TY  - JOUR
AU  - Paripović, Dušan
AU  - Kotur-Stevuljević, Jelena
AU  - Vukašinović, Aleksandra
AU  - Ilisić, Tamara
AU  - Miloševski-Lomić, Gordana
AU  - Peco-Antić, Amira
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3144
AB  - Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - The influence of oxidative stress on cardiac remodeling in obese adolescents
VL  - 78
IS  - 7-8
SP  - 595
EP  - 600
DO  - 10.1080/00365513.2018.1528504
ER  - 

@article{
author = "Paripović, Dušan and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Ilisić, Tamara and Miloševski-Lomić, Gordana and Peco-Antić, Amira",
year = "2018",
abstract = "Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "The influence of oxidative stress on cardiac remodeling in obese adolescents",
volume = "78",
number = "7-8",
pages = "595-600",
doi = "10.1080/00365513.2018.1528504"
}

Paripović, D., Kotur-Stevuljević, J., Vukašinović, A., Ilisić, T., Miloševski-Lomić, G.,& Peco-Antić, A.. (2018). The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 78(7-8), 595-600.
https://doi.org/10.1080/00365513.2018.1528504

Paripović D, Kotur-Stevuljević J, Vukašinović A, Ilisić T, Miloševski-Lomić G, Peco-Antić A. The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2018;78(7-8):595-600.
doi:10.1080/00365513.2018.1528504 .

Paripović, Dušan, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Ilisić, Tamara, Miloševski-Lomić, Gordana, Peco-Antić, Amira, "The influence of oxidative stress on cardiac remodeling in obese adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 78, no. 7-8 (2018):595-600,
https://doi.org/10.1080/00365513.2018.1528504 . .

TY  - JOUR
AU  - Pejović, Biljana
AU  - Erić-Marinković, Jelena
AU  - Pejović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2329
AB  - Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.
PB  - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
T2  - Biochemia Medica
T1  - Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker
VL  - 25
IS  - 3
SP  - 450
EP  - 459
DO  - 10.11613/BM.2015.046
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2329
ER  - 

@article{
author = "Pejović, Biljana and Erić-Marinković, Jelena and Pejović, Marija and Kotur-Stevuljević, Jelena and Peco-Antić, Amira",
year = "2015",
abstract = "Introduction: Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates after perinatal asphyxia. Therefore, our aim was to assess the diagnostic accuracy of sNGAL for AKI in premature asphyxiated neonates. Materials and methods: AKI was defined in the third day of life (DOL 3) as a serum creatinine (sCr) increase >= 26.5 mu mol/L from baseline (the lowest previous sCr). According to the increase of sCr, AKI patients were divided in AKIN1 (sCr increase up to 1.9 baseline) and AKIN2 (sCr increase from 2.0 to 2.9 baseline). sNGAL levels were measured on DOL 1, 3 and 7. Results: AKI was diagnosed in 73 (0.676) of 108 enrolled premature asphyxiated neonates. Sixty one patients (0.836) were classified in AKIN1 and 12 patients (0.164) in AKIN2. sNGAL reached the maximal concentrations on DOL 1 within 4 hours after admission to NICU, being higher in AKI compared with no-AKI group (160.8 +/- 113.1 vs. 87.1 +/- 81.6; P  lt  0.001) as well as in AKIN2 compared with AKIN1 group (222.8 +/- 112.9 vs. 147.8 +/- 109.9; P  lt  0.001). The best areas under the receiver operating characteristic curves (AUC) for prediction of AKI were 0.72 [95% (0.62-0.80) P  lt  0.001] on DOL1 at 2h and 0.72 [95% (0.63-0.80) P  lt  0.001] at 4th hour after admission respectively. The corresponding sNGAL cutoff concentrations were 84.87 ng/mL (sensitivity 69.0% and specificity 71.9%) and 89.43 ng/mL (sensitivity 65.7% and specificity 74.3%). Conclusions: In premature asphyxiated neonates sNGAL measured within the first 4 hours of DOL 1 is predictive of the occurrence and severity of AKI. Therefore, plasma levels of NGAL may be used for early diagnosis of AKI in these patients.",
publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb",
journal = "Biochemia Medica",
title = "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker",
volume = "25",
number = "3",
pages = "450-459",
doi = "10.11613/BM.2015.046",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2329"
}

Pejović, B., Erić-Marinković, J., Pejović, M., Kotur-Stevuljević, J.,& Peco-Antić, A.. (2015). Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica
Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(3), 450-459.
https://doi.org/10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329

Pejović B, Erić-Marinković J, Pejović M, Kotur-Stevuljević J, Peco-Antić A. Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker. in Biochemia Medica. 2015;25(3):450-459.
doi:10.11613/BM.2015.046
https://hdl.handle.net/21.15107/rcub_farfar_2329 .

Pejović, Biljana, Erić-Marinković, Jelena, Pejović, Marija, Kotur-Stevuljević, Jelena, Peco-Antić, Amira, "Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) - sensitivity and specificity of a potential new biomarker" in Biochemia Medica, 25, no. 3 (2015):450-459,
https://doi.org/10.11613/BM.2015.046 .,
https://hdl.handle.net/21.15107/rcub_farfar_2329 .

TY  - JOUR
AU  - Pavlović, Branko
AU  - Milosavljević, Jovana
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2514
AB  - Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk.
AB  - Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Resistin, inflammation and dyslipidemia in obese children and adolescents
T1  - Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata
VL  - 65
IS  - 2
SP  - 115
EP  - 128
DO  - 10.5937/arhfarm1502115P
ER  - 

@article{
author = "Pavlović, Branko and Milosavljević, Jovana and Zeljković, Aleksandra and Vekić, Jelena and Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Paripović, Dušan and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk., Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Resistin, inflammation and dyslipidemia in obese children and adolescents, Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata",
volume = "65",
number = "2",
pages = "115-128",
doi = "10.5937/arhfarm1502115P"
}

Pavlović, B., Milosavljević, J., Zeljković, A., Vekić, J., Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Paripović, D., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2015). Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(2), 115-128.
https://doi.org/10.5937/arhfarm1502115P

Pavlović B, Milosavljević J, Zeljković A, Vekić J, Joksić J, Sopić M, Spasojević-Kalimanovska V, Paripović D, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju. 2015;65(2):115-128.
doi:10.5937/arhfarm1502115P .

Pavlović, Branko, Milosavljević, Jovana, Zeljković, Aleksandra, Vekić, Jelena, Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Paripović, Dušan, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Resistin, inflammation and dyslipidemia in obese children and adolescents" in Arhiv za farmaciju, 65, no. 2 (2015):115-128,
https://doi.org/10.5937/arhfarm1502115P . .

TY  - JOUR
AU  - Ivanišević, Ivana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995
AB  - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - L-FABP can be an early marker of acute kidney injury in children
VL  - 28
IS  - 6
SP  - 963
EP  - 969
DO  - 10.1007/s00467-013-2421-z
ER  - 

@article{
author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola",
year = "2013",
abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "L-FABP can be an early marker of acute kidney injury in children",
volume = "28",
number = "6",
pages = "963-969",
doi = "10.1007/s00467-013-2421-z"
}

Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology
Springer, New York., 28(6), 963-969.
https://doi.org/10.1007/s00467-013-2421-z

Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969.
doi:10.1007/s00467-013-2421-z .

Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969,
https://doi.org/10.1007/s00467-013-2421-z . .

TY  - JOUR
AU  - Peco-Antić, Amira
AU  - Paripović, Dušan
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Scekić, Gordana
AU  - Miloševski-Lomić, Gordana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1625
AB  - Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Renal functional reserve in children with apparently normal congenital solitary functioning kidney
VL  - 45
IS  - 15
SP  - 1173
EP  - 1177
DO  - 10.1016/j.clinbiochem.2012.06.018
ER  - 

@article{
author = "Peco-Antić, Amira and Paripović, Dušan and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Scekić, Gordana and Miloševski-Lomić, Gordana",
year = "2012",
abstract = "Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Renal functional reserve in children with apparently normal congenital solitary functioning kidney",
volume = "45",
number = "15",
pages = "1173-1177",
doi = "10.1016/j.clinbiochem.2012.06.018"
}

Peco-Antić, A., Paripović, D., Kotur-Stevuljević, J., Stefanović, A., Scekić, G.,& Miloševski-Lomić, G.. (2012). Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(15), 1173-1177.
https://doi.org/10.1016/j.clinbiochem.2012.06.018

Peco-Antić A, Paripović D, Kotur-Stevuljević J, Stefanović A, Scekić G, Miloševski-Lomić G. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry. 2012;45(15):1173-1177.
doi:10.1016/j.clinbiochem.2012.06.018 .

Peco-Antić, Amira, Paripović, Dušan, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Scekić, Gordana, Miloševski-Lomić, Gordana, "Renal functional reserve in children with apparently normal congenital solitary functioning kidney" in Clinical Biochemistry, 45, no. 15 (2012):1173-1177,
https://doi.org/10.1016/j.clinbiochem.2012.06.018 . .