TY  - JOUR
AU  - Sieghart, Werner
AU  - Chiou, Lih-Chu
AU  - Ernst, Margot
AU  - Fabjan, Jure
AU  - Savić, Miroslav
AU  - Lee, Ming Tatt
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4107
AB  - GABAA receptors containing the α6 subunit are highly expressed in cerebellar granule cells and less abundantly in many other neuronal and peripheral tissues. Here, we for the first time summarize their importance for the functions of the cerebellum and the nervous system. The cerebellum is not only involved in motor control but also in cognitive, emotional, and social behaviors. α6βγ2 GABAA receptors located at cerebellar Golgi cell/granule cell synapses enhance the precision of inputs required for cerebellar timing of motor activity and are thus involved in cognitive processing and adequate responses to our environment. Extrasynaptic α6βδ GABAA receptors regulate the amount of information entering the cerebellum by their tonic inhibition of granule cells, and their optimal functioning enhances input filtering or contrast. The complex roles of the cerebellum in multiple brain functions can be compromised by genetic or neurodevelopmental causes that lead to a hypofunction of cerebellar α6-containing GABAA receptors. Animal models mimicking neuropsychiatric phenotypes suggest that compounds selectively activating or positively modulating cerebellar α6-containing GABAA receptors can alleviate essential tremor and motor disturbances in Angelman and Down syndrome as well as impaired prepulse inhibition in neuropsychiatric disorders and reduce migraine and trigeminal-related pain via α6-containing GABAA receptors in trigeminal ganglia. Genetic studies in humans suggest an association of the human GABAA receptor α6 subunit gene with stress-associated disorders. Animal studies support this conclusion. Neuroimaging and post-mortem studies in humans further support an involvement of α6-containing GABAA receptors in various neuropsychiatric disorders, pointing to a broad therapeutic potential of drugs modulating α6-containing GABAA receptors.
PB  - American Society for Pharmacology and Experimental Therapy
T2  - Pharmacological Reviews
T1  - α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials
VL  - 74
IS  - 1
SP  - 238
EP  - 270
DO  - 10.1124/PHARMREV.121.000293
ER  - 

@article{
author = "Sieghart, Werner and Chiou, Lih-Chu and Ernst, Margot and Fabjan, Jure and Savić, Miroslav and Lee, Ming Tatt",
year = "2022",
abstract = "GABAA receptors containing the α6 subunit are highly expressed in cerebellar granule cells and less abundantly in many other neuronal and peripheral tissues. Here, we for the first time summarize their importance for the functions of the cerebellum and the nervous system. The cerebellum is not only involved in motor control but also in cognitive, emotional, and social behaviors. α6βγ2 GABAA receptors located at cerebellar Golgi cell/granule cell synapses enhance the precision of inputs required for cerebellar timing of motor activity and are thus involved in cognitive processing and adequate responses to our environment. Extrasynaptic α6βδ GABAA receptors regulate the amount of information entering the cerebellum by their tonic inhibition of granule cells, and their optimal functioning enhances input filtering or contrast. The complex roles of the cerebellum in multiple brain functions can be compromised by genetic or neurodevelopmental causes that lead to a hypofunction of cerebellar α6-containing GABAA receptors. Animal models mimicking neuropsychiatric phenotypes suggest that compounds selectively activating or positively modulating cerebellar α6-containing GABAA receptors can alleviate essential tremor and motor disturbances in Angelman and Down syndrome as well as impaired prepulse inhibition in neuropsychiatric disorders and reduce migraine and trigeminal-related pain via α6-containing GABAA receptors in trigeminal ganglia. Genetic studies in humans suggest an association of the human GABAA receptor α6 subunit gene with stress-associated disorders. Animal studies support this conclusion. Neuroimaging and post-mortem studies in humans further support an involvement of α6-containing GABAA receptors in various neuropsychiatric disorders, pointing to a broad therapeutic potential of drugs modulating α6-containing GABAA receptors.",
publisher = "American Society for Pharmacology and Experimental Therapy",
journal = "Pharmacological Reviews",
title = "α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials",
volume = "74",
number = "1",
pages = "238-270",
doi = "10.1124/PHARMREV.121.000293"
}

Sieghart, W., Chiou, L., Ernst, M., Fabjan, J., Savić, M.,& Lee, M. T.. (2022). α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials. in Pharmacological Reviews
American Society for Pharmacology and Experimental Therapy., 74(1), 238-270.
https://doi.org/10.1124/PHARMREV.121.000293

Sieghart W, Chiou L, Ernst M, Fabjan J, Savić M, Lee MT. α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials. in Pharmacological Reviews. 2022;74(1):238-270.
doi:10.1124/PHARMREV.121.000293 .

Sieghart, Werner, Chiou, Lih-Chu, Ernst, Margot, Fabjan, Jure, Savić, Miroslav, Lee, Ming Tatt, "α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials" in Pharmacological Reviews, 74, no. 1 (2022):238-270,
https://doi.org/10.1124/PHARMREV.121.000293 . .