TY  - JOUR
AU  - Cekić, Nebojša
AU  - Milić, Jela
AU  - Savić, Snežana
AU  - Savić, Miroslav
AU  - Jović, Žarko
AU  - Daniels, Rolf
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1261
AB  - Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted based on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles
VL  - 35
IS  - 9
SP  - 1092
EP  - 1102
DO  - 10.1080/03639040902774164
ER  - 

@article{
author = "Cekić, Nebojša and Milić, Jela and Savić, Snežana and Savić, Miroslav and Jović, Žarko and Daniels, Rolf",
year = "2009",
abstract = "Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted based on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles",
volume = "35",
number = "9",
pages = "1092-1102",
doi = "10.1080/03639040902774164"
}

Cekić, N., Milić, J., Savić, S., Savić, M., Jović, Ž.,& Daniels, R.. (2009). Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 35(9), 1092-1102.
https://doi.org/10.1080/03639040902774164

Cekić N, Milić J, Savić S, Savić M, Jović Ž, Daniels R. Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. in Drug Development and Industrial Pharmacy. 2009;35(9):1092-1102.
doi:10.1080/03639040902774164 .

Cekić, Nebojša, Milić, Jela, Savić, Snežana, Savić, Miroslav, Jović, Žarko, Daniels, Rolf, "Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles" in Drug Development and Industrial Pharmacy, 35, no. 9 (2009):1092-1102,
https://doi.org/10.1080/03639040902774164 . .

TY  - JOUR
AU  - Cekić, Nebojša
AU  - Savić, Snežana
AU  - Milić, Jela
AU  - Savić, Miroslav
AU  - Jović, Žarko
AU  - Malesević, Marjia
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/890
AB  - We aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Drug Delivery
T1  - Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles
VL  - 14
IS  - 8
SP  - 483
EP  - 490
DO  - 10.1080/10717540701604769
ER  - 

@article{
author = "Cekić, Nebojša and Savić, Snežana and Milić, Jela and Savić, Miroslav and Jović, Žarko and Malesević, Marjia",
year = "2007",
abstract = "We aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Drug Delivery",
title = "Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles",
volume = "14",
number = "8",
pages = "483-490",
doi = "10.1080/10717540701604769"
}

Cekić, N., Savić, S., Milić, J., Savić, M., Jović, Ž.,& Malesević, M.. (2007). Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles. in Drug Delivery
Taylor & Francis Inc, Philadelphia., 14(8), 483-490.
https://doi.org/10.1080/10717540701604769

Cekić N, Savić S, Milić J, Savić M, Jović Ž, Malesević M. Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles. in Drug Delivery. 2007;14(8):483-490.
doi:10.1080/10717540701604769 .

Cekić, Nebojša, Savić, Snežana, Milić, Jela, Savić, Miroslav, Jović, Žarko, Malesević, Marjia, "Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles" in Drug Delivery, 14, no. 8 (2007):483-490,
https://doi.org/10.1080/10717540701604769 . .