TY  - JOUR
AU  - Dodevska, Margarita
AU  - Šobajić, Slađana
AU  - Dragićević, Vesna
AU  - Stanković, Ivan
AU  - Ivanović, Nevena
AU  - Đorđević, Brižita
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3776
AB  - The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.
PB  - MDPI
T2  - Nutrients
T1  - The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults
VL  - 13
IS  - 2
SP  - 1
EP  - 16
DO  - 10.3390/nu13020487
ER  - 

@article{
author = "Dodevska, Margarita and Šobajić, Slađana and Dragićević, Vesna and Stanković, Ivan and Ivanović, Nevena and Đorđević, Brižita",
year = "2021",
abstract = "The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.",
publisher = "MDPI",
journal = "Nutrients",
title = "The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults",
volume = "13",
number = "2",
pages = "1-16",
doi = "10.3390/nu13020487"
}

Dodevska, M., Šobajić, S., Dragićević, V., Stanković, I., Ivanović, N.,& Đorđević, B.. (2021). The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults. in Nutrients
MDPI., 13(2), 1-16.
https://doi.org/10.3390/nu13020487

Dodevska M, Šobajić S, Dragićević V, Stanković I, Ivanović N, Đorđević B. The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults. in Nutrients. 2021;13(2):1-16.
doi:10.3390/nu13020487 .

Dodevska, Margarita, Šobajić, Slađana, Dragićević, Vesna, Stanković, Ivan, Ivanović, Nevena, Đorđević, Brižita, "The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults" in Nutrients, 13, no. 2 (2021):1-16,
https://doi.org/10.3390/nu13020487 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Vidović, Bojana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5397
AB  - Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - Impact of defatting process on antioxidant potential of grape seeds
SP  - 34
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5397
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Vidović, Bojana and Šobajić, Slađana",
year = "2020",
abstract = "Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "Impact of defatting process on antioxidant potential of grape seeds",
pages = "34-34",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5397"
}

Dabetić, N., Todorović, V., Vidović, B.,& Šobajić, S.. (2020). Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397

Dabetić N, Todorović V, Vidović B, Šobajić S. Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

Dabetić, Nevena, Todorović, Vanja, Vidović, Bojana, Šobajić, Slađana, "Impact of defatting process on antioxidant potential of grape seeds" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):34-34,
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

TY  - JOUR
AU  - Zrnić-Ćirić, Milica
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuriš, Jelena
AU  - Vidović, Bojana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3628
AB  - Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects.
AB  - ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Beta-glucan content and antioxidant activities of mushroom-derived food supplements
VL  - 85
IS  - 4
SP  - 439
EP  - 451
DO  - 10.2298/JSC190701121Z
ER  - 

@article{
author = "Zrnić-Ćirić, Milica and Dabetić, Nevena and Todorović, Vanja and Đuriš, Jelena and Vidović, Bojana",
year = "2020",
abstract = "Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects., ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Beta-glucan content and antioxidant activities of mushroom-derived food supplements",
volume = "85",
number = "4",
pages = "439-451",
doi = "10.2298/JSC190701121Z"
}

Zrnić-Ćirić, M., Dabetić, N., Todorović, V., Đuriš, J.,& Vidović, B.. (2020). Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 85(4), 439-451.
https://doi.org/10.2298/JSC190701121Z

Zrnić-Ćirić M, Dabetić N, Todorović V, Đuriš J, Vidović B. Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society. 2020;85(4):439-451.
doi:10.2298/JSC190701121Z .

Zrnić-Ćirić, Milica, Dabetić, Nevena, Todorović, Vanja, Đuriš, Jelena, Vidović, Bojana, "Beta-glucan content and antioxidant activities of mushroom-derived food supplements" in Journal of the Serbian Chemical Society, 85, no. 4 (2020):439-451,
https://doi.org/10.2298/JSC190701121Z . .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Bašić, Zorica N.
AU  - Vujović, Dragan S.
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3608
AB  - The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.
PB  - Wiley-VCH Verlag
T2  - European Journal of Lipid Science and Technology
T1  - Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment
VL  - 122
IS  - 6
DO  - DOI: 10.1002/ejlt.201900447
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Đuričić, Ivana and Antić-Stanković, Jelena and Bašić, Zorica N. and Vujović, Dragan S. and Šobajić, Slađana",
year = "2020",
abstract = "The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.",
publisher = "Wiley-VCH Verlag",
journal = "European Journal of Lipid Science and Technology",
title = "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment",
volume = "122",
number = "6",
doi = "DOI: 10.1002/ejlt.201900447"
}

Dabetić, N., Todorović, V., Đuričić, I., Antić-Stanković, J., Bašić, Z. N., Vujović, D. S.,& Šobajić, S.. (2020). Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology
Wiley-VCH Verlag., 122(6).
https://doi.org/DOI: 10.1002/ejlt.201900447

Dabetić N, Todorović V, Đuričić I, Antić-Stanković J, Bašić ZN, Vujović DS, Šobajić S. Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology. 2020;122(6).
doi:DOI: 10.1002/ejlt.201900447 .

Dabetić, Nevena, Todorović, Vanja, Đuričić, Ivana, Antić-Stanković, Jelena, Bašić, Zorica N., Vujović, Dragan S., Šobajić, Slađana, "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment" in European Journal of Lipid Science and Technology, 122, no. 6 (2020),
https://doi.org/DOI: 10.1002/ejlt.201900447 . .

TY  - JOUR
AU  - Grozdanić, Nađa
AU  - Đuričić, Ivana
AU  - Kosanić, Marijana
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Etahiri, Samira
AU  - Assobhei, Omar
AU  - Benba, Jamila
AU  - Petović, Slavica
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3605
AB  - Purpose: Sea macroalgae are an important source of biologically highly valuable compounds. The main aim of this study was to investigate the in vitro anticancer properties and chemical composition of the dichloromethane-methanol extract and three fractions of the Fucus spiralis from coastline of Morocco. Methods: Fractions were made from dichloromethane: methanol (1:1) extract of Fucus spiralis: petroleum-ether, ethyl-acetate and n-butanol. Extract and fractions were screened for in vitro cytotoxicity by MTT assay against human cervical adenocarcinoma (HeLa), colorectal adenocarcinoma (LS-174T), lung carcinoma (A549), and normal human lung fibroblasts (MRC-5). Cell cycle distribution of the HeLa cells was evaluated using flow cytometry. Acridine orange (AO)-ethidium bromide (EB) staining was used to assess morphological changes of HeLa cells under fluorescence microscope. Anti-migration and anti-angiogenic properties were investigated using scratch and tube formation assays against human endothelium-derived permanent EA.hy926 cell line. Antidiabetic activity was tested using anti-α-glucosidase assay. Antimicrobial effect was tested using micro- dilution method. Results: Petroleum-ether fraction оf Fucus spiralis rich in fatty acids exerted the highest cytotoxicity against HeLa cells. Ethyl-acetate and petroleum-ether fractions induced the highest accumulation of the HeLa cells in sub-G1 and G2/M phases. Extract and fractions showed proapoptotic effect on HeLa cells under fluorescent microscope. They exhibited antimigratory and antiangiogenic effects in vitro. IC50 value for α-glucosidase inhibitory activity was much stronger than standard acarbose. n-Butanol fraction exerted the highest antibacterial and antifungal activity. Conclusions: The investigation of various biological activities of the extract and fractions obtained from Fucus spiralis may suggest a promising anticancer and pharmacological potential of this edible macroalga.
PB  - Zerbinis Publications
T2  - Journal of B.U.ON.
T1  - Fucus spiralis extract and fractions: Anticancer and pharmacological potentials
VL  - 25
IS  - 2
SP  - 1219
EP  - 1229
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3605
ER  - 

@article{
author = "Grozdanić, Nađa and Đuričić, Ivana and Kosanić, Marijana and Zdunić, Gordana and Šavikin, Katarina and Etahiri, Samira and Assobhei, Omar and Benba, Jamila and Petović, Slavica and Matić, Ivana Z. and Stanojković, Tatjana P.",
year = "2020",
abstract = "Purpose: Sea macroalgae are an important source of biologically highly valuable compounds. The main aim of this study was to investigate the in vitro anticancer properties and chemical composition of the dichloromethane-methanol extract and three fractions of the Fucus spiralis from coastline of Morocco. Methods: Fractions were made from dichloromethane: methanol (1:1) extract of Fucus spiralis: petroleum-ether, ethyl-acetate and n-butanol. Extract and fractions were screened for in vitro cytotoxicity by MTT assay against human cervical adenocarcinoma (HeLa), colorectal adenocarcinoma (LS-174T), lung carcinoma (A549), and normal human lung fibroblasts (MRC-5). Cell cycle distribution of the HeLa cells was evaluated using flow cytometry. Acridine orange (AO)-ethidium bromide (EB) staining was used to assess morphological changes of HeLa cells under fluorescence microscope. Anti-migration and anti-angiogenic properties were investigated using scratch and tube formation assays against human endothelium-derived permanent EA.hy926 cell line. Antidiabetic activity was tested using anti-α-glucosidase assay. Antimicrobial effect was tested using micro- dilution method. Results: Petroleum-ether fraction оf Fucus spiralis rich in fatty acids exerted the highest cytotoxicity against HeLa cells. Ethyl-acetate and petroleum-ether fractions induced the highest accumulation of the HeLa cells in sub-G1 and G2/M phases. Extract and fractions showed proapoptotic effect on HeLa cells under fluorescent microscope. They exhibited antimigratory and antiangiogenic effects in vitro. IC50 value for α-glucosidase inhibitory activity was much stronger than standard acarbose. n-Butanol fraction exerted the highest antibacterial and antifungal activity. Conclusions: The investigation of various biological activities of the extract and fractions obtained from Fucus spiralis may suggest a promising anticancer and pharmacological potential of this edible macroalga.",
publisher = "Zerbinis Publications",
journal = "Journal of B.U.ON.",
title = "Fucus spiralis extract and fractions: Anticancer and pharmacological potentials",
volume = "25",
number = "2",
pages = "1219-1229",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3605"
}

Grozdanić, N., Đuričić, I., Kosanić, M., Zdunić, G., Šavikin, K., Etahiri, S., Assobhei, O., Benba, J., Petović, S., Matić, I. Z.,& Stanojković, T. P.. (2020). Fucus spiralis extract and fractions: Anticancer and pharmacological potentials. in Journal of B.U.ON.
Zerbinis Publications., 25(2), 1219-1229.
https://hdl.handle.net/21.15107/rcub_farfar_3605

Grozdanić N, Đuričić I, Kosanić M, Zdunić G, Šavikin K, Etahiri S, Assobhei O, Benba J, Petović S, Matić IZ, Stanojković TP. Fucus spiralis extract and fractions: Anticancer and pharmacological potentials. in Journal of B.U.ON.. 2020;25(2):1219-1229.
https://hdl.handle.net/21.15107/rcub_farfar_3605 .

Grozdanić, Nađa, Đuričić, Ivana, Kosanić, Marijana, Zdunić, Gordana, Šavikin, Katarina, Etahiri, Samira, Assobhei, Omar, Benba, Jamila, Petović, Slavica, Matić, Ivana Z., Stanojković, Tatjana P., "Fucus spiralis extract and fractions: Anticancer and pharmacological potentials" in Journal of B.U.ON., 25, no. 2 (2020):1219-1229,
https://hdl.handle.net/21.15107/rcub_farfar_3605 .

TY  - CONF
AU  - Vidović, Bojana
AU  - Marčetić, Mirjana
AU  - Janković, Snežana
AU  - Rakić, Sveto
AU  - Pavlović, Maja
AU  - Perišić, Katarina
AU  - Rakić, Radojica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5306
AB  - Amaranth (Amaranthus sp., Amaranthaceae), quinoa (Chenopodium quinoa, Amaranthaceae)
and canihua (Chenopodium pallidicaule, Amaranthaceae) are pseudograins originating from
South America. They are widely used in the diet as well as chia seeds (Salvia hispanica,
Lamiaceae) from South America and wheat (Triticum aestivum, Poaceae) and millet (Panicum
miliaceum, Poaceae), characteristic for our climate. The aim of the study was to determine the
nutritive characteristics, phenolic content and antioxidant activity of commercial samples of
pseudograins (аmaranth, quinoa and canihua) from our market, as well as a comparative
analysis to chia seeds, common and khorasan wheat and millet. Basic nutritive value
parameters and mineral contents were assessed for pseudograins and chia seeds. The content
of total phenolic compounds (TPC) and total flavonoid compounds (TFC), antioxidant
activity by DPPH and FRAP tests were determined for all samples. The results of the nutrient
composition indicates that analyzed pseudograins are good sources of proteins (13.39%) and
unlike chia seeds are characterized by relatively low fat content (5.97%). Analyzed
pseudograins contain calcium, magnesium, zinc and iron in a significant amount. The highest
TPC content was observed in chia seeds (395.7 mg GAE/100 g), following canihua (327.4 mg
GAE/100 g), quinoa (161.9 mg GAE/100 g), common wheat (61.8 mg GAE/100 g), Khorasan
wheat (51.1 mg GAE/100 g), while the lowest content was identified in millet (32.9 mg
GAE/100 mg). TFC content was in a range from 0.001 % (common wheat, khorasan wheat)
to 0.099 % (canihua). Antioxidant properties of pseudograins were lower compared to chia
seeds, but similar to common wheat and khorasan wheat while even higher comparing to
millet.
C3  - X International Scientific Agricultural Symposium “Agrosym 2019”, Book of Proceedings
T1  - Nutritive characteristics and antioxidant activity of pseudograins
SP  - 401
EP  - 407
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5306
ER  - 

@conference{
author = "Vidović, Bojana and Marčetić, Mirjana and Janković, Snežana and Rakić, Sveto and Pavlović, Maja and Perišić, Katarina and Rakić, Radojica",
year = "2019",
abstract = "Amaranth (Amaranthus sp., Amaranthaceae), quinoa (Chenopodium quinoa, Amaranthaceae)
and canihua (Chenopodium pallidicaule, Amaranthaceae) are pseudograins originating from
South America. They are widely used in the diet as well as chia seeds (Salvia hispanica,
Lamiaceae) from South America and wheat (Triticum aestivum, Poaceae) and millet (Panicum
miliaceum, Poaceae), characteristic for our climate. The aim of the study was to determine the
nutritive characteristics, phenolic content and antioxidant activity of commercial samples of
pseudograins (аmaranth, quinoa and canihua) from our market, as well as a comparative
analysis to chia seeds, common and khorasan wheat and millet. Basic nutritive value
parameters and mineral contents were assessed for pseudograins and chia seeds. The content
of total phenolic compounds (TPC) and total flavonoid compounds (TFC), antioxidant
activity by DPPH and FRAP tests were determined for all samples. The results of the nutrient
composition indicates that analyzed pseudograins are good sources of proteins (13.39%) and
unlike chia seeds are characterized by relatively low fat content (5.97%). Analyzed
pseudograins contain calcium, magnesium, zinc and iron in a significant amount. The highest
TPC content was observed in chia seeds (395.7 mg GAE/100 g), following canihua (327.4 mg
GAE/100 g), quinoa (161.9 mg GAE/100 g), common wheat (61.8 mg GAE/100 g), Khorasan
wheat (51.1 mg GAE/100 g), while the lowest content was identified in millet (32.9 mg
GAE/100 mg). TFC content was in a range from 0.001 % (common wheat, khorasan wheat)
to 0.099 % (canihua). Antioxidant properties of pseudograins were lower compared to chia
seeds, but similar to common wheat and khorasan wheat while even higher comparing to
millet.",
journal = "X International Scientific Agricultural Symposium “Agrosym 2019”, Book of Proceedings",
title = "Nutritive characteristics and antioxidant activity of pseudograins",
pages = "401-407",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5306"
}

Vidović, B., Marčetić, M., Janković, S., Rakić, S., Pavlović, M., Perišić, K.,& Rakić, R.. (2019). Nutritive characteristics and antioxidant activity of pseudograins. in X International Scientific Agricultural Symposium “Agrosym 2019”, Book of Proceedings, 401-407.
https://hdl.handle.net/21.15107/rcub_farfar_5306

Vidović B, Marčetić M, Janković S, Rakić S, Pavlović M, Perišić K, Rakić R. Nutritive characteristics and antioxidant activity of pseudograins. in X International Scientific Agricultural Symposium “Agrosym 2019”, Book of Proceedings. 2019;:401-407.
https://hdl.handle.net/21.15107/rcub_farfar_5306 .

Vidović, Bojana, Marčetić, Mirjana, Janković, Snežana, Rakić, Sveto, Pavlović, Maja, Perišić, Katarina, Rakić, Radojica, "Nutritive characteristics and antioxidant activity of pseudograins" in X International Scientific Agricultural Symposium “Agrosym 2019”, Book of Proceedings (2019):401-407,
https://hdl.handle.net/21.15107/rcub_farfar_5306 .

TY  - JOUR
AU  - Stanisavljević, Dragana
AU  - Đorđević, Sofija
AU  - Milenković, Marina
AU  - Zlatković, Branislav
AU  - Nikolova, Milena T.
AU  - Veličković, Dragan
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3312
AB  - Isolates of medicinal and aromatic herbs are used as additives in non-alcoholic drinks to improve the sensory characteristics and antioxidant potential. The method of drying the plant material, among other factors, has a profound influence on the chemical composition and pharmacological activities of plant extracts. This paper analyzes the effect of the drying technique (I - natural drying, II - in the laboratory oven, III - in low-temperature condensational drier) on the volatile fraction of the wild mint (Mentha longifolia (L.) Hudson) extract, in order to select an extract of the best quality for preparation of non-alcoholic drinks. The volatile profile of the extracts was determined by the GC-FID and GC-MS techniques, the antimicrobial activity by the microdilution technique, the antioxidant activity by the DPPH and FRAP assays, and the sensory acceptance according to the Regulation on quality for refreshing non-alcoholic beverages. The results showed that piperitone was the major component of the volatile fraction extract of the natural drying herb and low-temperature condensational drier herb (53.9% and 61.1%, respectively), while the extract of laboratory oven herb was rich in menthone (35.5%). At the concentrations in the range of 0.8-3.2 mg/mL the extracts better inhibited the Gram (+) bacteria. The beverage to which the extract of naturally dried wild mint was added, showed the antioxidant activity (9.09 +/- 0.17 mu mol Fe2+/mL by FRAP and 14.00 +/- 3.00 mu L/mL by DPPH method) and good sensorial characteristics (concentration of the extract 0.8 g/L).
PB  - Mattioli 1885, Fidenza
T2  - Psychiatry Research
T1  - Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages
VL  - 21
IS  - 1
SP  - 202
EP  - 209
DO  - 10.23751/pn.v21i1.7256
ER  - 

@article{
author = "Stanisavljević, Dragana and Đorđević, Sofija and Milenković, Marina and Zlatković, Branislav and Nikolova, Milena T. and Veličković, Dragan",
year = "2019",
abstract = "Isolates of medicinal and aromatic herbs are used as additives in non-alcoholic drinks to improve the sensory characteristics and antioxidant potential. The method of drying the plant material, among other factors, has a profound influence on the chemical composition and pharmacological activities of plant extracts. This paper analyzes the effect of the drying technique (I - natural drying, II - in the laboratory oven, III - in low-temperature condensational drier) on the volatile fraction of the wild mint (Mentha longifolia (L.) Hudson) extract, in order to select an extract of the best quality for preparation of non-alcoholic drinks. The volatile profile of the extracts was determined by the GC-FID and GC-MS techniques, the antimicrobial activity by the microdilution technique, the antioxidant activity by the DPPH and FRAP assays, and the sensory acceptance according to the Regulation on quality for refreshing non-alcoholic beverages. The results showed that piperitone was the major component of the volatile fraction extract of the natural drying herb and low-temperature condensational drier herb (53.9% and 61.1%, respectively), while the extract of laboratory oven herb was rich in menthone (35.5%). At the concentrations in the range of 0.8-3.2 mg/mL the extracts better inhibited the Gram (+) bacteria. The beverage to which the extract of naturally dried wild mint was added, showed the antioxidant activity (9.09 +/- 0.17 mu mol Fe2+/mL by FRAP and 14.00 +/- 3.00 mu L/mL by DPPH method) and good sensorial characteristics (concentration of the extract 0.8 g/L).",
publisher = "Mattioli 1885, Fidenza",
journal = "Psychiatry Research",
title = "Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages",
volume = "21",
number = "1",
pages = "202-209",
doi = "10.23751/pn.v21i1.7256"
}

Stanisavljević, D., Đorđević, S., Milenković, M., Zlatković, B., Nikolova, M. T.,& Veličković, D.. (2019). Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages. in Psychiatry Research
Mattioli 1885, Fidenza., 21(1), 202-209.
https://doi.org/10.23751/pn.v21i1.7256

Stanisavljević D, Đorđević S, Milenković M, Zlatković B, Nikolova MT, Veličković D. Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages. in Psychiatry Research. 2019;21(1):202-209.
doi:10.23751/pn.v21i1.7256 .

Stanisavljević, Dragana, Đorđević, Sofija, Milenković, Marina, Zlatković, Branislav, Nikolova, Milena T., Veličković, Dragan, "Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages" in Psychiatry Research, 21, no. 1 (2019):202-209,
https://doi.org/10.23751/pn.v21i1.7256 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandar V.
AU  - Pejin, Boris
AU  - Čakar, Mira
AU  - Živković, Marijana
AU  - Vajs, Vlatka
AU  - Đorđević, Brižita
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3320
AB  - This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.
PB  - Elsevier Science BV, Amsterdam
T2  - Scientific Reports
T1  - Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines
VL  - 244
SP  - 42
EP  - 49
DO  - 10.1016/j.scienta.2018.09.020
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandar V. and Pejin, Boris and Čakar, Mira and Živković, Marijana and Vajs, Vlatka and Đorđević, Brižita",
year = "2019",
abstract = "This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Scientific Reports",
title = "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines",
volume = "244",
pages = "42-49",
doi = "10.1016/j.scienta.2018.09.020"
}

Čakar, U., Petrović, A. V., Pejin, B., Čakar, M., Živković, M., Vajs, V.,& Đorđević, B.. (2019). Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientific Reports
Elsevier Science BV, Amsterdam., 244, 42-49.
https://doi.org/10.1016/j.scienta.2018.09.020

Čakar U, Petrović AV, Pejin B, Čakar M, Živković M, Vajs V, Đorđević B. Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientific Reports. 2019;244:42-49.
doi:10.1016/j.scienta.2018.09.020 .

Čakar, Uroš, Petrović, Aleksandar V., Pejin, Boris, Čakar, Mira, Živković, Marijana, Vajs, Vlatka, Đorđević, Brižita, "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines" in Scientific Reports, 244 (2019):42-49,
https://doi.org/10.1016/j.scienta.2018.09.020 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Belović, Miona
AU  - Ilić, Nebojša
AU  - Kotur-Stevuljević, Jelena
AU  - Slanar, Ondrej
AU  - Šobajić, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3358
AB  - There is a growing body of evidence that tomato consumption reduces the risk of cardiovascular disease, through antioxidative, anti-inflammatory and hypotensive effects. We compared the effects of polyphenol-enriched and standard tomato juice on parameters of lipid and oxidative status and blood pressure in subjects with stage 1 hypertension. The experimental group (n=13) was supplemented with 200g of tomato fruit juice enriched with 1g of ethanolic extract of whole tomato fruit, while the control group (n=13) was consuming 200g tomato fruit juice. Before and after the treatment, blood samples were collected, and blood pressure was measured. Markers of oxidative stress and antioxidative defense: paraoxonase (PON1), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), pro-oxidant-antioxidant balance (PAB) and C reactive protein (CRP) were determined in serum. Prothrombin time (PT) was measured in the whole blood samples. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant reduction in total cholesterol and LDL-C only in the control group at the end of the study. No significant differences were observed in the remainder of the assessed parameters along the study. In conclusion, tomato juice may have favorable effects on lipid metabolism, but polyphenol fortification does not constitute additional beneficial cardiovascular effects.
PB  - Springer, Dordrecht
T2  - Plant Foods for Human Nutrition
T1  - Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study
VL  - 74
IS  - 1
SP  - 122
EP  - 127
DO  - 10.1007/s11130-019-0714-5
ER  - 

@article{
author = "Michalickova, Danica and Belović, Miona and Ilić, Nebojša and Kotur-Stevuljević, Jelena and Slanar, Ondrej and Šobajić, Slađana",
year = "2019",
abstract = "There is a growing body of evidence that tomato consumption reduces the risk of cardiovascular disease, through antioxidative, anti-inflammatory and hypotensive effects. We compared the effects of polyphenol-enriched and standard tomato juice on parameters of lipid and oxidative status and blood pressure in subjects with stage 1 hypertension. The experimental group (n=13) was supplemented with 200g of tomato fruit juice enriched with 1g of ethanolic extract of whole tomato fruit, while the control group (n=13) was consuming 200g tomato fruit juice. Before and after the treatment, blood samples were collected, and blood pressure was measured. Markers of oxidative stress and antioxidative defense: paraoxonase (PON1), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), pro-oxidant-antioxidant balance (PAB) and C reactive protein (CRP) were determined in serum. Prothrombin time (PT) was measured in the whole blood samples. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant reduction in total cholesterol and LDL-C only in the control group at the end of the study. No significant differences were observed in the remainder of the assessed parameters along the study. In conclusion, tomato juice may have favorable effects on lipid metabolism, but polyphenol fortification does not constitute additional beneficial cardiovascular effects.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study",
volume = "74",
number = "1",
pages = "122-127",
doi = "10.1007/s11130-019-0714-5"
}

Michalickova, D., Belović, M., Ilić, N., Kotur-Stevuljević, J., Slanar, O.,& Šobajić, S.. (2019). Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study. in Plant Foods for Human Nutrition
Springer, Dordrecht., 74(1), 122-127.
https://doi.org/10.1007/s11130-019-0714-5

Michalickova D, Belović M, Ilić N, Kotur-Stevuljević J, Slanar O, Šobajić S. Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study. in Plant Foods for Human Nutrition. 2019;74(1):122-127.
doi:10.1007/s11130-019-0714-5 .

Michalickova, Danica, Belović, Miona, Ilić, Nebojša, Kotur-Stevuljević, Jelena, Slanar, Ondrej, Šobajić, Slađana, "Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study" in Plant Foods for Human Nutrition, 74, no. 1 (2019):122-127,
https://doi.org/10.1007/s11130-019-0714-5 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandra
AU  - Janković, M.
AU  - Pejin, Boris
AU  - Vajs, Vlatka
AU  - Čakar, Mira
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3173
AB  - Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.
PB  - Int Soc Horticultural Science-Ishs, Leuven
T2  - European Journal of Horticultural Science
T1  - Differentiation of wines made from berry and drupe fruits according to their phenolic profiles
VL  - 83
IS  - 1
SP  - 49
EP  - 61
DO  - 10.17660/eJHS.2018/83.1.7
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandra and Janković, M. and Pejin, Boris and Vajs, Vlatka and Čakar, Mira and Đorđević, Brižita",
year = "2018",
abstract = "Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.",
publisher = "Int Soc Horticultural Science-Ishs, Leuven",
journal = "European Journal of Horticultural Science",
title = "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles",
volume = "83",
number = "1",
pages = "49-61",
doi = "10.17660/eJHS.2018/83.1.7"
}

Čakar, U., Petrović, A., Janković, M., Pejin, B., Vajs, V., Čakar, M.,& Đorđević, B.. (2018). Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science
Int Soc Horticultural Science-Ishs, Leuven., 83(1), 49-61.
https://doi.org/10.17660/eJHS.2018/83.1.7

Čakar U, Petrović A, Janković M, Pejin B, Vajs V, Čakar M, Đorđević B. Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science. 2018;83(1):49-61.
doi:10.17660/eJHS.2018/83.1.7 .

Čakar, Uroš, Petrović, Aleksandra, Janković, M., Pejin, Boris, Vajs, Vlatka, Čakar, Mira, Đorđević, Brižita, "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles" in European Journal of Horticultural Science, 83, no. 1 (2018):49-61,
https://doi.org/10.17660/eJHS.2018/83.1.7 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Šobajić, Slađana
AU  - Vidović, Bojana
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3149
AB  - Aim: Balanced nutrition and healthy lifestyle habits are very important, especially in young population. By this way it is possible to prevent many non-communicable diseases. As a health care professionals, pharmacists have very important role in this mission. The aim of this study was to evaluate basic nutritional knowledge and lifestyle habits of pharmacy undergraduate students in the context of their future health profession. Methods: The study group consisted of 591 European undergraduate pharmacy students. The data related to anthropometry, eating and lifestyle habits were obtained based on self-administered cross-sectional survey. Analysis of gender differences was performed using the chi-square test. Statistically significance was set at p value  lt  0.05. Results: Anthropometric characteristics of students showed that 10.5 % female students were underweight, while 62.6% of the males were overweight and 0.7% were obese. Regular breakfast had 80.9% of the students. Breakfast skipping was statistically higher in male participants (p lt 0.05). Only 35% of students reported daily intake of vegetables. Also, low fruit consumption was observed in all students with statistically lower fruit intake in males (p lt 0.05). Consumption of alcohol, fried food and tobacco was not common among students. Basic principle of balanced nutrition was recognized by 58.4% of study population. Conclusion: Results of our study indicate that European pharmacy students have some unsatisfactory eating habits and nutritional knowledge which is already related to their inadequate nutritional status. Our finding suggests that increased level of nutritional education should be incorporated into European pharmacy curriculum.
PB  - Mattioli 1885, Fidenza
T2  - Psychiatry Research
T1  - Nutritional and lifestyle habits of European pharmacy undergraduate students
VL  - 20
IS  - 1
SP  - 38
EP  - 45
DO  - 10.23751/pn.v20i1.5435
ER  - 

@article{
author = "Čakar, Uroš and Šobajić, Slađana and Vidović, Bojana and Đorđević, Brižita",
year = "2018",
abstract = "Aim: Balanced nutrition and healthy lifestyle habits are very important, especially in young population. By this way it is possible to prevent many non-communicable diseases. As a health care professionals, pharmacists have very important role in this mission. The aim of this study was to evaluate basic nutritional knowledge and lifestyle habits of pharmacy undergraduate students in the context of their future health profession. Methods: The study group consisted of 591 European undergraduate pharmacy students. The data related to anthropometry, eating and lifestyle habits were obtained based on self-administered cross-sectional survey. Analysis of gender differences was performed using the chi-square test. Statistically significance was set at p value  lt  0.05. Results: Anthropometric characteristics of students showed that 10.5 % female students were underweight, while 62.6% of the males were overweight and 0.7% were obese. Regular breakfast had 80.9% of the students. Breakfast skipping was statistically higher in male participants (p lt 0.05). Only 35% of students reported daily intake of vegetables. Also, low fruit consumption was observed in all students with statistically lower fruit intake in males (p lt 0.05). Consumption of alcohol, fried food and tobacco was not common among students. Basic principle of balanced nutrition was recognized by 58.4% of study population. Conclusion: Results of our study indicate that European pharmacy students have some unsatisfactory eating habits and nutritional knowledge which is already related to their inadequate nutritional status. Our finding suggests that increased level of nutritional education should be incorporated into European pharmacy curriculum.",
publisher = "Mattioli 1885, Fidenza",
journal = "Psychiatry Research",
title = "Nutritional and lifestyle habits of European pharmacy undergraduate students",
volume = "20",
number = "1",
pages = "38-45",
doi = "10.23751/pn.v20i1.5435"
}

Čakar, U., Šobajić, S., Vidović, B.,& Đorđević, B.. (2018). Nutritional and lifestyle habits of European pharmacy undergraduate students. in Psychiatry Research
Mattioli 1885, Fidenza., 20(1), 38-45.
https://doi.org/10.23751/pn.v20i1.5435

Čakar U, Šobajić S, Vidović B, Đorđević B. Nutritional and lifestyle habits of European pharmacy undergraduate students. in Psychiatry Research. 2018;20(1):38-45.
doi:10.23751/pn.v20i1.5435 .

Čakar, Uroš, Šobajić, Slađana, Vidović, Bojana, Đorđević, Brižita, "Nutritional and lifestyle habits of European pharmacy undergraduate students" in Psychiatry Research, 20, no. 1 (2018):38-45,
https://doi.org/10.23751/pn.v20i1.5435 . .

TY  - JOUR
AU  - Timić, Jasmina
AU  - Đuričić, Ivana
AU  - Ristić-Medić, Danijela K.
AU  - Šobajić, Slađana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3238
AB  - The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market
VL  - 83
IS  - 6
SP  - 685
EP  - 698
DO  - 10.2298/JSC180207039T
ER  - 

@article{
author = "Timić, Jasmina and Đuričić, Ivana and Ristić-Medić, Danijela K. and Šobajić, Slađana",
year = "2018",
abstract = "The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market",
volume = "83",
number = "6",
pages = "685-698",
doi = "10.2298/JSC180207039T"
}

Timić, J., Đuričić, I., Ristić-Medić, D. K.,& Šobajić, S.. (2018). Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(6), 685-698.
https://doi.org/10.2298/JSC180207039T

Timić J, Đuričić I, Ristić-Medić DK, Šobajić S. Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society. 2018;83(6):685-698.
doi:10.2298/JSC180207039T .

Timić, Jasmina, Đuričić, Ivana, Ristić-Medić, Danijela K., Šobajić, Slađana, "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market" in Journal of the Serbian Chemical Society, 83, no. 6 (2018):685-698,
https://doi.org/10.2298/JSC180207039T . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Grozdanić, Nada
AU  - Petrović, Aleksandar V.
AU  - Pejin, Boris
AU  - Nastasijević, Branislav
AU  - Marković, Bojan
AU  - Đorđević, Brižita
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2791
AB  - Background: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. Objectives: Potential alpha-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. Method: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. Results: Compared with acarbose used as a positive control (IC50 = 73.78 mu g/mL), all fruit wine samples exhibited higher alpha-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 mu g/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 mu g/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to alpha-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent alpha-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. Conclusion: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Fruit Wines Inhibitory Activity Against alpha-Glucosidase
VL  - 18
IS  - 15
SP  - 1264
EP  - 1272
DO  - 10.2174/1389201019666180410112439
ER  - 

@article{
author = "Čakar, Uroš and Grozdanić, Nada and Petrović, Aleksandar V. and Pejin, Boris and Nastasijević, Branislav and Marković, Bojan and Đorđević, Brižita",
year = "2017",
abstract = "Background: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. Objectives: Potential alpha-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. Method: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. Results: Compared with acarbose used as a positive control (IC50 = 73.78 mu g/mL), all fruit wine samples exhibited higher alpha-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 mu g/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 mu g/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to alpha-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent alpha-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. Conclusion: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Fruit Wines Inhibitory Activity Against alpha-Glucosidase",
volume = "18",
number = "15",
pages = "1264-1272",
doi = "10.2174/1389201019666180410112439"
}

Čakar, U., Grozdanić, N., Petrović, A. V., Pejin, B., Nastasijević, B., Marković, B.,& Đorđević, B.. (2017). Fruit Wines Inhibitory Activity Against alpha-Glucosidase. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 18(15), 1264-1272.
https://doi.org/10.2174/1389201019666180410112439

Čakar U, Grozdanić N, Petrović AV, Pejin B, Nastasijević B, Marković B, Đorđević B. Fruit Wines Inhibitory Activity Against alpha-Glucosidase. in Current Pharmaceutical Biotechnology. 2017;18(15):1264-1272.
doi:10.2174/1389201019666180410112439 .

Čakar, Uroš, Grozdanić, Nada, Petrović, Aleksandar V., Pejin, Boris, Nastasijević, Branislav, Marković, Bojan, Đorđević, Brižita, "Fruit Wines Inhibitory Activity Against alpha-Glucosidase" in Current Pharmaceutical Biotechnology, 18, no. 15 (2017):1264-1272,
https://doi.org/10.2174/1389201019666180410112439 . .

TY  - JOUR
AU  - Todorović, Vanja
AU  - Milenković, Marina
AU  - Vidović, Bojana
AU  - Todorović, Zoran B.
AU  - Šobajić, Slađana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3014
AB  - Many factors can influence antioxidative and antimicrobial characteristics of plant materials. The quality of cocoa as functional food ingredient is influenced through its processing. The main aim of this study was to test if there is difference in polyphenol content, antioxidant capacity, and antimicrobial activity between nonalkalized and alkalized cocoa powders. To estimate polyphenol and flavonoid content in cocoa samples the spectrophotometric microassays were used. Flavan-3ols were determined with reversed-phase high-performance liquid chromatography (RP-HPLC). Antimicrobial activity against 3 Gram positive bacteria, 4 Gram negative bacteria and 1 strain of yeast was determined using broth microdilution method. Total polyphenol content was 1.8 times lower in alkalized cocoa samples than in natural ones. Epicatechin/catechin ratio was changed due to the process of alkalization in favor of catechin (2.21 in natural and 1.45 in alkalized cocoa powders). Combined results of 3 antioxidative tests (DPPH, FRAP, ABTS) were used for calculation of RACI (Relative Antioxidant Capacity Index) and GAS (Global Antioxidant Score) values that were consistently higher in natural than in alkalized cocoa extracts. Obtained results have shown significant correlations between these values and phenolic content (0.929  lt = r  lt = 0.957, P  lt  0.01). Antimicrobial activity varied from 5.0 to 25.0 mg/ml (MICs), while Candida albicans was the most sensitive tested microorganism. Cocoa powders subjected to alkalization had significantly reduced content of total and specific phenolic compounds and reduced antioxidant capacity (P  lt  0.05), but their antimicrobial activity was equal for Gram-positive bacteria or even significantly enhanced for Gram-negative bacteria.
PB  - Wiley, Hoboken
T2  - Journal of Food Science
T1  - Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders
VL  - 82
IS  - 4
SP  - 1020
EP  - 1027
DO  - 10.1111/1750-3841.13672
ER  - 

@article{
author = "Todorović, Vanja and Milenković, Marina and Vidović, Bojana and Todorović, Zoran B. and Šobajić, Slađana",
year = "2017",
abstract = "Many factors can influence antioxidative and antimicrobial characteristics of plant materials. The quality of cocoa as functional food ingredient is influenced through its processing. The main aim of this study was to test if there is difference in polyphenol content, antioxidant capacity, and antimicrobial activity between nonalkalized and alkalized cocoa powders. To estimate polyphenol and flavonoid content in cocoa samples the spectrophotometric microassays were used. Flavan-3ols were determined with reversed-phase high-performance liquid chromatography (RP-HPLC). Antimicrobial activity against 3 Gram positive bacteria, 4 Gram negative bacteria and 1 strain of yeast was determined using broth microdilution method. Total polyphenol content was 1.8 times lower in alkalized cocoa samples than in natural ones. Epicatechin/catechin ratio was changed due to the process of alkalization in favor of catechin (2.21 in natural and 1.45 in alkalized cocoa powders). Combined results of 3 antioxidative tests (DPPH, FRAP, ABTS) were used for calculation of RACI (Relative Antioxidant Capacity Index) and GAS (Global Antioxidant Score) values that were consistently higher in natural than in alkalized cocoa extracts. Obtained results have shown significant correlations between these values and phenolic content (0.929  lt = r  lt = 0.957, P  lt  0.01). Antimicrobial activity varied from 5.0 to 25.0 mg/ml (MICs), while Candida albicans was the most sensitive tested microorganism. Cocoa powders subjected to alkalization had significantly reduced content of total and specific phenolic compounds and reduced antioxidant capacity (P  lt  0.05), but their antimicrobial activity was equal for Gram-positive bacteria or even significantly enhanced for Gram-negative bacteria.",
publisher = "Wiley, Hoboken",
journal = "Journal of Food Science",
title = "Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders",
volume = "82",
number = "4",
pages = "1020-1027",
doi = "10.1111/1750-3841.13672"
}

Todorović, V., Milenković, M., Vidović, B., Todorović, Z. B.,& Šobajić, S.. (2017). Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders. in Journal of Food Science
Wiley, Hoboken., 82(4), 1020-1027.
https://doi.org/10.1111/1750-3841.13672

Todorović V, Milenković M, Vidović B, Todorović ZB, Šobajić S. Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders. in Journal of Food Science. 2017;82(4):1020-1027.
doi:10.1111/1750-3841.13672 .

Todorović, Vanja, Milenković, Marina, Vidović, Bojana, Todorović, Zoran B., Šobajić, Slađana, "Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders" in Journal of Food Science, 82, no. 4 (2017):1020-1027,
https://doi.org/10.1111/1750-3841.13672 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milovanović, Srđan
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Takić, Marija
AU  - Debeljak-Martacić, Jasmina
AU  - Pantović, Maja
AU  - Đorđević, Brižita
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2957
AB  - Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia
VL  - 20
IS  - 1
SP  - 79
EP  - 85
DO  - 10.1089/jmf.2016.0070
ER  - 

@article{
author = "Vidović, Bojana and Milovanović, Srđan and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Takić, Marija and Debeljak-Martacić, Jasmina and Pantović, Maja and Đorđević, Brižita",
year = "2017",
abstract = "Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia",
volume = "20",
number = "1",
pages = "79-85",
doi = "10.1089/jmf.2016.0070"
}

Vidović, B., Milovanović, S., Stefanović, A., Kotur-Stevuljević, J., Takić, M., Debeljak-Martacić, J., Pantović, M.,& Đorđević, B.. (2017). Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 20(1), 79-85.
https://doi.org/10.1089/jmf.2016.0070

Vidović B, Milovanović S, Stefanović A, Kotur-Stevuljević J, Takić M, Debeljak-Martacić J, Pantović M, Đorđević B. Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food. 2017;20(1):79-85.
doi:10.1089/jmf.2016.0070 .

Vidović, Bojana, Milovanović, Srđan, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Takić, Marija, Debeljak-Martacić, Jasmina, Pantović, Maja, Đorđević, Brižita, "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia" in Journal of Medicinal Food, 20, no. 1 (2017):79-85,
https://doi.org/10.1089/jmf.2016.0070 . .

TY  - JOUR
AU  - Dodevska, Margarita
AU  - Šobajić, Slađana
AU  - Đorđević, Predrag B.
AU  - Dimitrijević-Srećković, Vesna
AU  - Spasojević-Kalimanovska, Vesna
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2569
AB  - Starting from the evidence-based health benefits that resistant starch (RS) shows when added to the diet, our aim in this study was to evaluate the effects of increased fibre intake with two different levels of RS coming from regular daily consumed foods on normalization of glycaemia within lifestyle intervention in the population with risk factors for developing diabetes. Study included 47 overweight and obese men and women with disordered glucoregulation and dyslipidaemia, aged between 45-74, divided into RS and Fibre group. Participants were subjected to the lifestyle and dietary intervention with low-fat and high-fibre (> 25 g/day) diet for 12 months and were offered two different dietary advices aimed at increasing total fibre intake in Fibre group and at increasing RS intake in RS group. The intake of macronutrients and total fibre was similar between groups at the end of the study, but achieved RS intake was two times higher in the RS group. Decrease in total cholesterol and non-HDL-cholesterol was more pronounced in RS group in comparison with Fibre group (p = 0.010, p = 0.031, respectively), whereas in Fibre group, a more pronounced effect on glucoregulation was observed: significant fall in glycaemia after 2-h oral glucose tolerance test (7.93 vs 6.96 mmol/L, p = 0.034). At the end of the study, RS-rich diet failed to affect glycaemic control in prediabetic obese individuals in contrast to the regular fibre-rich diet, which indicated that fibre profile could be an important determinant of the effect of dietary intervention.
PB  - Springer Heidelberg, Heidelberg
T2  - European Journal of Nutrition
T1  - Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults
VL  - 55
IS  - 1
SP  - 127
EP  - 137
DO  - 10.1007/s00394-015-0831-3
ER  - 

@article{
author = "Dodevska, Margarita and Šobajić, Slađana and Đorđević, Predrag B. and Dimitrijević-Srećković, Vesna and Spasojević-Kalimanovska, Vesna and Đorđević, Brižita",
year = "2016",
abstract = "Starting from the evidence-based health benefits that resistant starch (RS) shows when added to the diet, our aim in this study was to evaluate the effects of increased fibre intake with two different levels of RS coming from regular daily consumed foods on normalization of glycaemia within lifestyle intervention in the population with risk factors for developing diabetes. Study included 47 overweight and obese men and women with disordered glucoregulation and dyslipidaemia, aged between 45-74, divided into RS and Fibre group. Participants were subjected to the lifestyle and dietary intervention with low-fat and high-fibre (> 25 g/day) diet for 12 months and were offered two different dietary advices aimed at increasing total fibre intake in Fibre group and at increasing RS intake in RS group. The intake of macronutrients and total fibre was similar between groups at the end of the study, but achieved RS intake was two times higher in the RS group. Decrease in total cholesterol and non-HDL-cholesterol was more pronounced in RS group in comparison with Fibre group (p = 0.010, p = 0.031, respectively), whereas in Fibre group, a more pronounced effect on glucoregulation was observed: significant fall in glycaemia after 2-h oral glucose tolerance test (7.93 vs 6.96 mmol/L, p = 0.034). At the end of the study, RS-rich diet failed to affect glycaemic control in prediabetic obese individuals in contrast to the regular fibre-rich diet, which indicated that fibre profile could be an important determinant of the effect of dietary intervention.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "European Journal of Nutrition",
title = "Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults",
volume = "55",
number = "1",
pages = "127-137",
doi = "10.1007/s00394-015-0831-3"
}

Dodevska, M., Šobajić, S., Đorđević, P. B., Dimitrijević-Srećković, V., Spasojević-Kalimanovska, V.,& Đorđević, B.. (2016). Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults. in European Journal of Nutrition
Springer Heidelberg, Heidelberg., 55(1), 127-137.
https://doi.org/10.1007/s00394-015-0831-3

Dodevska M, Šobajić S, Đorđević PB, Dimitrijević-Srećković V, Spasojević-Kalimanovska V, Đorđević B. Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults. in European Journal of Nutrition. 2016;55(1):127-137.
doi:10.1007/s00394-015-0831-3 .

Dodevska, Margarita, Šobajić, Slađana, Đorđević, Predrag B., Dimitrijević-Srećković, Vesna, Spasojević-Kalimanovska, Vesna, Đorđević, Brižita, "Effects of total fibre or resistant starch-rich diets within lifestyle intervention in obese prediabetic adults" in European Journal of Nutrition, 55, no. 1 (2016):127-137,
https://doi.org/10.1007/s00394-015-0831-3 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandar V.
AU  - Živković, Marijana
AU  - Vajs, Vlatka
AU  - Milovanović, Miodrag M.
AU  - Zeravik, Jiri
AU  - Đorđević, Brižita
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2675
AB  - The composition and content of individual phenolic compounds in various fruit wines and overall antioxidant properties of these fruit wines were studied. Phenolic compounds were separated by reverse phase (RP) HPLC techniques, and their content was determined by means of mass spectrometer (MS) with triple quadrupole (TQ) analyser, which recorded specific precursor-product transitions. Antioxidant activity was monitored by the following spectrophotometric methods: DPPH, FRAP and Folin-Ciocalteu assay, respectively. Four types of berries (raspberry, blackberry, chokeberry and blueberry), one type of pome (apple) and one type of stone fruit (cherries) were used for the production of fruit wines. Corresponding fruit wines were produced by microvinification with or without adding sugar into the must before fermentation. Increase in alcohol level was responsible for the increased content of phenolic compounds in fruit wine due to improved extraction conditions. Produced fruit wines were preserved by adding SO2 which interferes with the determination of antioxidant activity of phenolic compounds. In this case, the development of a correlation method based on FRAP assay was introduced. Fruit wines are a rich source of substances which show beneficial effects on human health. Depending on the fruit type, different antioxidant compounds were predominant in wine samples.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Phenolic profile of some fruit wines and their antioxidant properties
VL  - 70
IS  - 6
SP  - 661
EP  - 672
DO  - 10.2298/HEMIND150722002C
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandar V. and Živković, Marijana and Vajs, Vlatka and Milovanović, Miodrag M. and Zeravik, Jiri and Đorđević, Brižita",
year = "2016",
abstract = "The composition and content of individual phenolic compounds in various fruit wines and overall antioxidant properties of these fruit wines were studied. Phenolic compounds were separated by reverse phase (RP) HPLC techniques, and their content was determined by means of mass spectrometer (MS) with triple quadrupole (TQ) analyser, which recorded specific precursor-product transitions. Antioxidant activity was monitored by the following spectrophotometric methods: DPPH, FRAP and Folin-Ciocalteu assay, respectively. Four types of berries (raspberry, blackberry, chokeberry and blueberry), one type of pome (apple) and one type of stone fruit (cherries) were used for the production of fruit wines. Corresponding fruit wines were produced by microvinification with or without adding sugar into the must before fermentation. Increase in alcohol level was responsible for the increased content of phenolic compounds in fruit wine due to improved extraction conditions. Produced fruit wines were preserved by adding SO2 which interferes with the determination of antioxidant activity of phenolic compounds. In this case, the development of a correlation method based on FRAP assay was introduced. Fruit wines are a rich source of substances which show beneficial effects on human health. Depending on the fruit type, different antioxidant compounds were predominant in wine samples.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Phenolic profile of some fruit wines and their antioxidant properties",
volume = "70",
number = "6",
pages = "661-672",
doi = "10.2298/HEMIND150722002C"
}

Čakar, U., Petrović, A. V., Živković, M., Vajs, V., Milovanović, M. M., Zeravik, J.,& Đorđević, B.. (2016). Phenolic profile of some fruit wines and their antioxidant properties. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 70(6), 661-672.
https://doi.org/10.2298/HEMIND150722002C

Čakar U, Petrović AV, Živković M, Vajs V, Milovanović MM, Zeravik J, Đorđević B. Phenolic profile of some fruit wines and their antioxidant properties. in Hemijska industrija. 2016;70(6):661-672.
doi:10.2298/HEMIND150722002C .

Čakar, Uroš, Petrović, Aleksandar V., Živković, Marijana, Vajs, Vlatka, Milovanović, Miodrag M., Zeravik, Jiri, Đorđević, Brižita, "Phenolic profile of some fruit wines and their antioxidant properties" in Hemijska industrija, 70, no. 6 (2016):661-672,
https://doi.org/10.2298/HEMIND150722002C . .

TY  - THES
AU  - Ivanović, Nevena
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=4001
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13471/bdef:Content/download
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13587/bdef:Izvestaj/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48325135
UR  - http://nardus.mpn.gov.rs/123456789/6949
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3389
AB  - Prema definiciji Svetske Zdravstvene Organizacije, probiotici su živi mikroorganizmi kojikada su konzumirani u adekvatnoj količini imaju povoljne efekte na zdravlje domaćina.Pod pojmom probiotskih bakterija misli se većinom na bakterije mlečne kiseline (BMK)koje obuhvataju uglavnom vrste iz rodova Lactobacillus i Bifidobacterium. Rastući je brojdokaza koji ukazuju da primena BMK može ispoljiti povoljne efekte u tretmanukomponenata metaboličkog sindroma, kao što su gojaznost, dijabetes tip 2, dislipidemije,nealkoholna masna bolest jetre (engl. Nonalcoholic Fatty Liver Disease, NAFLD). NAFLDobuhvata čitav spektar oboljenja, počev od hepatične steatoze preko nealkoholnogsteatohepatitisa do hepatične fibroze. Predstavlja najčešći uzrok ozbiljnih i hroničnihoboljenja jetre kod odraslih i kod dece u zapadnim zemljama, sa prevalencom od 20-30% uopštoj odrasloj populaciji, pri čemu prevalenca korelira sa povećanom incidencomgojaznosti i metaboličkog sindroma. Nedavno objavljena istraživanja ukazuju na ulogucrevne mikrobiote u razvoju steatoze i progresiji NAFLD-a, a s obzirom da probiotici mogudelovati na više nivoa na patogenezu oboljenja, a uz to su još i bezbedni i pristupačni, nijeiznenađujuće što LAB postaju sve privlačniji kao potencijalna dugoročna terapija NAFLDa.Kliničke i eksperimentalne studije sugerišu da se probiotici značajno razlikuju u efektimai mehanizmima dejstva a razlike postoje, ne samo između različitih vrsta, već i izmeđurazličitih soje iste vrste. Zbog toga je najvažniji cilj ove studije bio da se razvije modelNAFLD (stadijum steatoze) ishranom visokog sadržaja masti (VSM), a zatim da se ispita iizvrši poređenje dejstva oralne primene dva različita soja BMK, Lactobacillus rhamnosusLA68 i Lactobacillus plantarum WCFS1, na imunološke i metaboličke parametre, narazvoj steatoze, kao i na sastav masnih kiselina organa kod miševa soja C57BL/6 uuslovima VSM ishrane.Nakon 16 nedelja VSM ishrane, u kojoj je 41% energije poticao od masti, kod miševa sojaC57BL/6 došlo je do značajnog porasta telesne mase, i razvoja steatoze koju je pratioporemećaj lipidnih parametara i porast nivoa leptina, što odgovara početnoj fazi NAFLD(stadijum steatoze)...
AB  - According to the World Health Organisation's definition, probiotics are alivemicroorganisms which, when consumed in adequate quantities, have beneficial effects onhost's health. The term probiotics bacteria mostly refers to lactic acid bacteria (LAB)which include species from the genera Lactobacillus and Bifidobacteria. The increasingamount of evidence indicates that the usage of LAB can have positive effects on thetreatment of metabolic syndrome components, such as: obesity, type 2 diabetes,dyslipidemia, nonalcoholic fatty liver disease (NAFLD). NAFLD includes a whole spectarof diseases, starting from hepatic steatosis through nonalcoholic steatohepatitis to hepaticfibrosis which may further progress into ireversibile cirrhosis and hepatocellular carcinoma.NAFLD represents the most common cause of severe and chronic liver diseases in adultsand children in Western countres, with the prevelance correlating with increased incidenceof obesity and metabolic syndrome. Recently published research points to the role ofintestinal microbiota in the development of steatosis and progression of NAFLD.Probiotics, especially LAB, can have an influence on disease pathogenesis at multiplelevels and besides that they are safe and affordable. Taking into account all abovementionedreasons, it is not surprising that LAB are becoming more and more attractive aspotential long-term NAFLD therapy. Clinical and experimental studies suggest that LABdiffer significantly in the effects and mechanisms of action. Those differences are not onlyamong different species but also among different strains within the same species. Becauseof that, the most important goal of this study was to develop a model of NAFLD (steatosisstadium) with use of high fat diet (HFD) and then to examine and to compare the effects oforal administration of two different LAB species/strains, Lactobacillus rhamnosus LA68and Lactobacillus plantarum WCFS1, on immunological and metabolic parameters, onsteatosis development status, as well as on fatty acid composition of liver and brain inC57BL/6 mice under high fat diet regime...
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre
UR  - https://hdl.handle.net/21.15107/rcub_nardus_6949
ER  - 

@phdthesis{
author = "Ivanović, Nevena",
year = "2016",
abstract = "Prema definiciji Svetske Zdravstvene Organizacije, probiotici su živi mikroorganizmi kojikada su konzumirani u adekvatnoj količini imaju povoljne efekte na zdravlje domaćina.Pod pojmom probiotskih bakterija misli se većinom na bakterije mlečne kiseline (BMK)koje obuhvataju uglavnom vrste iz rodova Lactobacillus i Bifidobacterium. Rastući je brojdokaza koji ukazuju da primena BMK može ispoljiti povoljne efekte u tretmanukomponenata metaboličkog sindroma, kao što su gojaznost, dijabetes tip 2, dislipidemije,nealkoholna masna bolest jetre (engl. Nonalcoholic Fatty Liver Disease, NAFLD). NAFLDobuhvata čitav spektar oboljenja, počev od hepatične steatoze preko nealkoholnogsteatohepatitisa do hepatične fibroze. Predstavlja najčešći uzrok ozbiljnih i hroničnihoboljenja jetre kod odraslih i kod dece u zapadnim zemljama, sa prevalencom od 20-30% uopštoj odrasloj populaciji, pri čemu prevalenca korelira sa povećanom incidencomgojaznosti i metaboličkog sindroma. Nedavno objavljena istraživanja ukazuju na ulogucrevne mikrobiote u razvoju steatoze i progresiji NAFLD-a, a s obzirom da probiotici mogudelovati na više nivoa na patogenezu oboljenja, a uz to su još i bezbedni i pristupačni, nijeiznenađujuće što LAB postaju sve privlačniji kao potencijalna dugoročna terapija NAFLDa.Kliničke i eksperimentalne studije sugerišu da se probiotici značajno razlikuju u efektimai mehanizmima dejstva a razlike postoje, ne samo između različitih vrsta, već i izmeđurazličitih soje iste vrste. Zbog toga je najvažniji cilj ove studije bio da se razvije modelNAFLD (stadijum steatoze) ishranom visokog sadržaja masti (VSM), a zatim da se ispita iizvrši poređenje dejstva oralne primene dva različita soja BMK, Lactobacillus rhamnosusLA68 i Lactobacillus plantarum WCFS1, na imunološke i metaboličke parametre, narazvoj steatoze, kao i na sastav masnih kiselina organa kod miševa soja C57BL/6 uuslovima VSM ishrane.Nakon 16 nedelja VSM ishrane, u kojoj je 41% energije poticao od masti, kod miševa sojaC57BL/6 došlo je do značajnog porasta telesne mase, i razvoja steatoze koju je pratioporemećaj lipidnih parametara i porast nivoa leptina, što odgovara početnoj fazi NAFLD(stadijum steatoze)..., According to the World Health Organisation's definition, probiotics are alivemicroorganisms which, when consumed in adequate quantities, have beneficial effects onhost's health. The term probiotics bacteria mostly refers to lactic acid bacteria (LAB)which include species from the genera Lactobacillus and Bifidobacteria. The increasingamount of evidence indicates that the usage of LAB can have positive effects on thetreatment of metabolic syndrome components, such as: obesity, type 2 diabetes,dyslipidemia, nonalcoholic fatty liver disease (NAFLD). NAFLD includes a whole spectarof diseases, starting from hepatic steatosis through nonalcoholic steatohepatitis to hepaticfibrosis which may further progress into ireversibile cirrhosis and hepatocellular carcinoma.NAFLD represents the most common cause of severe and chronic liver diseases in adultsand children in Western countres, with the prevelance correlating with increased incidenceof obesity and metabolic syndrome. Recently published research points to the role ofintestinal microbiota in the development of steatosis and progression of NAFLD.Probiotics, especially LAB, can have an influence on disease pathogenesis at multiplelevels and besides that they are safe and affordable. Taking into account all abovementionedreasons, it is not surprising that LAB are becoming more and more attractive aspotential long-term NAFLD therapy. Clinical and experimental studies suggest that LABdiffer significantly in the effects and mechanisms of action. Those differences are not onlyamong different species but also among different strains within the same species. Becauseof that, the most important goal of this study was to develop a model of NAFLD (steatosisstadium) with use of high fat diet (HFD) and then to examine and to compare the effects oforal administration of two different LAB species/strains, Lactobacillus rhamnosus LA68and Lactobacillus plantarum WCFS1, on immunological and metabolic parameters, onsteatosis development status, as well as on fatty acid composition of liver and brain inC57BL/6 mice under high fat diet regime...",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre",
url = "https://hdl.handle.net/21.15107/rcub_nardus_6949"
}

Ivanović, N.. (2016). Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_6949

Ivanović N. Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre. in Универзитет у Београду. 2016;.
https://hdl.handle.net/21.15107/rcub_nardus_6949 .

Ivanović, Nevena, "Uticaj oralne primene Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1 na imunološke i metaboličke parametre miševa u uslovima eksperimentalno indukovane nealkoholne masne jetre" in Универзитет у Београду (2016),
https://hdl.handle.net/21.15107/rcub_nardus_6949 .

TY  - JOUR
AU  - Todorović, Vanja
AU  - Radojčić-Redovniković, Ivana
AU  - Todorović, Zoran B.
AU  - Janković, Goran
AU  - Dodevska, Margarita
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2459
AB  - Different kinds of chocolates produced in Serbia were analyzed regarding total polyphenol, flavonoid and proanthocyanidin content using spectrophotometric methods. Flavan-3ols and methylxanthines in all samples were determined with RP-HPLC. DPPH, FRAP, ABTS and ORAC assays were applied for measuring antioxidant capacity. The average of all four antioxidant tests for each cocoa product was used for calculating antioxidant potency composite index (ACI). Obtained results for all four assays have shown that antioxidant capacity of analyzed chocolate/cocoa extracts followed cocoa, polyphenol, flavonoid, and proanthocyanidin contents. Although the addition of raspberries to dark chocolates had no significant influence on their total polyphenol, flavonoid and proanthocyanidin contents, statistical analysis showed that there was significant increase in the antioxidant capacity of dark chocolates with raspberry compared to plain dark chocolates (p = 0.007). Overall range for theobromine content varied from 5.5 to 22.3 mg/g depending on the product type, while the content of caffeine was 13-30 times lower in all analyzed cocoa products. In addition, correlation between antioxidant potency composite index and declared percentage of cocoa was high (R-2 = 0.798,p  lt  0.05) and indicated that declared cocoa content was a reliable indication for antioxidant capacity of chocolates produced in Serbia.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Food Composition and Analysis
T1  - Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia
VL  - 41
SP  - 137
EP  - 143
DO  - 10.1016/j.jfca.2015.01.018
ER  - 

@article{
author = "Todorović, Vanja and Radojčić-Redovniković, Ivana and Todorović, Zoran B. and Janković, Goran and Dodevska, Margarita and Šobajić, Slađana",
year = "2015",
abstract = "Different kinds of chocolates produced in Serbia were analyzed regarding total polyphenol, flavonoid and proanthocyanidin content using spectrophotometric methods. Flavan-3ols and methylxanthines in all samples were determined with RP-HPLC. DPPH, FRAP, ABTS and ORAC assays were applied for measuring antioxidant capacity. The average of all four antioxidant tests for each cocoa product was used for calculating antioxidant potency composite index (ACI). Obtained results for all four assays have shown that antioxidant capacity of analyzed chocolate/cocoa extracts followed cocoa, polyphenol, flavonoid, and proanthocyanidin contents. Although the addition of raspberries to dark chocolates had no significant influence on their total polyphenol, flavonoid and proanthocyanidin contents, statistical analysis showed that there was significant increase in the antioxidant capacity of dark chocolates with raspberry compared to plain dark chocolates (p = 0.007). Overall range for theobromine content varied from 5.5 to 22.3 mg/g depending on the product type, while the content of caffeine was 13-30 times lower in all analyzed cocoa products. In addition, correlation between antioxidant potency composite index and declared percentage of cocoa was high (R-2 = 0.798,p  lt  0.05) and indicated that declared cocoa content was a reliable indication for antioxidant capacity of chocolates produced in Serbia.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Food Composition and Analysis",
title = "Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia",
volume = "41",
pages = "137-143",
doi = "10.1016/j.jfca.2015.01.018"
}

Todorović, V., Radojčić-Redovniković, I., Todorović, Z. B., Janković, G., Dodevska, M.,& Šobajić, S.. (2015). Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia. in Journal of Food Composition and Analysis
Academic Press Inc Elsevier Science, San Diego., 41, 137-143.
https://doi.org/10.1016/j.jfca.2015.01.018

Todorović V, Radojčić-Redovniković I, Todorović ZB, Janković G, Dodevska M, Šobajić S. Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia. in Journal of Food Composition and Analysis. 2015;41:137-143.
doi:10.1016/j.jfca.2015.01.018 .

Todorović, Vanja, Radojčić-Redovniković, Ivana, Todorović, Zoran B., Janković, Goran, Dodevska, Margarita, Šobajić, Slađana, "Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia" in Journal of Food Composition and Analysis, 41 (2015):137-143,
https://doi.org/10.1016/j.jfca.2015.01.018 . .

TY  - JOUR
AU  - Dodevska, Margarita
AU  - Šobajić, Slađana
AU  - Đorđević, Brižita
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2389
AB  - Fruits and vegetables are known as good sources of numerous bioactive compounds among which polyphenols and dietary fibre are considered essential because of their protective health effects. The aim of this study was to characterize the quality of selected plant foods of Serbia regarding the amount of total phenols, fibres and ratio of certain fractions of fibre. Fifteen samples of plant foods (green leafy vegetables, fruits and nuts) were evaluated for their total antioxidant activity, total phenolic content, total, soluble and insoluble fibre and fractions of fibre: beta-glucans, arabinoxylan, cellulose and resistant starch. Generally, nuts were the richest sources of fibre and total phenols. However, when serving size was taken into consideration, it appeared that raspberry and blackberry were the richest in total, soluble fibre and cellulose. Furthermore, almonds and hazelnuts were particularly rich in insoluble fibre, while walnuts had the highest polyphenol content. The analyzed plant foods were poor sources of arabinoxylan and beta-glucan. Data on the presence of resistant starch in cashew nut was the first confirmation that resistant starch could be found in significant amount in some nuts. The results give rare insight into the quality of selected plant foods regarding dietary fibre and polyphenols from the nutritive point of view.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Fibre and polyphenols of selected fruits, nuts and green leafy vegetables used in Serbian diet
VL  - 80
IS  - 1
SP  - 21
EP  - 33
DO  - 10.2298/JSC140407062D
ER  - 

@article{
author = "Dodevska, Margarita and Šobajić, Slađana and Đorđević, Brižita",
year = "2015",
abstract = "Fruits and vegetables are known as good sources of numerous bioactive compounds among which polyphenols and dietary fibre are considered essential because of their protective health effects. The aim of this study was to characterize the quality of selected plant foods of Serbia regarding the amount of total phenols, fibres and ratio of certain fractions of fibre. Fifteen samples of plant foods (green leafy vegetables, fruits and nuts) were evaluated for their total antioxidant activity, total phenolic content, total, soluble and insoluble fibre and fractions of fibre: beta-glucans, arabinoxylan, cellulose and resistant starch. Generally, nuts were the richest sources of fibre and total phenols. However, when serving size was taken into consideration, it appeared that raspberry and blackberry were the richest in total, soluble fibre and cellulose. Furthermore, almonds and hazelnuts were particularly rich in insoluble fibre, while walnuts had the highest polyphenol content. The analyzed plant foods were poor sources of arabinoxylan and beta-glucan. Data on the presence of resistant starch in cashew nut was the first confirmation that resistant starch could be found in significant amount in some nuts. The results give rare insight into the quality of selected plant foods regarding dietary fibre and polyphenols from the nutritive point of view.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Fibre and polyphenols of selected fruits, nuts and green leafy vegetables used in Serbian diet",
volume = "80",
number = "1",
pages = "21-33",
doi = "10.2298/JSC140407062D"
}

Dodevska, M., Šobajić, S.,& Đorđević, B.. (2015). Fibre and polyphenols of selected fruits, nuts and green leafy vegetables used in Serbian diet. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 80(1), 21-33.
https://doi.org/10.2298/JSC140407062D

Dodevska M, Šobajić S, Đorđević B. Fibre and polyphenols of selected fruits, nuts and green leafy vegetables used in Serbian diet. in Journal of the Serbian Chemical Society. 2015;80(1):21-33.
doi:10.2298/JSC140407062D .

Dodevska, Margarita, Šobajić, Slađana, Đorđević, Brižita, "Fibre and polyphenols of selected fruits, nuts and green leafy vegetables used in Serbian diet" in Journal of the Serbian Chemical Society, 80, no. 1 (2015):21-33,
https://doi.org/10.2298/JSC140407062D . .

TY  - JOUR
AU  - Baralić, Ivana
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Dikić, Nenad
AU  - Radivojević, Nenad
AU  - Suzin-Živković, Violeta
AU  - Radojević-Skodrić, Sanja
AU  - Pejić, Snežana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2445
AB  - The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.
PB  - Hindawi Publishing Corp, New York
T2  - Evidence-Based Complementary and Alternative Medicine
T1  - Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
DO  - 10.1155/2015/783761
ER  - 

@article{
author = "Baralić, Ivana and Anđelković, Marija and Đorđević, Brižita and Dikić, Nenad and Radivojević, Nenad and Suzin-Živković, Violeta and Radojević-Skodrić, Sanja and Pejić, Snežana",
year = "2015",
abstract = "The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.",
publisher = "Hindawi Publishing Corp, New York",
journal = "Evidence-Based Complementary and Alternative Medicine",
title = "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players",
doi = "10.1155/2015/783761"
}

Baralić, I., Anđelković, M., Đorđević, B., Dikić, N., Radivojević, N., Suzin-Živković, V., Radojević-Skodrić, S.,& Pejić, S.. (2015). Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-Based Complementary and Alternative Medicine
Hindawi Publishing Corp, New York..
https://doi.org/10.1155/2015/783761

Baralić I, Anđelković M, Đorđević B, Dikić N, Radivojević N, Suzin-Živković V, Radojević-Skodrić S, Pejić S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-Based Complementary and Alternative Medicine. 2015;.
doi:10.1155/2015/783761 .

Baralić, Ivana, Anđelković, Marija, Đorđević, Brižita, Dikić, Nenad, Radivojević, Nenad, Suzin-Živković, Violeta, Radojević-Skodrić, Sanja, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players" in Evidence-Based Complementary and Alternative Medicine (2015),
https://doi.org/10.1155/2015/783761 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Šobajić, Slađana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2431
AB  - Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population
VL  - 34
IS  - 3
SP  - 304
EP  - 313
DO  - 10.2478/jomb-2014-0039
ER  - 

@article{
author = "Đuričić, Ivana and Kotur-Stevuljević, Jelena and Miljković, Milica and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Šobajić, Slađana",
year = "2015",
abstract = "Background: This study investigated the effects of a nutritionally relevant intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids derived from oily fish or a fish oil supplement on selected cardiovascular risk factors in average middle-aged individuals. Methods: Thirty-three participants were randomized to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or a commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/day in a cross-over trial over an 8-week period separated by a 6-month washout period. Blood samples were collected before and after each intervention and lipids, inflammatory and oxidative stress parameters were determined. Results: Plasma levels of EPA, DHA and total n-3 fatty acids significantly increased after both interventions. A decreasing trend in triglycerides was more pronounced with salmon than with the fish oil supplement, but the changes noticed were not significant. Although there were no relevant changes in inflammatory marker concentrations at the end of both interventions, significant negative correlations were noticed between total plasma n-3 fatty acids and soluble intercellular adhesion molecule and C-reactive protein throughout the whole intervention period (p  lt  0.05). Among the oxidative stress parameters, intervention with salmon showed a prooxidative effect through a superoxide anion increase (p = 0.025). A relevant positive correlation was also found between its concentration and total plasma n-3 fatty acids (p  lt  0.05). Other oxidative stress markers were not significantly influenced by the dietary interventions applied. Conclusions: Following two sets of recommendations for n-3 fatty acids intake aimed at the general public had only a moderate effect on the selected cardiovascular risk factors in average healthy middle-aged subjects over a short-term period.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population",
volume = "34",
number = "3",
pages = "304-313",
doi = "10.2478/jomb-2014-0039"
}

Đuričić, I., Kotur-Stevuljević, J., Miljković, M., Kerkez, M., Đorđević, V., Đurasić, L.,& Šobajić, S.. (2015). Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 304-313.
https://doi.org/10.2478/jomb-2014-0039

Đuričić I, Kotur-Stevuljević J, Miljković M, Kerkez M, Đorđević V, Đurasić L, Šobajić S. Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population. in Journal of Medical Biochemistry. 2015;34(3):304-313.
doi:10.2478/jomb-2014-0039 .

Đuričić, Ivana, Kotur-Stevuljević, Jelena, Miljković, Milica, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Šobajić, Slađana, "Effect of nutritionally relevant doses of long-chain N-3 pufa on lipid status, oxidative stress and inflammatory markers in an average middle-aged serbian population" in Journal of Medical Biochemistry, 34, no. 3 (2015):304-313,
https://doi.org/10.2478/jomb-2014-0039 . .

TY  - THES
AU  - Vidović, Bojana
PY  - 2014
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=1863
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:9553/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=46648079
UR  - http://nardus.mpn.gov.rs/123456789/3179
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3417
AB  - U odnosu na opštu populaciju, oboleli od shizofrenije imaju kraći životni vek i povećanirizik za razvoj somatskih pratećih bolesti. Visoka prevalenca metaboličkog sindroma ushizofreniji predstavlja značajan faktor rizika za razvoj koronarne bolesti i dijabetes melitusatip 2. Iako su odnosi između metaboličkog sindroma i shizofrenije kompleksni i još uveknedovoljno proučeni, pretpostavlja se da oksidativni stres predstavlja mehanizam koji imaintegrativnu ulogu kako u razvoju metaboličkog sindroma, tako i njegovih komplikacija.Zbog toga su ciljevi ovog istraživanja bili da se odrede parametri oksidativnog stresa iantioksidativne zaštite kod obolelih od shizofrenije i zdravih ispitanika, kao i da se ispita nivooksidativnog stresa u odnosu na prisustvo metaboličkog sindroma kod obolelih odshizofrenije. Iako rezultati dosadašnjih istraživanja ukazuju na izmenjenu enzimskuantioksidativnu aktivnost, redukovani nivo neenzimskih antioksidanasa, kao i povećanistepen lipidne peroksidacije, ograničen je broj studija koje ukazuju na mogućnost modulacijeoksidativno-stresnog statusa u shizofreniji primenom antioksidanasa.Suplementacija dijetarnim antioksidansima može pružiti značajnu podršku endogenomantioksidativnom zaštitnom sistemu u prevenciji oksidativnih oštećenja, kao i regulacijiredoks osetljivih signalnih puteva. Uzimajući u obzir činjenicu da se alfa-liponska kiselinasmatra jednim od najsnažnijih antioksidanasa, njenu sposobnost da prolazi krvno-moždanubarijeru i povećava nivo endogenih antioksidanasa, posebno glutationa, koji predstavljaglavni endogeni antioksidans u centralnom nervnom sistemu, kao i potencijalne pozitivnemetaboličke efekte, pretpostavljeno je da suplementacija alfa-liponskom može imatipotencijalno povoljne efekte kao dodatak antipsihotičnoj terapiji kod klinički stabilnihpacijenata sa shizofrenijom.U istraživanju je učestvovalo ukupno 60 pacijenata sa shizofrenijom, oba pola, starosti od18 do 60 godina, u stabilnoj fazi bolesti. Kontrolna grupa je obuhvatila 60 zdravih ispitanika,sličnih godina i pola. Ispitivanjem uticaja suplementacije alfa-liponskom kiselinom naparametre oksidativnog stresa i antioksidativne zaštite, obuhvaćena je grupa od 18 obolelihod shizofrenije, kao i grupa od 38 zdravih ispitanika...
AB  - Patients with schizophrenia have a reduced life expectancy and increased rates of physicalillness compared with the general population. Metabolic syndrome is highly prevalent inindividuals with schizophrenia and conveys a significantly increases risk of type 2 diabetesand cardiovascular disease. Although it may not be the main cause, increasing evidenceindicate that oxidative stress may play an integral role in the pathogenesis of metabolicsyndrome, as well as the pathogenesis of metabolic syndrome-related conditions. In recentyears there has been an increasing interest in the oxidative stress in the schizophrenia.However, up to now, there have been no studies investigating the association betweenoxidative stress status and metabolic syndrome in schizophrenia. Therefore, the objectives ofthis study were to determine the presence of metabolic syndrome and evaluate the oxidativestress status, as well as possible associations amongst them in schizophrenic patients.Recent years, increasing interest exists in using nonenzymatic antioxidants as adjunctiveor supplements to prevent oxidative damage and to improve some of the psychopathologyand treatment-related side effects of antipsychotic drugs. Alpha-lipoic acid is recognized as apowerful antioxidant. The ability of alpha-lipoic acid to cross the blood-brain barrier andincreases levels of endogenous antioxidants, especially glutathione, who presents a majorendogenous antioxidant in the brain, may have particular importance for schizophrenia.The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matchedhealthy controls. Eighteen medicated patients with schizophrenia and 38 healthy subjects(control group) received daily supplements of alpha-lipoic acid (500 mg/day) for threemonths.Analysis of oxidative stress parameters showed significantly higher lipid peroxidation andhigher plasma total antioxidant status in patients with schizophrenia than in the control group.In contrast, their PON1 activity was lower compared to control subjects. There were nosignificant differences between the patients and controls when plasma superoxide dismutaseactivity and serum prooxidant-antioxidant balance levels were compared...
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Uticaj suplementacije alfa-liponskom kiselinom na parametre oksidativnog stresa i antioksidativne zaštite kod obolelih od shizofrenije
T1  - The effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia
UR  - https://hdl.handle.net/21.15107/rcub_nardus_3179
ER  - 

@phdthesis{
author = "Vidović, Bojana",
year = "2014",
abstract = "U odnosu na opštu populaciju, oboleli od shizofrenije imaju kraći životni vek i povećanirizik za razvoj somatskih pratećih bolesti. Visoka prevalenca metaboličkog sindroma ushizofreniji predstavlja značajan faktor rizika za razvoj koronarne bolesti i dijabetes melitusatip 2. Iako su odnosi između metaboličkog sindroma i shizofrenije kompleksni i još uveknedovoljno proučeni, pretpostavlja se da oksidativni stres predstavlja mehanizam koji imaintegrativnu ulogu kako u razvoju metaboličkog sindroma, tako i njegovih komplikacija.Zbog toga su ciljevi ovog istraživanja bili da se odrede parametri oksidativnog stresa iantioksidativne zaštite kod obolelih od shizofrenije i zdravih ispitanika, kao i da se ispita nivooksidativnog stresa u odnosu na prisustvo metaboličkog sindroma kod obolelih odshizofrenije. Iako rezultati dosadašnjih istraživanja ukazuju na izmenjenu enzimskuantioksidativnu aktivnost, redukovani nivo neenzimskih antioksidanasa, kao i povećanistepen lipidne peroksidacije, ograničen je broj studija koje ukazuju na mogućnost modulacijeoksidativno-stresnog statusa u shizofreniji primenom antioksidanasa.Suplementacija dijetarnim antioksidansima može pružiti značajnu podršku endogenomantioksidativnom zaštitnom sistemu u prevenciji oksidativnih oštećenja, kao i regulacijiredoks osetljivih signalnih puteva. Uzimajući u obzir činjenicu da se alfa-liponska kiselinasmatra jednim od najsnažnijih antioksidanasa, njenu sposobnost da prolazi krvno-moždanubarijeru i povećava nivo endogenih antioksidanasa, posebno glutationa, koji predstavljaglavni endogeni antioksidans u centralnom nervnom sistemu, kao i potencijalne pozitivnemetaboličke efekte, pretpostavljeno je da suplementacija alfa-liponskom može imatipotencijalno povoljne efekte kao dodatak antipsihotičnoj terapiji kod klinički stabilnihpacijenata sa shizofrenijom.U istraživanju je učestvovalo ukupno 60 pacijenata sa shizofrenijom, oba pola, starosti od18 do 60 godina, u stabilnoj fazi bolesti. Kontrolna grupa je obuhvatila 60 zdravih ispitanika,sličnih godina i pola. Ispitivanjem uticaja suplementacije alfa-liponskom kiselinom naparametre oksidativnog stresa i antioksidativne zaštite, obuhvaćena je grupa od 18 obolelihod shizofrenije, kao i grupa od 38 zdravih ispitanika..., Patients with schizophrenia have a reduced life expectancy and increased rates of physicalillness compared with the general population. Metabolic syndrome is highly prevalent inindividuals with schizophrenia and conveys a significantly increases risk of type 2 diabetesand cardiovascular disease. Although it may not be the main cause, increasing evidenceindicate that oxidative stress may play an integral role in the pathogenesis of metabolicsyndrome, as well as the pathogenesis of metabolic syndrome-related conditions. In recentyears there has been an increasing interest in the oxidative stress in the schizophrenia.However, up to now, there have been no studies investigating the association betweenoxidative stress status and metabolic syndrome in schizophrenia. Therefore, the objectives ofthis study were to determine the presence of metabolic syndrome and evaluate the oxidativestress status, as well as possible associations amongst them in schizophrenic patients.Recent years, increasing interest exists in using nonenzymatic antioxidants as adjunctiveor supplements to prevent oxidative damage and to improve some of the psychopathologyand treatment-related side effects of antipsychotic drugs. Alpha-lipoic acid is recognized as apowerful antioxidant. The ability of alpha-lipoic acid to cross the blood-brain barrier andincreases levels of endogenous antioxidants, especially glutathione, who presents a majorendogenous antioxidant in the brain, may have particular importance for schizophrenia.The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matchedhealthy controls. Eighteen medicated patients with schizophrenia and 38 healthy subjects(control group) received daily supplements of alpha-lipoic acid (500 mg/day) for threemonths.Analysis of oxidative stress parameters showed significantly higher lipid peroxidation andhigher plasma total antioxidant status in patients with schizophrenia than in the control group.In contrast, their PON1 activity was lower compared to control subjects. There were nosignificant differences between the patients and controls when plasma superoxide dismutaseactivity and serum prooxidant-antioxidant balance levels were compared...",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Uticaj suplementacije alfa-liponskom kiselinom na parametre oksidativnog stresa i antioksidativne zaštite kod obolelih od shizofrenije, The effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia",
url = "https://hdl.handle.net/21.15107/rcub_nardus_3179"
}

Vidović, B.. (2014). Uticaj suplementacije alfa-liponskom kiselinom na parametre oksidativnog stresa i antioksidativne zaštite kod obolelih od shizofrenije. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_3179

Vidović B. Uticaj suplementacije alfa-liponskom kiselinom na parametre oksidativnog stresa i antioksidativne zaštite kod obolelih od shizofrenije. in Универзитет у Београду. 2014;.
https://hdl.handle.net/21.15107/rcub_nardus_3179 .

Vidović, Bojana, "Uticaj suplementacije alfa-liponskom kiselinom na parametre oksidativnog stresa i antioksidativne zaštite kod obolelih od shizofrenije" in Универзитет у Београду (2014),
https://hdl.handle.net/21.15107/rcub_nardus_3179 .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milovanović, Srđan
AU  - Đorđević, Brižita
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Spasić, Slavica
AU  - Stojanović, Dragana
AU  - Pantović, Maja
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2095
AB  - Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia. Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O-2(center dot-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)]. Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days. Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.
PB  - Medicinska Naklada, Zagreb
T2  - Psychiatria Danubina
T1  - Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia
VL  - 26
IS  - 3
SP  - 205
EP  - 213
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2095
ER  - 

@article{
author = "Vidović, Bojana and Milovanović, Srđan and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Ivanišević, Jasmina and Miljković, Milica and Spasić, Slavica and Stojanović, Dragana and Pantović, Maja",
year = "2014",
abstract = "Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia. Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O-2(center dot-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)]. Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days. Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.",
publisher = "Medicinska Naklada, Zagreb",
journal = "Psychiatria Danubina",
title = "Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia",
volume = "26",
number = "3",
pages = "205-213",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2095"
}

Vidović, B., Milovanović, S., Đorđević, B., Kotur-Stevuljević, J., Stefanović, A., Ivanišević, J., Miljković, M., Spasić, S., Stojanović, D.,& Pantović, M.. (2014). Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. in Psychiatria Danubina
Medicinska Naklada, Zagreb., 26(3), 205-213.
https://hdl.handle.net/21.15107/rcub_farfar_2095

Vidović B, Milovanović S, Đorđević B, Kotur-Stevuljević J, Stefanović A, Ivanišević J, Miljković M, Spasić S, Stojanović D, Pantović M. Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. in Psychiatria Danubina. 2014;26(3):205-213.
https://hdl.handle.net/21.15107/rcub_farfar_2095 .

Vidović, Bojana, Milovanović, Srđan, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Ivanišević, Jasmina, Miljković, Milica, Spasić, Slavica, Stojanović, Dragana, Pantović, Maja, "Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia" in Psychiatria Danubina, 26, no. 3 (2014):205-213,
https://hdl.handle.net/21.15107/rcub_farfar_2095 .

TY  - JOUR
AU  - Stanisavljević, Dragana
AU  - Đorđević, Sofija
AU  - Milenković, Marina
AU  - Lazić, Miodrag
AU  - Veličković, Dragan
AU  - Ranđelović, Novica
AU  - Zlatković, Branislav
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2145
AB  - The way of drying the fresh herbal material influences the chemical content and the biological activities of their essential oils. The influence of the different drying methods of the herb Mentha longifolia (L.) Hudson on the antioxidant and antimicrobial activity of the extracted essential oils has been analyzed in this study. Drying has been carried out in three ways: in the natural way, in the laboratory oven (45 degrees C) and in the absorptional low-temperature condensational drier (35 degrees C). The antioxidant activity of the essential oil has been estimated by FRAP and DPPH assays, while the antimicrobial activity has been estimated by the diffusible and micro-delusional method, testing on the nine types of bacteria and two types of fungi. The essential oil obtained from the herb dried in the natural way has shown the highest antioxidant activity and the lowest from the herb dried in the laboratory oven. Bacillus subtilis, Micrococcus luteus and Enterococcus faecalis have shown the highest sensitivity on the three samples. The oil obtained from the herb dried in the absorptional low-temperature drier has shown the strongest antimicrobial effect.
PB  - Acg Publications, Gebze-Kocaeli
T2  - Renal Failure
T1  - Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques
VL  - 8
IS  - 1
SP  - 61
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2145
ER  - 

@article{
author = "Stanisavljević, Dragana and Đorđević, Sofija and Milenković, Marina and Lazić, Miodrag and Veličković, Dragan and Ranđelović, Novica and Zlatković, Branislav",
year = "2014",
abstract = "The way of drying the fresh herbal material influences the chemical content and the biological activities of their essential oils. The influence of the different drying methods of the herb Mentha longifolia (L.) Hudson on the antioxidant and antimicrobial activity of the extracted essential oils has been analyzed in this study. Drying has been carried out in three ways: in the natural way, in the laboratory oven (45 degrees C) and in the absorptional low-temperature condensational drier (35 degrees C). The antioxidant activity of the essential oil has been estimated by FRAP and DPPH assays, while the antimicrobial activity has been estimated by the diffusible and micro-delusional method, testing on the nine types of bacteria and two types of fungi. The essential oil obtained from the herb dried in the natural way has shown the highest antioxidant activity and the lowest from the herb dried in the laboratory oven. Bacillus subtilis, Micrococcus luteus and Enterococcus faecalis have shown the highest sensitivity on the three samples. The oil obtained from the herb dried in the absorptional low-temperature drier has shown the strongest antimicrobial effect.",
publisher = "Acg Publications, Gebze-Kocaeli",
journal = "Renal Failure",
title = "Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques",
volume = "8",
number = "1",
pages = "61-65",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2145"
}

Stanisavljević, D., Đorđević, S., Milenković, M., Lazić, M., Veličković, D., Ranđelović, N.,& Zlatković, B.. (2014). Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques. in Renal Failure
Acg Publications, Gebze-Kocaeli., 8(1), 61-65.
https://hdl.handle.net/21.15107/rcub_farfar_2145

Stanisavljević D, Đorđević S, Milenković M, Lazić M, Veličković D, Ranđelović N, Zlatković B. Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques. in Renal Failure. 2014;8(1):61-65.
https://hdl.handle.net/21.15107/rcub_farfar_2145 .

Stanisavljević, Dragana, Đorđević, Sofija, Milenković, Marina, Lazić, Miodrag, Veličković, Dragan, Ranđelović, Novica, Zlatković, Branislav, "Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques" in Renal Failure, 8, no. 1 (2014):61-65,
https://hdl.handle.net/21.15107/rcub_farfar_2145 .