TY  - JOUR
AU  - Milovanović, Vesna
AU  - Ćirić, Biljana
AU  - Milenković, Jasna
AU  - Kilibarda, Vesna
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1830
AB  - Background/Aim. Saliva represents an alternative specimen for substances abuse determination in toxicology. Hence, the aim of this study was to optimize a method for saliva specimen preparation for heroin metabolites, morphine and 6-monoacetylmorphine (6-mam), and codeine determination by liquid chromatography-mass spectrometry (LC/MS), and to apply this method on saliva samples taken from the patients. Methods. Saliva specimen was prepared using liqiud/liquid extraction of morphine, codeine and 6- mam by mixture of chloroform and isopropanol (9 : 1; v/v). Extracts were analysed by HPLC/MS technique: separation column Waters Spherisorb® 5 μm, ODS2, 4.6 × 100 mm; mobile phase: ammonium acetate : acetonitile (80 : 20; v/v), mobile phase flow rate 0.3 mL/min; mass detection range: 100-400 m/z. Regression and correlation analyses were performed with the probalility level of 0.05. Concentrations of morphine, codeine and 6-mam were determined in saliva samples of the patients with 'opiates' in urine identified by the test strips. Results. Calibration for each analysed substance was done in the concentration range from 0.1 to 1 mg/L and the coefficient of correlation was R2 > 0.99. We obtained following calibration curves: y = 385531x + 14584; y = 398036x + 31542; and y = 524162x - 27105, for morphine, codeine and 6-mam, respectively. Recovery for morphine and codeine determination was 99%, while for 6- mam it was 94%. Limits of detection and quantification of a proposed method were 0.01 mg/L and 0.05 mg/L, respectively. Concentration of morphine in the saliva of the heroin users ranged between 0.54 and 5.82 mg/L, concentration of codeine between 0.05 and 5.33, and 6-mam between 0.01 and 0.68 mg/L. A statistically significant correlation between codeine and 6-mam concentrations was obtained. Conclusion. A proposed HPLC/MS method for morphine, codeine and 6-mam determination in saliva is accurate, simple, cheap and suitable for routine analysis and monitoring of heroin abuse.
AB  - Uvod/Cilj. Saliva predstavlja alternativni matriks za identifikaciju sredstava zloupotrebe. Cilj ovog rada bio je optimizacija metode pripreme uzorka salive i određivanja metabolita heroina, morfina i 6-monoacetilmorfina (6-mam), i kodeina liquid chromatography-mass spectrometry (LC/MS) metodom i provera metode u realnim uslovima kod heroinomana. Metode. Priprema uzoraka vršena je tečno-tečnom ekstrakcijom uz smešu hloroforma i izopropil alkohola u odnosu 9 : 1. Ekstrakti su analizirani tehnikom HPLC/MS: razdvajanje na koloni Waters Spherisorb® 5 μm, ODS2, 4,6 × 100 mm, vršeno je primenom mobilne faze amonijum-acetat : acetonitril u odnosu 80 : 20 pri protoku od 0,3 mL/min. Masena detekcija je vršena u opsegu masa od 100 do 400 m/z. Primenjene su regresiona i korelaciona analiza za nivo verovatnoće 0,05. Određivanje prisustva morfina, kodeina i 6-mam vršeno je u uzorcima salive kod osoba kod kojih je test trakama utvrđeno prisustvo 'opijata' u urinu. Rezultati. Kalibracija je vršena u opsegu koncentracija 0,1-1 mg/L sa koeficijentom determinacije R2 > 0,99. Dobijene su kalibracione krive: za morfin, y = 385531x + 14584; kodein, y = 398036x + 31542 i 6- monoacetilmorfin, y = 524162x - 27105. Recovery vrednosti za određivanje morfina i kodeina iznosile su 99%, a za 6-mam 94%. Limit detekcije predložene metode iznosio je 0,01 mg/L, a limit kvantifikacije 0,05 mg/L. U salivi uživalaca heroina koncentracija morfina kretala se u opsegu od 0,54 do 5,82 mg/L, kodeina od 0,05 do 5,33, a 6-mam od 0,01 do 0,68 mg/L i dobijena je statistički značajna korelacija između vrednosti za kodein i 6-mam. Zaključak. Predložena HPLC/MS metoda za određivanje sadržaja morfina, kodeina i 6-monoacetilmorfina u salivi je tačna, jednostavna, ekonomična i pogodna za rutinsku primenu, kao i za biomonitoring zloupotrebe heroina.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods
T1  - Određivanje morfina, kodeina i 6-monoacetilmorfina metodom HPLC/MS u salivi heroinskih zavisnika
VL  - 69
IS  - 2
SP  - 141
EP  - 146
DO  - 10.2298/VSP1202141M
ER  - 

@article{
author = "Milovanović, Vesna and Ćirić, Biljana and Milenković, Jasna and Kilibarda, Vesna and Ćurčić, Marijana and Vučinić, Slavica and Antonijević, Biljana",
year = "2012",
abstract = "Background/Aim. Saliva represents an alternative specimen for substances abuse determination in toxicology. Hence, the aim of this study was to optimize a method for saliva specimen preparation for heroin metabolites, morphine and 6-monoacetylmorphine (6-mam), and codeine determination by liquid chromatography-mass spectrometry (LC/MS), and to apply this method on saliva samples taken from the patients. Methods. Saliva specimen was prepared using liqiud/liquid extraction of morphine, codeine and 6- mam by mixture of chloroform and isopropanol (9 : 1; v/v). Extracts were analysed by HPLC/MS technique: separation column Waters Spherisorb® 5 μm, ODS2, 4.6 × 100 mm; mobile phase: ammonium acetate : acetonitile (80 : 20; v/v), mobile phase flow rate 0.3 mL/min; mass detection range: 100-400 m/z. Regression and correlation analyses were performed with the probalility level of 0.05. Concentrations of morphine, codeine and 6-mam were determined in saliva samples of the patients with 'opiates' in urine identified by the test strips. Results. Calibration for each analysed substance was done in the concentration range from 0.1 to 1 mg/L and the coefficient of correlation was R2 > 0.99. We obtained following calibration curves: y = 385531x + 14584; y = 398036x + 31542; and y = 524162x - 27105, for morphine, codeine and 6-mam, respectively. Recovery for morphine and codeine determination was 99%, while for 6- mam it was 94%. Limits of detection and quantification of a proposed method were 0.01 mg/L and 0.05 mg/L, respectively. Concentration of morphine in the saliva of the heroin users ranged between 0.54 and 5.82 mg/L, concentration of codeine between 0.05 and 5.33, and 6-mam between 0.01 and 0.68 mg/L. A statistically significant correlation between codeine and 6-mam concentrations was obtained. Conclusion. A proposed HPLC/MS method for morphine, codeine and 6-mam determination in saliva is accurate, simple, cheap and suitable for routine analysis and monitoring of heroin abuse., Uvod/Cilj. Saliva predstavlja alternativni matriks za identifikaciju sredstava zloupotrebe. Cilj ovog rada bio je optimizacija metode pripreme uzorka salive i određivanja metabolita heroina, morfina i 6-monoacetilmorfina (6-mam), i kodeina liquid chromatography-mass spectrometry (LC/MS) metodom i provera metode u realnim uslovima kod heroinomana. Metode. Priprema uzoraka vršena je tečno-tečnom ekstrakcijom uz smešu hloroforma i izopropil alkohola u odnosu 9 : 1. Ekstrakti su analizirani tehnikom HPLC/MS: razdvajanje na koloni Waters Spherisorb® 5 μm, ODS2, 4,6 × 100 mm, vršeno je primenom mobilne faze amonijum-acetat : acetonitril u odnosu 80 : 20 pri protoku od 0,3 mL/min. Masena detekcija je vršena u opsegu masa od 100 do 400 m/z. Primenjene su regresiona i korelaciona analiza za nivo verovatnoće 0,05. Određivanje prisustva morfina, kodeina i 6-mam vršeno je u uzorcima salive kod osoba kod kojih je test trakama utvrđeno prisustvo 'opijata' u urinu. Rezultati. Kalibracija je vršena u opsegu koncentracija 0,1-1 mg/L sa koeficijentom determinacije R2 > 0,99. Dobijene su kalibracione krive: za morfin, y = 385531x + 14584; kodein, y = 398036x + 31542 i 6- monoacetilmorfin, y = 524162x - 27105. Recovery vrednosti za određivanje morfina i kodeina iznosile su 99%, a za 6-mam 94%. Limit detekcije predložene metode iznosio je 0,01 mg/L, a limit kvantifikacije 0,05 mg/L. U salivi uživalaca heroina koncentracija morfina kretala se u opsegu od 0,54 do 5,82 mg/L, kodeina od 0,05 do 5,33, a 6-mam od 0,01 do 0,68 mg/L i dobijena je statistički značajna korelacija između vrednosti za kodein i 6-mam. Zaključak. Predložena HPLC/MS metoda za određivanje sadržaja morfina, kodeina i 6-monoacetilmorfina u salivi je tačna, jednostavna, ekonomična i pogodna za rutinsku primenu, kao i za biomonitoring zloupotrebe heroina.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods, Određivanje morfina, kodeina i 6-monoacetilmorfina metodom HPLC/MS u salivi heroinskih zavisnika",
volume = "69",
number = "2",
pages = "141-146",
doi = "10.2298/VSP1202141M"
}

Milovanović, V., Ćirić, B., Milenković, J., Kilibarda, V., Ćurčić, M., Vučinić, S.,& Antonijević, B.. (2012). Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(2), 141-146.
https://doi.org/10.2298/VSP1202141M

Milovanović V, Ćirić B, Milenković J, Kilibarda V, Ćurčić M, Vučinić S, Antonijević B. Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods. in Vojnosanitetski pregled. 2012;69(2):141-146.
doi:10.2298/VSP1202141M .

Milovanović, Vesna, Ćirić, Biljana, Milenković, Jasna, Kilibarda, Vesna, Ćurčić, Marijana, Vučinić, Slavica, Antonijević, Biljana, "Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods" in Vojnosanitetski pregled, 69, no. 2 (2012):141-146,
https://doi.org/10.2298/VSP1202141M . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Stojiljković, Miloš P.
AU  - Bokonjić, Dubravko
AU  - Vučinić, Slavica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1602
AB  - Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. Methods. Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy - ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously - sc). Results. Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 mmoL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 mmoL/kg in dichlorvos poisoning; 21.56 vs 6.63 mmoL/kg in heptenophos poisoning). Memantine and midazolam succeeded to counteract the soman-induced proconvulsive activity. Conclusion. Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties.
AB  - Uvod/Cilj. Poseban problem pri trovanju organofosfornim jedinjenjima predstavljaju mišićne fascikulacije i konvulzije, koje se ne mogu u potpunosti antagonizovati primenom atropina i oksima. Cilj ovog rada bio je ispitivanje antidotskog efekta kombinacije memantina i oksima HI-6 kod trovanja somanom, kao i kombinacije memantina sa obidoksimom kod trovanja dihlorvosom i heptenofosom. Metode. Albino miševima, mužjacima, u repnu venu date su rastuće doze oksima i/ili memantina (10 mg/kg) u različitim vremenskim intervalima pre intravenskog (iv) davanja 1,3 LD-50 somana, dihlorvosa ili heptenofosa. Praćenjem stepena preživljanja, izračunate su srednje efektivne doze i poluvreme efikasnosti. U odvojenom eksperimentu praćena je cerebralna ekstravazacija boje Evans plavo (40 mg/kg iv) nakon primene memantina (10 mg/kg iv), midazolama (2,5 mg/kg intraoperitonealno - ip) i ketamina (20 mg/kg ip) 5 min pre davanja somana (1 LD-50 supkutano - sc). Rezultati. Primenom kombinacija sa memantinom srednje efektivne doze u nultom vremenu i HI-6 (7,96 vs 1,79 mmoL/kg kod trovanja somanom) i obidoksima (16,80 vs 2,75 mmoL/kg kod trovanja dihlorvosom; 21,56 vs 6,63 mmoL/kg kod trovanja heptenofosom) bile su višestruko niže u odnosu na dozu samog oksima. Memantin i midazolam uspešno su suprimirali prokonvulzivni efekat somana. Zaključak. Rezultati ove studije pokazuju da primena memantina u kombinaciji sa oksimima obezbeđuje bolji zaštitni efekat nego sam oksim, a u osnovi ovog efekta verovatno leži i njegov antikonvulzivni potencijal.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos
T1  - Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom
VL  - 68
IS  - 12
SP  - 1033
EP  - 1040
DO  - 10.2298/VSP1112033A
ER  - 

@article{
author = "Antonijević, Biljana and Stojiljković, Miloš P. and Bokonjić, Dubravko and Vučinić, Slavica",
year = "2011",
abstract = "Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. Methods. Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy - ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously - sc). Results. Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 mmoL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 mmoL/kg in dichlorvos poisoning; 21.56 vs 6.63 mmoL/kg in heptenophos poisoning). Memantine and midazolam succeeded to counteract the soman-induced proconvulsive activity. Conclusion. Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties., Uvod/Cilj. Poseban problem pri trovanju organofosfornim jedinjenjima predstavljaju mišićne fascikulacije i konvulzije, koje se ne mogu u potpunosti antagonizovati primenom atropina i oksima. Cilj ovog rada bio je ispitivanje antidotskog efekta kombinacije memantina i oksima HI-6 kod trovanja somanom, kao i kombinacije memantina sa obidoksimom kod trovanja dihlorvosom i heptenofosom. Metode. Albino miševima, mužjacima, u repnu venu date su rastuće doze oksima i/ili memantina (10 mg/kg) u različitim vremenskim intervalima pre intravenskog (iv) davanja 1,3 LD-50 somana, dihlorvosa ili heptenofosa. Praćenjem stepena preživljanja, izračunate su srednje efektivne doze i poluvreme efikasnosti. U odvojenom eksperimentu praćena je cerebralna ekstravazacija boje Evans plavo (40 mg/kg iv) nakon primene memantina (10 mg/kg iv), midazolama (2,5 mg/kg intraoperitonealno - ip) i ketamina (20 mg/kg ip) 5 min pre davanja somana (1 LD-50 supkutano - sc). Rezultati. Primenom kombinacija sa memantinom srednje efektivne doze u nultom vremenu i HI-6 (7,96 vs 1,79 mmoL/kg kod trovanja somanom) i obidoksima (16,80 vs 2,75 mmoL/kg kod trovanja dihlorvosom; 21,56 vs 6,63 mmoL/kg kod trovanja heptenofosom) bile su višestruko niže u odnosu na dozu samog oksima. Memantin i midazolam uspešno su suprimirali prokonvulzivni efekat somana. Zaključak. Rezultati ove studije pokazuju da primena memantina u kombinaciji sa oksimima obezbeđuje bolji zaštitni efekat nego sam oksim, a u osnovi ovog efekta verovatno leži i njegov antikonvulzivni potencijal.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos, Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom",
volume = "68",
number = "12",
pages = "1033-1040",
doi = "10.2298/VSP1112033A"
}

Antonijević, B., Stojiljković, M. P., Bokonjić, D.,& Vučinić, S.. (2011). Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(12), 1033-1040.
https://doi.org/10.2298/VSP1112033A

Antonijević B, Stojiljković MP, Bokonjić D, Vučinić S. Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos. in Vojnosanitetski pregled. 2011;68(12):1033-1040.
doi:10.2298/VSP1112033A .

Antonijević, Biljana, Stojiljković, Miloš P., Bokonjić, Dubravko, Vučinić, Slavica, "Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos" in Vojnosanitetski pregled, 68, no. 12 (2011):1033-1040,
https://doi.org/10.2298/VSP1112033A . .

TY  - JOUR
AU  - Janković, Saša
AU  - Ćurčić, Marijana
AU  - Radičević, Tatjana
AU  - Stefanović, Srđan
AU  - Lenhardt, Mirjana
AU  - Durgo, Ksenija
AU  - Antonijević, Biljana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1455
AB  - This work has been developed to examine the level of non-dioxin-like (ndl) PCBs (28, 52, 101, 138, 153 and 180) in (a) ten different freshwater fish species from the Danube river, (b) two sampling points: up and downstream of the industrial zone of the city of Pancevo (ecological hot spot in Serbia) and
PB  - Springer, Dordrecht
T2  - Environmental Monitoring and Assessment
T1  - Non-dioxin-like PCBs in ten different fish species from the Danube river in Serbia
VL  - 181
IS  - 1-4
SP  - 153
EP  - 163
DO  - 10.1007/s10661-010-1820-x
ER  - 

@article{
author = "Janković, Saša and Ćurčić, Marijana and Radičević, Tatjana and Stefanović, Srđan and Lenhardt, Mirjana and Durgo, Ksenija and Antonijević, Biljana",
year = "2011",
abstract = "This work has been developed to examine the level of non-dioxin-like (ndl) PCBs (28, 52, 101, 138, 153 and 180) in (a) ten different freshwater fish species from the Danube river, (b) two sampling points: up and downstream of the industrial zone of the city of Pancevo (ecological hot spot in Serbia) and",
publisher = "Springer, Dordrecht",
journal = "Environmental Monitoring and Assessment",
title = "Non-dioxin-like PCBs in ten different fish species from the Danube river in Serbia",
volume = "181",
number = "1-4",
pages = "153-163",
doi = "10.1007/s10661-010-1820-x"
}

Janković, S., Ćurčić, M., Radičević, T., Stefanović, S., Lenhardt, M., Durgo, K.,& Antonijević, B.. (2011). Non-dioxin-like PCBs in ten different fish species from the Danube river in Serbia. in Environmental Monitoring and Assessment
Springer, Dordrecht., 181(1-4), 153-163.
https://doi.org/10.1007/s10661-010-1820-x

Janković S, Ćurčić M, Radičević T, Stefanović S, Lenhardt M, Durgo K, Antonijević B. Non-dioxin-like PCBs in ten different fish species from the Danube river in Serbia. in Environmental Monitoring and Assessment. 2011;181(1-4):153-163.
doi:10.1007/s10661-010-1820-x .

Janković, Saša, Ćurčić, Marijana, Radičević, Tatjana, Stefanović, Srđan, Lenhardt, Mirjana, Durgo, Ksenija, Antonijević, Biljana, "Non-dioxin-like PCBs in ten different fish species from the Danube river in Serbia" in Environmental Monitoring and Assessment, 181, no. 1-4 (2011):153-163,
https://doi.org/10.1007/s10661-010-1820-x . .

TY  - CONF
AU  - Radosević, B.
AU  - Milovanović, V.
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Janković, Saša
AU  - Radičević, Tatjana
AU  - Stefanović, S.
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1394
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Estimation of indicator PCBs intake by freshwater fish consumption
VL  - 196
IS  - Supplement
SP  - S337
EP  - S337
DO  - 10.1016/j.toxlet.2010.03.1066
ER  - 

@conference{
author = "Radosević, B. and Milovanović, V. and Ćurčić, Marijana and Antonijević, Biljana and Janković, Saša and Radičević, Tatjana and Stefanović, S.",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Estimation of indicator PCBs intake by freshwater fish consumption",
volume = "196",
number = "Supplement",
pages = "S337-S337",
doi = "10.1016/j.toxlet.2010.03.1066"
}

Radosević, B., Milovanović, V., Ćurčić, M., Antonijević, B., Janković, S., Radičević, T.,& Stefanović, S.. (2010). Estimation of indicator PCBs intake by freshwater fish consumption. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 196(Supplement), S337-S337.
https://doi.org/10.1016/j.toxlet.2010.03.1066

Radosević B, Milovanović V, Ćurčić M, Antonijević B, Janković S, Radičević T, Stefanović S. Estimation of indicator PCBs intake by freshwater fish consumption. in Toxicology Letters. 2010;196(Supplement):S337-S337.
doi:10.1016/j.toxlet.2010.03.1066 .

Radosević, B., Milovanović, V., Ćurčić, Marijana, Antonijević, Biljana, Janković, Saša, Radičević, Tatjana, Stefanović, S., "Estimation of indicator PCBs intake by freshwater fish consumption" in Toxicology Letters, 196, no. Supplement (2010):S337-S337,
https://doi.org/10.1016/j.toxlet.2010.03.1066 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Durgo, Ksenija
AU  - Janković, Saša
AU  - Jaćević, Vesna
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1442
AB  - Polybrominated diphenyl ethers (PBDEs) represent group of persistant organic chemicals (POPs), usually used as flame retardant additives in a variety of matherials and commercial products. Since 2009, PBDEs have been placed on the list of POPs chemicals, covered by Stockholm convention which is aimed to limit or ban production, use, emission, import and export of persistent organic pollutants, due to human health and environmental protection. Predominant routes of human exposure by PBDEs are ingestion by food, inhalation or dermal. Based on experimental studies, targets for PBDEs toxicity are nervous system, liver, thyroid gland and development. According to International Agency for Research on Cancer (IARC) PBDEs are not classified as a carcinogens, whereas according to Environmental Protection Agency (EPA) only deca BDE is classified as possible human carcinogen. So far, PBDEs have not been incoporated in national legislative framework. There are no data on environmental contamination, occupational exposure and exposure of general population. Therefore, placing the data on PBDEs in the focus of publics could contribute to the process of risk characterisation, and give directions for risk management in the Republic of Serbia.
AB  - Polibromovani difeniletri (PBDEs) su hemikalije koje se dodaju različitim proizvodima kojima smo okruženi u svakodnevnom životu da bi usporili i/ili sprečili izbijanja požara. Polibromovani difeniletri su 2009. godine pridruženi listi perzistentnih organskih polutanata (POPs) usvojenoj Stokholmskom konvencijom čiji je cilj da ograniči ili zabrani proizvodnju, upotrebu, emisiju ili uvoz i izvoz toksičnih supstanci označenih kao POPs radi zaštite zdravlja ljudi i životne sredine. Do ekspozicije ljudi PBDEs može doći ingestijom, inhalacijom, dermalno. Eksperimentalne studije ukazuju da PBDEs najznačajnije toksične efekte ispoljavaju na jetru, štitnu žlezdu, nervni sistem, rast i razvoj. Međunarodna agencija za istraživanje karcinoma (IARC) ne klasifikuje PBDEs kao karcinogene za ljude, a Američka agencija za zaštitu životne sredine (EPA) klasifikuje samo dekaBDE kao moguć karcinogen za ljude. U našoj zemlji PBDEs nisu inkorporirani u nacionalnu regulativu, nema podataka o nivou zagađenja životne sredine, o sadržaju ovih jedinjenja u radnom okruženju i ekpoziciji opšte populacije, stoga bi saznanja u ovoj oblasti doprinela procesu evaluacije i karakterizacije rizika, ali i dala smernice za upravljanje rizikom PBDEs hemikalijama u Republici Srbiji.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Toxicological relevance and potential risk due to polybrominated diphenylethers exposure
T1  - Toksikološki značaj i potencijalni rizik pri ekspoziciji polibromovanim difeniletrima
VL  - 60
IS  - 3
SP  - 311
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1442
ER  - 

@article{
author = "Ćurčić, Marijana and Antonijević, Biljana and Durgo, Ksenija and Janković, Saša and Jaćević, Vesna",
year = "2010",
abstract = "Polybrominated diphenyl ethers (PBDEs) represent group of persistant organic chemicals (POPs), usually used as flame retardant additives in a variety of matherials and commercial products. Since 2009, PBDEs have been placed on the list of POPs chemicals, covered by Stockholm convention which is aimed to limit or ban production, use, emission, import and export of persistent organic pollutants, due to human health and environmental protection. Predominant routes of human exposure by PBDEs are ingestion by food, inhalation or dermal. Based on experimental studies, targets for PBDEs toxicity are nervous system, liver, thyroid gland and development. According to International Agency for Research on Cancer (IARC) PBDEs are not classified as a carcinogens, whereas according to Environmental Protection Agency (EPA) only deca BDE is classified as possible human carcinogen. So far, PBDEs have not been incoporated in national legislative framework. There are no data on environmental contamination, occupational exposure and exposure of general population. Therefore, placing the data on PBDEs in the focus of publics could contribute to the process of risk characterisation, and give directions for risk management in the Republic of Serbia., Polibromovani difeniletri (PBDEs) su hemikalije koje se dodaju različitim proizvodima kojima smo okruženi u svakodnevnom životu da bi usporili i/ili sprečili izbijanja požara. Polibromovani difeniletri su 2009. godine pridruženi listi perzistentnih organskih polutanata (POPs) usvojenoj Stokholmskom konvencijom čiji je cilj da ograniči ili zabrani proizvodnju, upotrebu, emisiju ili uvoz i izvoz toksičnih supstanci označenih kao POPs radi zaštite zdravlja ljudi i životne sredine. Do ekspozicije ljudi PBDEs može doći ingestijom, inhalacijom, dermalno. Eksperimentalne studije ukazuju da PBDEs najznačajnije toksične efekte ispoljavaju na jetru, štitnu žlezdu, nervni sistem, rast i razvoj. Međunarodna agencija za istraživanje karcinoma (IARC) ne klasifikuje PBDEs kao karcinogene za ljude, a Američka agencija za zaštitu životne sredine (EPA) klasifikuje samo dekaBDE kao moguć karcinogen za ljude. U našoj zemlji PBDEs nisu inkorporirani u nacionalnu regulativu, nema podataka o nivou zagađenja životne sredine, o sadržaju ovih jedinjenja u radnom okruženju i ekpoziciji opšte populacije, stoga bi saznanja u ovoj oblasti doprinela procesu evaluacije i karakterizacije rizika, ali i dala smernice za upravljanje rizikom PBDEs hemikalijama u Republici Srbiji.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Toxicological relevance and potential risk due to polybrominated diphenylethers exposure, Toksikološki značaj i potencijalni rizik pri ekspoziciji polibromovanim difeniletrima",
volume = "60",
number = "3",
pages = "311-322",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1442"
}

Ćurčić, M., Antonijević, B., Durgo, K., Janković, S.,& Jaćević, V.. (2010). Toxicological relevance and potential risk due to polybrominated diphenylethers exposure. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 60(3), 311-322.
https://hdl.handle.net/21.15107/rcub_farfar_1442

Ćurčić M, Antonijević B, Durgo K, Janković S, Jaćević V. Toxicological relevance and potential risk due to polybrominated diphenylethers exposure. in Arhiv za farmaciju. 2010;60(3):311-322.
https://hdl.handle.net/21.15107/rcub_farfar_1442 .

Ćurčić, Marijana, Antonijević, Biljana, Durgo, Ksenija, Janković, Saša, Jaćević, Vesna, "Toxicological relevance and potential risk due to polybrominated diphenylethers exposure" in Arhiv za farmaciju, 60, no. 3 (2010):311-322,
https://hdl.handle.net/21.15107/rcub_farfar_1442 .

TY  - JOUR
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Carević, Momir
AU  - Mandić, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Lekić, Charles P.
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1405
AB  - In this study we determined the fluoride content in drinking water and hair of 12-year-old schoolchildren from different Serbian municipalities, i.e. Valley, Veliko Gradiste, Kacarevo and Vranjska Banja. The analyses were performed using composite fluoride ion-selective electrode. Average fluoride levels were 0.10, 0.15, 0.79 and 11 ppm in well water, 0.07, 0.10, 0.17 and 0.15 ppm in tap water, 19.3, 21.5, 25.4, and 32.5 ppm in hair samples, in Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja, respectively. Correlation analysis indicated statistically significant positive relationship between fluoride in wells water and fluoride in hair, for all municipalities: correlation coefficients were 0.54 (p lt 0.05), 0.89, 0.97 and 0.99 (p lt 0.001), in Vranjska Banja, Valjevo, Veliko Gradiste, and Kacarevo, respectively. Positive correlation was obtained also between fluoride in tap water and hair samples in all regions under the study, with statistical significance only in Valjevo municipality, p lt 0.05. Dental examination of schoolchildren confirmed dental fluorosis only in the region of Vranjska Banja. Moreover, in endemic fluorotic region of Vranjska Banja, positive and statistically significant correlations were confirmed between fluoride in well water and dental fluorosis level (r = 0.61; p lt 0.01) and additionally between fluoride in hair and dental fluorosis level (0.62; p lt 0.01). The primary findings from this study have shown that fluoride content in hair is highly correlated with fluoride content in drinking water and dental fluorosis level, indicating that hair may be regarded as biomaterial of high informative potential in evaluating prolonged exposure to fluorides and to individuate children at risk of fluorosis regardless of the phase of teeth eruption.
PB  - Elsevier Science BV, Amsterdam
T2  - Scientia Horticulturae
T1  - Fluoride in drinking water and dental fluorosis
VL  - 408
IS  - 17
SP  - 3507
EP  - 3512
DO  - 10.1016/j.scitotenv.2010.04.029
ER  - 

@article{
author = "Mandinić, Zoran and Ćurčić, Marijana and Antonijević, Biljana and Carević, Momir and Mandić, Jelena and Đukić-Ćosić, Danijela and Lekić, Charles P.",
year = "2010",
abstract = "In this study we determined the fluoride content in drinking water and hair of 12-year-old schoolchildren from different Serbian municipalities, i.e. Valley, Veliko Gradiste, Kacarevo and Vranjska Banja. The analyses were performed using composite fluoride ion-selective electrode. Average fluoride levels were 0.10, 0.15, 0.79 and 11 ppm in well water, 0.07, 0.10, 0.17 and 0.15 ppm in tap water, 19.3, 21.5, 25.4, and 32.5 ppm in hair samples, in Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja, respectively. Correlation analysis indicated statistically significant positive relationship between fluoride in wells water and fluoride in hair, for all municipalities: correlation coefficients were 0.54 (p lt 0.05), 0.89, 0.97 and 0.99 (p lt 0.001), in Vranjska Banja, Valjevo, Veliko Gradiste, and Kacarevo, respectively. Positive correlation was obtained also between fluoride in tap water and hair samples in all regions under the study, with statistical significance only in Valjevo municipality, p lt 0.05. Dental examination of schoolchildren confirmed dental fluorosis only in the region of Vranjska Banja. Moreover, in endemic fluorotic region of Vranjska Banja, positive and statistically significant correlations were confirmed between fluoride in well water and dental fluorosis level (r = 0.61; p lt 0.01) and additionally between fluoride in hair and dental fluorosis level (0.62; p lt 0.01). The primary findings from this study have shown that fluoride content in hair is highly correlated with fluoride content in drinking water and dental fluorosis level, indicating that hair may be regarded as biomaterial of high informative potential in evaluating prolonged exposure to fluorides and to individuate children at risk of fluorosis regardless of the phase of teeth eruption.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Scientia Horticulturae",
title = "Fluoride in drinking water and dental fluorosis",
volume = "408",
number = "17",
pages = "3507-3512",
doi = "10.1016/j.scitotenv.2010.04.029"
}

Mandinić, Z., Ćurčić, M., Antonijević, B., Carević, M., Mandić, J., Đukić-Ćosić, D.,& Lekić, C. P.. (2010). Fluoride in drinking water and dental fluorosis. in Scientia Horticulturae
Elsevier Science BV, Amsterdam., 408(17), 3507-3512.
https://doi.org/10.1016/j.scitotenv.2010.04.029

Mandinić Z, Ćurčić M, Antonijević B, Carević M, Mandić J, Đukić-Ćosić D, Lekić CP. Fluoride in drinking water and dental fluorosis. in Scientia Horticulturae. 2010;408(17):3507-3512.
doi:10.1016/j.scitotenv.2010.04.029 .

Mandinić, Zoran, Ćurčić, Marijana, Antonijević, Biljana, Carević, Momir, Mandić, Jelena, Đukić-Ćosić, Danijela, Lekić, Charles P., "Fluoride in drinking water and dental fluorosis" in Scientia Horticulturae, 408, no. 17 (2010):3507-3512,
https://doi.org/10.1016/j.scitotenv.2010.04.029 . .

TY  - JOUR
AU  - Matović, Vesna
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Soldatović, Danilo
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1376
AB  - One of the important mechanisms of cadmium (Cd) toxicity is its interactions with bioelements, including magnesium (Mg). Exposure to Cd leads to disturbances in Mg metabolism in the organism, while Mg supplementation has an adverse effect on Cd absorption, accumulation and toxicity. According to the available results, which indicate a protective role of Mg against Cd toxicity, it remains to be seen whether magnesium may influence the important unsolved problem of Cd intoxication therapy. In this review, the interactions between the toxic metal Cd and the bioelement Mg are discussed on the basis of the available literature and our own results. We discuss these interactions mainly based on experimental data because data from human studies are scarce.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication
VL  - 23
IS  - 1
SP  - 19
EP  - 26
DO  - 10.1684/mrh.2010.0196
ER  - 

@article{
author = "Matović, Vesna and Bulat, Zorica and Đukić-Ćosić, Danijela and Soldatović, Danilo",
year = "2010",
abstract = "One of the important mechanisms of cadmium (Cd) toxicity is its interactions with bioelements, including magnesium (Mg). Exposure to Cd leads to disturbances in Mg metabolism in the organism, while Mg supplementation has an adverse effect on Cd absorption, accumulation and toxicity. According to the available results, which indicate a protective role of Mg against Cd toxicity, it remains to be seen whether magnesium may influence the important unsolved problem of Cd intoxication therapy. In this review, the interactions between the toxic metal Cd and the bioelement Mg are discussed on the basis of the available literature and our own results. We discuss these interactions mainly based on experimental data because data from human studies are scarce.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication",
volume = "23",
number = "1",
pages = "19-26",
doi = "10.1684/mrh.2010.0196"
}

Matović, V., Bulat, Z., Đukić-Ćosić, D.,& Soldatović, D.. (2010). Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 23(1), 19-26.
https://doi.org/10.1684/mrh.2010.0196

Matović V, Bulat Z, Đukić-Ćosić D, Soldatović D. Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. in Magnesium Research. 2010;23(1):19-26.
doi:10.1684/mrh.2010.0196 .

Matović, Vesna, Bulat, Zorica, Đukić-Ćosić, Danijela, Soldatović, Danilo, "Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication" in Magnesium Research, 23, no. 1 (2010):19-26,
https://doi.org/10.1684/mrh.2010.0196 . .