TY  - JOUR
AU  - Bajić, Vladan
AU  - Mandusić, Vesna
AU  - Stefanova, Elka
AU  - Bozović, Ana
AU  - Davidović, Radoslav
AU  - Živković, Lada
AU  - Pirković, Andrea
AU  - Potparević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2386
AB  - X-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.
PB  - Ios Press, Amsterdam
T2  - Journal of Alzheimers Disease
T1  - Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease
VL  - 43
IS  - 4
SP  - 1251
EP  - 1259
DO  - 10.3233/JAD-141674
ER  - 

@article{
author = "Bajić, Vladan and Mandusić, Vesna and Stefanova, Elka and Bozović, Ana and Davidović, Radoslav and Živković, Lada and Pirković, Andrea and Potparević, Biljana",
year = "2015",
abstract = "X-chromosome instability has been a long established feature in Alzheimer's disease ( AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes ofwomen affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes ofwomen with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.",
publisher = "Ios Press, Amsterdam",
journal = "Journal of Alzheimers Disease",
title = "Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease",
volume = "43",
number = "4",
pages = "1251-1259",
doi = "10.3233/JAD-141674"
}

Bajić, V., Mandusić, V., Stefanova, E., Bozović, A., Davidović, R., Živković, L., Pirković, A.,& Potparević, B.. (2015). Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease. in Journal of Alzheimers Disease
Ios Press, Amsterdam., 43(4), 1251-1259.
https://doi.org/10.3233/JAD-141674

Bajić V, Mandusić V, Stefanova E, Bozović A, Davidović R, Živković L, Pirković A, Potparević B. Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease. in Journal of Alzheimers Disease. 2015;43(4):1251-1259.
doi:10.3233/JAD-141674 .

Bajić, Vladan, Mandusić, Vesna, Stefanova, Elka, Bozović, Ana, Davidović, Radoslav, Živković, Lada, Pirković, Andrea, Potparević, Biljana, "Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease" in Journal of Alzheimers Disease, 43, no. 4 (2015):1251-1259,
https://doi.org/10.3233/JAD-141674 . .