TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Gojgić-Cvijović, Gordana
AU  - Jakovljević, Dragica
AU  - Nikolić, Ines
AU  - Lunter, Dominique Jasmin
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3500
AB  - Ongoing demand in sustainable and biocompatible drug dosage forms is reflected in the search for novel pharmaceutical excipients with equal properties. A group of microbial exopolysaccharides offers a variety of biopolymers with many alleged uses and effects. This study aims to assess applicative properties of levan obtained from Bacillus licheniformis NS032, focusing on its potential co-stabilizing and drug release-controlling functions in pertaining emulsion systems. Despite its high molecular weight and partial existence in globular nanometric structures (180-190 nm), levan was successfully incorporated into both tested colloidal systems: those stabilized with synthetic/anionic or natural-origin/non-ionic emulsifiers. In the tested levan concentrations range (0.2-3.0% w/w) the monitored flow and thermal parameters failed to show linear concentration dependence, which prompted us to revisit certain colloidal fundamentals of this biopolymer. Being a part of the external phase of the investigated emulsion systems, levan contributed to formation of a matrix-like environment, offering additional stabilization of the microstructure and rheology modifying properties (hysteresis loop elevation as high as 4167±98 to 20792±3166 Pa•s−1), especially in case of the samples where lamellar liquid crystalline formation occurred. Apart from its good water solubility and considerable conformational flexibility, the investigated homofructan easily saturated the external phase of the samples stabilized with a conventional anionic emulsifier, leading to similar properties of 0.2% and 3.0% levan-containing samples. After closer consideration of thermal and release behavior, this was considered as a favorable property for a novel excipient, offering tailored formulation characteristics even with lower levan concentrations, consequently not compromising the potential cost of the final drug dosage form.
PB  - Elsevier
T2  - European Journal of Pharmaceutical Sciences
T1  - Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application
VL  - 142
DO  - 10.1016/j.ejps.2019.105109
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Gojgić-Cvijović, Gordana and Jakovljević, Dragica and Nikolić, Ines and Lunter, Dominique Jasmin and Daniels, Rolf and Savić, Snežana",
year = "2020",
abstract = "Ongoing demand in sustainable and biocompatible drug dosage forms is reflected in the search for novel pharmaceutical excipients with equal properties. A group of microbial exopolysaccharides offers a variety of biopolymers with many alleged uses and effects. This study aims to assess applicative properties of levan obtained from Bacillus licheniformis NS032, focusing on its potential co-stabilizing and drug release-controlling functions in pertaining emulsion systems. Despite its high molecular weight and partial existence in globular nanometric structures (180-190 nm), levan was successfully incorporated into both tested colloidal systems: those stabilized with synthetic/anionic or natural-origin/non-ionic emulsifiers. In the tested levan concentrations range (0.2-3.0% w/w) the monitored flow and thermal parameters failed to show linear concentration dependence, which prompted us to revisit certain colloidal fundamentals of this biopolymer. Being a part of the external phase of the investigated emulsion systems, levan contributed to formation of a matrix-like environment, offering additional stabilization of the microstructure and rheology modifying properties (hysteresis loop elevation as high as 4167±98 to 20792±3166 Pa•s−1), especially in case of the samples where lamellar liquid crystalline formation occurred. Apart from its good water solubility and considerable conformational flexibility, the investigated homofructan easily saturated the external phase of the samples stabilized with a conventional anionic emulsifier, leading to similar properties of 0.2% and 3.0% levan-containing samples. After closer consideration of thermal and release behavior, this was considered as a favorable property for a novel excipient, offering tailored formulation characteristics even with lower levan concentrations, consequently not compromising the potential cost of the final drug dosage form.",
publisher = "Elsevier",
journal = "European Journal of Pharmaceutical Sciences",
title = "Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application",
volume = "142",
doi = "10.1016/j.ejps.2019.105109"
}

Pantelić, I., Lukić, M., Gojgić-Cvijović, G., Jakovljević, D., Nikolić, I., Lunter, D. J., Daniels, R.,& Savić, S.. (2020). Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application. in European Journal of Pharmaceutical Sciences
Elsevier., 142.
https://doi.org/10.1016/j.ejps.2019.105109

Pantelić I, Lukić M, Gojgić-Cvijović G, Jakovljević D, Nikolić I, Lunter DJ, Daniels R, Savić S. Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application. in European Journal of Pharmaceutical Sciences. 2020;142.
doi:10.1016/j.ejps.2019.105109 .

Pantelić, Ivana, Lukić, Milica, Gojgić-Cvijović, Gordana, Jakovljević, Dragica, Nikolić, Ines, Lunter, Dominique Jasmin, Daniels, Rolf, Savić, Snežana, "Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application" in European Journal of Pharmaceutical Sciences, 142 (2020),
https://doi.org/10.1016/j.ejps.2019.105109 . .

TY  - JOUR
AU  - Milić, J.
AU  - Ćurčić, Marijana
AU  - Brnjas, Zvonko
AU  - Carapina, H
AU  - Ranđelović, J
AU  - Krinulović, Katarina
AU  - Jovović, Aleksandar
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3254
AB  - Assessing the socio-economic impact of dangerous chemicals, including persistent organic pollutants (POPs) as a specific segment, includes analysis of their impacts on human health, on the environment and on local economic development. Abundant evidence of these effects of dangerous chemicals throughout the world is provided by published research. According to WHO, these chemicals cause around 4.9 million deaths (8.3%) and 86 million Disability-Adjusted Life Years (5.7%) globally; according to very conservative estimates, 20% of cancer deaths are the consequence of the cancerous effects of chemicals in the work place. Their impact on economic development is manifested primarily through reduced productivity of society due to health impairment of both the population and natural resources. Specific research, the results of which are presented in this article, has been focused on the impact of POPs on human health. This impact is presented in very general terms through estimation of the monetized cost effects for treating those diseases and cancers assumed to be caused by POPs in Serbia. The cost estimation based on available data amounts to approximately € 68 million for a 5-year period.
PB  - Elsevier B.V.
T2  - Scientia Horticulturae
T1  - The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs)
VL  - 688
SP  - 486
EP  - 493
DO  - 10.1016/j.scitotenv.2019.06.161
ER  - 

@article{
author = "Milić, J. and Ćurčić, Marijana and Brnjas, Zvonko and Carapina, H and Ranđelović, J and Krinulović, Katarina and Jovović, Aleksandar",
year = "2019",
abstract = "Assessing the socio-economic impact of dangerous chemicals, including persistent organic pollutants (POPs) as a specific segment, includes analysis of their impacts on human health, on the environment and on local economic development. Abundant evidence of these effects of dangerous chemicals throughout the world is provided by published research. According to WHO, these chemicals cause around 4.9 million deaths (8.3%) and 86 million Disability-Adjusted Life Years (5.7%) globally; according to very conservative estimates, 20% of cancer deaths are the consequence of the cancerous effects of chemicals in the work place. Their impact on economic development is manifested primarily through reduced productivity of society due to health impairment of both the population and natural resources. Specific research, the results of which are presented in this article, has been focused on the impact of POPs on human health. This impact is presented in very general terms through estimation of the monetized cost effects for treating those diseases and cancers assumed to be caused by POPs in Serbia. The cost estimation based on available data amounts to approximately € 68 million for a 5-year period.",
publisher = "Elsevier B.V.",
journal = "Scientia Horticulturae",
title = "The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs)",
volume = "688",
pages = "486-493",
doi = "10.1016/j.scitotenv.2019.06.161"
}

Milić, J., Ćurčić, M., Brnjas, Z., Carapina, H., Ranđelović, J., Krinulović, K.,& Jovović, A.. (2019). The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs). in Scientia Horticulturae
Elsevier B.V.., 688, 486-493.
https://doi.org/10.1016/j.scitotenv.2019.06.161

Milić J, Ćurčić M, Brnjas Z, Carapina H, Ranđelović J, Krinulović K, Jovović A. The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs). in Scientia Horticulturae. 2019;688:486-493.
doi:10.1016/j.scitotenv.2019.06.161 .

Milić, J., Ćurčić, Marijana, Brnjas, Zvonko, Carapina, H, Ranđelović, J, Krinulović, Katarina, Jovović, Aleksandar, "The socio-economic impact timeline in Serbia for persistent organic pollutants (POPs)" in Scientia Horticulturae, 688 (2019):486-493,
https://doi.org/10.1016/j.scitotenv.2019.06.161 . .