TY  - JOUR
AU  - Ninković, Milica
AU  - Maličević, Živorad
AU  - Stojanović, Dragica
AU  - Vasiljević, Ivana
AU  - Jovanović, Marina
AU  - Đukić, Mirjana
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1121
AB  - Although brain complications in sepsis are not rare, early pathophysiologic events had not been made clear yet. We have considered antioxidative components-glutathione peroxidase (GSHPx) activity and reduced glutathione (GSH) concentration in two brain integrative centers, Le the brain stem (BS) and thalamus. Sepsis was induced in adult male Wistar rats (200-250 g) by cecal ligation and perforation (CLP) with inoculation of Escherichia coli suspension (ATCC 25922) (n=40). The control group was sham operated (n=40). For each time point (0, 12, 24 and 72 hours) after treatment, ten animals within each group were decapitated. In BS, GSHPx activity increased at 12 and 24 hours after CLP, while in the thalamus, GSHPx activity increased at 72 hours, compared to controls. In BS, GSH concentration decreased at the 12(th) and 24(th) hour, and in the thalamus it decreased at the 72(nd) hour. Changed oxidative status in BS, recorded as soon as the 12(th) hour reflects a prompt reaction of the central nervous system. This could be of great consequence for disturbed vasomotor response during sepsis.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Brain stem and thalamus antioxidative defensein experimental sepsis
VL  - 58
IS  - 2-3
SP  - 129
EP  - 137
DO  - 10.2298/AVB0803129N
ER  - 

@article{
author = "Ninković, Milica and Maličević, Živorad and Stojanović, Dragica and Vasiljević, Ivana and Jovanović, Marina and Đukić, Mirjana",
year = "2008",
abstract = "Although brain complications in sepsis are not rare, early pathophysiologic events had not been made clear yet. We have considered antioxidative components-glutathione peroxidase (GSHPx) activity and reduced glutathione (GSH) concentration in two brain integrative centers, Le the brain stem (BS) and thalamus. Sepsis was induced in adult male Wistar rats (200-250 g) by cecal ligation and perforation (CLP) with inoculation of Escherichia coli suspension (ATCC 25922) (n=40). The control group was sham operated (n=40). For each time point (0, 12, 24 and 72 hours) after treatment, ten animals within each group were decapitated. In BS, GSHPx activity increased at 12 and 24 hours after CLP, while in the thalamus, GSHPx activity increased at 72 hours, compared to controls. In BS, GSH concentration decreased at the 12(th) and 24(th) hour, and in the thalamus it decreased at the 72(nd) hour. Changed oxidative status in BS, recorded as soon as the 12(th) hour reflects a prompt reaction of the central nervous system. This could be of great consequence for disturbed vasomotor response during sepsis.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Brain stem and thalamus antioxidative defensein experimental sepsis",
volume = "58",
number = "2-3",
pages = "129-137",
doi = "10.2298/AVB0803129N"
}

Ninković, M., Maličević, Ž., Stojanović, D., Vasiljević, I., Jovanović, M.,& Đukić, M.. (2008). Brain stem and thalamus antioxidative defensein experimental sepsis. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(2-3), 129-137.
https://doi.org/10.2298/AVB0803129N

Ninković M, Maličević Ž, Stojanović D, Vasiljević I, Jovanović M, Đukić M. Brain stem and thalamus antioxidative defensein experimental sepsis. in Acta veterinaria. 2008;58(2-3):129-137.
doi:10.2298/AVB0803129N .

Ninković, Milica, Maličević, Živorad, Stojanović, Dragica, Vasiljević, Ivana, Jovanović, Marina, Đukić, Mirjana, "Brain stem and thalamus antioxidative defensein experimental sepsis" in Acta veterinaria, 58, no. 2-3 (2008):129-137,
https://doi.org/10.2298/AVB0803129N . .