TY  - JOUR
AU  - Vekić, Jelena
AU  - Joppa, Pavol
AU  - Habalova, Viera
AU  - Tisko, Radovan
AU  - Zeljković, Aleksandra
AU  - Pobeha, Pavol
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Strbova, Zuzana
AU  - Kuklisova, Zuzana
AU  - Slaba, Eva
AU  - Rizzo, Manfredi
AU  - Tkacova, Ruzena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2765
AB  - Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P  lt  .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P  lt  .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Angiology
T1  - Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea
VL  - 67
IS  - 10
SP  - 937
EP  - 944
DO  - 10.1177/0003319716636512
ER  - 

@article{
author = "Vekić, Jelena and Joppa, Pavol and Habalova, Viera and Tisko, Radovan and Zeljković, Aleksandra and Pobeha, Pavol and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Strbova, Zuzana and Kuklisova, Zuzana and Slaba, Eva and Rizzo, Manfredi and Tkacova, Ruzena",
year = "2016",
abstract = "Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P  lt  .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P  lt  .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Angiology",
title = "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea",
volume = "67",
number = "10",
pages = "937-944",
doi = "10.1177/0003319716636512"
}

Vekić, J., Joppa, P., Habalova, V., Tisko, R., Zeljković, A., Pobeha, P., Gojković, T., Spasojević-Kalimanovska, V., Strbova, Z., Kuklisova, Z., Slaba, E., Rizzo, M.,& Tkacova, R.. (2016). Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology
Sage Publications Inc, Thousand Oaks., 67(10), 937-944.
https://doi.org/10.1177/0003319716636512

Vekić J, Joppa P, Habalova V, Tisko R, Zeljković A, Pobeha P, Gojković T, Spasojević-Kalimanovska V, Strbova Z, Kuklisova Z, Slaba E, Rizzo M, Tkacova R. Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology. 2016;67(10):937-944.
doi:10.1177/0003319716636512 .

Vekić, Jelena, Joppa, Pavol, Habalova, Viera, Tisko, Radovan, Zeljković, Aleksandra, Pobeha, Pavol, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Strbova, Zuzana, Kuklisova, Zuzana, Slaba, Eva, Rizzo, Manfredi, Tkacova, Ruzena, "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea" in Angiology, 67, no. 10 (2016):937-944,
https://doi.org/10.1177/0003319716636512 . .