TY  - JOUR
AU  - Homšek, Irena
AU  - Popadić, Dragica
AU  - Simić, Slobodanka
AU  - Ristić, Slavica M.
AU  - Vučićević, Katarina
AU  - Miljković, Branislava
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1613
AB  - Controlled-release (CR) pharmaceutical formulations offer several advantages over the conventional, immediate release dosage forms of the same drug, including reduced dosing frequency, decreased incidence and/or intensity of adverse effects, greater selectivity of pharmacological activity, reduced drug plasma fluctuation, and better compliance. After a drug product has been registered, and is already on market, minor changes in formulation might be needed. At the same time, the product has to remain effective and safe for patients that could be confirmed via plasma drug concentrations and pharmacokinetic characteristics. It is challenging to predict human absorption and pharmacokinetic characteristics of a drug based on the in vitro dissolution test and the animal pharmacokinetic data. Therefore, the objective of this study was to establish correlation of the pharmacokinetic parameters of carbamazepine (CBZ) CR tablet formulation between the rabbit and the human model, and to establish in vitro in vivo correlation (IVIVC) based on the predicted fractions of absorbed CBZ. Although differences in mean plasma concentration profiles were notified, the data concerning the predicted fraction of drug absorbed were almost superimposable. Accordingly, it can be concluded that rabbits may be representative as an in vivo model for predicting the pharmacokinetics of the CR formulation of CBZ in humans.
AB  - Farmaceutske formulacije sa kontrolisanim oslobađanjem imaju nekoliko prednosti u odnosu na konvencionalne dozirane oblike sa trenutnim oslobađanjem iste lekovite supstance. To se pre svega ogleda u redukovanoj učestalosti doziranja, smanjenoj pojavi i/ili intenzitetu neželjenih efekata, većoj farmakološkoj selektivnosti, redukovanoj fluktuaciji lekovite supstance u plazmi i boljoj podnošljivosti. Kada se posle završene registracije preparat nađe na tržištu, može se javiti potreba za manjim izmenama u formulaciji. U isto vreme on treba da ostane efikasan i bezbedan za pacijente, što može biti potvrđeno na osnovu koncentracije lekovite supstance u plazmi i farmakokinetičkih podataka. Poseban izazov predstavlja predviđanje resorpcije i farmakokinetičkih osobina lekovite supstance kod ljudi na osnovu određivanja in vitro brzine rastvaranja i farmakokinetičkih podataka dobijenih ispitivanjem na životinjskom modelu. Zbog toga je cilj ovog ispitivanja bio da se uspostavi korelacija farmakokinetičkih parametara između modela kunića i humanog modela za formulacije tableta sa kontrolisanim oslobađanjem karbamazepina (KBZ) kao i in vitro in vivo korelacija zasnovana na predviđenoj frakciji resorbovanog leka. I pored uočenih razlika u srednjim profilima plazma koncentracija, rezultati koji se odnose na predviđenu frakciju resorbovane lekovite supstance bili su gotovo identični. Na osnovu toga se može zaključiti da se kunić može koristiti kao reprezentativan in vivo model za predviđanje farmakokinetičkih karakteristika formulacije sa kontrolisanim oslobađanjem KBZ kod ljudi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Predicting absorption and pharmacokinetic profile of carbamazepine from controlled-release tablet formulation in humans using rabbit model
T1  - Predviđanje resorpcije i farmakokinetičkog profila karbamazepina iz tableta sa kontrolisanim oslobađanjem kod ljudi korišćenjem modela kunića
VL  - 65
IS  - 1-2
SP  - 71
EP  - 81
DO  - 10.2298/VETGL1102071H
ER  - 

@article{
author = "Homšek, Irena and Popadić, Dragica and Simić, Slobodanka and Ristić, Slavica M. and Vučićević, Katarina and Miljković, Branislava",
year = "2011",
abstract = "Controlled-release (CR) pharmaceutical formulations offer several advantages over the conventional, immediate release dosage forms of the same drug, including reduced dosing frequency, decreased incidence and/or intensity of adverse effects, greater selectivity of pharmacological activity, reduced drug plasma fluctuation, and better compliance. After a drug product has been registered, and is already on market, minor changes in formulation might be needed. At the same time, the product has to remain effective and safe for patients that could be confirmed via plasma drug concentrations and pharmacokinetic characteristics. It is challenging to predict human absorption and pharmacokinetic characteristics of a drug based on the in vitro dissolution test and the animal pharmacokinetic data. Therefore, the objective of this study was to establish correlation of the pharmacokinetic parameters of carbamazepine (CBZ) CR tablet formulation between the rabbit and the human model, and to establish in vitro in vivo correlation (IVIVC) based on the predicted fractions of absorbed CBZ. Although differences in mean plasma concentration profiles were notified, the data concerning the predicted fraction of drug absorbed were almost superimposable. Accordingly, it can be concluded that rabbits may be representative as an in vivo model for predicting the pharmacokinetics of the CR formulation of CBZ in humans., Farmaceutske formulacije sa kontrolisanim oslobađanjem imaju nekoliko prednosti u odnosu na konvencionalne dozirane oblike sa trenutnim oslobađanjem iste lekovite supstance. To se pre svega ogleda u redukovanoj učestalosti doziranja, smanjenoj pojavi i/ili intenzitetu neželjenih efekata, većoj farmakološkoj selektivnosti, redukovanoj fluktuaciji lekovite supstance u plazmi i boljoj podnošljivosti. Kada se posle završene registracije preparat nađe na tržištu, može se javiti potreba za manjim izmenama u formulaciji. U isto vreme on treba da ostane efikasan i bezbedan za pacijente, što može biti potvrđeno na osnovu koncentracije lekovite supstance u plazmi i farmakokinetičkih podataka. Poseban izazov predstavlja predviđanje resorpcije i farmakokinetičkih osobina lekovite supstance kod ljudi na osnovu određivanja in vitro brzine rastvaranja i farmakokinetičkih podataka dobijenih ispitivanjem na životinjskom modelu. Zbog toga je cilj ovog ispitivanja bio da se uspostavi korelacija farmakokinetičkih parametara između modela kunića i humanog modela za formulacije tableta sa kontrolisanim oslobađanjem karbamazepina (KBZ) kao i in vitro in vivo korelacija zasnovana na predviđenoj frakciji resorbovanog leka. I pored uočenih razlika u srednjim profilima plazma koncentracija, rezultati koji se odnose na predviđenu frakciju resorbovane lekovite supstance bili su gotovo identični. Na osnovu toga se može zaključiti da se kunić može koristiti kao reprezentativan in vivo model za predviđanje farmakokinetičkih karakteristika formulacije sa kontrolisanim oslobađanjem KBZ kod ljudi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Predicting absorption and pharmacokinetic profile of carbamazepine from controlled-release tablet formulation in humans using rabbit model, Predviđanje resorpcije i farmakokinetičkog profila karbamazepina iz tableta sa kontrolisanim oslobađanjem kod ljudi korišćenjem modela kunića",
volume = "65",
number = "1-2",
pages = "71-81",
doi = "10.2298/VETGL1102071H"
}

Homšek, I., Popadić, D., Simić, S., Ristić, S. M., Vučićević, K.,& Miljković, B.. (2011). Predicting absorption and pharmacokinetic profile of carbamazepine from controlled-release tablet formulation in humans using rabbit model. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 65(1-2), 71-81.
https://doi.org/10.2298/VETGL1102071H

Homšek I, Popadić D, Simić S, Ristić SM, Vučićević K, Miljković B. Predicting absorption and pharmacokinetic profile of carbamazepine from controlled-release tablet formulation in humans using rabbit model. in Veterinarski glasnik. 2011;65(1-2):71-81.
doi:10.2298/VETGL1102071H .

Homšek, Irena, Popadić, Dragica, Simić, Slobodanka, Ristić, Slavica M., Vučićević, Katarina, Miljković, Branislava, "Predicting absorption and pharmacokinetic profile of carbamazepine from controlled-release tablet formulation in humans using rabbit model" in Veterinarski glasnik, 65, no. 1-2 (2011):71-81,
https://doi.org/10.2298/VETGL1102071H . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Popović, Radmila
AU  - Đurić, Zorica
AU  - Popadić, Dragica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1284
AB  - The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design
VL  - 32
IS  - 7
SP  - 1087
EP  - 1096
DO  - 10.1007/s12272-009-1715-y
ER  - 

@article{
author = "Petrović, Aleksandra and Ibrić, Svetlana and Trajković, Svetlana and Popović, Radmila and Đurić, Zorica and Popadić, Dragica",
year = "2009",
abstract = "The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design",
volume = "32",
number = "7",
pages = "1087-1096",
doi = "10.1007/s12272-009-1715-y"
}

Petrović, A., Ibrić, S., Trajković, S., Popović, R., Đurić, Z.,& Popadić, D.. (2009). An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(7), 1087-1096.
https://doi.org/10.1007/s12272-009-1715-y

Petrović A, Ibrić S, Trajković S, Popović R, Đurić Z, Popadić D. An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research. 2009;32(7):1087-1096.
doi:10.1007/s12272-009-1715-y .

Petrović, Aleksandra, Ibrić, Svetlana, Trajković, Svetlana, Popović, Radmila, Đurić, Zorica, Popadić, Dragica, "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design" in Archives of Pharmacal Research, 32, no. 7 (2009):1087-1096,
https://doi.org/10.1007/s12272-009-1715-y . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Đurić, Zorica
AU  - Popadić, Dragica
AU  - Popović, Radmila
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1191
AB  - Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose
VL  - 32
IS  - 12
SP  - 1767
EP  - 1774
DO  - 10.1007/s12272-009-2215-9
ER  - 

@article{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Đurić, Zorica and Popadić, Dragica and Popović, Radmila",
year = "2009",
abstract = "Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose",
volume = "32",
number = "12",
pages = "1767-1774",
doi = "10.1007/s12272-009-2215-9"
}

Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Đurić, Z., Popadić, D.,& Popović, R.. (2009). Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(12), 1767-1774.
https://doi.org/10.1007/s12272-009-2215-9

Petrović A, Cvetković N, Ibrić S, Trajković S, Đurić Z, Popadić D, Popović R. Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research. 2009;32(12):1767-1774.
doi:10.1007/s12272-009-2215-9 .

Petrović, Aleksandra, Cvetković, Nebojša, Ibrić, Svetlana, Trajković, Svetlana, Đurić, Zorica, Popadić, Dragica, Popović, Radmila, "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose" in Archives of Pharmacal Research, 32, no. 12 (2009):1767-1774,
https://doi.org/10.1007/s12272-009-2215-9 . .

TY  - JOUR
AU  - Homšek, Irena
AU  - Parojčić, Jelena
AU  - Cvetković, Nebojša
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/938
AB  - A growing concern for the biopharmaceutical characterization of pharmaceutical products increased the interest in the evaluation and identification of physicochemical properties of drugs and dosage forms that govern its biological performance. In vitro and in vivo characteristics of two carbamazepine (CAS 298-46-4) immediate release tablets were investigated and compared in order to establish level A in vitro-in vivo correlation. An in vivo study was conducted as a controlled, two-way, complete cross-over, single dose, pharmacokinetic trial in 18 subjects. The in vitro study was performed using various dissolution media in order to evaluate their potential influence on drug release and distinguish the set of experimental conditions relevant to the in vivo behavior of the investigated drug products. Beside significant differences among in vitro release profiles, the in vivo data indicated bioequivalence of the two formulations. Although a high level of correlation between in vivo and in vitro data was observed in some media, there was no single in vitro-in vivo correlation model applicable products. The obtained results add to the existing debate on the rationale for the use of surfactants in drug release media and their in vivo relevance, emphasizing the importance of in vitro dissolution testing in addition to in vivo bioequivalence testing.
PB  - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2  - Arzneimittelforschung - Drug Research
T1  - Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison
VL  - 57
IS  - 8
SP  - 511
EP  - 516
DO  - 10.1055/s-0031-1296640
UR  - https://hdl.handle.net/21.15107/rcub_farfar_938
ER  - 

@article{
author = "Homšek, Irena and Parojčić, Jelena and Cvetković, Nebojša and Popadić, Dragica and Đurić, Zorica",
year = "2007",
abstract = "A growing concern for the biopharmaceutical characterization of pharmaceutical products increased the interest in the evaluation and identification of physicochemical properties of drugs and dosage forms that govern its biological performance. In vitro and in vivo characteristics of two carbamazepine (CAS 298-46-4) immediate release tablets were investigated and compared in order to establish level A in vitro-in vivo correlation. An in vivo study was conducted as a controlled, two-way, complete cross-over, single dose, pharmacokinetic trial in 18 subjects. The in vitro study was performed using various dissolution media in order to evaluate their potential influence on drug release and distinguish the set of experimental conditions relevant to the in vivo behavior of the investigated drug products. Beside significant differences among in vitro release profiles, the in vivo data indicated bioequivalence of the two formulations. Although a high level of correlation between in vivo and in vitro data was observed in some media, there was no single in vitro-in vivo correlation model applicable products. The obtained results add to the existing debate on the rationale for the use of surfactants in drug release media and their in vivo relevance, emphasizing the importance of in vitro dissolution testing in addition to in vivo bioequivalence testing.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Arzneimittelforschung - Drug Research",
title = "Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison",
volume = "57",
number = "8",
pages = "511-516",
doi = "10.1055/s-0031-1296640",
url = "https://hdl.handle.net/21.15107/rcub_farfar_938"
}

Homšek, I., Parojčić, J., Cvetković, N., Popadić, D.,& Đurić, Z.. (2007). Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison. in Arzneimittelforschung - Drug Research
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 57(8), 511-516.
https://doi.org/10.1055/s-0031-1296640
https://hdl.handle.net/21.15107/rcub_farfar_938

Homšek I, Parojčić J, Cvetković N, Popadić D, Đurić Z. Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison. in Arzneimittelforschung - Drug Research. 2007;57(8):511-516.
doi:10.1055/s-0031-1296640
https://hdl.handle.net/21.15107/rcub_farfar_938 .

Homšek, Irena, Parojčić, Jelena, Cvetković, Nebojša, Popadić, Dragica, Đurić, Zorica, "Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison" in Arzneimittelforschung - Drug Research, 57, no. 8 (2007):511-516,
https://doi.org/10.1055/s-0031-1296640 .,
https://hdl.handle.net/21.15107/rcub_farfar_938 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Raić, M.
AU  - Trajković, Svetlana
AU  - Ibrić, Svetlana
AU  - Popović, R.
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/787
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Effect of film coating and storage conditions on tablets quality with moisture sensitive drug
T1  - Uticaj film obloge i uslova čuvanja na kvalitet tableta sa aktivnom supstancom osetljivom na vlagu
VL  - 56
IS  - 4
SP  - 458
EP  - 459
UR  - https://hdl.handle.net/21.15107/rcub_farfar_787
ER  - 

@conference{
author = "Petrović, Aleksandra and Raić, M. and Trajković, Svetlana and Ibrić, Svetlana and Popović, R. and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Effect of film coating and storage conditions on tablets quality with moisture sensitive drug, Uticaj film obloge i uslova čuvanja na kvalitet tableta sa aktivnom supstancom osetljivom na vlagu",
volume = "56",
number = "4",
pages = "458-459",
url = "https://hdl.handle.net/21.15107/rcub_farfar_787"
}

Petrović, A., Raić, M., Trajković, S., Ibrić, S., Popović, R., Popadić, D.,& Đurić, Z.. (2006). Effect of film coating and storage conditions on tablets quality with moisture sensitive drug. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 458-459.
https://hdl.handle.net/21.15107/rcub_farfar_787

Petrović A, Raić M, Trajković S, Ibrić S, Popović R, Popadić D, Đurić Z. Effect of film coating and storage conditions on tablets quality with moisture sensitive drug. in Arhiv za farmaciju. 2006;56(4):458-459.
https://hdl.handle.net/21.15107/rcub_farfar_787 .

Petrović, Aleksandra, Raić, M., Trajković, Svetlana, Ibrić, Svetlana, Popović, R., Popadić, Dragica, Đurić, Zorica, "Effect of film coating and storage conditions on tablets quality with moisture sensitive drug" in Arhiv za farmaciju, 56, no. 4 (2006):458-459,
https://hdl.handle.net/21.15107/rcub_farfar_787 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/788
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design
T1  - Ispitivanje oslobađanja leka iz matriks tableta na bazi karbomer-a i HPMC-a primenom eksperimentalnog dizajna
VL  - 56
IS  - 4
SP  - 460
EP  - 461
UR  - https://hdl.handle.net/21.15107/rcub_farfar_788
ER  - 

@conference{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design, Ispitivanje oslobađanja leka iz matriks tableta na bazi karbomer-a i HPMC-a primenom eksperimentalnog dizajna",
volume = "56",
number = "4",
pages = "460-461",
url = "https://hdl.handle.net/21.15107/rcub_farfar_788"
}

Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Popadić, D.,& Đurić, Z.. (2006). Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 460-461.
https://hdl.handle.net/21.15107/rcub_farfar_788

Petrović A, Cvetković N, Ibrić S, Trajković S, Popadić D, Đurić Z. Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design. in Arhiv za farmaciju. 2006;56(4):460-461.
https://hdl.handle.net/21.15107/rcub_farfar_788 .

Petrović, Aleksandra, Cvetković, Nebojša, Ibrić, Svetlana, Trajković, Svetlana, Popadić, Dragica, Đurić, Zorica, "Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design" in Arhiv za farmaciju, 56, no. 4 (2006):460-461,
https://hdl.handle.net/21.15107/rcub_farfar_788 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Trajković, Svetlana
AU  - Ibrić, Svetlana
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/792
PB  - Elsevier Science BV, Amsterdam
C3  - Journal of Controlled Release
T1  - Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC
VL  - 116
IS  - 2
DO  - 10.1016/j.jconrel.2006.09.073
ER  - 

@conference{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Trajković, Svetlana and Ibrić, Svetlana and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Controlled Release",
title = "Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC",
volume = "116",
number = "2",
doi = "10.1016/j.jconrel.2006.09.073"
}

Petrović, A., Cvetković, N., Trajković, S., Ibrić, S., Popadić, D.,& Đurić, Z.. (2006). Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC. in Journal of Controlled Release
Elsevier Science BV, Amsterdam., 116(2).
https://doi.org/10.1016/j.jconrel.2006.09.073

Petrović A, Cvetković N, Trajković S, Ibrić S, Popadić D, Đurić Z. Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC. in Journal of Controlled Release. 2006;116(2).
doi:10.1016/j.jconrel.2006.09.073 .

Petrović, Aleksandra, Cvetković, Nebojša, Trajković, Svetlana, Ibrić, Svetlana, Popadić, Dragica, Đurić, Zorica, "Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC" in Journal of Controlled Release, 116, no. 2 (2006),
https://doi.org/10.1016/j.jconrel.2006.09.073 . .

TY  - CONF
AU  - Homšek, Irena
AU  - Parojčić, Jelena
AU  - Cvetković, N
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/583
PB  - Elsevier Science BV
C3  - European Journal of Pharmaceutical Sciences
T1  - Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets
VL  - 25
IS  - SUPPL. 1
SP  - 117
EP  - 119
DO  - 10.1016/j.ejps.2005.04.007
ER  - 

@conference{
author = "Homšek, Irena and Parojčić, Jelena and Cvetković, N and Popadić, Dragica and Đurić, Zorica",
year = "2005",
publisher = "Elsevier Science BV",
journal = "European Journal of Pharmaceutical Sciences",
title = "Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets",
volume = "25",
number = "SUPPL. 1",
pages = "117-119",
doi = "10.1016/j.ejps.2005.04.007"
}

Homšek, I., Parojčić, J., Cvetković, N., Popadić, D.,& Đurić, Z.. (2005). Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets. in European Journal of Pharmaceutical Sciences
Elsevier Science BV., 25(SUPPL. 1), 117-119.
https://doi.org/10.1016/j.ejps.2005.04.007

Homšek I, Parojčić J, Cvetković N, Popadić D, Đurić Z. Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets. in European Journal of Pharmaceutical Sciences. 2005;25(SUPPL. 1):117-119.
doi:10.1016/j.ejps.2005.04.007 .

Homšek, Irena, Parojčić, Jelena, Cvetković, N, Popadić, Dragica, Đurić, Zorica, "Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets" in European Journal of Pharmaceutical Sciences, 25, no. SUPPL. 1 (2005):117-119,
https://doi.org/10.1016/j.ejps.2005.04.007 . .