",
publisher = "Springeropen, London",
journal = "Clinical and Translational Medicine",
title = "A perspective on multi-target drug discovery and design for complex diseases",
volume = "7",
doi = "10.1186/s40169-017-0181-2"
}

Ramsay, R. R., Popović-Nikolić, M., Nikolić, K., Uliassi, E.,& Bolognesi, M. L.. (2018). A perspective on multi-target drug discovery and design for complex diseases. in Clinical and Translational Medicine
Springeropen, London., 7.
https://doi.org/10.1186/s40169-017-0181-2

Ramsay RR, Popović-Nikolić M, Nikolić K, Uliassi E, Bolognesi ML. A perspective on multi-target drug discovery and design for complex diseases. in Clinical and Translational Medicine. 2018;7.
doi:10.1186/s40169-017-0181-2 .

Ramsay, Rona R., Popović-Nikolić, Marija, Nikolić, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura, "A perspective on multi-target drug discovery and design for complex diseases" in Clinical and Translational Medicine, 7 (2018),
https://doi.org/10.1186/s40169-017-0181-2 . .