TY  - JOUR
AU  - Selaković, Snežana
AU  - Rodić, Marko
AU  - Novaković, Irena
AU  - Matić, Ivana
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Milčić, Vesna
AU  - Dimiza, Filitsa
AU  - Psomas, George
AU  - Anđelković, Katarina
AU  - Šumar-Ristović, Maja
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5522
AB  - Copper(ii) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(ii) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf-thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.
PB  - Royal Society of Chemistry
T2  - Dalton Transactions
T1  - Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach
VL  - 53
IS  - 6
SP  - 2770
EP  - 2788
DO  - 10.1039/d3dt03862a
ER  - 

@article{
author = "Selaković, Snežana and Rodić, Marko and Novaković, Irena and Matić, Ivana and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Milčić, Vesna and Dimiza, Filitsa and Psomas, George and Anđelković, Katarina and Šumar-Ristović, Maja",
year = "2024",
abstract = "Copper(ii) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(ii) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf-thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.",
publisher = "Royal Society of Chemistry",
journal = "Dalton Transactions",
title = "Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach",
volume = "53",
number = "6",
pages = "2770-2788",
doi = "10.1039/d3dt03862a"
}

Selaković, S., Rodić, M., Novaković, I., Matić, I., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Milčić, V., Dimiza, F., Psomas, G., Anđelković, K.,& Šumar-Ristović, M.. (2024). Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions
Royal Society of Chemistry., 53(6), 2770-2788.
https://doi.org/10.1039/d3dt03862a

Selaković S, Rodić M, Novaković I, Matić I, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Milčić V, Dimiza F, Psomas G, Anđelković K, Šumar-Ristović M. Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions. 2024;53(6):2770-2788.
doi:10.1039/d3dt03862a .

Selaković, Snežana, Rodić, Marko, Novaković, Irena, Matić, Ivana, Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Milčić, Vesna, Dimiza, Filitsa, Psomas, George, Anđelković, Katarina, Šumar-Ristović, Maja, "Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach" in Dalton Transactions, 53, no. 6 (2024):2770-2788,
https://doi.org/10.1039/d3dt03862a . .

TY  - JOUR
AU  - Ražić, Slavica
AU  - Gadžurić, Slobodan
AU  - Trtić-Petrović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5299
AB  - The widespread use of ionic liquids (ILs) as greener solvents in analytical sciences, especially in sample pretreatment, has focused attention on exploiting their enormous potential, not only on eliminating and improving the drawbacks faced by scientists. These ionic compounds with unique physicochemical properties can be tuned through smart synthesis, combining cations and anions, so that the compound exhibits excellent properties for its intended purpose. Ionic liquids are rightly referred to as designer solvents. Validation of a newly proposed analytical methods using ionic liquids, either in sample preparation or in further analysis, is a critical process to demonstrate that a particular analytical method is fit for purpose and provides reliable and accurate results. In addition, this article specially addressed the potential toxicity of ionic liquids with the modest goal of assisting researchers in this field by expanding their target areas. Graphical Abstract: [Figure not available: see fulltext.].
PB  - Springer Nature
T2  - Analytical and Bioanalytical Chemistry
T1  - Ionic liquids in green analytical chemistry—are they that good and green enough?
DO  - 10.1007/s00216-023-05045-3
ER  - 

@article{
author = "Ražić, Slavica and Gadžurić, Slobodan and Trtić-Petrović, Tatjana",
year = "2023",
abstract = "The widespread use of ionic liquids (ILs) as greener solvents in analytical sciences, especially in sample pretreatment, has focused attention on exploiting their enormous potential, not only on eliminating and improving the drawbacks faced by scientists. These ionic compounds with unique physicochemical properties can be tuned through smart synthesis, combining cations and anions, so that the compound exhibits excellent properties for its intended purpose. Ionic liquids are rightly referred to as designer solvents. Validation of a newly proposed analytical methods using ionic liquids, either in sample preparation or in further analysis, is a critical process to demonstrate that a particular analytical method is fit for purpose and provides reliable and accurate results. In addition, this article specially addressed the potential toxicity of ionic liquids with the modest goal of assisting researchers in this field by expanding their target areas. Graphical Abstract: [Figure not available: see fulltext.].",
publisher = "Springer Nature",
journal = "Analytical and Bioanalytical Chemistry",
title = "Ionic liquids in green analytical chemistry—are they that good and green enough?",
doi = "10.1007/s00216-023-05045-3"
}

Ražić, S., Gadžurić, S.,& Trtić-Petrović, T.. (2023). Ionic liquids in green analytical chemistry—are they that good and green enough?. in Analytical and Bioanalytical Chemistry
Springer Nature..
https://doi.org/10.1007/s00216-023-05045-3

Ražić S, Gadžurić S, Trtić-Petrović T. Ionic liquids in green analytical chemistry—are they that good and green enough?. in Analytical and Bioanalytical Chemistry. 2023;.
doi:10.1007/s00216-023-05045-3 .

Ražić, Slavica, Gadžurić, Slobodan, Trtić-Petrović, Tatjana, "Ionic liquids in green analytical chemistry—are they that good and green enough?" in Analytical and Bioanalytical Chemistry (2023),
https://doi.org/10.1007/s00216-023-05045-3 . .

TY  - JOUR
AU  - Petronijević, M.
AU  - Ražić, Slavica
AU  - Tubić, A.
AU  - Molnar Jazić, J.
AU  - Watson, M.
AU  - Dalmacija, B.
AU  - Agbaba, J.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4552
AB  - The aim of this study was to investigate the influence of UV/H2O2 advanced oxidation process on the natural organic matter content and disinfection by-products formation potential of different water matrices. Three water matrices (two natural waters and a synthetic humic acid solution) with different natural organic matter characteristics and concentrations were analysed. The carbonaceous disinfection by-products: trihalomethanes, haloacetic acids and haloketones, as well as nitrogenous disinfection by-products: haloacetonitriles and chloropicrin were investigated after chlorination. The UV/H2O2 treatment resulted in significant trihalomethane and haloacetic acids precursors removal (up to 53% and 30%, respectively) in humic acid solution in conditions ≥ 1.0 mg H2O2/mg DOC, in combination with a dose of UV irradiation ≥ 3000 mJ/cm2. Under the same reaction conditions, in natural groundwater rich in hydrophobic natural organic matter, the advanced process was less effective in DBP precursors removal. On the other hand, the advanced process was very effective in trihalomethaneprecursors removal (up to 76%) in groundwater with hydrophyilic natural organic matter. Haloketones were formed after treatment in very low concentrations. Nitrogenous disinfection by-products were only formed in the natural water containing hydrophilic organic matter, during the advanced process at 3.0 mg H2O2/mg DOC. The UV/H2O2 process resulted in negligible organic matter mineralization, but increased the brominated disinfection by-products formation in waters with low to medium bromide contents. It was concluded that under the same advanced oxidation process reaction conditions different natural organic matter structures showed different reactivities with chlorine toward the formation of the investigated disinfection by-products.
PB  - Institute for Ionics
T2  - International Journal of Environmental Science and Technology
T1  - Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices
DO  - 10.1007/s13762-023-04862-4
ER  - 

@article{
author = "Petronijević, M. and Ražić, Slavica and Tubić, A. and Molnar Jazić, J. and Watson, M. and Dalmacija, B. and Agbaba, J.",
year = "2023",
abstract = "The aim of this study was to investigate the influence of UV/H2O2 advanced oxidation process on the natural organic matter content and disinfection by-products formation potential of different water matrices. Three water matrices (two natural waters and a synthetic humic acid solution) with different natural organic matter characteristics and concentrations were analysed. The carbonaceous disinfection by-products: trihalomethanes, haloacetic acids and haloketones, as well as nitrogenous disinfection by-products: haloacetonitriles and chloropicrin were investigated after chlorination. The UV/H2O2 treatment resulted in significant trihalomethane and haloacetic acids precursors removal (up to 53% and 30%, respectively) in humic acid solution in conditions ≥ 1.0 mg H2O2/mg DOC, in combination with a dose of UV irradiation ≥ 3000 mJ/cm2. Under the same reaction conditions, in natural groundwater rich in hydrophobic natural organic matter, the advanced process was less effective in DBP precursors removal. On the other hand, the advanced process was very effective in trihalomethaneprecursors removal (up to 76%) in groundwater with hydrophyilic natural organic matter. Haloketones were formed after treatment in very low concentrations. Nitrogenous disinfection by-products were only formed in the natural water containing hydrophilic organic matter, during the advanced process at 3.0 mg H2O2/mg DOC. The UV/H2O2 process resulted in negligible organic matter mineralization, but increased the brominated disinfection by-products formation in waters with low to medium bromide contents. It was concluded that under the same advanced oxidation process reaction conditions different natural organic matter structures showed different reactivities with chlorine toward the formation of the investigated disinfection by-products.",
publisher = "Institute for Ionics",
journal = "International Journal of Environmental Science and Technology",
title = "Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices",
doi = "10.1007/s13762-023-04862-4"
}

Petronijević, M., Ražić, S., Tubić, A., Molnar Jazić, J., Watson, M., Dalmacija, B.,& Agbaba, J.. (2023). Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices. in International Journal of Environmental Science and Technology
Institute for Ionics..
https://doi.org/10.1007/s13762-023-04862-4

Petronijević M, Ražić S, Tubić A, Molnar Jazić J, Watson M, Dalmacija B, Agbaba J. Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices. in International Journal of Environmental Science and Technology. 2023;.
doi:10.1007/s13762-023-04862-4 .

Petronijević, M., Ražić, Slavica, Tubić, A., Molnar Jazić, J., Watson, M., Dalmacija, B., Agbaba, J., "Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices" in International Journal of Environmental Science and Technology (2023),
https://doi.org/10.1007/s13762-023-04862-4 . .

TY  - JOUR
AU  - Mušović, Jasmina
AU  - Vraneš, Milan
AU  - Papović, Snežana
AU  - Gadžurić, Slobodan
AU  - Ražić, Slavica
AU  - Trtić-Petrović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4382
AB  - Although sample preparation, as an unavoidable step of the analytical process should be simple, it is very often identified as a bottleneck. Simplicity of sample preparation based on cost-effective and non-hazardous materials is mandatory for any sustainable and environmental friendly approach. Aqueous biphasic systems (ABS), based on functionalized ionic liquids (FILs) are acceptable alternatives to classical extraction procedures, due to the replacement of organic solvent with diluted aqueous-soluble ionic liquids. In this work, two water soluble FILs based on 2-mercaptobenzothiazolate anion, [mbt]: 1-butyl-3-methylimidazolium [mbt] ([bmim][mbt]) and 1-ethyl-3-methylimidazolium [mbt] ([emim][mbt]), were designed and synthesized in order to selectively extract Cd(II) and Pb(II) from the river sediment. It was found that [mbt]– anion acts as the ligand and forms complexes with Cd(II) and Pb(II) which are responsible for their efficient extraction, while cation is more responsible for the formation of ABS. Partition coefficients of 408 and 180 for Cd(II) and Pb(II), respectively, were obtained using ABS based on [bmim][mbt]. Direct extraction of Cd(II) and Pb(II) from the river sediment has been investigated and obtained optimal conditions are: 60 min direct contact of the aqueous solution of [bmim][mbt] and the sediment sample at 90 °C, followed by formation of ABS upon addition of potassium citrate. Using AGRE and AGREEprep tools greenness of the proposed method for direct extraction of Cd(II) and Pb(II) from the sediment are calculated. Obtained values of 0.69 and 0.71 for Cd(II) and Pb(II) extraction, respectively, showed a high level of the greenness of the proposed method.
PB  - Elsevier B.V.
T2  - Journal of Molecular Liquids
T1  - Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids
VL  - 369
DO  - 10.1016/j.molliq.2022.120974
ER  - 

@article{
author = "Mušović, Jasmina and Vraneš, Milan and Papović, Snežana and Gadžurić, Slobodan and Ražić, Slavica and Trtić-Petrović, Tatjana",
year = "2023",
abstract = "Although sample preparation, as an unavoidable step of the analytical process should be simple, it is very often identified as a bottleneck. Simplicity of sample preparation based on cost-effective and non-hazardous materials is mandatory for any sustainable and environmental friendly approach. Aqueous biphasic systems (ABS), based on functionalized ionic liquids (FILs) are acceptable alternatives to classical extraction procedures, due to the replacement of organic solvent with diluted aqueous-soluble ionic liquids. In this work, two water soluble FILs based on 2-mercaptobenzothiazolate anion, [mbt]: 1-butyl-3-methylimidazolium [mbt] ([bmim][mbt]) and 1-ethyl-3-methylimidazolium [mbt] ([emim][mbt]), were designed and synthesized in order to selectively extract Cd(II) and Pb(II) from the river sediment. It was found that [mbt]– anion acts as the ligand and forms complexes with Cd(II) and Pb(II) which are responsible for their efficient extraction, while cation is more responsible for the formation of ABS. Partition coefficients of 408 and 180 for Cd(II) and Pb(II), respectively, were obtained using ABS based on [bmim][mbt]. Direct extraction of Cd(II) and Pb(II) from the river sediment has been investigated and obtained optimal conditions are: 60 min direct contact of the aqueous solution of [bmim][mbt] and the sediment sample at 90 °C, followed by formation of ABS upon addition of potassium citrate. Using AGRE and AGREEprep tools greenness of the proposed method for direct extraction of Cd(II) and Pb(II) from the sediment are calculated. Obtained values of 0.69 and 0.71 for Cd(II) and Pb(II) extraction, respectively, showed a high level of the greenness of the proposed method.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Liquids",
title = "Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids",
volume = "369",
doi = "10.1016/j.molliq.2022.120974"
}

Mušović, J., Vraneš, M., Papović, S., Gadžurić, S., Ražić, S.,& Trtić-Petrović, T.. (2023). Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids. in Journal of Molecular Liquids
Elsevier B.V.., 369.
https://doi.org/10.1016/j.molliq.2022.120974

Mušović J, Vraneš M, Papović S, Gadžurić S, Ražić S, Trtić-Petrović T. Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids. in Journal of Molecular Liquids. 2023;369.
doi:10.1016/j.molliq.2022.120974 .

Mušović, Jasmina, Vraneš, Milan, Papović, Snežana, Gadžurić, Slobodan, Ražić, Slavica, Trtić-Petrović, Tatjana, "Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids" in Journal of Molecular Liquids, 369 (2023),
https://doi.org/10.1016/j.molliq.2022.120974 . .

TY  - JOUR
AU  - Krstić, Sanja
AU  - Miljić, Milorad
AU  - Antić-Stanković, Jelena
AU  - Božić, Dragana
AU  - Jovanović Krivokuća, Milica
AU  - Pirković, Andrea
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5034
AB  - Methanolic pulp extracts from the four selected Serbian accessions of Cucurbita maxima were evaluated for phenol profile cytotoxic effects and antimicrobial activity. The results revealed that quinic acid and amentoflavone were the most abundant phenols. The extracts increased the viability of HTR-8 SV/Neo, JEG-3, JAR cells, with the most pronounced increase in the treatment with MAX 113 extract. Furthermore, in HeLa cells, the extracts showed a modest cytotoxic effect. The antimicrobial effects evaluation showed that out of four pumpkin extracts, MAX 117 could moderately suppress the growth of Staphylococcus aureus and Staphylococcus epidermidis (MIC=1000 µg/mL). The observed biological effects indicate the potential medicinal properties of these pumpkin extracts and contribute to the varietal selection of the most suitable accessions in national breeding programs as candidates for improving human health.
PB  - Elsevier Ltd
T2  - Food Chemistry Advances
T1  - Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity
VL  - 3
DO  - 10.1016/j.focha.2023.100395
ER  - 

@article{
author = "Krstić, Sanja and Miljić, Milorad and Antić-Stanković, Jelena and Božić, Dragana and Jovanović Krivokuća, Milica and Pirković, Andrea",
year = "2023",
abstract = "Methanolic pulp extracts from the four selected Serbian accessions of Cucurbita maxima were evaluated for phenol profile cytotoxic effects and antimicrobial activity. The results revealed that quinic acid and amentoflavone were the most abundant phenols. The extracts increased the viability of HTR-8 SV/Neo, JEG-3, JAR cells, with the most pronounced increase in the treatment with MAX 113 extract. Furthermore, in HeLa cells, the extracts showed a modest cytotoxic effect. The antimicrobial effects evaluation showed that out of four pumpkin extracts, MAX 117 could moderately suppress the growth of Staphylococcus aureus and Staphylococcus epidermidis (MIC=1000 µg/mL). The observed biological effects indicate the potential medicinal properties of these pumpkin extracts and contribute to the varietal selection of the most suitable accessions in national breeding programs as candidates for improving human health.",
publisher = "Elsevier Ltd",
journal = "Food Chemistry Advances",
title = "Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity",
volume = "3",
doi = "10.1016/j.focha.2023.100395"
}

Krstić, S., Miljić, M., Antić-Stanković, J., Božić, D., Jovanović Krivokuća, M.,& Pirković, A.. (2023). Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity. in Food Chemistry Advances
Elsevier Ltd., 3.
https://doi.org/10.1016/j.focha.2023.100395

Krstić S, Miljić M, Antić-Stanković J, Božić D, Jovanović Krivokuća M, Pirković A. Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity. in Food Chemistry Advances. 2023;3.
doi:10.1016/j.focha.2023.100395 .

Krstić, Sanja, Miljić, Milorad, Antić-Stanković, Jelena, Božić, Dragana, Jovanović Krivokuća, Milica, Pirković, Andrea, "Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity" in Food Chemistry Advances, 3 (2023),
https://doi.org/10.1016/j.focha.2023.100395 . .

TY  - JOUR
AU  - Antonijević Nikolić, Mirjana
AU  - Mészáros Szécsényi, Katalin
AU  - Dražić, Branka
AU  - Rodić, Marko
AU  - Stanić, Vojislav
AU  - Tanasković, Slađana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3811
AB  - In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior
VL  - 1236
DO  - 10.1016/j.molstruc.2021.130133
ER  - 

@article{
author = "Antonijević Nikolić, Mirjana and Mészáros Szécsényi, Katalin and Dražić, Branka and Rodić, Marko and Stanić, Vojislav and Tanasković, Slađana",
year = "2021",
abstract = "In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate co-ligands of formulas [Co2(benz)2tpmc](ClO4)2•3H2O (1), benz– = benzoate anion; [Co2(L)tpmc](ClO4)2•nH2O, L = pht2– (phthalate dianion), n=2 (2), L = ipht2– (isophthalate dianion), n=4 (3) and L = tpht2–(terephthalate dianion), n=4 (4) are reported. The stoichiometric composition of the compounds in the solution were determined spectrophotometrically using Job's methods. Formation constants, K and Gibbs free energy, ΔG values were calculated. The thermal behavior of the complexes was investigated by simultaneous TG/DSC and TG – MS measurements. The cytotoxic effect of the complexes, the free ligands, the DMSO solvent and cis-platin, as referent cytostatic drug, was evaluated on Human cervix adenocarcinoma (HeLa), human melanoma (Fem-x) and human colon carcinoma (LS174) cell lines. The IC50 values were between 12.7–42.3 μM. The first crystal structure determination of the Co(II) complex [Co2(µ-pht)tpmc](ClO4)2•H2O with boat conformation of tpmc ligand, was also done. The complex crystallizes in monoclinic crystal system, C2/c space group. The geometries around both Co(II) atoms are highly distorted octahedral. The Co(II) ions exhibit CoN4O2 coordination environments with the four nitrogen donor atoms of the tpmc ligand and two oxygen atoms belonging to the one carboxylate group of pht2− ligand. The carboxylate groups of pht2− are coordinated in an endo-bidentate mode. The tpmc ligand adopted a boat conformation in which the two coordinated Co(II) atoms are located on the same side of the ring, with Co•••Co distance amounting 5.4799(5) Å.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior",
volume = "1236",
doi = "10.1016/j.molstruc.2021.130133"
}

Antonijević Nikolić, M., Mészáros Szécsényi, K., Dražić, B., Rodić, M., Stanić, V.,& Tanasković, S.. (2021). Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure
Elsevier B.V.., 1236.
https://doi.org/10.1016/j.molstruc.2021.130133

Antonijević Nikolić M, Mészáros Szécsényi K, Dražić B, Rodić M, Stanić V, Tanasković S. Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior. in Journal of Molecular Structure. 2021;1236.
doi:10.1016/j.molstruc.2021.130133 .

Antonijević Nikolić, Mirjana, Mészáros Szécsényi, Katalin, Dražić, Branka, Rodić, Marko, Stanić, Vojislav, Tanasković, Slađana, "Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior" in Journal of Molecular Structure, 1236 (2021),
https://doi.org/10.1016/j.molstruc.2021.130133 . .

TY  - JOUR
AU  - Jevrosimov, Irina
AU  - Kragulj-Isakovski, Marijana
AU  - Apostolović, Tamara
AU  - Maletić, Snežana
AU  - Ražić, Slavica
AU  - Mihajlović, Marija
AU  - Tričković, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3765
AB  - This work investigates the adsorption mechanism of alachlor and pentachlorobenzene on chars (hydrochars and biochars) originated from Miscanthus giganteus and sugar beet shreds. Two different processes were used: hydrothermal conversion at three temperatures (180, 200, and 220 °C) and slow pyrolysis at 400 °C. Specific surface area (SSA) for all investigated chars ranged 3.87–260 m2/g, whereby biochars had a higher SSA. For hydrochars from sugar beet shreds, both the SSA (3.87–5.53 m2/g) and pore volume (0.023–0.0277 cm3/g) increased with increasing temperature, while the opposite trend was observed for hydrochars from miscanthus. The opposite trend could be a consequence of the different chemical composition of the used feedstock such as hemicelluloses and cellulose which can produce volatile organic products at higher temperatures and may cause the reduction of SSA. All adsorption isotherms were well described by the Freundlich model. The nonlinearity of the isotherms ranged from 0.450 to 0.986. Kd values for both investigated compounds followed the order: hydrochars from sugar beet shred < hydrochars from miscanthus < biochars, implying that the SSA of the chars affects the adsorption mechanism. In general, all the investigated adsorbents demonstrated higher adsorption affinity for pentachlorobenzene in comparison with alachlor, implying that hydrophobic interactions enhanced the adsorption of the more hydrophobic organic compound. In addition, for all hydrochars, adsorption affinities for the smaller pentachlorobenzene are significantly greater than for the larger alachlor, probably due to its ability to better penetrate into the pores of the adsorbents. This type of research is necessary to obtain safe adsorbents for water remediation.
PB  - Springer
T2  - Chemical Papers
T1  - Mechanisms of alachlor and pentachlorobenzene adsorption on biochar and hydrochar originating from Miscanthus giganteus and sugar beet shreds
VL  - 75
SP  - 2105
EP  - 2120
DO  - 10.1007/s11696-020-01439-0
ER  - 

@article{
author = "Jevrosimov, Irina and Kragulj-Isakovski, Marijana and Apostolović, Tamara and Maletić, Snežana and Ražić, Slavica and Mihajlović, Marija and Tričković, Jelena",
year = "2021",
abstract = "This work investigates the adsorption mechanism of alachlor and pentachlorobenzene on chars (hydrochars and biochars) originated from Miscanthus giganteus and sugar beet shreds. Two different processes were used: hydrothermal conversion at three temperatures (180, 200, and 220 °C) and slow pyrolysis at 400 °C. Specific surface area (SSA) for all investigated chars ranged 3.87–260 m2/g, whereby biochars had a higher SSA. For hydrochars from sugar beet shreds, both the SSA (3.87–5.53 m2/g) and pore volume (0.023–0.0277 cm3/g) increased with increasing temperature, while the opposite trend was observed for hydrochars from miscanthus. The opposite trend could be a consequence of the different chemical composition of the used feedstock such as hemicelluloses and cellulose which can produce volatile organic products at higher temperatures and may cause the reduction of SSA. All adsorption isotherms were well described by the Freundlich model. The nonlinearity of the isotherms ranged from 0.450 to 0.986. Kd values for both investigated compounds followed the order: hydrochars from sugar beet shred < hydrochars from miscanthus < biochars, implying that the SSA of the chars affects the adsorption mechanism. In general, all the investigated adsorbents demonstrated higher adsorption affinity for pentachlorobenzene in comparison with alachlor, implying that hydrophobic interactions enhanced the adsorption of the more hydrophobic organic compound. In addition, for all hydrochars, adsorption affinities for the smaller pentachlorobenzene are significantly greater than for the larger alachlor, probably due to its ability to better penetrate into the pores of the adsorbents. This type of research is necessary to obtain safe adsorbents for water remediation.",
publisher = "Springer",
journal = "Chemical Papers",
title = "Mechanisms of alachlor and pentachlorobenzene adsorption on biochar and hydrochar originating from Miscanthus giganteus and sugar beet shreds",
volume = "75",
pages = "2105-2120",
doi = "10.1007/s11696-020-01439-0"
}

Jevrosimov, I., Kragulj-Isakovski, M., Apostolović, T., Maletić, S., Ražić, S., Mihajlović, M.,& Tričković, J.. (2021). Mechanisms of alachlor and pentachlorobenzene adsorption on biochar and hydrochar originating from Miscanthus giganteus and sugar beet shreds. in Chemical Papers
Springer., 75, 2105-2120.
https://doi.org/10.1007/s11696-020-01439-0

Jevrosimov I, Kragulj-Isakovski M, Apostolović T, Maletić S, Ražić S, Mihajlović M, Tričković J. Mechanisms of alachlor and pentachlorobenzene adsorption on biochar and hydrochar originating from Miscanthus giganteus and sugar beet shreds. in Chemical Papers. 2021;75:2105-2120.
doi:10.1007/s11696-020-01439-0 .

Jevrosimov, Irina, Kragulj-Isakovski, Marijana, Apostolović, Tamara, Maletić, Snežana, Ražić, Slavica, Mihajlović, Marija, Tričković, Jelena, "Mechanisms of alachlor and pentachlorobenzene adsorption on biochar and hydrochar originating from Miscanthus giganteus and sugar beet shreds" in Chemical Papers, 75 (2021):2105-2120,
https://doi.org/10.1007/s11696-020-01439-0 . .

TY  - JOUR
AU  - Ilijević, Konstantin
AU  - Vujanović, Dragana
AU  - Orčić, Snežana
AU  - Purać, Jelena
AU  - Kojić, Danijela
AU  - Zarić, Nenad
AU  - Gržetić, Ivan
AU  - Blagojević, Duško P.
AU  - Čelić, Tatjana V.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3648
AB  - Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.
PB  - Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
T1  - Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph
VL  - 239
DO  - 10.1016/j.cbpc.2020.108852
ER  - 

@article{
author = "Ilijević, Konstantin and Vujanović, Dragana and Orčić, Snežana and Purać, Jelena and Kojić, Danijela and Zarić, Nenad and Gržetić, Ivan and Blagojević, Duško P. and Čelić, Tatjana V.",
year = "2021",
abstract = "Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.",
publisher = "Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology",
title = "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph",
volume = "239",
doi = "10.1016/j.cbpc.2020.108852"
}

Ilijević, K., Vujanović, D., Orčić, S., Purać, J., Kojić, D., Zarić, N., Gržetić, I., Blagojević, D. P.,& Čelić, T. V.. (2021). Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Elsevier Inc.., 239.
https://doi.org/10.1016/j.cbpc.2020.108852

Ilijević K, Vujanović D, Orčić S, Purać J, Kojić D, Zarić N, Gržetić I, Blagojević DP, Čelić TV. Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2021;239.
doi:10.1016/j.cbpc.2020.108852 .

Ilijević, Konstantin, Vujanović, Dragana, Orčić, Snežana, Purać, Jelena, Kojić, Danijela, Zarić, Nenad, Gržetić, Ivan, Blagojević, Duško P., Čelić, Tatjana V., "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph" in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 239 (2021),
https://doi.org/10.1016/j.cbpc.2020.108852 . .