TY  - JOUR
AU  - Salkić, Alma
AU  - Otašević, Biljana
AU  - Rašević, Marija
AU  - Zečević, Mira
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5143
AB  - A selective eco-friendly micellar HPLC method was developed for investigation of moxifloxacin and related compounds in the presence of its degradation products. Central composite design was used to optimize the experimental conditions. The proposed method is based on isocratic elution on a C18 column using 92.5% (v/v) biodegradable aqueous mobile phase containing 0.01 M sodium dihydrogen phosphate, 0.15 M sodium dodecyl sulfate (SDS) and 0.5% triethylamine (v/v) with a pH of 3.5 and 7.5% isopropanol (v/v) as eco- friendly organic solvent. The flow rate and injection volume were 0.6 ml/min and 5 µl, respectively. Experiments were performed at a temperature of 60 °C and detection was performed at 295 nm. The optimized method was validated. The method was found to be suitable for the quantification of moxifloxacin and its related compounds in moxifloxacin drug substance. The Green Analytical Procedure Index (GAPI) proves the superiority of the developed method against other reported methods.
PB  - Slovensko Kemijsko Drustvo
T2  - Acta Chimica Slovenica
T1  - Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities
VL  - 70
IS  - 3
SP  - 385
EP  - 397
DO  - 10.17344/acsi.2023.8022
ER  - 

@article{
author = "Salkić, Alma and Otašević, Biljana and Rašević, Marija and Zečević, Mira",
year = "2023",
abstract = "A selective eco-friendly micellar HPLC method was developed for investigation of moxifloxacin and related compounds in the presence of its degradation products. Central composite design was used to optimize the experimental conditions. The proposed method is based on isocratic elution on a C18 column using 92.5% (v/v) biodegradable aqueous mobile phase containing 0.01 M sodium dihydrogen phosphate, 0.15 M sodium dodecyl sulfate (SDS) and 0.5% triethylamine (v/v) with a pH of 3.5 and 7.5% isopropanol (v/v) as eco- friendly organic solvent. The flow rate and injection volume were 0.6 ml/min and 5 µl, respectively. Experiments were performed at a temperature of 60 °C and detection was performed at 295 nm. The optimized method was validated. The method was found to be suitable for the quantification of moxifloxacin and its related compounds in moxifloxacin drug substance. The Green Analytical Procedure Index (GAPI) proves the superiority of the developed method against other reported methods.",
publisher = "Slovensko Kemijsko Drustvo",
journal = "Acta Chimica Slovenica",
title = "Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities",
volume = "70",
number = "3",
pages = "385-397",
doi = "10.17344/acsi.2023.8022"
}

Salkić, A., Otašević, B., Rašević, M.,& Zečević, M.. (2023). Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo., 70(3), 385-397.
https://doi.org/10.17344/acsi.2023.8022

Salkić A, Otašević B, Rašević M, Zečević M. Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities. in Acta Chimica Slovenica. 2023;70(3):385-397.
doi:10.17344/acsi.2023.8022 .

Salkić, Alma, Otašević, Biljana, Rašević, Marija, Zečević, Mira, "Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities" in Acta Chimica Slovenica, 70, no. 3 (2023):385-397,
https://doi.org/10.17344/acsi.2023.8022 . .

TY  - CONF
AU  - Salkić, Alma
AU  - Zečević, Mira
AU  - Otašević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4695
PB  - National Institute of Chemistry, Slovenia
C3  - 26th International Symposium on Separation Sciences, 28th June - 1st July 2022, Ljubljana, Slovenia
T1  - Micellar liquid chromatographic method for determination of moxifloxacin impurities
SP  - 113
EP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4695
ER  - 

@conference{
author = "Salkić, Alma and Zečević, Mira and Otašević, Biljana",
year = "2022",
publisher = "National Institute of Chemistry, Slovenia",
journal = "26th International Symposium on Separation Sciences, 28th June - 1st July 2022, Ljubljana, Slovenia",
title = "Micellar liquid chromatographic method for determination of moxifloxacin impurities",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4695"
}

Salkić, A., Zečević, M.,& Otašević, B.. (2022). Micellar liquid chromatographic method for determination of moxifloxacin impurities. in 26th International Symposium on Separation Sciences, 28th June - 1st July 2022, Ljubljana, Slovenia
National Institute of Chemistry, Slovenia., 113-113.
https://hdl.handle.net/21.15107/rcub_farfar_4695

Salkić A, Zečević M, Otašević B. Micellar liquid chromatographic method for determination of moxifloxacin impurities. in 26th International Symposium on Separation Sciences, 28th June - 1st July 2022, Ljubljana, Slovenia. 2022;:113-113.
https://hdl.handle.net/21.15107/rcub_farfar_4695 .

Salkić, Alma, Zečević, Mira, Otašević, Biljana, "Micellar liquid chromatographic method for determination of moxifloxacin impurities" in 26th International Symposium on Separation Sciences, 28th June - 1st July 2022, Ljubljana, Slovenia (2022):113-113,
https://hdl.handle.net/21.15107/rcub_farfar_4695 .