TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5614
AB  - Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.
PB  - Elsevier Inc.
T2  - Environmental Research
T1  - Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
VL  - 252
IS  - 1
SP  - 118680
DO  - 10.1016/j.envres.2024.118680
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.",
publisher = "Elsevier Inc.",
journal = "Environmental Research",
title = "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach",
volume = "252",
number = "1",
pages = "118680",
doi = "10.1016/j.envres.2024.118680"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research
Elsevier Inc.., 252(1), 118680.
https://doi.org/10.1016/j.envres.2024.118680

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research. 2024;252(1):118680.
doi:10.1016/j.envres.2024.118680 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach" in Environmental Research, 252, no. 1 (2024):118680,
https://doi.org/10.1016/j.envres.2024.118680 . .

TY  - JOUR
AU  - Zbiljić, Miloš
AU  - Lakušić, Branislava
AU  - Kuzmanović, Nevena
AU  - Stojanović, Danilo
AU  - Lakušić, Dmitar
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5125
AB  - In this work, the overall morpho-anatomical variability of Teucrium montanum sensu lato on the Balkan Peninsula was described. A total of 60 populations were collected all over the Balkans. For each analysed individual, the morphological characters of the stem, leaves, and flowers, as well as the anatomical characters of leaves were measured. The habitats of each population were characterized by altitude zone, type of geological substrate, vegetation, and climate type. Basic descriptive statistics were calculated for each character state, and multivariate analyses were used to compare all assessed characters and groups. The results showed that the analysed populations exhibit high morphological variability and broad ecological preferences. Five of the seven morphologically defined groups fit the already described taxa (T. montanum subsp. montanum, T. montanum subsp. helianthemoides, T. pannonicum, T. skorpili, T. montanum var. parnassicum), whereas two groups are morphologically specific but did not fit the existing taxonomic concepts. The patterns of observed morphological variability only partially match the patterns of ecological differentiation of the habitats of the analysed populations. The occurrence of different morphological groups inhabiting similar habitats in the same biogeographic region suggests that the morpho-anatomical differentiation of T. montanum s.l. may be due to genetic or evolutionary factors.
PB  - Taylor and Francis
T2  - Plant Biosystems
T1  - Morphological diversification of Teucrium montanum sensu lato on the  Balkan Peninsula
VL  - 157
IS  - 3
SP  - 670
EP  - 687
DO  - 10.1080/11263504.2023.2186509
ER  - 

@article{
author = "Zbiljić, Miloš and Lakušić, Branislava and Kuzmanović, Nevena and Stojanović, Danilo and Lakušić, Dmitar",
year = "2023",
abstract = "In this work, the overall morpho-anatomical variability of Teucrium montanum sensu lato on the Balkan Peninsula was described. A total of 60 populations were collected all over the Balkans. For each analysed individual, the morphological characters of the stem, leaves, and flowers, as well as the anatomical characters of leaves were measured. The habitats of each population were characterized by altitude zone, type of geological substrate, vegetation, and climate type. Basic descriptive statistics were calculated for each character state, and multivariate analyses were used to compare all assessed characters and groups. The results showed that the analysed populations exhibit high morphological variability and broad ecological preferences. Five of the seven morphologically defined groups fit the already described taxa (T. montanum subsp. montanum, T. montanum subsp. helianthemoides, T. pannonicum, T. skorpili, T. montanum var. parnassicum), whereas two groups are morphologically specific but did not fit the existing taxonomic concepts. The patterns of observed morphological variability only partially match the patterns of ecological differentiation of the habitats of the analysed populations. The occurrence of different morphological groups inhabiting similar habitats in the same biogeographic region suggests that the morpho-anatomical differentiation of T. montanum s.l. may be due to genetic or evolutionary factors.",
publisher = "Taylor and Francis",
journal = "Plant Biosystems",
title = "Morphological diversification of Teucrium montanum sensu lato on the  Balkan Peninsula",
volume = "157",
number = "3",
pages = "670-687",
doi = "10.1080/11263504.2023.2186509"
}

Zbiljić, M., Lakušić, B., Kuzmanović, N., Stojanović, D.,& Lakušić, D.. (2023). Morphological diversification of Teucrium montanum sensu lato on the  Balkan Peninsula. in Plant Biosystems
Taylor and Francis., 157(3), 670-687.
https://doi.org/10.1080/11263504.2023.2186509

Zbiljić M, Lakušić B, Kuzmanović N, Stojanović D, Lakušić D. Morphological diversification of Teucrium montanum sensu lato on the  Balkan Peninsula. in Plant Biosystems. 2023;157(3):670-687.
doi:10.1080/11263504.2023.2186509 .

Zbiljić, Miloš, Lakušić, Branislava, Kuzmanović, Nevena, Stojanović, Danilo, Lakušić, Dmitar, "Morphological diversification of Teucrium montanum sensu lato on the  Balkan Peninsula" in Plant Biosystems, 157, no. 3 (2023):670-687,
https://doi.org/10.1080/11263504.2023.2186509 . .

TY  - JOUR
AU  - Novović, Katarina
AU  - Kuzmanović Nedeljković, Snežana
AU  - Poledica, Mirjana
AU  - Nikolić, Gordana
AU  - Grujić, Bojana
AU  - Jovčić, Branko
AU  - Kojić, Milan
AU  - Filipić, Brankica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4471
AB  - Since the WHO declared the COVID-19 pandemic in March 2020, the disease has spread rapidly leading to overload of the health system and many of the patients infected with SARS-CoV-2 needed to be admitted to the intensive care unit (ICU). Around 10% of patients with the severe manifestation of COVID-19 need noninvasive or invasive mechanical ventilation, which represent a risk factor for Acinetobacter baumannii superinfection. The 64 A. baumannii isolates were recovered from COVID-19 patients admitted to ICU at General Hospital “Dr Laza K. Lazarević” Šabac, Serbia, during the period from December 2020 to February 2021. All patients required mechanical ventilation and mortality rate was 100%. The goal of this study was to evaluate antibiotic resistance profiles and virulence potential of A. baumannii isolates recovered from patients with severe form of COVID-19 who had a need for mechanical ventilation. All tested A. baumannii isolates (n = 64) were sensitive to colistin, while resistant to meropenem, imipenem, gentamicin, tobramycin, and levofloxacin according to the broth microdilution method and MDR phenotype was confirmed. In all tested isolates, representatives of international clone 2 (IC2) classified by multiplex PCR for clonal lineage identification, blaAmpC, blaOXA-51, and blaOXA-23 genes were present, as well as ISAba1 insertion sequence upstream of blaOXA-23. Clonal distribution of one dominant strain was found, but individual strains showed phenotypic differences in the level of antibiotic resistance, biofilm formation, and binding to mucin and motility. According to PFGE, four isolates were sequenced and antibiotic resistance genes as well as virulence factors genes were analyzed in these genomes. The results of this study represent the first report on virulence potential of MDR A. baumannii from hospital in Serbia.
PB  - Frontiers Media S.A.
T2  - Frontiers in Microbiology
T1  - Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia
VL  - 14
DO  - 10.3389/fmicb.2023.1094184
ER  - 

@article{
author = "Novović, Katarina and Kuzmanović Nedeljković, Snežana and Poledica, Mirjana and Nikolić, Gordana and Grujić, Bojana and Jovčić, Branko and Kojić, Milan and Filipić, Brankica",
year = "2023",
abstract = "Since the WHO declared the COVID-19 pandemic in March 2020, the disease has spread rapidly leading to overload of the health system and many of the patients infected with SARS-CoV-2 needed to be admitted to the intensive care unit (ICU). Around 10% of patients with the severe manifestation of COVID-19 need noninvasive or invasive mechanical ventilation, which represent a risk factor for Acinetobacter baumannii superinfection. The 64 A. baumannii isolates were recovered from COVID-19 patients admitted to ICU at General Hospital “Dr Laza K. Lazarević” Šabac, Serbia, during the period from December 2020 to February 2021. All patients required mechanical ventilation and mortality rate was 100%. The goal of this study was to evaluate antibiotic resistance profiles and virulence potential of A. baumannii isolates recovered from patients with severe form of COVID-19 who had a need for mechanical ventilation. All tested A. baumannii isolates (n = 64) were sensitive to colistin, while resistant to meropenem, imipenem, gentamicin, tobramycin, and levofloxacin according to the broth microdilution method and MDR phenotype was confirmed. In all tested isolates, representatives of international clone 2 (IC2) classified by multiplex PCR for clonal lineage identification, blaAmpC, blaOXA-51, and blaOXA-23 genes were present, as well as ISAba1 insertion sequence upstream of blaOXA-23. Clonal distribution of one dominant strain was found, but individual strains showed phenotypic differences in the level of antibiotic resistance, biofilm formation, and binding to mucin and motility. According to PFGE, four isolates were sequenced and antibiotic resistance genes as well as virulence factors genes were analyzed in these genomes. The results of this study represent the first report on virulence potential of MDR A. baumannii from hospital in Serbia.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Microbiology",
title = "Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia",
volume = "14",
doi = "10.3389/fmicb.2023.1094184"
}

Novović, K., Kuzmanović Nedeljković, S., Poledica, M., Nikolić, G., Grujić, B., Jovčić, B., Kojić, M.,& Filipić, B.. (2023). Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia. in Frontiers in Microbiology
Frontiers Media S.A.., 14.
https://doi.org/10.3389/fmicb.2023.1094184

Novović K, Kuzmanović Nedeljković S, Poledica M, Nikolić G, Grujić B, Jovčić B, Kojić M, Filipić B. Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia. in Frontiers in Microbiology. 2023;14.
doi:10.3389/fmicb.2023.1094184 .

Novović, Katarina, Kuzmanović Nedeljković, Snežana, Poledica, Mirjana, Nikolić, Gordana, Grujić, Bojana, Jovčić, Branko, Kojić, Milan, Filipić, Brankica, "Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia" in Frontiers in Microbiology, 14 (2023),
https://doi.org/10.3389/fmicb.2023.1094184 . .

TY  - JOUR
AU  - Đurović, Sanja
AU  - Ranimirović, Milana
AU  - Tomović, Gordana
AU  - Petkovski, Gorana
AU  - Niketić, Marjan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5446
AB  - This paper contains information on specimens of the genus Euphorbia L. 
collected in Serbia and deposited in the Herbarium of the Natural History Museum in Belgrade (BEO) and in the Herbarium of the University of Belgrade (BEOU). A total of 2199 herbarium sheets were examined, of which 915 are deposited in BEO and 1284 in BEOU. The catalogue with herbarium data on 37 taxa of the genus Euphorbia distributed in Serbia is presented as well as distribution maps for all recorded taxa.
AB  - Овај рад садржи информације о примерцима рода Euphorbia L. 
сакупљеним у Србији и депонованим у Хербаријуму Природњачког
музеја у Београду (BEO) и у Хербаријуму Универзитета у Београду
(BEOU). Испитано је укупно 2199 хербаријумских табака, од којих је
915 депоновано у BEO, а 1284 у BEOU. Дат је каталог хербарских
података о примерцима 37 таксона у оквиру рода Euphorbia распрострањених у Србији, као и карте распрострањења за све забележене
таксоне.
PB  - Natural History Museum, Belgrade, Serbia
T2  - Bulletin of the Natural History Museum
T1  - Genus Euphorbia L. (Euphorbiaceae Juss.) in Serbia based on herbarium data from the collections BEO and BEOU
T1  - Род Euphorbia L. (Euphorbiaceae Juss.) у Србији - хербаријумски подаци у збиркама BEO и BEOU
VL  - 15
SP  - 97
EP  - 120
DO  - 10.5937/bnhmb2215097D
ER  - 

@article{
author = "Đurović, Sanja and Ranimirović, Milana and Tomović, Gordana and Petkovski, Gorana and Niketić, Marjan",
year = "2022",
abstract = "This paper contains information on specimens of the genus Euphorbia L. 
collected in Serbia and deposited in the Herbarium of the Natural History Museum in Belgrade (BEO) and in the Herbarium of the University of Belgrade (BEOU). A total of 2199 herbarium sheets were examined, of which 915 are deposited in BEO and 1284 in BEOU. The catalogue with herbarium data on 37 taxa of the genus Euphorbia distributed in Serbia is presented as well as distribution maps for all recorded taxa., Овај рад садржи информације о примерцима рода Euphorbia L. 
сакупљеним у Србији и депонованим у Хербаријуму Природњачког
музеја у Београду (BEO) и у Хербаријуму Универзитета у Београду
(BEOU). Испитано је укупно 2199 хербаријумских табака, од којих је
915 депоновано у BEO, а 1284 у BEOU. Дат је каталог хербарских
података о примерцима 37 таксона у оквиру рода Euphorbia распрострањених у Србији, као и карте распрострањења за све забележене
таксоне.",
publisher = "Natural History Museum, Belgrade, Serbia",
journal = "Bulletin of the Natural History Museum",
title = "Genus Euphorbia L. (Euphorbiaceae Juss.) in Serbia based on herbarium data from the collections BEO and BEOU, Род Euphorbia L. (Euphorbiaceae Juss.) у Србији - хербаријумски подаци у збиркама BEO и BEOU",
volume = "15",
pages = "97-120",
doi = "10.5937/bnhmb2215097D"
}

Đurović, S., Ranimirović, M., Tomović, G., Petkovski, G.,& Niketić, M.. (2022). Genus Euphorbia L. (Euphorbiaceae Juss.) in Serbia based on herbarium data from the collections BEO and BEOU. in Bulletin of the Natural History Museum
Natural History Museum, Belgrade, Serbia., 15, 97-120.
https://doi.org/10.5937/bnhmb2215097D

Đurović S, Ranimirović M, Tomović G, Petkovski G, Niketić M. Genus Euphorbia L. (Euphorbiaceae Juss.) in Serbia based on herbarium data from the collections BEO and BEOU. in Bulletin of the Natural History Museum. 2022;15:97-120.
doi:10.5937/bnhmb2215097D .

Đurović, Sanja, Ranimirović, Milana, Tomović, Gordana, Petkovski, Gorana, Niketić, Marjan, "Genus Euphorbia L. (Euphorbiaceae Juss.) in Serbia based on herbarium data from the collections BEO and BEOU" in Bulletin of the Natural History Museum, 15 (2022):97-120,
https://doi.org/10.5937/bnhmb2215097D . .

TY  - JOUR
AU  - Niketić, Marjan
AU  - Tomović, Gordana
AU  - Anačkov, Goran
AU  - Đorđević, Vladan
AU  - Đurović, Sanja
AU  - Duraki, Šemija
AU  - Kabaš, Eva
AU  - Lakušić, Dmitar
AU  - Petkovski, Gorana
AU  - Petrović, Silvana
AU  - Ranimirović, Milana
AU  - Slavkovska, Violeta
AU  - Ušjak, Ljuboš
AU  - Zbiljić, Miloš
AU  - Zlatković, Bojan
AU  - Stevanović, Vladimir
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4958
AB  - This paper represents the fourth part of the inventory of the flora of Serbia (Niketić et al. 2018, 2020, 2021), which contains nomenclatural, taxonomic and floristic notes related to taxa from the Magnoliopsida group. At the same time, this contribution is the basis for publication of subsequent volumes of the An annotated checklist of vascular flora of Serbia in order to supplement the data on vascular plants in our country.
AB  - У раду је предложено пет нових номенклатурних комбинација, а поред тога, представљено је 17 таксона (врста, подврста и хибрида) васкуларне флоре који су нови за флору Србије (од тога 12 аутохтоних и пет алохтоних биљак). Потврђени су стари или непоуздани наводи за две аутохтоне биљке у флори Србије. У последњем делу рада дате су информације о деветнаест таксона чије је присуство у Србији или у њеним територијалним јединицама оповргнуто.
PB  - Natural History Museum, Belgrade, Serbia
T2  - Bulletin of the Natural History Museum
T1  - Material on the Annotated checklist of vascular flora of Serbia. Nomenclatural, taxonomic and floristic notes IV
T1  - Mатеријал за Kритичку листу врста васкуларне флоре Србије. Номенклатурни, таксономски и флористички прилози IV
VL  - 15
SP  - 27
EP  - 96
DO  - 10.5937/bnhmb2215027N
ER  - 

@article{
author = "Niketić, Marjan and Tomović, Gordana and Anačkov, Goran and Đorđević, Vladan and Đurović, Sanja and Duraki, Šemija and Kabaš, Eva and Lakušić, Dmitar and Petkovski, Gorana and Petrović, Silvana and Ranimirović, Milana and Slavkovska, Violeta and Ušjak, Ljuboš and Zbiljić, Miloš and Zlatković, Bojan and Stevanović, Vladimir",
year = "2022",
abstract = "This paper represents the fourth part of the inventory of the flora of Serbia (Niketić et al. 2018, 2020, 2021), which contains nomenclatural, taxonomic and floristic notes related to taxa from the Magnoliopsida group. At the same time, this contribution is the basis for publication of subsequent volumes of the An annotated checklist of vascular flora of Serbia in order to supplement the data on vascular plants in our country., У раду је предложено пет нових номенклатурних комбинација, а поред тога, представљено је 17 таксона (врста, подврста и хибрида) васкуларне флоре који су нови за флору Србије (од тога 12 аутохтоних и пет алохтоних биљак). Потврђени су стари или непоуздани наводи за две аутохтоне биљке у флори Србије. У последњем делу рада дате су информације о деветнаест таксона чије је присуство у Србији или у њеним територијалним јединицама оповргнуто.",
publisher = "Natural History Museum, Belgrade, Serbia",
journal = "Bulletin of the Natural History Museum",
title = "Material on the Annotated checklist of vascular flora of Serbia. Nomenclatural, taxonomic and floristic notes IV, Mатеријал за Kритичку листу врста васкуларне флоре Србије. Номенклатурни, таксономски и флористички прилози IV",
volume = "15",
pages = "27-96",
doi = "10.5937/bnhmb2215027N"
}

Niketić, M., Tomović, G., Anačkov, G., Đorđević, V., Đurović, S., Duraki, Š., Kabaš, E., Lakušić, D., Petkovski, G., Petrović, S., Ranimirović, M., Slavkovska, V., Ušjak, L., Zbiljić, M., Zlatković, B.,& Stevanović, V.. (2022). Material on the Annotated checklist of vascular flora of Serbia. Nomenclatural, taxonomic and floristic notes IV. in Bulletin of the Natural History Museum
Natural History Museum, Belgrade, Serbia., 15, 27-96.
https://doi.org/10.5937/bnhmb2215027N

Niketić M, Tomović G, Anačkov G, Đorđević V, Đurović S, Duraki Š, Kabaš E, Lakušić D, Petkovski G, Petrović S, Ranimirović M, Slavkovska V, Ušjak L, Zbiljić M, Zlatković B, Stevanović V. Material on the Annotated checklist of vascular flora of Serbia. Nomenclatural, taxonomic and floristic notes IV. in Bulletin of the Natural History Museum. 2022;15:27-96.
doi:10.5937/bnhmb2215027N .

Niketić, Marjan, Tomović, Gordana, Anačkov, Goran, Đorđević, Vladan, Đurović, Sanja, Duraki, Šemija, Kabaš, Eva, Lakušić, Dmitar, Petkovski, Gorana, Petrović, Silvana, Ranimirović, Milana, Slavkovska, Violeta, Ušjak, Ljuboš, Zbiljić, Miloš, Zlatković, Bojan, Stevanović, Vladimir, "Material on the Annotated checklist of vascular flora of Serbia. Nomenclatural, taxonomic and floristic notes IV" in Bulletin of the Natural History Museum, 15 (2022):27-96,
https://doi.org/10.5937/bnhmb2215027N . .

TY  - JOUR
AU  - Filipić, Brankica
AU  - Malešević, Milka
AU  - Vasiljević, Zorica
AU  - Novović, Katarina
AU  - Kojić, Milan
AU  - Jovčić, Branko
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4370
AB  - Trimethoprim-sulfamethoxazole (SXT) is the preferable treatment option of the infections caused by Achromobacter spp. Our study aimed to analyze the SXT resistance of 98 Achromobacter spp. isolates from pediatric patients, among which 33 isolates were SXT-resistant. The presence of intI1 was screened by PCR and genome sequence analyses. The intI1 gene was detected in 10 of SXT-resistant isolates that had shorter intI1 PCR fragments named intI1S. Structural changes in intI1S were confirmed by genome sequencing and analyses which revealed 86 amino acids deletion in IntI1S protein compared to canonical IntI1 protein. All IntI1S isolates were of non-CF origin. Pan-genome analysis of intI1S bearing A. xylosoxidans isolates comprised 9052 genes, with the core genome consisting of 5455 protein-coding genes. Results in this study indicate that IntI1S isolates were derived from clinical settings and that cystic fibrosis (CF) patients were potential reservoirs for healthcare-associated infections that occurred in non-CF patients.
PB  - Springer Science and Business Media B.V.
T2  - Folia Microbiologica
T1  - Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene
VL  - n/d
DO  - 10.1007/s12223-022-01026-8
ER  - 

@article{
author = "Filipić, Brankica and Malešević, Milka and Vasiljević, Zorica and Novović, Katarina and Kojić, Milan and Jovčić, Branko",
year = "2022",
abstract = "Trimethoprim-sulfamethoxazole (SXT) is the preferable treatment option of the infections caused by Achromobacter spp. Our study aimed to analyze the SXT resistance of 98 Achromobacter spp. isolates from pediatric patients, among which 33 isolates were SXT-resistant. The presence of intI1 was screened by PCR and genome sequence analyses. The intI1 gene was detected in 10 of SXT-resistant isolates that had shorter intI1 PCR fragments named intI1S. Structural changes in intI1S were confirmed by genome sequencing and analyses which revealed 86 amino acids deletion in IntI1S protein compared to canonical IntI1 protein. All IntI1S isolates were of non-CF origin. Pan-genome analysis of intI1S bearing A. xylosoxidans isolates comprised 9052 genes, with the core genome consisting of 5455 protein-coding genes. Results in this study indicate that IntI1S isolates were derived from clinical settings and that cystic fibrosis (CF) patients were potential reservoirs for healthcare-associated infections that occurred in non-CF patients.",
publisher = "Springer Science and Business Media B.V.",
journal = "Folia Microbiologica",
title = "Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene",
volume = "n/d",
doi = "10.1007/s12223-022-01026-8"
}

Filipić, B., Malešević, M., Vasiljević, Z., Novović, K., Kojić, M.,& Jovčić, B.. (2022). Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene. in Folia Microbiologica
Springer Science and Business Media B.V.., n/d.
https://doi.org/10.1007/s12223-022-01026-8

Filipić B, Malešević M, Vasiljević Z, Novović K, Kojić M, Jovčić B. Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene. in Folia Microbiologica. 2022;n/d.
doi:10.1007/s12223-022-01026-8 .

Filipić, Brankica, Malešević, Milka, Vasiljević, Zorica, Novović, Katarina, Kojić, Milan, Jovčić, Branko, "Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene" in Folia Microbiologica, n/d (2022),
https://doi.org/10.1007/s12223-022-01026-8 . .

TY  - JOUR
AU  - Božić, Bojan
AU  - Lađarević, Jelena
AU  - Petković, Miloš
AU  - Mijin, Dušan
AU  - Stavber, Stojan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4433
AB  - The susceptibility of the carbonyl group towards nucleophilic attack affords the construction of various organic compounds. Thus, investigations of carbonyl activation applying greener methodologies are highly important. In the present work, among the investigated N-halo compounds, N-fluorobenzenesulfonimide (NFSi) has been found as an efficient and selective catalyst in the reaction of direct esterification of aryl and alkyl carboxylic acids supported by microwave (MW) irradiation. The comprehensive esterification of different benzoic acids and mono-, di-and tri-carboxy alkyl derivatives was performed, whereby significant reaction time reductions were achieved. The presented method used NFSi as an easily manipulatable, non-metal, water-and air-tolerant catalyst, allowing simple synthetic and isolation procedures and energy saving, compared to conventional methodologies. Importantly, in contrast to esterification under thermal conditions, where N-halo compounds behave as pre-catalysts, in the MW-supported protocol, a distinct reaction mechanism has been proposed that assumes NFSi as a sustainable catalyst. Moreover, a scale-up of the industrially important derivative was performed.
PB  - MDPI
T2  - Catalysts
T1  - Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide
VL  - 12
IS  - 11
DO  - 10.3390/catal12111413
ER  - 

@article{
author = "Božić, Bojan and Lađarević, Jelena and Petković, Miloš and Mijin, Dušan and Stavber, Stojan",
year = "2022",
abstract = "The susceptibility of the carbonyl group towards nucleophilic attack affords the construction of various organic compounds. Thus, investigations of carbonyl activation applying greener methodologies are highly important. In the present work, among the investigated N-halo compounds, N-fluorobenzenesulfonimide (NFSi) has been found as an efficient and selective catalyst in the reaction of direct esterification of aryl and alkyl carboxylic acids supported by microwave (MW) irradiation. The comprehensive esterification of different benzoic acids and mono-, di-and tri-carboxy alkyl derivatives was performed, whereby significant reaction time reductions were achieved. The presented method used NFSi as an easily manipulatable, non-metal, water-and air-tolerant catalyst, allowing simple synthetic and isolation procedures and energy saving, compared to conventional methodologies. Importantly, in contrast to esterification under thermal conditions, where N-halo compounds behave as pre-catalysts, in the MW-supported protocol, a distinct reaction mechanism has been proposed that assumes NFSi as a sustainable catalyst. Moreover, a scale-up of the industrially important derivative was performed.",
publisher = "MDPI",
journal = "Catalysts",
title = "Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide",
volume = "12",
number = "11",
doi = "10.3390/catal12111413"
}

Božić, B., Lađarević, J., Petković, M., Mijin, D.,& Stavber, S.. (2022). Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide. in Catalysts
MDPI., 12(11).
https://doi.org/10.3390/catal12111413

Božić B, Lađarević J, Petković M, Mijin D, Stavber S. Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide. in Catalysts. 2022;12(11).
doi:10.3390/catal12111413 .

Božić, Bojan, Lađarević, Jelena, Petković, Miloš, Mijin, Dušan, Stavber, Stojan, "Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide" in Catalysts, 12, no. 11 (2022),
https://doi.org/10.3390/catal12111413 . .

TY  - JOUR
AU  - Jovanović, Maja
AU  - Lakušić, Dmitar
AU  - Lakušić, Branislava
AU  - Zlatković, Bojan
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3999
AB  - Several related yellow-flowered houseleek species which occur on the Balkan Peninsula are divided into two complexes: Sempervivum ciliosum (S. ciliosum, S. jakucsii, S. klepa, S. octopodes, and S. galicicum) and the S. ruthenicum complex (S. ruthenicum, S. leucanthum, S. kindingeri, and S. zeleborii). Due to strong phenotypic plasticity and a limited number of studies, it is difficult to assert at this point whether all the above species are well defined in the taxonomic sense. Detailed studies of the epidermal structures have not been conducted for any of the species in either complex. The aim of this study was to investigate the degree of variability of the epidermal structures together with their potential usefulness for the taxonomic characterization of the species studied. A total of 18 quantitative characters of the epidermal structures of the adaxial and abaxial surfaces of the rosette leaves were analysed within 16 populations. In all species, the epidermal cells are polygonal or irregularly shaped, with straight or sinuous anticlinal walls, while the rosette leaves are amphistomatic with anisocytic stomata. Simple biseriate multicellular glandular trichomes were found on the adaxial and abaxial surfaces and the margins of the rosette leaves. The results of the descriptive statistics, univariate (ANOVA) and multivariate statistical analysis (CDA, AHC) showed low to high variability in the epidermal cells, guard cells and trichomes. The multivariate analysis showed diversification among the complexes and species. The length of the marginal and apical trichomes of the rosette leaves contributed most to diversification.
AB  - Balkansko poluostrvo nastanjuje nekoliko sličnih, žutocvetnih vrsta čuvarkuća svrstanih u dva kompleksa: Sempervivum ciliosum (S. ciliosum, S. jakucsii, S. klepa, S. octopodes, S. galicicum) i S. ruthenicum (S. ruthenicum, S. leucanthum, S. kindingeri, S. zeleborii). Usled izrazite fenotipske plastičnosti trenutno je teško utvrditi da li su sve vrste pomenutih kompleksa dobro definisane u taksonomskom smislu. Detaljna istraživanja epidermalnih struktura do sada nisu sprovedena ni za jednu od navedenih vrsta. Cilj ove studije bio je da se ispita stepen varijabilnosti epidermalnih struktura i mogućnost njihove primene u taksonomskoj karakterizaciji navedenih vrsta. Ukupno 18 kvantitativnih osobina epidermalnih struktura adaksijalne i abaksijalne površine listova rozete je analizirano na nivou 16 populacija. Kod svih vrsta, epidermalne ćelije su poligonalnog ili nepravilnog oblika, sa ravnim ili vijugavim antiklinalnim zidovima, dok su listovi amfistomatični sa anizocitnim tipom stoma. Prosti biserijatni višećelijski žlezdani trihomi pronađeni su na adaksijalnoj i abaksijalnoj površini, kao i na marginama listova rozete. Rezultati deskriptivne statistike, univarijantnih (ANOVA) i multivarijantnih statističkih analiza (CDA, AHC) ukazuju na nizak do visok stepen varijabilnosti epidermalnih ćelija, ćelija zatvaračica i trihoma. Multivarijantne analize ukazuju na raznolikost kompleksa i vrsta, dok dužine marginalnih i apikalnih trihoma listova u najvećoj meri doprinose njihovoj različitosti.
PB  - Institute of Botany and Botanical Garden "Jevremovac", University of Belgrade
T2  - Botanica Serbica
T1  - Diversification of yellow-flowered Sempervivum (Crassulaceae) species from the Balkan Peninsula: evidence from the morphometric study of the epidermal structures of rosette leaves
T1  - Različitost žutocvetnih vrsta roda Sempervivum (Crassulaceae) Balkanskog poluostrva: rezultati morfometrijskog istraživanja epidermalnih struktura listova rozete.
VL  - 45
IS  - 2
SP  - 163
EP  - 176
DO  - 10.2298/BOTSERB2102163J
ER  - 

@article{
author = "Jovanović, Maja and Lakušić, Dmitar and Lakušić, Branislava and Zlatković, Bojan",
year = "2021",
abstract = "Several related yellow-flowered houseleek species which occur on the Balkan Peninsula are divided into two complexes: Sempervivum ciliosum (S. ciliosum, S. jakucsii, S. klepa, S. octopodes, and S. galicicum) and the S. ruthenicum complex (S. ruthenicum, S. leucanthum, S. kindingeri, and S. zeleborii). Due to strong phenotypic plasticity and a limited number of studies, it is difficult to assert at this point whether all the above species are well defined in the taxonomic sense. Detailed studies of the epidermal structures have not been conducted for any of the species in either complex. The aim of this study was to investigate the degree of variability of the epidermal structures together with their potential usefulness for the taxonomic characterization of the species studied. A total of 18 quantitative characters of the epidermal structures of the adaxial and abaxial surfaces of the rosette leaves were analysed within 16 populations. In all species, the epidermal cells are polygonal or irregularly shaped, with straight or sinuous anticlinal walls, while the rosette leaves are amphistomatic with anisocytic stomata. Simple biseriate multicellular glandular trichomes were found on the adaxial and abaxial surfaces and the margins of the rosette leaves. The results of the descriptive statistics, univariate (ANOVA) and multivariate statistical analysis (CDA, AHC) showed low to high variability in the epidermal cells, guard cells and trichomes. The multivariate analysis showed diversification among the complexes and species. The length of the marginal and apical trichomes of the rosette leaves contributed most to diversification., Balkansko poluostrvo nastanjuje nekoliko sličnih, žutocvetnih vrsta čuvarkuća svrstanih u dva kompleksa: Sempervivum ciliosum (S. ciliosum, S. jakucsii, S. klepa, S. octopodes, S. galicicum) i S. ruthenicum (S. ruthenicum, S. leucanthum, S. kindingeri, S. zeleborii). Usled izrazite fenotipske plastičnosti trenutno je teško utvrditi da li su sve vrste pomenutih kompleksa dobro definisane u taksonomskom smislu. Detaljna istraživanja epidermalnih struktura do sada nisu sprovedena ni za jednu od navedenih vrsta. Cilj ove studije bio je da se ispita stepen varijabilnosti epidermalnih struktura i mogućnost njihove primene u taksonomskoj karakterizaciji navedenih vrsta. Ukupno 18 kvantitativnih osobina epidermalnih struktura adaksijalne i abaksijalne površine listova rozete je analizirano na nivou 16 populacija. Kod svih vrsta, epidermalne ćelije su poligonalnog ili nepravilnog oblika, sa ravnim ili vijugavim antiklinalnim zidovima, dok su listovi amfistomatični sa anizocitnim tipom stoma. Prosti biserijatni višećelijski žlezdani trihomi pronađeni su na adaksijalnoj i abaksijalnoj površini, kao i na marginama listova rozete. Rezultati deskriptivne statistike, univarijantnih (ANOVA) i multivarijantnih statističkih analiza (CDA, AHC) ukazuju na nizak do visok stepen varijabilnosti epidermalnih ćelija, ćelija zatvaračica i trihoma. Multivarijantne analize ukazuju na raznolikost kompleksa i vrsta, dok dužine marginalnih i apikalnih trihoma listova u najvećoj meri doprinose njihovoj različitosti.",
publisher = "Institute of Botany and Botanical Garden "Jevremovac", University of Belgrade",
journal = "Botanica Serbica",
title = "Diversification of yellow-flowered Sempervivum (Crassulaceae) species from the Balkan Peninsula: evidence from the morphometric study of the epidermal structures of rosette leaves, Različitost žutocvetnih vrsta roda Sempervivum (Crassulaceae) Balkanskog poluostrva: rezultati morfometrijskog istraživanja epidermalnih struktura listova rozete.",
volume = "45",
number = "2",
pages = "163-176",
doi = "10.2298/BOTSERB2102163J"
}

Jovanović, M., Lakušić, D., Lakušić, B.,& Zlatković, B.. (2021). Diversification of yellow-flowered Sempervivum (Crassulaceae) species from the Balkan Peninsula: evidence from the morphometric study of the epidermal structures of rosette leaves. in Botanica Serbica
Institute of Botany and Botanical Garden "Jevremovac", University of Belgrade., 45(2), 163-176.
https://doi.org/10.2298/BOTSERB2102163J

Jovanović M, Lakušić D, Lakušić B, Zlatković B. Diversification of yellow-flowered Sempervivum (Crassulaceae) species from the Balkan Peninsula: evidence from the morphometric study of the epidermal structures of rosette leaves. in Botanica Serbica. 2021;45(2):163-176.
doi:10.2298/BOTSERB2102163J .

Jovanović, Maja, Lakušić, Dmitar, Lakušić, Branislava, Zlatković, Bojan, "Diversification of yellow-flowered Sempervivum (Crassulaceae) species from the Balkan Peninsula: evidence from the morphometric study of the epidermal structures of rosette leaves" in Botanica Serbica, 45, no. 2 (2021):163-176,
https://doi.org/10.2298/BOTSERB2102163J . .

TY  - JOUR
AU  - Zbiljić, Miloš
AU  - Lakušić, Branislava
AU  - Marčetić, Mirjana
AU  - Bogdanović, Sandro
AU  - Lakušić, Dmitar
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3941
AB  - Several natural hybrids of Teucrium montanum L. and T. polium L. have been described in certain parts of the area where these two species are sympatric. A new population with intermediate individuals that share morphological characteristics of both T. montanum and T. polium has been found in Croatia (Bisko near Trilj), and most likely represents a hybridogenous taxon. The aim of this study is to compare the morpho-anatomical and phytochemical characteristics of the two parental species and their putative hybrid, as well as to determine the most important distinguishing characters between these three groups. In order to describe the variability and significance of morpho-anatomical and phytochemical differentiation of the analysed groups several multivariate statistical analysis were conducted (PCA, CDA, DFA, UPGMA-clustering). All analyses confirm the separation of two species, T. polium and T. montanum, and reveal the intermediate position of the putative hybrid. In this way, data on morphological and anatomical analysis together with data on the composition of the essential oils support the assumption of the hybridogenous origin of the intermediate individuals. Based on descriptions and original indication of parental species of previously described hybrids T. × castrense Verg., T. × bogoutdinovae Melinkov and T. × rohlenae K.Malý, we found that the intermediate specimens collected in Croatia perfectly correspond to T. × rohlenae, a hybridogenous taxon discovered by Rohlena in the vicinity of Kotor in Montenegro, and thus prove the presence of a new natural hybrid in the flora of Croatia.
PB  - Department of Biology, Faculty of Science, University of Zagreb
T2  - Acta Botanica Croatica
T1  - Morphological and chemical evidence of Teucrium × rohlenae K. Malý (Lamiaceae), a new hybrid in Croatia
VL  - 80
IS  - 1
SP  - 48
EP  - 55
DO  - 10.37427/botcro-2020-033
ER  - 

@article{
author = "Zbiljić, Miloš and Lakušić, Branislava and Marčetić, Mirjana and Bogdanović, Sandro and Lakušić, Dmitar",
year = "2021",
abstract = "Several natural hybrids of Teucrium montanum L. and T. polium L. have been described in certain parts of the area where these two species are sympatric. A new population with intermediate individuals that share morphological characteristics of both T. montanum and T. polium has been found in Croatia (Bisko near Trilj), and most likely represents a hybridogenous taxon. The aim of this study is to compare the morpho-anatomical and phytochemical characteristics of the two parental species and their putative hybrid, as well as to determine the most important distinguishing characters between these three groups. In order to describe the variability and significance of morpho-anatomical and phytochemical differentiation of the analysed groups several multivariate statistical analysis were conducted (PCA, CDA, DFA, UPGMA-clustering). All analyses confirm the separation of two species, T. polium and T. montanum, and reveal the intermediate position of the putative hybrid. In this way, data on morphological and anatomical analysis together with data on the composition of the essential oils support the assumption of the hybridogenous origin of the intermediate individuals. Based on descriptions and original indication of parental species of previously described hybrids T. × castrense Verg., T. × bogoutdinovae Melinkov and T. × rohlenae K.Malý, we found that the intermediate specimens collected in Croatia perfectly correspond to T. × rohlenae, a hybridogenous taxon discovered by Rohlena in the vicinity of Kotor in Montenegro, and thus prove the presence of a new natural hybrid in the flora of Croatia.",
publisher = "Department of Biology, Faculty of Science, University of Zagreb",
journal = "Acta Botanica Croatica",
title = "Morphological and chemical evidence of Teucrium × rohlenae K. Malý (Lamiaceae), a new hybrid in Croatia",
volume = "80",
number = "1",
pages = "48-55",
doi = "10.37427/botcro-2020-033"
}

Zbiljić, M., Lakušić, B., Marčetić, M., Bogdanović, S.,& Lakušić, D.. (2021). Morphological and chemical evidence of Teucrium × rohlenae K. Malý (Lamiaceae), a new hybrid in Croatia. in Acta Botanica Croatica
Department of Biology, Faculty of Science, University of Zagreb., 80(1), 48-55.
https://doi.org/10.37427/botcro-2020-033

Zbiljić M, Lakušić B, Marčetić M, Bogdanović S, Lakušić D. Morphological and chemical evidence of Teucrium × rohlenae K. Malý (Lamiaceae), a new hybrid in Croatia. in Acta Botanica Croatica. 2021;80(1):48-55.
doi:10.37427/botcro-2020-033 .

Zbiljić, Miloš, Lakušić, Branislava, Marčetić, Mirjana, Bogdanović, Sandro, Lakušić, Dmitar, "Morphological and chemical evidence of Teucrium × rohlenae K. Malý (Lamiaceae), a new hybrid in Croatia" in Acta Botanica Croatica, 80, no. 1 (2021):48-55,
https://doi.org/10.37427/botcro-2020-033 . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Stupar, Miloš
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Đogo-Mračević, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3963
AB  - This study aimed to: (i) determine the content of toxic metals and toxigenic fungi in 14 commercial herbal tea samples from the market of Belgrade, Serbia; and (ii) assess their risk to human health. After the microwave digestion (HNO3/H2O2, 7:1,v/v), toxic metal content was determined by graphite furnace atomic absorption spectroscopy (GF-AAS). The health risk as a result of Cd, Pb, As, Mn, Ni, and Cr exposure via herbal tea intake was assessed through estimated daily intake (EDI), target hazard quotient (THQ), and hazard index (HI). Fungi isolated from the tested herbal tea samples were identified on the basis of colony morphology and microscopic characteristics of reproductive structures. Toxic metals concentration in herbal tea samples for Cd, Pb, As, Mn, Ni and Cr ranged 0.04-0.93, 0.09-2.54, 0.03-0.77, 1.82-651.04, 0.97-9.01, 0.49-3.47 mg/kg of dried plant material, respectively. Values of THQ for investigated toxic metals and HI were below 1, indicating the absence of human health risk. All 14 samples of the tested herbal teas were contaminated with fungi, while total count of cultivable fungi in each sample did not exceed national standards (105 CFU/g). Presence of 23 morphologically different isolates suggested moderate fungal diversity of the samples, while the highest isolation frequency (IF) of 100% was documented for Penicillium spp. and Aspergillus spp. The obtained risk assessment results suggest that all the tested samples are safe for human health regarding the toxic metal and fungal content and provide an important basis for understanding the potential risks of toxic metals and toxigenic fungi intake via commercially available herbal teas.
PB  - Academic Press Inc.
T2  - Journal of Food Composition and Analysis
T1  - Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia
VL  - 104
DO  - 10.1016/j.jfca.2021.104159
ER  - 

@article{
author = "Krstić, Marko and Stupar, Miloš and Đukić-Ćosić, Danijela and Baralić, Katarina and Đogo-Mračević, Svetlana",
year = "2021",
abstract = "This study aimed to: (i) determine the content of toxic metals and toxigenic fungi in 14 commercial herbal tea samples from the market of Belgrade, Serbia; and (ii) assess their risk to human health. After the microwave digestion (HNO3/H2O2, 7:1,v/v), toxic metal content was determined by graphite furnace atomic absorption spectroscopy (GF-AAS). The health risk as a result of Cd, Pb, As, Mn, Ni, and Cr exposure via herbal tea intake was assessed through estimated daily intake (EDI), target hazard quotient (THQ), and hazard index (HI). Fungi isolated from the tested herbal tea samples were identified on the basis of colony morphology and microscopic characteristics of reproductive structures. Toxic metals concentration in herbal tea samples for Cd, Pb, As, Mn, Ni and Cr ranged 0.04-0.93, 0.09-2.54, 0.03-0.77, 1.82-651.04, 0.97-9.01, 0.49-3.47 mg/kg of dried plant material, respectively. Values of THQ for investigated toxic metals and HI were below 1, indicating the absence of human health risk. All 14 samples of the tested herbal teas were contaminated with fungi, while total count of cultivable fungi in each sample did not exceed national standards (105 CFU/g). Presence of 23 morphologically different isolates suggested moderate fungal diversity of the samples, while the highest isolation frequency (IF) of 100% was documented for Penicillium spp. and Aspergillus spp. The obtained risk assessment results suggest that all the tested samples are safe for human health regarding the toxic metal and fungal content and provide an important basis for understanding the potential risks of toxic metals and toxigenic fungi intake via commercially available herbal teas.",
publisher = "Academic Press Inc.",
journal = "Journal of Food Composition and Analysis",
title = "Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia",
volume = "104",
doi = "10.1016/j.jfca.2021.104159"
}

Krstić, M., Stupar, M., Đukić-Ćosić, D., Baralić, K.,& Đogo-Mračević, S.. (2021). Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia. in Journal of Food Composition and Analysis
Academic Press Inc.., 104.
https://doi.org/10.1016/j.jfca.2021.104159

Krstić M, Stupar M, Đukić-Ćosić D, Baralić K, Đogo-Mračević S. Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia. in Journal of Food Composition and Analysis. 2021;104.
doi:10.1016/j.jfca.2021.104159 .

Krstić, Marko, Stupar, Miloš, Đukić-Ćosić, Danijela, Baralić, Katarina, Đogo-Mračević, Svetlana, "Health risk assessment of toxic metals and toxigenic fungi in commercial herbal tea samples from Belgrade, Serbia" in Journal of Food Composition and Analysis, 104 (2021),
https://doi.org/10.1016/j.jfca.2021.104159 . .

TY  - JOUR
AU  - Ilijević, Konstantin
AU  - Vujanović, Dragana
AU  - Orčić, Snežana
AU  - Purać, Jelena
AU  - Kojić, Danijela
AU  - Zarić, Nenad
AU  - Gržetić, Ivan
AU  - Blagojević, Duško P.
AU  - Čelić, Tatjana V.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3648
AB  - Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.
PB  - Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
T1  - Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph
VL  - 239
DO  - 10.1016/j.cbpc.2020.108852
ER  - 

@article{
author = "Ilijević, Konstantin and Vujanović, Dragana and Orčić, Snežana and Purać, Jelena and Kojić, Danijela and Zarić, Nenad and Gržetić, Ivan and Blagojević, Duško P. and Čelić, Tatjana V.",
year = "2021",
abstract = "Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.",
publisher = "Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology",
title = "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph",
volume = "239",
doi = "10.1016/j.cbpc.2020.108852"
}

Ilijević, K., Vujanović, D., Orčić, S., Purać, J., Kojić, D., Zarić, N., Gržetić, I., Blagojević, D. P.,& Čelić, T. V.. (2021). Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Elsevier Inc.., 239.
https://doi.org/10.1016/j.cbpc.2020.108852

Ilijević K, Vujanović D, Orčić S, Purać J, Kojić D, Zarić N, Gržetić I, Blagojević DP, Čelić TV. Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2021;239.
doi:10.1016/j.cbpc.2020.108852 .

Ilijević, Konstantin, Vujanović, Dragana, Orčić, Snežana, Purać, Jelena, Kojić, Danijela, Zarić, Nenad, Gržetić, Ivan, Blagojević, Duško P., Čelić, Tatjana V., "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph" in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 239 (2021),
https://doi.org/10.1016/j.cbpc.2020.108852 . .

TY  - JOUR
AU  - Milojković, Marko
AU  - Nenadović, Željka
AU  - Stanković, Slaviša
AU  - Božić, Dragana
AU  - Stanković-Nedeljković, Nataša
AU  - Ćirković, Ivana
AU  - Petrović, Marija
AU  - Dimkić, Ivica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3716
AB  - Drug resistance of Pseudomonas aeruginosa is a leading problem in hospital infections. The aim of this study was to determine the best molecular genetic discrimination method for Pseudomonas spp. isolates among 94 outpatients and inpatients and see their grouping by phenotype characteristics (biofilm formation, frequency of serotypes, pigmentation, production of different class of beta-lactamases, and susceptibility to different antibiotic classes) and genotype. The most common serotypes were P1, P6, and P11, while co-productions of pyoverdine and pyocyanin were observed in 70 % of isolates. A total of 77.66 % isolates were mostly weak and moderate biofilm producers. Isolates were susceptible to colistin (100 %), aztreonam (97.87 %), imipenem (91.49 %), doripenem (90.43 %), and meropenem (84.04 %). MICs values confirmed susceptibility to ceftazidime and cefepime and singled out meripenem as the most effective inhibitor. Most isolates were resistant to aminoglycosides and fluoroquinolones. Only two isolates produced ESBL, eight were carbapenemase producers, and five isolates produced MBLs. Twenty-nine isolates were multidrug-resistant; 82.8 % of which produced both pigments, 58.3 % were non-typeable, while the P6 and P11 serotypes were equally distributed (16.7 %). Thirteen MDR isolates were strong enzyme producers. RAPD PCR analysis using primer 272 proved the best at discriminatory fingerprinting for Pseudomonas isolates, as it allocated 12 clusters. A correlation between DNA patterns and antibiotic resistance, production of pigments, serotypes distribution, and biofilm formation was not observed, and only confirmed higher genetic heterogeneity among P. aeruginosa isolates, which suggests that other molecular methods are needed to reveal potential relations between genotypic patterns and phenotypic characteristics.
AB  - Antibiotska rezistencija Pseudomonas aeruginosa vodeći je problem u bolničkim infekcijama. Cilj ovoga istraživanja bio je utvrditi najbolju diskriminatorno molekularno-genetičku metodu među 94 ambulantna i bolnička Pseudomonas spp. izolata kako bi se uvidjelo njihovo grupiranje u smislu različitih fenotipskih obilježja (stvaranje biofilma, učestalost serotipova, pigmentacija, proizvodnja različitih klasa beta-laktamaza i osjetljivost na različite skupine antibiotika) u skladu s genotipom. Najčešći serotipovi bili su P1, P6 i P11, a proizvodnja i pioverdina i piocijanina primijećena je kod 70 % izolata. Ukupno 77,66 % izolata uglavnom je iskazalo slabu i umjerenu proizvodnju biofilma. Izolati su bili osjetljivi na kolistin (100 %), aztreonam (97,87 %), imipenem (91,49 %), doripenem (90,43 %) i meropenem (84,04 %). Vrijednosti MIC-ova potvrdile su podložnost izolata ceftazidimu i cefepimu, a izdvojile su meropenem kao najučinkovitiji inhibitor. Većina izolata bila je otporna na aminoglikozid i fluorokinolon. Samo dva izolata proizvela su ESBL, osam izolata sintetiziralo je karbapenemaze, a pet izolata imalo je sposobnost proizvodnje MBL-a. Dvadeset devet izolata bilo je višestruko rezistentno na antibiotike, od kojih je 82,8 % proizvodilo oba pigmenta, 58,3 % bili su netipabilni, a serotipovi P6 i P11 bili su podjednako zastupljeni među njima (16,7 %). Trinaest MDR izolata bili su snažni proizvođači enzima. RAPD PCR analiza korištenjem 272 početnica pokazala se kao najbolja diskriminatorna metoda otiskom prsta (fingerprinting) za Pseudomonas izolate, izdvajajući čak 12 različitih klastera. U ovom istraživanju nije zabilježena povezanost između DNA obrazaca i otpornosti na antibiotike, proizvodnje pigmenata, distribucije serotipova i stvaranja biofilma, što potvrđuje puno veću genetičku heterogenost unutar samih izolata P. aeruginosa, pod čim se podrazumijeva uključivanje drugih molekularnih metoda u otkrivanju potencijalnih odnosa između genetičkih obrazaca i fenotipskih obilježja.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia
T1  - Fenotipska i genetička obilježja osjetljivih i višestruko otpornih izolata Pseudomonas aeruginosa u južnoj Srbiji
VL  - 71
IS  - 3
SP  - 231
EP  - 250
DO  - 10.2478/aiht-2020-71-3418
ER  - 

@article{
author = "Milojković, Marko and Nenadović, Željka and Stanković, Slaviša and Božić, Dragana and Stanković-Nedeljković, Nataša and Ćirković, Ivana and Petrović, Marija and Dimkić, Ivica",
year = "2020",
abstract = "Drug resistance of Pseudomonas aeruginosa is a leading problem in hospital infections. The aim of this study was to determine the best molecular genetic discrimination method for Pseudomonas spp. isolates among 94 outpatients and inpatients and see their grouping by phenotype characteristics (biofilm formation, frequency of serotypes, pigmentation, production of different class of beta-lactamases, and susceptibility to different antibiotic classes) and genotype. The most common serotypes were P1, P6, and P11, while co-productions of pyoverdine and pyocyanin were observed in 70 % of isolates. A total of 77.66 % isolates were mostly weak and moderate biofilm producers. Isolates were susceptible to colistin (100 %), aztreonam (97.87 %), imipenem (91.49 %), doripenem (90.43 %), and meropenem (84.04 %). MICs values confirmed susceptibility to ceftazidime and cefepime and singled out meripenem as the most effective inhibitor. Most isolates were resistant to aminoglycosides and fluoroquinolones. Only two isolates produced ESBL, eight were carbapenemase producers, and five isolates produced MBLs. Twenty-nine isolates were multidrug-resistant; 82.8 % of which produced both pigments, 58.3 % were non-typeable, while the P6 and P11 serotypes were equally distributed (16.7 %). Thirteen MDR isolates were strong enzyme producers. RAPD PCR analysis using primer 272 proved the best at discriminatory fingerprinting for Pseudomonas isolates, as it allocated 12 clusters. A correlation between DNA patterns and antibiotic resistance, production of pigments, serotypes distribution, and biofilm formation was not observed, and only confirmed higher genetic heterogeneity among P. aeruginosa isolates, which suggests that other molecular methods are needed to reveal potential relations between genotypic patterns and phenotypic characteristics., Antibiotska rezistencija Pseudomonas aeruginosa vodeći je problem u bolničkim infekcijama. Cilj ovoga istraživanja bio je utvrditi najbolju diskriminatorno molekularno-genetičku metodu među 94 ambulantna i bolnička Pseudomonas spp. izolata kako bi se uvidjelo njihovo grupiranje u smislu različitih fenotipskih obilježja (stvaranje biofilma, učestalost serotipova, pigmentacija, proizvodnja različitih klasa beta-laktamaza i osjetljivost na različite skupine antibiotika) u skladu s genotipom. Najčešći serotipovi bili su P1, P6 i P11, a proizvodnja i pioverdina i piocijanina primijećena je kod 70 % izolata. Ukupno 77,66 % izolata uglavnom je iskazalo slabu i umjerenu proizvodnju biofilma. Izolati su bili osjetljivi na kolistin (100 %), aztreonam (97,87 %), imipenem (91,49 %), doripenem (90,43 %) i meropenem (84,04 %). Vrijednosti MIC-ova potvrdile su podložnost izolata ceftazidimu i cefepimu, a izdvojile su meropenem kao najučinkovitiji inhibitor. Većina izolata bila je otporna na aminoglikozid i fluorokinolon. Samo dva izolata proizvela su ESBL, osam izolata sintetiziralo je karbapenemaze, a pet izolata imalo je sposobnost proizvodnje MBL-a. Dvadeset devet izolata bilo je višestruko rezistentno na antibiotike, od kojih je 82,8 % proizvodilo oba pigmenta, 58,3 % bili su netipabilni, a serotipovi P6 i P11 bili su podjednako zastupljeni među njima (16,7 %). Trinaest MDR izolata bili su snažni proizvođači enzima. RAPD PCR analiza korištenjem 272 početnica pokazala se kao najbolja diskriminatorna metoda otiskom prsta (fingerprinting) za Pseudomonas izolate, izdvajajući čak 12 različitih klastera. U ovom istraživanju nije zabilježena povezanost između DNA obrazaca i otpornosti na antibiotike, proizvodnje pigmenata, distribucije serotipova i stvaranja biofilma, što potvrđuje puno veću genetičku heterogenost unutar samih izolata P. aeruginosa, pod čim se podrazumijeva uključivanje drugih molekularnih metoda u otkrivanju potencijalnih odnosa između genetičkih obrazaca i fenotipskih obilježja.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia, Fenotipska i genetička obilježja osjetljivih i višestruko otpornih izolata Pseudomonas aeruginosa u južnoj Srbiji",
volume = "71",
number = "3",
pages = "231-250",
doi = "10.2478/aiht-2020-71-3418"
}

Milojković, M., Nenadović, Ž., Stanković, S., Božić, D., Stanković-Nedeljković, N., Ćirković, I., Petrović, M.,& Dimkić, I.. (2020). Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 71(3), 231-250.
https://doi.org/10.2478/aiht-2020-71-3418

Milojković M, Nenadović Ž, Stanković S, Božić D, Stanković-Nedeljković N, Ćirković I, Petrović M, Dimkić I. Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2020;71(3):231-250.
doi:10.2478/aiht-2020-71-3418 .

Milojković, Marko, Nenadović, Željka, Stanković, Slaviša, Božić, Dragana, Stanković-Nedeljković, Nataša, Ćirković, Ivana, Petrović, Marija, Dimkić, Ivica, "Phenotypic and genetic properties of susceptible and multidrug-resistant Pseudomonas aeruginosa isolates in Southern Serbia" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 71, no. 3 (2020):231-250,
https://doi.org/10.2478/aiht-2020-71-3418 . .