TY  - JOUR
AU  - Brzaković, Branka
AU  - Vučićević, Katarina
AU  - Vezmar-Kovačević, Sandra
AU  - Miljković, Branislava
AU  - Prostran, Milica
AU  - Martinović, Žarko J.
AU  - Pokrajac, Milena
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2183
AB  - The purpose of the study was to examine and describe adjunctive lamotrigine (LTG) pharmacokinetics in paediatric and young adult patients using a nonlinear mixed effects modelling (NONMEM) approach. The study included 53 patients (age range 3-35 years) who were concomitantly treated with carbamazepine (CBZ) and/or valproic acid (VPA). A total of 70 blood samples corresponding to trough levels were available for analysis. Data were modelled, and the final model was evaluated using NONMEM and auxiliary software tools. The final LTG population model included the effects of concomitant drugs and patient's weight (WT) which stratified the population into three groups: a parts per thousand currency sign25 kg, > 25 to  lt  60 kg and a parts per thousand yen60 kg. Based on the final model, the estimated LTG oral clearance (CL/F) for a typical patient weighing a parts per thousand currency sign25 kg, > 25 to  lt  60 kg or a parts per thousand yen60 kg who was concomitantly treated with CBZ was estimated to be 3.28, 4.23, or 7.15 l/h, respectively. If a patient was concomitantly treated with CBZ + VPA, the CL/F decreased on average by 69.5 % relative to LTG + CBZ co-therapy. VPA was found to decrease the LTG CL/F by 87.6 % compared to co-therapy with only CBZ. The LTG population pharmacokinetic model developed in this study may be a reliable method for individualising the LTG dosing regimen in paediatric and young adult patients on combination therapy during therapeutic drug monitoring.
PB  - Springer Heidelberg, Heidelberg
T2  - European Journal of Clinical Pharmacology
T1  - Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach
VL  - 70
IS  - 2
SP  - 179
EP  - 185
DO  - 10.1007/s00228-013-1606-5
ER  - 

@article{
author = "Brzaković, Branka and Vučićević, Katarina and Vezmar-Kovačević, Sandra and Miljković, Branislava and Prostran, Milica and Martinović, Žarko J. and Pokrajac, Milena",
year = "2014",
abstract = "The purpose of the study was to examine and describe adjunctive lamotrigine (LTG) pharmacokinetics in paediatric and young adult patients using a nonlinear mixed effects modelling (NONMEM) approach. The study included 53 patients (age range 3-35 years) who were concomitantly treated with carbamazepine (CBZ) and/or valproic acid (VPA). A total of 70 blood samples corresponding to trough levels were available for analysis. Data were modelled, and the final model was evaluated using NONMEM and auxiliary software tools. The final LTG population model included the effects of concomitant drugs and patient's weight (WT) which stratified the population into three groups: a parts per thousand currency sign25 kg, > 25 to  lt  60 kg and a parts per thousand yen60 kg. Based on the final model, the estimated LTG oral clearance (CL/F) for a typical patient weighing a parts per thousand currency sign25 kg, > 25 to  lt  60 kg or a parts per thousand yen60 kg who was concomitantly treated with CBZ was estimated to be 3.28, 4.23, or 7.15 l/h, respectively. If a patient was concomitantly treated with CBZ + VPA, the CL/F decreased on average by 69.5 % relative to LTG + CBZ co-therapy. VPA was found to decrease the LTG CL/F by 87.6 % compared to co-therapy with only CBZ. The LTG population pharmacokinetic model developed in this study may be a reliable method for individualising the LTG dosing regimen in paediatric and young adult patients on combination therapy during therapeutic drug monitoring.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "European Journal of Clinical Pharmacology",
title = "Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach",
volume = "70",
number = "2",
pages = "179-185",
doi = "10.1007/s00228-013-1606-5"
}

Brzaković, B., Vučićević, K., Vezmar-Kovačević, S., Miljković, B., Prostran, M., Martinović, Ž. J.,& Pokrajac, M.. (2014). Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach. in European Journal of Clinical Pharmacology
Springer Heidelberg, Heidelberg., 70(2), 179-185.
https://doi.org/10.1007/s00228-013-1606-5

Brzaković B, Vučićević K, Vezmar-Kovačević S, Miljković B, Prostran M, Martinović ŽJ, Pokrajac M. Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach. in European Journal of Clinical Pharmacology. 2014;70(2):179-185.
doi:10.1007/s00228-013-1606-5 .

Brzaković, Branka, Vučićević, Katarina, Vezmar-Kovačević, Sandra, Miljković, Branislava, Prostran, Milica, Martinović, Žarko J., Pokrajac, Milena, "Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients-nonlinear mixed effects modelling approach" in European Journal of Clinical Pharmacology, 70, no. 2 (2014):179-185,
https://doi.org/10.1007/s00228-013-1606-5 . .

TY  - CONF
AU  - Brzaković, Branka
AU  - Pokrajac, Milena
AU  - Miljković, Branislava
AU  - Martinović, Žarko J.
AU  - Veličković, Ružica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/972
PB  - Springer, Dordrecht
C3  - Pharmacy World & Science
T1  - Correlation between dose and plasma concentrations of lamotrigine in adult patients and children with epilepsy
VL  - 29
IS  - 5
SP  - 499
EP  - 499
UR  - https://hdl.handle.net/21.15107/rcub_farfar_972
ER  - 

@conference{
author = "Brzaković, Branka and Pokrajac, Milena and Miljković, Branislava and Martinović, Žarko J. and Veličković, Ružica",
year = "2007",
publisher = "Springer, Dordrecht",
journal = "Pharmacy World & Science",
title = "Correlation between dose and plasma concentrations of lamotrigine in adult patients and children with epilepsy",
volume = "29",
number = "5",
pages = "499-499",
url = "https://hdl.handle.net/21.15107/rcub_farfar_972"
}

Brzaković, B., Pokrajac, M., Miljković, B., Martinović, Ž. J.,& Veličković, R.. (2007). Correlation between dose and plasma concentrations of lamotrigine in adult patients and children with epilepsy. in Pharmacy World & Science
Springer, Dordrecht., 29(5), 499-499.
https://hdl.handle.net/21.15107/rcub_farfar_972

Brzaković B, Pokrajac M, Miljković B, Martinović ŽJ, Veličković R. Correlation between dose and plasma concentrations of lamotrigine in adult patients and children with epilepsy. in Pharmacy World & Science. 2007;29(5):499-499.
https://hdl.handle.net/21.15107/rcub_farfar_972 .

Brzaković, Branka, Pokrajac, Milena, Miljković, Branislava, Martinović, Žarko J., Veličković, Ružica, "Correlation between dose and plasma concentrations of lamotrigine in adult patients and children with epilepsy" in Pharmacy World & Science, 29, no. 5 (2007):499-499,
https://hdl.handle.net/21.15107/rcub_farfar_972 .

TY  - JOUR
AU  - Kovačević, Ivan
AU  - Miljković, Branislava
AU  - Brzaković, Branka
AU  - Mehmedagić, Aida
AU  - Brujić, Jelena
AU  - Milanović, Marija
AU  - Pokrajac, Milena
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/497
AB  - The aim of this study was to evaluate the influence of smoking on the urine paracetamol elimination. Fourteen healthy female volunteers took part in this controlled study. Seven (23+/-3 years; 50 +/- 2 kg; x+/-SD) were non-smokers and seven (26 +/- 9 years; 58 +/- 8 kg) were smokers (15 cigarettes per day). After administration of 500 mg of paracetamol, urine sampling was performed at specific times (before drug administration and 1, 2, 3, 4, 6, 9, 12, 16 and 24 hours after). The bioanalytical method used for determination of hydrolyzed paracetamol conjugates in urine samples was UV-spectrometry. The obtained pharmacokinetic parameters of paracetamol, first-order elimination rate constant (â) and elimination half-life (t1/2â), were statistically compared between non-smokers and smokers. There were no significant differences in both elimination parameters (â 0.311 1/h; t1/2â 2.23 h non-smokers vs. â 0.346 1/h; t1/2â 2.19 h smokers) between the groups. However, the differences obtained in inter-individual variability in pharmacokinetic parameters (â SD 0.013 , KV 13.4 % ; t1/2â SD 0.227, KV 4.57% nonsmokers vs. â SD 0.108 , KV 90 % ; t1/2â SD 0.684 , KV 14 % smokers) indicate relatively low predictability of paracetamol elimination in smokers. That requires higher attention in dosing this drug in smokers, especially if some other factors also influence.
AB  - U radu je ispitivan uticaj sastojaka duvanskog dima na brzinu eliminacije paracetamola urinom. U kontrolisanom ispitivanju je učestvovalo 14 zdravih dobrovoljaca ženskog pola. Sedam su bili nepušači (23±8 godine; 50±2 kg: X±SD), a sedam (26±9 godina; 58±8 kg; X±SD) pušači (15 cigareta dnevno). Određivan je „ukupan” paracetamol u urinu UV- spektrometrijskom metodom, posle hidrolize konjugata paracetamola i oksidacije dobijenog proizvoda, u prisustvu hipobromita, do obojenog jedinjenja - derivata indofenola. Farmakokinetičkom analizom izmerenih koncentracija u urinu izračunati su farmakokinetički parametri: konstanta brzine eliminacije (â) i poluvreme eliminacije paracetamola (t1/2â). Mada vrednosti ovih parametara kod pušača ukazuju na bržu eliminaciju paracetamola, statističkim poređenjem farmakokinetičkih parametara eliminacije kod pušača (â=0,346 1/h i t1/2â=2,19 h) i nepušača (â=0,311 1/h, t1/2â=2,23 h), nije dobijena značajna razlika ( P lt 0,05). Veće vrednosti SD=0,108 i KV=90 % za â i SD=0,684 i KV= 14, 25 % za t1/2â u grupi pušača, u poređenju sa istim parametrima u grupi nepušača (SD=0,013 i KV=13,4 % za â i SD=0,227 i KV=4,57 % za t1/2â), pokazuju veću inter-individualnu varijabilnost farmakokinetičkih parametara eliminacije paracetamola kod pušača. Posledica je relativno niska predvidivost farmakokinetike paracetamola kod pušača, pa je kod njih potrebna veća pažnja u doziranju leka, naročito ako postoji i uticaj drugih faktora farmakokinetičke varijabilnosti.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The influence of smoking on the urine paracetamol elimination
T1  - Eliminacija paracetamola urinom kod pušača
VL  - 54
IS  - 5
SP  - 655
EP  - 664
UR  - https://hdl.handle.net/21.15107/rcub_farfar_497
ER  - 

@article{
author = "Kovačević, Ivan and Miljković, Branislava and Brzaković, Branka and Mehmedagić, Aida and Brujić, Jelena and Milanović, Marija and Pokrajac, Milena",
year = "2004",
abstract = "The aim of this study was to evaluate the influence of smoking on the urine paracetamol elimination. Fourteen healthy female volunteers took part in this controlled study. Seven (23+/-3 years; 50 +/- 2 kg; x+/-SD) were non-smokers and seven (26 +/- 9 years; 58 +/- 8 kg) were smokers (15 cigarettes per day). After administration of 500 mg of paracetamol, urine sampling was performed at specific times (before drug administration and 1, 2, 3, 4, 6, 9, 12, 16 and 24 hours after). The bioanalytical method used for determination of hydrolyzed paracetamol conjugates in urine samples was UV-spectrometry. The obtained pharmacokinetic parameters of paracetamol, first-order elimination rate constant (â) and elimination half-life (t1/2â), were statistically compared between non-smokers and smokers. There were no significant differences in both elimination parameters (â 0.311 1/h; t1/2â 2.23 h non-smokers vs. â 0.346 1/h; t1/2â 2.19 h smokers) between the groups. However, the differences obtained in inter-individual variability in pharmacokinetic parameters (â SD 0.013 , KV 13.4 % ; t1/2â SD 0.227, KV 4.57% nonsmokers vs. â SD 0.108 , KV 90 % ; t1/2â SD 0.684 , KV 14 % smokers) indicate relatively low predictability of paracetamol elimination in smokers. That requires higher attention in dosing this drug in smokers, especially if some other factors also influence., U radu je ispitivan uticaj sastojaka duvanskog dima na brzinu eliminacije paracetamola urinom. U kontrolisanom ispitivanju je učestvovalo 14 zdravih dobrovoljaca ženskog pola. Sedam su bili nepušači (23±8 godine; 50±2 kg: X±SD), a sedam (26±9 godina; 58±8 kg; X±SD) pušači (15 cigareta dnevno). Određivan je „ukupan” paracetamol u urinu UV- spektrometrijskom metodom, posle hidrolize konjugata paracetamola i oksidacije dobijenog proizvoda, u prisustvu hipobromita, do obojenog jedinjenja - derivata indofenola. Farmakokinetičkom analizom izmerenih koncentracija u urinu izračunati su farmakokinetički parametri: konstanta brzine eliminacije (â) i poluvreme eliminacije paracetamola (t1/2â). Mada vrednosti ovih parametara kod pušača ukazuju na bržu eliminaciju paracetamola, statističkim poređenjem farmakokinetičkih parametara eliminacije kod pušača (â=0,346 1/h i t1/2â=2,19 h) i nepušača (â=0,311 1/h, t1/2â=2,23 h), nije dobijena značajna razlika ( P lt 0,05). Veće vrednosti SD=0,108 i KV=90 % za â i SD=0,684 i KV= 14, 25 % za t1/2â u grupi pušača, u poređenju sa istim parametrima u grupi nepušača (SD=0,013 i KV=13,4 % za â i SD=0,227 i KV=4,57 % za t1/2â), pokazuju veću inter-individualnu varijabilnost farmakokinetičkih parametara eliminacije paracetamola kod pušača. Posledica je relativno niska predvidivost farmakokinetike paracetamola kod pušača, pa je kod njih potrebna veća pažnja u doziranju leka, naročito ako postoji i uticaj drugih faktora farmakokinetičke varijabilnosti.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The influence of smoking on the urine paracetamol elimination, Eliminacija paracetamola urinom kod pušača",
volume = "54",
number = "5",
pages = "655-664",
url = "https://hdl.handle.net/21.15107/rcub_farfar_497"
}

Kovačević, I., Miljković, B., Brzaković, B., Mehmedagić, A., Brujić, J., Milanović, M.,& Pokrajac, M.. (2004). The influence of smoking on the urine paracetamol elimination. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(5), 655-664.
https://hdl.handle.net/21.15107/rcub_farfar_497

Kovačević I, Miljković B, Brzaković B, Mehmedagić A, Brujić J, Milanović M, Pokrajac M. The influence of smoking on the urine paracetamol elimination. in Arhiv za farmaciju. 2004;54(5):655-664.
https://hdl.handle.net/21.15107/rcub_farfar_497 .

Kovačević, Ivan, Miljković, Branislava, Brzaković, Branka, Mehmedagić, Aida, Brujić, Jelena, Milanović, Marija, Pokrajac, Milena, "The influence of smoking on the urine paracetamol elimination" in Arhiv za farmaciju, 54, no. 5 (2004):655-664,
https://hdl.handle.net/21.15107/rcub_farfar_497 .

TY  - CONF
AU  - Brzaković, Branka
AU  - Pokrajac, Milena
AU  - Martinović, Žarko J.
AU  - Veličković, Ružica
AU  - Miljković, Branislava
AU  - Varagić, V.M.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/363
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Disposition of Lamotrigine in children with epilepsy receiving politherapy
T1  - Dispozicija Lamotrigina u kombinovano terapiji dece sa epilepsijom
VL  - 52
IS  - 4
SP  - 668
EP  - 669
UR  - https://hdl.handle.net/21.15107/rcub_farfar_363
ER  - 

@conference{
author = "Brzaković, Branka and Pokrajac, Milena and Martinović, Žarko J. and Veličković, Ružica and Miljković, Branislava and Varagić, V.M.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Disposition of Lamotrigine in children with epilepsy receiving politherapy, Dispozicija Lamotrigina u kombinovano terapiji dece sa epilepsijom",
volume = "52",
number = "4",
pages = "668-669",
url = "https://hdl.handle.net/21.15107/rcub_farfar_363"
}

Brzaković, B., Pokrajac, M., Martinović, Ž. J., Veličković, R., Miljković, B.,& Varagić, V.M.. (2002). Disposition of Lamotrigine in children with epilepsy receiving politherapy. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 668-669.
https://hdl.handle.net/21.15107/rcub_farfar_363

Brzaković B, Pokrajac M, Martinović ŽJ, Veličković R, Miljković B, Varagić V. Disposition of Lamotrigine in children with epilepsy receiving politherapy. in Arhiv za farmaciju. 2002;52(4):668-669.
https://hdl.handle.net/21.15107/rcub_farfar_363 .

Brzaković, Branka, Pokrajac, Milena, Martinović, Žarko J., Veličković, Ružica, Miljković, Branislava, Varagić, V.M., "Disposition of Lamotrigine in children with epilepsy receiving politherapy" in Arhiv za farmaciju, 52, no. 4 (2002):668-669,
https://hdl.handle.net/21.15107/rcub_farfar_363 .

TY  - CONF
AU  - Kovačević, Ivan
AU  - Miljković, Branislava
AU  - Brzaković, Branka
AU  - Brujić, Jelena
AU  - Milanović, Marija
AU  - Pokrajac, Milena
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/396
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Urine paracetamol elimination in healthy smokers
T1  - Eliminacija paracetamola urinom kod pušača
VL  - 52
IS  - 4
SP  - 670
EP  - 671
UR  - https://hdl.handle.net/21.15107/rcub_farfar_396
ER  - 

@conference{
author = "Kovačević, Ivan and Miljković, Branislava and Brzaković, Branka and Brujić, Jelena and Milanović, Marija and Pokrajac, Milena",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Urine paracetamol elimination in healthy smokers, Eliminacija paracetamola urinom kod pušača",
volume = "52",
number = "4",
pages = "670-671",
url = "https://hdl.handle.net/21.15107/rcub_farfar_396"
}

Kovačević, I., Miljković, B., Brzaković, B., Brujić, J., Milanović, M.,& Pokrajac, M.. (2002). Urine paracetamol elimination in healthy smokers. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 670-671.
https://hdl.handle.net/21.15107/rcub_farfar_396

Kovačević I, Miljković B, Brzaković B, Brujić J, Milanović M, Pokrajac M. Urine paracetamol elimination in healthy smokers. in Arhiv za farmaciju. 2002;52(4):670-671.
https://hdl.handle.net/21.15107/rcub_farfar_396 .

Kovačević, Ivan, Miljković, Branislava, Brzaković, Branka, Brujić, Jelena, Milanović, Marija, Pokrajac, Milena, "Urine paracetamol elimination in healthy smokers" in Arhiv za farmaciju, 52, no. 4 (2002):670-671,
https://hdl.handle.net/21.15107/rcub_farfar_396 .