TY  - JOUR
AU  - Zhang, Z.
AU  - Lukić, Milica
AU  - Savić, Snežana
AU  - Lunter, Dominique
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3043
AB  - Objective The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. MethodsResultsPhysiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid-deficient skin samples and confocal Raman microspectroscopy. A 7-day invivo study was performed on volunteers to study the repairing efficacy. Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid-deficient skin in exvivo study. Twice-a-day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. ConclusionResumeThe skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum. ObjectifMethodesl'objectif de l'etude etait de developper des formulations pour delivrer des lipides physiologiques dans la peau dans le but de reparer une fonction barriere defectueuse. du cholesterol et de l'acide linoleique physiologiques ont ete incorpores dans une creme basique et une creme non-ionique afin de realiser des formulations pour la reparation de la peau. L'homogeneite et la stabilite au cours de la conservation des cremes developpees ont ete examinees par microscopie en lumiere polarisee. Une evaluation exvivo a ete realisee en utilisant des echantillons de peau delipidee et la microspectroscopie confocale Raman. Une etude invivo de 7jours a ete realisee sur des volontaires pour etudier l'efficacite de la reparation. ResultatsConclusionune texture homogene a ete observee dans les formulations preparees pour reparation cutanee. L'application des cremes a conduit a une augmentation substantielle des taux de lipides par rapport au temoin dans l'etude exvivo sur la peau delipidee. Une application deux fois par jour des cremes reparatrices cutanees a permis de renforcer la barriere cutanee, car la perte d'eau transepidermique (transepidermal water loss, TEWL) a ete significativement diminuee. les cremes reparatrices cutanees ont montre une excellente efficacite au niveau de la regeneration de la peau. Elles possedent des potentiels eleves pour traiter une alteration de la barriere cutanee associee a un appauvrissement en lipides de la couche cornee.
PB  - Wiley, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin
VL  - 40
IS  - 5
SP  - 494
EP  - 501
DO  - 10.1111/ics.12491
ER  - 

@article{
author = "Zhang, Z. and Lukić, Milica and Savić, Snežana and Lunter, Dominique",
year = "2018",
abstract = "Objective The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. MethodsResultsPhysiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid-deficient skin samples and confocal Raman microspectroscopy. A 7-day invivo study was performed on volunteers to study the repairing efficacy. Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid-deficient skin in exvivo study. Twice-a-day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. ConclusionResumeThe skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum. ObjectifMethodesl'objectif de l'etude etait de developper des formulations pour delivrer des lipides physiologiques dans la peau dans le but de reparer une fonction barriere defectueuse. du cholesterol et de l'acide linoleique physiologiques ont ete incorpores dans une creme basique et une creme non-ionique afin de realiser des formulations pour la reparation de la peau. L'homogeneite et la stabilite au cours de la conservation des cremes developpees ont ete examinees par microscopie en lumiere polarisee. Une evaluation exvivo a ete realisee en utilisant des echantillons de peau delipidee et la microspectroscopie confocale Raman. Une etude invivo de 7jours a ete realisee sur des volontaires pour etudier l'efficacite de la reparation. ResultatsConclusionune texture homogene a ete observee dans les formulations preparees pour reparation cutanee. L'application des cremes a conduit a une augmentation substantielle des taux de lipides par rapport au temoin dans l'etude exvivo sur la peau delipidee. Une application deux fois par jour des cremes reparatrices cutanees a permis de renforcer la barriere cutanee, car la perte d'eau transepidermique (transepidermal water loss, TEWL) a ete significativement diminuee. les cremes reparatrices cutanees ont montre une excellente efficacite au niveau de la regeneration de la peau. Elles possedent des potentiels eleves pour traiter une alteration de la barriere cutanee associee a un appauvrissement en lipides de la couche cornee.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin",
volume = "40",
number = "5",
pages = "494-501",
doi = "10.1111/ics.12491"
}

Zhang, Z., Lukić, M., Savić, S.,& Lunter, D.. (2018). Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin. in International Journal of Cosmetic Science
Wiley, Hoboken., 40(5), 494-501.
https://doi.org/10.1111/ics.12491

Zhang Z, Lukić M, Savić S, Lunter D. Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin. in International Journal of Cosmetic Science. 2018;40(5):494-501.
doi:10.1111/ics.12491 .

Zhang, Z., Lukić, Milica, Savić, Snežana, Lunter, Dominique, "Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin" in International Journal of Cosmetic Science, 40, no. 5 (2018):494-501,
https://doi.org/10.1111/ics.12491 . .