Vinča Institute of Nuclear Sciences (No. 451-03-1/2024-03/19-tr)

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Vinča Institute of Nuclear Sciences (No. 451-03-1/2024-03/19-tr)

Authors

Publications

Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining

Baralić, Katarina; Božović, Predrag; Đukić-Ćosić, Danijela

(Institute for Medical Research and Occupational Health, Zagreb, 2024) 

TY  - JOUR
AU  - Baralić, Katarina
AU  - Božović, Predrag
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5680
AB  - Even at low levels, exposure to ionising radiation can lead to eye damage. However, the underlying molecular mechanisms are not yet fully
understood. We aimed to address this gap with a comprehensive in silico approach to the issue. For this purpose we relied on the Comparative
Toxicogenomics Database (CTD), ToppGene Suite, Cytoscape, GeneMANIA, and Metascape to identify six key regulator genes associated
with radiation-induced eye damage (ATM, CRYAB, SIRT1, TGFB1, TREX1, and YAP1), all of which have physical interactions. Some
of the identified molecular functions revolve around DNA repair mechanisms, while others are involved in protein binding, enzymatic
activities, metabolic processes, and post-translational protein modifications. The biological processes are mostly centred on response to
DNA damage, the p53 signalling pathway in particular. We identified a significant role of several miRNAs, such as hsa-miR-183 and hsamiR-589, in the mechanisms behind ionising radiation-induced eye injuries. Our study offers a valuable method for gaining deeper insights
into the adverse effects of radiation exposure.
AB  - Izloženost ionizirajućem zračenju čak i pri niskim razinama može pridonijeti nastanku oštećenja oka. Međutim, osnovni molekulski
mehanizmi i dalje nisu potpuno razjašnjeni. Cilj našega istraživanja bio je ispuniti tu nedostajuću kariku primjenom sveobuhvatnog in silico
pristupa problemu. U tu svrhu, pomoću genomskih baza podataka, portala i poslužitelja (Comparative Toxicogenomics Database, ToppGene
Suite portal, Cytoscape, GeneMANIA i Metascape), identificirano je šest ključnih regulacijskih gena koji su povezani s oštećenjem oka
prouzročenog ionizirajućim zračenjem (ATM, CRYAB, SIRT1, TGFB1, TREX1 i YAP1) i koji su svi bili u fizičkoj interakciji. Neke od
identificiranih molekulskih funkcija odnosile su se na mehanizme popravka oštećenja DNA, a druge su bile uključene u vezanje proteina,
enzimsku aktivnost, metaboličke procese i posttranslacijske modifikacije proteina. Biološki procesi uglavnom su bili povezani s odgovorom
na oštećenje DNA, pogotovo sa signalnim putem p53. Uočena je i značajna uloga nekoliko miRNA, poput hsa-miR-183 i hsa-miR-589,
u mehanizmima povezanima s oštećenjem oka prouzročenog ionizirajućim zračenjem. Osim toga, u ovom je istraživanju opisana korisna
metoda za ispitivanje štetnih učinaka izloženosti zračenju.
PB  - Institute for Medical Research and Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining
T1  - Dekodiranje molekulskog aspekta oštećenja oka prouzročenog ionizirajućim zračenjem pomoću rudarenja genomskih podataka
VL  - 75
IS  - 2
SP  - 91
EP  - 101
DO  - 10.2478/aiht-2024-75-3817
ER  - 
@article{
author = "Baralić, Katarina and Božović, Predrag and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Even at low levels, exposure to ionising radiation can lead to eye damage. However, the underlying molecular mechanisms are not yet fully
understood. We aimed to address this gap with a comprehensive in silico approach to the issue. For this purpose we relied on the Comparative
Toxicogenomics Database (CTD), ToppGene Suite, Cytoscape, GeneMANIA, and Metascape to identify six key regulator genes associated
with radiation-induced eye damage (ATM, CRYAB, SIRT1, TGFB1, TREX1, and YAP1), all of which have physical interactions. Some
of the identified molecular functions revolve around DNA repair mechanisms, while others are involved in protein binding, enzymatic
activities, metabolic processes, and post-translational protein modifications. The biological processes are mostly centred on response to
DNA damage, the p53 signalling pathway in particular. We identified a significant role of several miRNAs, such as hsa-miR-183 and hsamiR-589, in the mechanisms behind ionising radiation-induced eye injuries. Our study offers a valuable method for gaining deeper insights
into the adverse effects of radiation exposure., Izloženost ionizirajućem zračenju čak i pri niskim razinama može pridonijeti nastanku oštećenja oka. Međutim, osnovni molekulski
mehanizmi i dalje nisu potpuno razjašnjeni. Cilj našega istraživanja bio je ispuniti tu nedostajuću kariku primjenom sveobuhvatnog in silico
pristupa problemu. U tu svrhu, pomoću genomskih baza podataka, portala i poslužitelja (Comparative Toxicogenomics Database, ToppGene
Suite portal, Cytoscape, GeneMANIA i Metascape), identificirano je šest ključnih regulacijskih gena koji su povezani s oštećenjem oka
prouzročenog ionizirajućim zračenjem (ATM, CRYAB, SIRT1, TGFB1, TREX1 i YAP1) i koji su svi bili u fizičkoj interakciji. Neke od
identificiranih molekulskih funkcija odnosile su se na mehanizme popravka oštećenja DNA, a druge su bile uključene u vezanje proteina,
enzimsku aktivnost, metaboličke procese i posttranslacijske modifikacije proteina. Biološki procesi uglavnom su bili povezani s odgovorom
na oštećenje DNA, pogotovo sa signalnim putem p53. Uočena je i značajna uloga nekoliko miRNA, poput hsa-miR-183 i hsa-miR-589,
u mehanizmima povezanima s oštećenjem oka prouzročenog ionizirajućim zračenjem. Osim toga, u ovom je istraživanju opisana korisna
metoda za ispitivanje štetnih učinaka izloženosti zračenju.",
publisher = "Institute for Medical Research and Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining, Dekodiranje molekulskog aspekta oštećenja oka prouzročenog ionizirajućim zračenjem pomoću rudarenja genomskih podataka",
volume = "75",
number = "2",
pages = "91-101",
doi = "10.2478/aiht-2024-75-3817"
}
Baralić, K., Božović, P.,& Đukić-Ćosić, D.. (2024). Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Institute for Medical Research and Occupational Health, Zagreb., 75(2), 91-101.
https://doi.org/10.2478/aiht-2024-75-3817
Baralić K, Božović P, Đukić-Ćosić D. Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2024;75(2):91-101.
doi:10.2478/aiht-2024-75-3817 .
Baralić, Katarina, Božović, Predrag, Đukić-Ćosić, Danijela, "Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 75, no. 2 (2024):91-101,
https://doi.org/10.2478/aiht-2024-75-3817 . .