TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Martinović, J.
AU  - Dopsaj, Milivoj
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1539
AB  - The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 +/- 61.02 vs. 276.98 +/- 50.08; P = 0.030), superoxide-dismutase (114.60 +/- 41.64 vs. 101.42 +/- 38.76; P = 0.001), lipid hydroperoxides (149.84 +/- 38.95 vs. 101.43 +/- 39.26; P  lt  0.001), pro-oxidant-antioxidant balance (512.40 +/- 148.67 vs. 413.09 +/- 120.30; P = 0.002), advanced oxidation protein products (1.49 +/- 0.30 vs. 0.91 +/- 0.25; P  lt  0.001) and superoxide (2.61 +/- 0.36 vs. 2.22 +/- 0.35; P = 0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P  lt  0.001), training experience (P = 0.004), Creactive protein (P = 0.002), soluble transferrin receptor (P = 0.004) and transferrin (P  lt  0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - International Journal of Sports Medicine
T1  - Gender-Specific Oxidative Stress Parameters
VL  - 32
IS  - 1
SP  - 14
EP  - 19
DO  - 10.1055/s-0030-1267930
ER  - 

@article{
author = "Dopsaj, Violeta and Martinović, J. and Dopsaj, Milivoj and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša",
year = "2011",
abstract = "The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 +/- 61.02 vs. 276.98 +/- 50.08; P = 0.030), superoxide-dismutase (114.60 +/- 41.64 vs. 101.42 +/- 38.76; P = 0.001), lipid hydroperoxides (149.84 +/- 38.95 vs. 101.43 +/- 39.26; P  lt  0.001), pro-oxidant-antioxidant balance (512.40 +/- 148.67 vs. 413.09 +/- 120.30; P = 0.002), advanced oxidation protein products (1.49 +/- 0.30 vs. 0.91 +/- 0.25; P  lt  0.001) and superoxide (2.61 +/- 0.36 vs. 2.22 +/- 0.35; P = 0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P  lt  0.001), training experience (P = 0.004), Creactive protein (P = 0.002), soluble transferrin receptor (P = 0.004) and transferrin (P  lt  0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "International Journal of Sports Medicine",
title = "Gender-Specific Oxidative Stress Parameters",
volume = "32",
number = "1",
pages = "14-19",
doi = "10.1055/s-0030-1267930"
}

Dopsaj, V., Martinović, J., Dopsaj, M., Kotur-Stevuljević, J.,& Bogavac-Stanojević, N.. (2011). Gender-Specific Oxidative Stress Parameters. in International Journal of Sports Medicine
Georg Thieme Verlag Kg, Stuttgart., 32(1), 14-19.
https://doi.org/10.1055/s-0030-1267930

Dopsaj V, Martinović J, Dopsaj M, Kotur-Stevuljević J, Bogavac-Stanojević N. Gender-Specific Oxidative Stress Parameters. in International Journal of Sports Medicine. 2011;32(1):14-19.
doi:10.1055/s-0030-1267930 .

Dopsaj, Violeta, Martinović, J., Dopsaj, Milivoj, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, "Gender-Specific Oxidative Stress Parameters" in International Journal of Sports Medicine, 32, no. 1 (2011):14-19,
https://doi.org/10.1055/s-0030-1267930 . .

TY  - JOUR
AU  - Martinović, J.
AU  - Dopsaj, Violeta
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Milivoj
AU  - Vujović, Ana
AU  - Stefanović, Aleksandra
AU  - Nesić, G.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1523
AB  - Aim. The objectives of this study were: 1) to evaluate pro-oxidant-antioxidant balance (PAB) associations with the commonly measured parameters of oxidative stress and antioxidative defence in elite female volleyball athletes; 2) to investigate changes in the parameters of oxidative stress during a period of intense training and dietary antioxidant supplementation. Methods. Twenty-seven female volleyball players participated in this study. Blood samples were collected the day before the pre-competitive mesocycle training period began. After the first blood sample donation and during the next six weeks fourteen players (supplemented group) received a cocktail of antioxidants while thirteen of them (control group) received no dietary supplementation. The following parameters were measured: reactive oxygen metabolites (ROMs), superoxide anion (O(2)(-)), malondialdehyde (AIDA), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), biological antioxidative potential (BAP), paraoxonase activity toward paraoxon (POase) and diazoxon (DZOase), superoxide dismutase (SOD), total sulphydryl group concentration (SH groups) and pro-oxidant-antioxidant balance. Results. Significant associations were observed between biomarkers of oxidative damage with PAB in multiple linear regression model in the supplemented and the control groups (82.3% vs. 83.1%) before training and in the control group (82.1%) after training. Significant associations between anti-oxidative defence parameters and PAB values were found in the supplemented group after six-weeks of training (57%). Conclusion. In the absence of antioxidant supplementation, PAB values were dependent on the association with biomarkers of oxidative damage before and after training. After a six-week training period and the applied antioxidant supplementation, PAB values were under the influence of nonenzymatic anti-oxidative defence.
PB  - Edizioni Minerva Medica, Turin
T2  - Journal of Sports Medicine and Physical Fitness
T1  - Proxidant antioxidant balance in supplemented elite female volleyball athletes during a six week training period
VL  - 51
IS  - 1
SP  - 145
EP  - 152
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1523
ER  - 

@article{
author = "Martinović, J. and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Dopsaj, Milivoj and Vujović, Ana and Stefanović, Aleksandra and Nesić, G.",
year = "2011",
abstract = "Aim. The objectives of this study were: 1) to evaluate pro-oxidant-antioxidant balance (PAB) associations with the commonly measured parameters of oxidative stress and antioxidative defence in elite female volleyball athletes; 2) to investigate changes in the parameters of oxidative stress during a period of intense training and dietary antioxidant supplementation. Methods. Twenty-seven female volleyball players participated in this study. Blood samples were collected the day before the pre-competitive mesocycle training period began. After the first blood sample donation and during the next six weeks fourteen players (supplemented group) received a cocktail of antioxidants while thirteen of them (control group) received no dietary supplementation. The following parameters were measured: reactive oxygen metabolites (ROMs), superoxide anion (O(2)(-)), malondialdehyde (AIDA), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), biological antioxidative potential (BAP), paraoxonase activity toward paraoxon (POase) and diazoxon (DZOase), superoxide dismutase (SOD), total sulphydryl group concentration (SH groups) and pro-oxidant-antioxidant balance. Results. Significant associations were observed between biomarkers of oxidative damage with PAB in multiple linear regression model in the supplemented and the control groups (82.3% vs. 83.1%) before training and in the control group (82.1%) after training. Significant associations between anti-oxidative defence parameters and PAB values were found in the supplemented group after six-weeks of training (57%). Conclusion. In the absence of antioxidant supplementation, PAB values were dependent on the association with biomarkers of oxidative damage before and after training. After a six-week training period and the applied antioxidant supplementation, PAB values were under the influence of nonenzymatic anti-oxidative defence.",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Journal of Sports Medicine and Physical Fitness",
title = "Proxidant antioxidant balance in supplemented elite female volleyball athletes during a six week training period",
volume = "51",
number = "1",
pages = "145-152",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1523"
}

Martinović, J., Dopsaj, V., Kotur-Stevuljević, J., Dopsaj, M., Vujović, A., Stefanović, A.,& Nesić, G.. (2011). Proxidant antioxidant balance in supplemented elite female volleyball athletes during a six week training period. in Journal of Sports Medicine and Physical Fitness
Edizioni Minerva Medica, Turin., 51(1), 145-152.
https://hdl.handle.net/21.15107/rcub_farfar_1523

Martinović J, Dopsaj V, Kotur-Stevuljević J, Dopsaj M, Vujović A, Stefanović A, Nesić G. Proxidant antioxidant balance in supplemented elite female volleyball athletes during a six week training period. in Journal of Sports Medicine and Physical Fitness. 2011;51(1):145-152.
https://hdl.handle.net/21.15107/rcub_farfar_1523 .

Martinović, J., Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Dopsaj, Milivoj, Vujović, Ana, Stefanović, Aleksandra, Nesić, G., "Proxidant antioxidant balance in supplemented elite female volleyball athletes during a six week training period" in Journal of Sports Medicine and Physical Fitness, 51, no. 1 (2011):145-152,
https://hdl.handle.net/21.15107/rcub_farfar_1523 .

TY  - JOUR
AU  - Topić, Aleksandra
AU  - Ljujić, Mila
AU  - Nikolić, Aleksandra
AU  - Petrović-Stanojević, Nataša
AU  - Dopuđa-Pantić, Vesna
AU  - Mitić-Milikić, Marija
AU  - Radojković, Dragica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1547
AB  - Imbalance between neutrophil elastase and alpha-1-antitrypsin (AAT) leads to emphysema in smokers as well as in patients with inherited alpha-1-antitrypsin deficiency. AAT as a proven inhibitor of apoptosis may play role in lung cancer (LC) progression. The aim was to analyse AAT protein variants and polymorphism in promoter region of the neutrophil elastase gene (ELA2) in patients with primary lung cancer. AAT phenotypisation by isoelectric focusing method and ELA2 gene promoter characterization by DNA sequencing were performed in 66 patients with primary lung cancer. Results showed that the frequency of M1 allele and PiM1 homozygotes in LC patients was significantly higher when compared to the healthy subjects (f = 0.6360 and 0.7424 respectively). The most frequent ELA2 promoter region genotypes in LC patients were -903TT and -741GG. There were significantly more patients with intermediate and high ELA2 genotype activity, compared to those with low activity (91% vs. 9%, respectively). In conclusion, we found that PiM1 homozygosity could be associated with the lung cancer, probably due to increased synthesis of this antiapoptotic protein. Non-MM variants of AAT and ELA2 genotypes with predicted intermediate or high activity could also represent a risk factor for aggressive form of lung cancer associated with extrathoracic metastases.
PB  - Springer, Dordrecht
T2  - Pathology & Oncology Research
T1  - Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer
VL  - 17
IS  - 1
SP  - 75
EP  - 80
DO  - 10.1007/s12253-010-9283-5
ER  - 

@article{
author = "Topić, Aleksandra and Ljujić, Mila and Nikolić, Aleksandra and Petrović-Stanojević, Nataša and Dopuđa-Pantić, Vesna and Mitić-Milikić, Marija and Radojković, Dragica",
year = "2011",
abstract = "Imbalance between neutrophil elastase and alpha-1-antitrypsin (AAT) leads to emphysema in smokers as well as in patients with inherited alpha-1-antitrypsin deficiency. AAT as a proven inhibitor of apoptosis may play role in lung cancer (LC) progression. The aim was to analyse AAT protein variants and polymorphism in promoter region of the neutrophil elastase gene (ELA2) in patients with primary lung cancer. AAT phenotypisation by isoelectric focusing method and ELA2 gene promoter characterization by DNA sequencing were performed in 66 patients with primary lung cancer. Results showed that the frequency of M1 allele and PiM1 homozygotes in LC patients was significantly higher when compared to the healthy subjects (f = 0.6360 and 0.7424 respectively). The most frequent ELA2 promoter region genotypes in LC patients were -903TT and -741GG. There were significantly more patients with intermediate and high ELA2 genotype activity, compared to those with low activity (91% vs. 9%, respectively). In conclusion, we found that PiM1 homozygosity could be associated with the lung cancer, probably due to increased synthesis of this antiapoptotic protein. Non-MM variants of AAT and ELA2 genotypes with predicted intermediate or high activity could also represent a risk factor for aggressive form of lung cancer associated with extrathoracic metastases.",
publisher = "Springer, Dordrecht",
journal = "Pathology & Oncology Research",
title = "Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer",
volume = "17",
number = "1",
pages = "75-80",
doi = "10.1007/s12253-010-9283-5"
}

Topić, A., Ljujić, M., Nikolić, A., Petrović-Stanojević, N., Dopuđa-Pantić, V., Mitić-Milikić, M.,& Radojković, D.. (2011). Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer. in Pathology & Oncology Research
Springer, Dordrecht., 17(1), 75-80.
https://doi.org/10.1007/s12253-010-9283-5

Topić A, Ljujić M, Nikolić A, Petrović-Stanojević N, Dopuđa-Pantić V, Mitić-Milikić M, Radojković D. Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer. in Pathology & Oncology Research. 2011;17(1):75-80.
doi:10.1007/s12253-010-9283-5 .

Topić, Aleksandra, Ljujić, Mila, Nikolić, Aleksandra, Petrović-Stanojević, Nataša, Dopuđa-Pantić, Vesna, Mitić-Milikić, Marija, Radojković, Dragica, "Alpha-1-antitrypsin Phenotypes and Neutrophil Elastase Gene Promoter Polymorphisms in Lung Cancer" in Pathology & Oncology Research, 17, no. 1 (2011):75-80,
https://doi.org/10.1007/s12253-010-9283-5 . .

TY  - JOUR
AU  - Martinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Violeta
AU  - Dopsaj, Milivoj
AU  - Stefanović, Aleksandra
AU  - Kasum, Goran
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1368
AB  - Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis
VL  - 43
IS  - 15
SP  - 1225
EP  - 1229
DO  - 10.1016/j.clinbiochem.2010.07.024
ER  - 

@article{
author = "Martinović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Dopsaj, Milivoj and Stefanović, Aleksandra and Kasum, Goran",
year = "2010",
abstract = "Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis",
volume = "43",
number = "15",
pages = "1225-1229",
doi = "10.1016/j.clinbiochem.2010.07.024"
}

Martinović, J., Kotur-Stevuljević, J., Dopsaj, V., Dopsaj, M., Stefanović, A.,& Kasum, G.. (2010). Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1225-1229.
https://doi.org/10.1016/j.clinbiochem.2010.07.024

Martinović J, Kotur-Stevuljević J, Dopsaj V, Dopsaj M, Stefanović A, Kasum G. Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry. 2010;43(15):1225-1229.
doi:10.1016/j.clinbiochem.2010.07.024 .

Martinović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Dopsaj, Milivoj, Stefanović, Aleksandra, Kasum, Goran, "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis" in Clinical Biochemistry, 43, no. 15 (2010):1225-1229,
https://doi.org/10.1016/j.clinbiochem.2010.07.024 . .

TY  - CHAP
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, S
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1436
AB  - PON1 is a high density lipoprotein (HDL)-associated serum enzyme. Its primary function is to degrade commonly used insecticides and nerve gases. PON1 is found to be more effective than lecithin:cholesterol acyltransferase (LCAT) or apoA-I in protecting low density lipoproteins (LDL) against oxidation. This chapter reveals that the antioxidative properties of HDL can be compromised under conditions associated with accelerated atherosclerosis. It reveals that PON1 is largely responsible for the breakdown of lipid peroxides before they accumulate in LDL particles. In addition, PON1 also renders HDL resistant to oxidation and hydrolyzes lipid peroxides in human atherosclerotic lesions. The study also reveals that PON1 is primarily a lactonase acting upon certain lactones/hydroxyl acids. Therefore, one of the physiological roles of PON1 is the metabolism of lipid species arising from the oxidation of polyunsaturated fatty acids. The relationship between PON1 and HDL relies on a unique reciprocal arrangement. HDL facilitates the secretion of PON1 and offers a hydrophobic harbor for its anchoring. The chapter also provides a hydrophobic environment that is essential for optimal PON1 activity. In return, the enzyme prevents the oxidation of HDL and stimulates the cholesterol efflux from cells. Therefore, the association between PON1 and HDL is considered in both normal and pathological conditions.
PB  - Elsevier Inc.
T2  - The HDL Handbook
T1  - Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress
SP  - 77
EP  - 98
DO  - 10.1016/B978-0-12-382171-3.10005-1
ER  - 

@inbook{
author = "Vekić, Jelena and Kotur-Stevuljević, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Jelić-Ivanović, Zorana and Spasić, S and Spasojević-Kalimanovska, Vesna",
year = "2010",
abstract = "PON1 is a high density lipoprotein (HDL)-associated serum enzyme. Its primary function is to degrade commonly used insecticides and nerve gases. PON1 is found to be more effective than lecithin:cholesterol acyltransferase (LCAT) or apoA-I in protecting low density lipoproteins (LDL) against oxidation. This chapter reveals that the antioxidative properties of HDL can be compromised under conditions associated with accelerated atherosclerosis. It reveals that PON1 is largely responsible for the breakdown of lipid peroxides before they accumulate in LDL particles. In addition, PON1 also renders HDL resistant to oxidation and hydrolyzes lipid peroxides in human atherosclerotic lesions. The study also reveals that PON1 is primarily a lactonase acting upon certain lactones/hydroxyl acids. Therefore, one of the physiological roles of PON1 is the metabolism of lipid species arising from the oxidation of polyunsaturated fatty acids. The relationship between PON1 and HDL relies on a unique reciprocal arrangement. HDL facilitates the secretion of PON1 and offers a hydrophobic harbor for its anchoring. The chapter also provides a hydrophobic environment that is essential for optimal PON1 activity. In return, the enzyme prevents the oxidation of HDL and stimulates the cholesterol efflux from cells. Therefore, the association between PON1 and HDL is considered in both normal and pathological conditions.",
publisher = "Elsevier Inc.",
journal = "The HDL Handbook",
booktitle = "Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress",
pages = "77-98",
doi = "10.1016/B978-0-12-382171-3.10005-1"
}

Vekić, J., Kotur-Stevuljević, J., Zeljković, A., Stefanović, A., Jelić-Ivanović, Z., Spasić, S.,& Spasojević-Kalimanovska, V.. (2010). Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress. in The HDL Handbook
Elsevier Inc.., 77-98.
https://doi.org/10.1016/B978-0-12-382171-3.10005-1

Vekić J, Kotur-Stevuljević J, Zeljković A, Stefanović A, Jelić-Ivanović Z, Spasić S, Spasojević-Kalimanovska V. Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress. in The HDL Handbook. 2010;:77-98.
doi:10.1016/B978-0-12-382171-3.10005-1 .

Vekić, Jelena, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Jelić-Ivanović, Zorana, Spasić, S, Spasojević-Kalimanovska, Vesna, "Serum paraoxonase (PON1) and its interactions with HDL: Relationship between PON1 and oxidative stress" in The HDL Handbook (2010):77-98,
https://doi.org/10.1016/B978-0-12-382171-3.10005-1 . .

TY  - JOUR
AU  - Vujović, Ana
AU  - Kotur-Stevuljević, Jelena
AU  - Kornić, D.
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Bogavac-Stanojević, Nataša
AU  - Stefanović, Aleksandra
AU  - Deanović, M.
AU  - Babka, Sofika
AU  - Aleksić, B.
AU  - Jelić-Ivanović, Zorana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1377
AB  - Objective: To evaluate the possible relationship between industrial air pollution and oxidative stress in schoolchildren by comparing parameters from children residing in two nearby localities with contrasting environmental conditions. Participants: 42 schoolchildren (12-15 years) from Pancevo (site of Serbia's largest petrochemical installation) formed the exposed group. 82 schoolchildren from Kovacica village, located 30 km north of Pancevo, formed the non-exposed group. Methods: Oxidative stress status, anti-oxidative defense parameters, paraoxonase-1 status, lipid status, glucose concentration and leukocyte counts were compared in two groups. Results: The children from Pancevo showed higher level of oxidative stress demonstrated by an elevated malondialdehyde concentration (P  lt 0.001) and decreased superoxide dismutase activity (P lt 0.01) in comparison to the non-exposed group. Conclusions: The results suggested a relationship between the presence of air pollutants and increased oxidative stress in schoolchildren residing in an industrial environment.
PB  - Indian Acad Pediatrics, New Delhi
T2  - Indian Pediatrics
T1  - Oxidative Stress and Anti-oxidative Defense in Schoolchildren Residing in a Petrochemical Industry Environment
VL  - 47
IS  - 3
SP  - 233
EP  - 239
DO  - 10.1007/s13312-010-0045-y
ER  - 

@article{
author = "Vujović, Ana and Kotur-Stevuljević, Jelena and Kornić, D. and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Bogavac-Stanojević, Nataša and Stefanović, Aleksandra and Deanović, M. and Babka, Sofika and Aleksić, B. and Jelić-Ivanović, Zorana",
year = "2010",
abstract = "Objective: To evaluate the possible relationship between industrial air pollution and oxidative stress in schoolchildren by comparing parameters from children residing in two nearby localities with contrasting environmental conditions. Participants: 42 schoolchildren (12-15 years) from Pancevo (site of Serbia's largest petrochemical installation) formed the exposed group. 82 schoolchildren from Kovacica village, located 30 km north of Pancevo, formed the non-exposed group. Methods: Oxidative stress status, anti-oxidative defense parameters, paraoxonase-1 status, lipid status, glucose concentration and leukocyte counts were compared in two groups. Results: The children from Pancevo showed higher level of oxidative stress demonstrated by an elevated malondialdehyde concentration (P  lt 0.001) and decreased superoxide dismutase activity (P lt 0.01) in comparison to the non-exposed group. Conclusions: The results suggested a relationship between the presence of air pollutants and increased oxidative stress in schoolchildren residing in an industrial environment.",
publisher = "Indian Acad Pediatrics, New Delhi",
journal = "Indian Pediatrics",
title = "Oxidative Stress and Anti-oxidative Defense in Schoolchildren Residing in a Petrochemical Industry Environment",
volume = "47",
number = "3",
pages = "233-239",
doi = "10.1007/s13312-010-0045-y"
}

Vujović, A., Kotur-Stevuljević, J., Kornić, D., Spasojević-Kalimanovska, V., Spasić, S., Bogavac-Stanojević, N., Stefanović, A., Deanović, M., Babka, S., Aleksić, B.,& Jelić-Ivanović, Z.. (2010). Oxidative Stress and Anti-oxidative Defense in Schoolchildren Residing in a Petrochemical Industry Environment. in Indian Pediatrics
Indian Acad Pediatrics, New Delhi., 47(3), 233-239.
https://doi.org/10.1007/s13312-010-0045-y

Vujović A, Kotur-Stevuljević J, Kornić D, Spasojević-Kalimanovska V, Spasić S, Bogavac-Stanojević N, Stefanović A, Deanović M, Babka S, Aleksić B, Jelić-Ivanović Z. Oxidative Stress and Anti-oxidative Defense in Schoolchildren Residing in a Petrochemical Industry Environment. in Indian Pediatrics. 2010;47(3):233-239.
doi:10.1007/s13312-010-0045-y .

Vujović, Ana, Kotur-Stevuljević, Jelena, Kornić, D., Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Bogavac-Stanojević, Nataša, Stefanović, Aleksandra, Deanović, M., Babka, Sofika, Aleksić, B., Jelić-Ivanović, Zorana, "Oxidative Stress and Anti-oxidative Defense in Schoolchildren Residing in a Petrochemical Industry Environment" in Indian Pediatrics, 47, no. 3 (2010):233-239,
https://doi.org/10.1007/s13312-010-0045-y . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1367
AB  - Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients
VL  - 43
IS  - 15
SP  - 1230
EP  - 1235
DO  - 10.1016/j.clinbiochem.2010.08.005
ER  - 

@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Vekić, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana",
year = "2010",
abstract = "Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients",
volume = "43",
number = "15",
pages = "1230-1235",
doi = "10.1016/j.clinbiochem.2010.08.005"
}

Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Vekić, J., Zeljković, A., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2010). HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1230-1235.
https://doi.org/10.1016/j.clinbiochem.2010.08.005

Stefanović A, Kotur-Stevuljević J, Spasić S, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Jelić-Ivanović Z. HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry. 2010;43(15):1230-1235.
doi:10.1016/j.clinbiochem.2010.08.005 .

Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients" in Clinical Biochemistry, 43, no. 15 (2010):1230-1235,
https://doi.org/10.1016/j.clinbiochem.2010.08.005 . .

TY  - JOUR
AU  - Lakić, Dragana
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Kos, Mitja
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1333
AB  - Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, and oxidative stress/antioxidative defense markers as CAD predictors. We assessed their cost-effectiveness compared with the Framingham risk score (FRS). Methods: Using a decision model, we evaluated the costs, accuracy, and cost-effectiveness of each model. The FRS was used as the baseline model. Other models were formed with the consecutive addition of selected markers: apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), apolipoprotein (a) [apo(a)] isoform, lipoprotein (a), high-sensitivity C-reactive protein, malondialdehyde, superoxide dismutase (SOD), sulfhydryl, and superoxide anion (O-2-). A best-case model was formed from a combination of diagnostic markers to yield the best patient stratification algorithm. All models were assessed by their predictive probabilities using receiver operating characteristic curves. To accomplish our goals, we recruited 188 CAD patients (verified by coronary angiography) and 197 asymptomatic CAD-free subjects for comparison. The analysis was performed from a third-party payer perspective. Results: Only two strategies had outstanding discriminative abilities: the best-case model (FRS, SOD, and O-2-) and FRS plus SOD with area under the curve (AUC) values of 0.924 and 0.906, respectively. The cost-effectiveness ratio varied between 593 per AUC for the baseline model to 2425 per AUC for FRS plus apo(a) isoform. Strategies involving oxidative stress/antioxidative defense markers were more cost-effective than strategies involving lipid or inflammatory markers. All results were robust. Conclusion: Our results support the feasibility of a multimarker approach for CAD screening. The introduction of oxidative stress/antioxidative defense markers in the clinical laboratory would be convenient and cost-effective.
PB  - Elsevier Science Inc
T2  - Value in Health
T1  - A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis
VL  - 13
IS  - 6
SP  - 770
EP  - 777
DO  - 10.1111/j.1524-4733.2010.00769.x
ER  - 

@article{
author = "Lakić, Dragana and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Kos, Mitja",
year = "2010",
abstract = "Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, and oxidative stress/antioxidative defense markers as CAD predictors. We assessed their cost-effectiveness compared with the Framingham risk score (FRS). Methods: Using a decision model, we evaluated the costs, accuracy, and cost-effectiveness of each model. The FRS was used as the baseline model. Other models were formed with the consecutive addition of selected markers: apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), apolipoprotein (a) [apo(a)] isoform, lipoprotein (a), high-sensitivity C-reactive protein, malondialdehyde, superoxide dismutase (SOD), sulfhydryl, and superoxide anion (O-2-). A best-case model was formed from a combination of diagnostic markers to yield the best patient stratification algorithm. All models were assessed by their predictive probabilities using receiver operating characteristic curves. To accomplish our goals, we recruited 188 CAD patients (verified by coronary angiography) and 197 asymptomatic CAD-free subjects for comparison. The analysis was performed from a third-party payer perspective. Results: Only two strategies had outstanding discriminative abilities: the best-case model (FRS, SOD, and O-2-) and FRS plus SOD with area under the curve (AUC) values of 0.924 and 0.906, respectively. The cost-effectiveness ratio varied between 593 per AUC for the baseline model to 2425 per AUC for FRS plus apo(a) isoform. Strategies involving oxidative stress/antioxidative defense markers were more cost-effective than strategies involving lipid or inflammatory markers. All results were robust. Conclusion: Our results support the feasibility of a multimarker approach for CAD screening. The introduction of oxidative stress/antioxidative defense markers in the clinical laboratory would be convenient and cost-effective.",
publisher = "Elsevier Science Inc",
journal = "Value in Health",
title = "A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis",
volume = "13",
number = "6",
pages = "770-777",
doi = "10.1111/j.1524-4733.2010.00769.x"
}

Lakić, D., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Kotur-Stevuljević, J., Spasić, S.,& Kos, M.. (2010). A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis. in Value in Health
Elsevier Science Inc., 13(6), 770-777.
https://doi.org/10.1111/j.1524-4733.2010.00769.x

Lakić D, Bogavac-Stanojević N, Jelić-Ivanović Z, Kotur-Stevuljević J, Spasić S, Kos M. A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis. in Value in Health. 2010;13(6):770-777.
doi:10.1111/j.1524-4733.2010.00769.x .

Lakić, Dragana, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Kos, Mitja, "A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis" in Value in Health, 13, no. 6 (2010):770-777,
https://doi.org/10.1111/j.1524-4733.2010.00769.x . .

TY  - JOUR
AU  - Vujović, Ana
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Bujisić, Nada
AU  - Martinović, Jelena
AU  - Vujović, Milica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Pajić, Dragoljub
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1374
AB  - Background: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG  lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p  lt  0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population.
PB  - BMC, LONDON
T2  - Lipids in Health and Disease
T1  - Evaluation of different formulas for LDL-C calculation
VL  - 9
DO  - 10.1186/1476-511X-9-27
ER  - 

@article{
author = "Vujović, Ana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Bujisić, Nada and Martinović, Jelena and Vujović, Milica and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Pajić, Dragoljub",
year = "2010",
abstract = "Background: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG  lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p  lt  0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population.",
publisher = "BMC, LONDON",
journal = "Lipids in Health and Disease",
title = "Evaluation of different formulas for LDL-C calculation",
volume = "9",
doi = "10.1186/1476-511X-9-27"
}

Vujović, A., Kotur-Stevuljević, J., Spasić, S., Bujisić, N., Martinović, J., Vujović, M., Spasojević-Kalimanovska, V., Zeljković, A.,& Pajić, D.. (2010). Evaluation of different formulas for LDL-C calculation. in Lipids in Health and Disease
BMC, LONDON., 9.
https://doi.org/10.1186/1476-511X-9-27

Vujović A, Kotur-Stevuljević J, Spasić S, Bujisić N, Martinović J, Vujović M, Spasojević-Kalimanovska V, Zeljković A, Pajić D. Evaluation of different formulas for LDL-C calculation. in Lipids in Health and Disease. 2010;9.
doi:10.1186/1476-511X-9-27 .

Vujović, Ana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Bujisić, Nada, Martinović, Jelena, Vujović, Milica, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Pajić, Dragoljub, "Evaluation of different formulas for LDL-C calculation" in Lipids in Health and Disease, 9 (2010),
https://doi.org/10.1186/1476-511X-9-27 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Gulan, Brankica
AU  - Spasić, Slavica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1415
AB  - Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P  lt  0.001 and P  lt  0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P  lt  0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P  lt  0.001) and in-hospital mortality after AIS (OR = 5.50; P  lt  0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality
VL  - 210
IS  - 2
SP  - 548
EP  - 554
DO  - 10.1016/j.atherosclerosis.2009.11.040
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Gulan, Brankica and Spasić, Slavica",
year = "2010",
abstract = "Objective: Small, dense low-density lipoprotein (sdLDL) and small-sized high-density lipoprotein (HDL) particles are established risk factors for ischemic heart disease. However, their clinical significance for acute ischemic stroke (AIS) is uncertain. This study evaluates associations of LDL and HDL particle sizes and subclasses with AIS risk and short-term mortality after AIS. Methods: Two hundred AIS patients hospitalised for first-in-a-lifetime stroke and 162 apparently healthy controls were included in the study. LDL and HDL particles were separated by gradient gel electrophoresis and serum lipid parameters were measured by standard laboratory methods. Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Results: AIS patients had significantly more LDL III and IVb, but less LDL I and II particles. They also had significantly smaller HDL size, more HDL 3a, 3b and 3c and less HDL 2b subclasses. The relative content of both sdLDL and small-sized HDL particles was significantly increased in patients (P  lt  0.001 and P  lt  0.001, respectively). In addition, sdLDL was significantly higher in AIS fatalities (n = 25) compared with survivors (n = 175, P  lt  0.05). Increased sdLDL was a significant predictor of AIS (OR = 4.31; P  lt  0.001) and in-hospital mortality after AIS (OR = 5.50; P  lt  0.05). The observed relationships persisted after adjustment for conventional risk factors. Conclusions: AIS is associated with adverse distributions of LDL and HDL subclasses. In addition, short-term mortality after AIS is associated with increased sdLDL particles. Our results indicate that sdLDL is an independent predictor of both AIS onset and consecutive short-term mortality.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality",
volume = "210",
number = "2",
pages = "548-554",
doi = "10.1016/j.atherosclerosis.2009.11.040"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Bogavac-Stanojević, N., Gulan, B.,& Spasić, S.. (2010). LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 210(2), 548-554.
https://doi.org/10.1016/j.atherosclerosis.2009.11.040

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Bogavac-Stanojević N, Gulan B, Spasić S. LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. in Atherosclerosis. 2010;210(2):548-554.
doi:10.1016/j.atherosclerosis.2009.11.040 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Gulan, Brankica, Spasić, Slavica, "LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality" in Atherosclerosis, 210, no. 2 (2010):548-554,
https://doi.org/10.1016/j.atherosclerosis.2009.11.040 . .

TY  - JOUR
AU  - Rizzo, Manfredi
AU  - Vekić, Jelena
AU  - Koulouris, Spyridon
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Rini, Giovam Battista
AU  - Sakellariou, Dimitrios
AU  - Pastromas, Socrates
AU  - Mikhailidis, Dimitri P.
AU  - Manolis, Antonis S.
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1398
AB  - Rosiglitazone may increase cardiovascular risk in patients with type 2 diabetes. Yet, its effects on atherogenic dyslipidemia are still not fully elucidated. In a prospective open-label study rosiglitazone (4 mg/day for 12 weeks) was added to a maximum of 2 oral antidiabetic drugs in 18 diabetic patients. We evaluated the effects on plasma lipids before and after an oral fat load. The size and subclasses of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were also determined (by gradient gel electrophoresis). Rosiglitazone improved glycosylated hemoglobin ([HbAlc] P = .0023), without significant effects on fasting and postprandial plasma lipids. Fasting LDL size increased (+1.4%, P = .034), with less small, dense LDL-IIIA (-25.1%, P = .018). Postprandially, larger HDL-2b reduced (-8.7%, P = .006) and smaller HDL-3b increased (+12.2%, P = .05), without any effects on HDL size. Rosiglitazone led to antiatherogenic changes in LDL size and subclasses, with proatherogenic changes in HDL subclasses, despite no effects on plasma lipids. Their clinical relevance remains to be established.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Angiology
T1  - Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes
VL  - 61
IS  - 6
SP  - 584
EP  - 590
DO  - 10.1177/0003319710366431
ER  - 

@article{
author = "Rizzo, Manfredi and Vekić, Jelena and Koulouris, Spyridon and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Rini, Giovam Battista and Sakellariou, Dimitrios and Pastromas, Socrates and Mikhailidis, Dimitri P. and Manolis, Antonis S.",
year = "2010",
abstract = "Rosiglitazone may increase cardiovascular risk in patients with type 2 diabetes. Yet, its effects on atherogenic dyslipidemia are still not fully elucidated. In a prospective open-label study rosiglitazone (4 mg/day for 12 weeks) was added to a maximum of 2 oral antidiabetic drugs in 18 diabetic patients. We evaluated the effects on plasma lipids before and after an oral fat load. The size and subclasses of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were also determined (by gradient gel electrophoresis). Rosiglitazone improved glycosylated hemoglobin ([HbAlc] P = .0023), without significant effects on fasting and postprandial plasma lipids. Fasting LDL size increased (+1.4%, P = .034), with less small, dense LDL-IIIA (-25.1%, P = .018). Postprandially, larger HDL-2b reduced (-8.7%, P = .006) and smaller HDL-3b increased (+12.2%, P = .05), without any effects on HDL size. Rosiglitazone led to antiatherogenic changes in LDL size and subclasses, with proatherogenic changes in HDL subclasses, despite no effects on plasma lipids. Their clinical relevance remains to be established.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Angiology",
title = "Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes",
volume = "61",
number = "6",
pages = "584-590",
doi = "10.1177/0003319710366431"
}

Rizzo, M., Vekić, J., Koulouris, S., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Rini, G. B., Sakellariou, D., Pastromas, S., Mikhailidis, D. P.,& Manolis, A. S.. (2010). Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes. in Angiology
Sage Publications Inc, Thousand Oaks., 61(6), 584-590.
https://doi.org/10.1177/0003319710366431

Rizzo M, Vekić J, Koulouris S, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Rini GB, Sakellariou D, Pastromas S, Mikhailidis DP, Manolis AS. Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes. in Angiology. 2010;61(6):584-590.
doi:10.1177/0003319710366431 .

Rizzo, Manfredi, Vekić, Jelena, Koulouris, Spyridon, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Rini, Giovam Battista, Sakellariou, Dimitrios, Pastromas, Socrates, Mikhailidis, Dimitri P., Manolis, Antonis S., "Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes" in Angiology, 61, no. 6 (2010):584-590,
https://doi.org/10.1177/0003319710366431 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Vekić, Jelena
AU  - Bujisić, Nada
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1226
AB  - Objectives: Oxidative stress and paraoxonase activity play a significant role in the pathogenesis of cardiovascular disease (CVD). The Prospective Cardiovascular Munster (PROCAM) study evaluated the prevalence of CVD risk factors and postulated the prediction of future CVD events. We therefore investigated the association between plasma markers of oxidative stress and paraoxonase status With PROCAM risk score. Design and methods: Oxidative stress status parameters [lipid peroxidation measured as thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2 center dot(-)), superoxide dismutase (SOD) activity, total sulphydryl group content] and paraoxonase (PONI) status were assessed in 211 participants. The predicted 10-year risk was calculated according to the PROCAM algorithm. Results: As expected subjects with high PROCAM risk score (high CVD risk) had significantly higher concentrations of oxidative stress parameters (TBARS and O-2 center dot(-) P lt 0-001 and P lt 0.05, respectively). The PONI192 phenotype distribution among CVD risk groups was not significantly different. Logistic regression analyses revealed significant associations of all the examined oxidative stress status parameters with calculated CVD risk score. The potential of the parameters for CVD risk prediction was tested via multivariate analysis. Only the O-2 center dot(-) level retained a strong association with high CVD risk. Conclusions: Our study demonstrated that high PROCAM risk score is associated with increased oxidative stress, indicating for the first time that elevated O-2 center dot(-) is independently associated with high CVD, risk.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Association of oxidative stress and paraoxonase status with PROCAM risk score
VL  - 42
IS  - 7-8
SP  - 617
EP  - 623
DO  - 10.1016/j.clinbiochem.2009.01.008
ER  - 

@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Vekić, Jelena and Bujisić, Nada",
year = "2009",
abstract = "Objectives: Oxidative stress and paraoxonase activity play a significant role in the pathogenesis of cardiovascular disease (CVD). The Prospective Cardiovascular Munster (PROCAM) study evaluated the prevalence of CVD risk factors and postulated the prediction of future CVD events. We therefore investigated the association between plasma markers of oxidative stress and paraoxonase status With PROCAM risk score. Design and methods: Oxidative stress status parameters [lipid peroxidation measured as thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2 center dot(-)), superoxide dismutase (SOD) activity, total sulphydryl group content] and paraoxonase (PONI) status were assessed in 211 participants. The predicted 10-year risk was calculated according to the PROCAM algorithm. Results: As expected subjects with high PROCAM risk score (high CVD risk) had significantly higher concentrations of oxidative stress parameters (TBARS and O-2 center dot(-) P lt 0-001 and P lt 0.05, respectively). The PONI192 phenotype distribution among CVD risk groups was not significantly different. Logistic regression analyses revealed significant associations of all the examined oxidative stress status parameters with calculated CVD risk score. The potential of the parameters for CVD risk prediction was tested via multivariate analysis. Only the O-2 center dot(-) level retained a strong association with high CVD risk. Conclusions: Our study demonstrated that high PROCAM risk score is associated with increased oxidative stress, indicating for the first time that elevated O-2 center dot(-) is independently associated with high CVD, risk.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Association of oxidative stress and paraoxonase status with PROCAM risk score",
volume = "42",
number = "7-8",
pages = "617-623",
doi = "10.1016/j.clinbiochem.2009.01.008"
}

Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Vekić, J.,& Bujisić, N.. (2009). Association of oxidative stress and paraoxonase status with PROCAM risk score. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 42(7-8), 617-623.
https://doi.org/10.1016/j.clinbiochem.2009.01.008

Stefanović A, Kotur-Stevuljević J, Spasić S, Vekić J, Bujisić N. Association of oxidative stress and paraoxonase status with PROCAM risk score. in Clinical Biochemistry. 2009;42(7-8):617-623.
doi:10.1016/j.clinbiochem.2009.01.008 .

Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Vekić, Jelena, Bujisić, Nada, "Association of oxidative stress and paraoxonase status with PROCAM risk score" in Clinical Biochemistry, 42, no. 7-8 (2009):617-623,
https://doi.org/10.1016/j.clinbiochem.2009.01.008 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Memon, Lidija
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1217
AB  - Elevated serum uric acid (UA) is associated with higher risk for cardiovascular disease (CVD). Smaller, denser low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles are the potential risk factors for CVD, while the role and diagnostic value of inflammatory markers are firmly established. This current cross-sectional study investigates interrelationships between UA, high sensitivity C-reactive protein (hsCRP) and fibrinogen concentrations with LDL and HDL sizes in healthy middle-aged subjects. The outcomes-of-interest were smaller, denser LDL and HDL particles (LDL size  lt = 25.5 nm and HDL size  lt = 8.8 nm). Serum UA, hsCRP and plasma fibrinogen concentrations were measured by standard laboratory methods in a sample of 194 healthy volunteers (112 men and 82 women). LDL and HDL particle sizes were determined by gradient gel electrophoresis. The subjects in the highest UA tertile had significantly smaller LDL and HDL particle sizes (P  lt  0.05 and P  lt  0.01, respectively) and higher concentrations of fibrinogen and hsCRP (P  lt  0.05 and P  lt  0.01, respectively). Elevated UA (>= 318 mu mol/L) was a significant predictor of smaller, denser LDL and HDL particles (OR = 3.09; P  lt  0.01; n = 19 and OR = 4.40: P  lt  0.001; n = 23, respectively). The observed relationship with smaller HDL size persisted after adjustment for conventional cardiovascular risk factors. UA strongly correlated with both markers of inflammation. In addition, the higher hsCRP level correlated with smaller LDL size (P  lt  0.05), while fibrinogen concentration was inversely related to HDL size (P lt 0.05). Multiple regression analysis revealed that HDL size and inflammatory markers remained independent determinants of UA concentration. In conclusion, higher serum UA and low-grade inflammation are closely linked to alterations in lipoprotein metabolism which may represent an early sign of atherosclerosis in asymptomatic subjects.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles
VL  - 203
IS  - 1
SP  - 236
EP  - 242
DO  - 10.1016/j.atherosclerosis.2008.05.047
ER  - 

@article{
author = "Vekić, Jelena and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Memon, Lidija and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Spasić, Slavica",
year = "2009",
abstract = "Elevated serum uric acid (UA) is associated with higher risk for cardiovascular disease (CVD). Smaller, denser low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles are the potential risk factors for CVD, while the role and diagnostic value of inflammatory markers are firmly established. This current cross-sectional study investigates interrelationships between UA, high sensitivity C-reactive protein (hsCRP) and fibrinogen concentrations with LDL and HDL sizes in healthy middle-aged subjects. The outcomes-of-interest were smaller, denser LDL and HDL particles (LDL size  lt = 25.5 nm and HDL size  lt = 8.8 nm). Serum UA, hsCRP and plasma fibrinogen concentrations were measured by standard laboratory methods in a sample of 194 healthy volunteers (112 men and 82 women). LDL and HDL particle sizes were determined by gradient gel electrophoresis. The subjects in the highest UA tertile had significantly smaller LDL and HDL particle sizes (P  lt  0.05 and P  lt  0.01, respectively) and higher concentrations of fibrinogen and hsCRP (P  lt  0.05 and P  lt  0.01, respectively). Elevated UA (>= 318 mu mol/L) was a significant predictor of smaller, denser LDL and HDL particles (OR = 3.09; P  lt  0.01; n = 19 and OR = 4.40: P  lt  0.001; n = 23, respectively). The observed relationship with smaller HDL size persisted after adjustment for conventional cardiovascular risk factors. UA strongly correlated with both markers of inflammation. In addition, the higher hsCRP level correlated with smaller LDL size (P  lt  0.05), while fibrinogen concentration was inversely related to HDL size (P lt 0.05). Multiple regression analysis revealed that HDL size and inflammatory markers remained independent determinants of UA concentration. In conclusion, higher serum UA and low-grade inflammation are closely linked to alterations in lipoprotein metabolism which may represent an early sign of atherosclerosis in asymptomatic subjects.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles",
volume = "203",
number = "1",
pages = "236-242",
doi = "10.1016/j.atherosclerosis.2008.05.047"
}

Vekić, J., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Memon, L., Zeljković, A., Bogavac-Stanojević, N.,& Spasić, S.. (2009). High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 203(1), 236-242.
https://doi.org/10.1016/j.atherosclerosis.2008.05.047

Vekić J, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Memon L, Zeljković A, Bogavac-Stanojević N, Spasić S. High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. in Atherosclerosis. 2009;203(1):236-242.
doi:10.1016/j.atherosclerosis.2008.05.047 .

Vekić, Jelena, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Memon, Lidija, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Spasić, Slavica, "High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles" in Atherosclerosis, 203, no. 1 (2009):236-242,
https://doi.org/10.1016/j.atherosclerosis.2008.05.047 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Memon, Lidija
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1186
AB  - Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size
VL  - 207
IS  - 2
SP  - 496
EP  - 501
DO  - 10.1016/j.atherosclerosis.2009.06.035
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Memon, Lidija and Spasić, Slavica",
year = "2009",
abstract = "Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size",
volume = "207",
number = "2",
pages = "496-501",
doi = "10.1016/j.atherosclerosis.2009.06.035"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Memon, L.,& Spasić, S.. (2009). Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 207(2), 496-501.
https://doi.org/10.1016/j.atherosclerosis.2009.06.035

Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Memon L, Spasić S. Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis. 2009;207(2):496-501.
doi:10.1016/j.atherosclerosis.2009.06.035 .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Memon, Lidija, Spasić, Slavica, "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size" in Atherosclerosis, 207, no. 2 (2009):496-501,
https://doi.org/10.1016/j.atherosclerosis.2009.06.035 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1235
AB  - Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study investigates the interrelationship of apo(a) and LDL size, as well as their possible synergistic effect on the increase of CAD risk. Methods. One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Lp(a) concentration was measured using immunoturbidimetry. The sizes of apo(a) isoforms were determined by SDS-agarose gel electrophoresis followed by immunoblotting. LDL particle size was determined by gradient gel electrophoresis. Results. We found an inverse correlation between apo(a) size and Lp(a) concentration (r(2) = 31% p  lt 0.001 in the control group and r(2) = 35%. p  lt 0.001 in the CAD group). Individuals with smaller apo(a) isoforms and small, dense LDL (sdLDL) > 50% had the highest risk of CAD development (OR = 4.23, p = 0.017). The synergy index (SIM) for the combination of smaller apo(a) isoforms and sdLDL > 50% was 1.2. Adjustment for Lp(a) and triacylglycerol concentrations eliminated smaller apo(a)/sdLDL > 50% related risk (1) = 0.233 and p = 0.09, respectively). Conclusions. Smaller apo(a) isoforms appear to be superior to sdLDL for the assessment of CAD risk. Their combined effect is synergistic.
PB  - Elsevier Science Inc, New York
T2  - Archives of Medical Research
T1  - Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk
VL  - 40
IS  - 1
SP  - 29
EP  - 35
DO  - 10.1016/j.arcmed.2008.10.010
ER  - 

@article{
author = "Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Spasić, Slavica",
year = "2009",
abstract = "Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study investigates the interrelationship of apo(a) and LDL size, as well as their possible synergistic effect on the increase of CAD risk. Methods. One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Lp(a) concentration was measured using immunoturbidimetry. The sizes of apo(a) isoforms were determined by SDS-agarose gel electrophoresis followed by immunoblotting. LDL particle size was determined by gradient gel electrophoresis. Results. We found an inverse correlation between apo(a) size and Lp(a) concentration (r(2) = 31% p  lt 0.001 in the control group and r(2) = 35%. p  lt 0.001 in the CAD group). Individuals with smaller apo(a) isoforms and small, dense LDL (sdLDL) > 50% had the highest risk of CAD development (OR = 4.23, p = 0.017). The synergy index (SIM) for the combination of smaller apo(a) isoforms and sdLDL > 50% was 1.2. Adjustment for Lp(a) and triacylglycerol concentrations eliminated smaller apo(a)/sdLDL > 50% related risk (1) = 0.233 and p = 0.09, respectively). Conclusions. Smaller apo(a) isoforms appear to be superior to sdLDL for the assessment of CAD risk. Their combined effect is synergistic.",
publisher = "Elsevier Science Inc, New York",
journal = "Archives of Medical Research",
title = "Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk",
volume = "40",
number = "1",
pages = "29-35",
doi = "10.1016/j.arcmed.2008.10.010"
}

Zeljković, A., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Vekić, J.,& Spasić, S.. (2009). Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk. in Archives of Medical Research
Elsevier Science Inc, New York., 40(1), 29-35.
https://doi.org/10.1016/j.arcmed.2008.10.010

Zeljković A, Bogavac-Stanojević N, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Vekić J, Spasić S. Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk. in Archives of Medical Research. 2009;40(1):29-35.
doi:10.1016/j.arcmed.2008.10.010 .

Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Spasić, Slavica, "Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk" in Archives of Medical Research, 40, no. 1 (2009):29-35,
https://doi.org/10.1016/j.arcmed.2008.10.010 . .

TY  - JOUR
AU  - Jelić-Ivanović, Zorana
AU  - Bujisić, Nada
AU  - Spasić, Slavica
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kotur-Stevuljević, Jelena
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1210
AB  - Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p  lt  0.001), even after adjusting for different confounders (p  lt  0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Circulating sTWEAK improves the prediction of coronary artery disease
VL  - 42
IS  - 13-14
SP  - 1381
EP  - 1386
DO  - 10.1016/j.clinbiochem.2009.06.001
ER  - 

@article{
author = "Jelić-Ivanović, Zorana and Bujisić, Nada and Spasić, Slavica and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena",
year = "2009",
abstract = "Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p  lt  0.001), even after adjusting for different confounders (p  lt  0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Circulating sTWEAK improves the prediction of coronary artery disease",
volume = "42",
number = "13-14",
pages = "1381-1386",
doi = "10.1016/j.clinbiochem.2009.06.001"
}

Jelić-Ivanović, Z., Bujisić, N., Spasić, S., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V.,& Kotur-Stevuljević, J.. (2009). Circulating sTWEAK improves the prediction of coronary artery disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 42(13-14), 1381-1386.
https://doi.org/10.1016/j.clinbiochem.2009.06.001

Jelić-Ivanović Z, Bujisić N, Spasić S, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Circulating sTWEAK improves the prediction of coronary artery disease. in Clinical Biochemistry. 2009;42(13-14):1381-1386.
doi:10.1016/j.clinbiochem.2009.06.001 .

Jelić-Ivanović, Zorana, Bujisić, Nada, Spasić, Slavica, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, "Circulating sTWEAK improves the prediction of coronary artery disease" in Clinical Biochemistry, 42, no. 13-14 (2009):1381-1386,
https://doi.org/10.1016/j.clinbiochem.2009.06.001 . .

TY  - JOUR
AU  - Rizzo, Manfredi
AU  - Kotur-Stevuljević, Jelena
AU  - Berneis, Kaspar
AU  - Spinas, Giatgen
AU  - Rini, Giovam Battista
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1228
AB  - Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
PB  - Elsevier Science Inc, New York
T2  - Transplant International
T1  - Atherogenic dyslipidemia and oxidative stress: a new look
VL  - 153
IS  - 5
SP  - 217
EP  - 223
DO  - 10.1016/j.trsl.2009.01.008
ER  - 

@article{
author = "Rizzo, Manfredi and Kotur-Stevuljević, Jelena and Berneis, Kaspar and Spinas, Giatgen and Rini, Giovam Battista and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Vekić, Jelena",
year = "2009",
abstract = "Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)",
publisher = "Elsevier Science Inc, New York",
journal = "Transplant International",
title = "Atherogenic dyslipidemia and oxidative stress: a new look",
volume = "153",
number = "5",
pages = "217-223",
doi = "10.1016/j.trsl.2009.01.008"
}

Rizzo, M., Kotur-Stevuljević, J., Berneis, K., Spinas, G., Rini, G. B., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Vekić, J.. (2009). Atherogenic dyslipidemia and oxidative stress: a new look. in Transplant International
Elsevier Science Inc, New York., 153(5), 217-223.
https://doi.org/10.1016/j.trsl.2009.01.008

Rizzo M, Kotur-Stevuljević J, Berneis K, Spinas G, Rini GB, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Vekić J. Atherogenic dyslipidemia and oxidative stress: a new look. in Transplant International. 2009;153(5):217-223.
doi:10.1016/j.trsl.2009.01.008 .

Rizzo, Manfredi, Kotur-Stevuljević, Jelena, Berneis, Kaspar, Spinas, Giatgen, Rini, Giovam Battista, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, "Atherogenic dyslipidemia and oxidative stress: a new look" in Transplant International, 153, no. 5 (2009):217-223,
https://doi.org/10.1016/j.trsl.2009.01.008 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Bogavac-Stanojević, Nataša
AU  - Bujisić, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1043
AB  - The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P  lt  0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P  lt  0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.
PB  - Elsevier Ireland Ltd, Clare
T2  - Diabetes Research and Clinical Practice
T1  - The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients
VL  - 79
IS  - 1
SP  - 156
EP  - 163
DO  - 10.1016/j.diabres.2007.07.019
ER  - 

@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Bogavac-Stanojević, Nataša and Bujisić, Nada",
year = "2008",
abstract = "The aim of this study was to determinate both the oxidative stress/anti-oxidative defense status and the concentration of leptin in obese, overweight and normal weight type 2 diabetes mellitus patients to seek possible association between oxidative stress and hyperleptinemia. Oxidative stress status parameters [thiobarbituric acid-reacting substances (TBARS), superoxide anion (O-2(center dot-)), superoxide dismutase (SOD) activity and total sulphydryl groups] and the concentration of leptin were measured in 312 subjects (178 patients and in 134 control subjects). Obese patients had a significantly higher concentration of leptin compared to obese subjects in the control population (P  lt  0.001). They also had significantly higher plasma concentrations of TBARS, O-2(center dot-) and SOD activity in combination with a lower sulphydryl group concentration when compared to control subjects. Obese patients had significantly higher concentrations of both TBARS and O-2(center dot-) and increased SOD activity compared to normal weight patients. The odds ratio for the degree of association between oxidative stress status parameters and hyperleptinemia was strongest for TBARS [odds ratio 2.66, 95% CI (1.02-6.94), P = 0.045]. The observed positive correlation between TBARS and leptin (p = 0.29, P  lt  0.01) in obese patients suggests that increased oxidative stress and hyperleptinemia, both consequences of obesity, may play a role in type 2 diabetes mellitus development.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Diabetes Research and Clinical Practice",
title = "The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients",
volume = "79",
number = "1",
pages = "156-163",
doi = "10.1016/j.diabres.2007.07.019"
}

Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Bogavac-Stanojević, N.,& Bujisić, N.. (2008). The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. in Diabetes Research and Clinical Practice
Elsevier Ireland Ltd, Clare., 79(1), 156-163.
https://doi.org/10.1016/j.diabres.2007.07.019

Stefanović A, Kotur-Stevuljević J, Spasić S, Bogavac-Stanojević N, Bujisić N. The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. in Diabetes Research and Clinical Practice. 2008;79(1):156-163.
doi:10.1016/j.diabres.2007.07.019 .

Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Bogavac-Stanojević, Nataša, Bujisić, Nada, "The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients" in Diabetes Research and Clinical Practice, 79, no. 1 (2008):156-163,
https://doi.org/10.1016/j.diabres.2007.07.019 . .

TY  - JOUR
AU  - Topić, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1120
AB  - Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects
VL  - 41
IS  - 6
SP  - 361
EP  - 367
DO  - 10.1016/j.clinbiochem.2007.11.013
ER  - 

@article{
author = "Topić, Aleksandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Jelić-Ivanović, Zorana",
year = "2008",
abstract = "Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects",
volume = "41",
number = "6",
pages = "361-367",
doi = "10.1016/j.clinbiochem.2007.11.013"
}

Topić, A., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J.,& Jelić-Ivanović, Z.. (2008). Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 41(6), 361-367.
https://doi.org/10.1016/j.clinbiochem.2007.11.013

Topić A, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Jelić-Ivanović Z. Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry. 2008;41(6):361-367.
doi:10.1016/j.clinbiochem.2007.11.013 .

Topić, Aleksandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Jelić-Ivanović, Zorana, "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects" in Clinical Biochemistry, 41, no. 6 (2008):361-367,
https://doi.org/10.1016/j.clinbiochem.2007.11.013 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Topić, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
AU  - Vujović, Ana
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1082
AB  - Background Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development. Methods Polyacrylamide gradient (3-31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls. Results Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p  lt  0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p  lt  0.01), even when adjusted for other traditional risk factors, while small HDL particles lost their significance after adjustment (OR = 2.071, p = 0.054). The area under the ROC curve for LDL (0.671) and HDL (0.643) particle size measurement demonstrated low clinical accuracy when compared to the combination of traditional lipid risk factor measurements. Conclusions CAD is associated with the predominance of smaller LDL and HDL particles. However, simultaneous determination of these two lipoprotein phenotypes provides no additional power in discriminating CAD and non-CAD subjects, beyond that obtained by the traditional risk factors.
PB  - Springer, New York
T2  - Clinical and Experimental Medicine
T1  - Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?
VL  - 8
IS  - 2
SP  - 109
EP  - 116
DO  - 10.1007/s10238-008-0165-z
ER  - 

@article{
author = "Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Jelić-Ivanović, Zorana and Topić, Aleksandra and Bogavac-Stanojević, Nataša and Spasić, Slavica and Vujović, Ana and Kalimanovska-Oštrić, Dimitra",
year = "2008",
abstract = "Background Alterations in plasma lipoprotein subclass distribution affect the risk for coronary artery disease (CAD). However, it is unclear whether the determination of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) phenotypes may or may not improve the ability to predict CAD development. Methods Polyacrylamide gradient (3-31%) gel electrophoresis was used to simultaneously determine size and distribution of lipoprotein subclasses in 181 CAD patients and 178 controls. Results Mean LDL and HDL subclass sizes were significantly smaller in patients than in controls (p  lt  0.001). Multivariate logistic regression analysis showed that small dense LDL particles were independent CAD risk predictors (OR = 2.867, p  lt  0.01), even when adjusted for other traditional risk factors, while small HDL particles lost their significance after adjustment (OR = 2.071, p = 0.054). The area under the ROC curve for LDL (0.671) and HDL (0.643) particle size measurement demonstrated low clinical accuracy when compared to the combination of traditional lipid risk factor measurements. Conclusions CAD is associated with the predominance of smaller LDL and HDL particles. However, simultaneous determination of these two lipoprotein phenotypes provides no additional power in discriminating CAD and non-CAD subjects, beyond that obtained by the traditional risk factors.",
publisher = "Springer, New York",
journal = "Clinical and Experimental Medicine",
title = "Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?",
volume = "8",
number = "2",
pages = "109-116",
doi = "10.1007/s10238-008-0165-z"
}

Zeljković, A., Spasojević-Kalimanovska, V., Vekić, J., Jelić-Ivanović, Z., Topić, A., Bogavac-Stanojević, N., Spasić, S., Vujović, A.,& Kalimanovska-Oštrić, D.. (2008). Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?. in Clinical and Experimental Medicine
Springer, New York., 8(2), 109-116.
https://doi.org/10.1007/s10238-008-0165-z

Zeljković A, Spasojević-Kalimanovska V, Vekić J, Jelić-Ivanović Z, Topić A, Bogavac-Stanojević N, Spasić S, Vujović A, Kalimanovska-Oštrić D. Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?. in Clinical and Experimental Medicine. 2008;8(2):109-116.
doi:10.1007/s10238-008-0165-z .

Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Jelić-Ivanović, Zorana, Topić, Aleksandra, Bogavac-Stanojević, Nataša, Spasić, Slavica, Vujović, Ana, Kalimanovska-Oštrić, Dimitra, "Does simultaneous determination of LDL and HDL particle size improve prediction of coronary artery disease risk?" in Clinical and Experimental Medicine, 8, no. 2 (2008):109-116,
https://doi.org/10.1007/s10238-008-0165-z . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Memon, Lidija
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
AU  - Zunić, Gordana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/947
AB  - Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients
VL  - 40
IS  - 3-4
SP  - 181
EP  - 187
DO  - 10.1016/j.clinbiochem.2006.09.007
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Memon, Lidija and Stefanović, Aleksandra and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana and Zunić, Gordana",
year = "2007",
abstract = "Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients",
volume = "40",
number = "3-4",
pages = "181-187",
doi = "10.1016/j.clinbiochem.2006.09.007"
}

Kotur-Stevuljević, J., Memon, L., Stefanović, A., Spasić, S., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Jelić-Ivanović, Z.,& Zunić, G.. (2007). Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(3-4), 181-187.
https://doi.org/10.1016/j.clinbiochem.2006.09.007

Kotur-Stevuljević J, Memon L, Stefanović A, Spasić S, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Jelić-Ivanović Z, Zunić G. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry. 2007;40(3-4):181-187.
doi:10.1016/j.clinbiochem.2006.09.007 .

Kotur-Stevuljević, Jelena, Memon, Lidija, Stefanović, Aleksandra, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, Zunić, Gordana, "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients" in Clinical Biochemistry, 40, no. 3-4 (2007):181-187,
https://doi.org/10.1016/j.clinbiochem.2006.09.007 . .

TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Petrova, Guenka
AU  - Jelić-Ivanović, Zorana
AU  - Memon, Lidija
AU  - Spasić, Slavica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/903
AB  - Objectives: The aim of our study was to determine the cost-effectiveness of coronary artery disease (CAD) diagnostic parameters in a clinical laboratory setting. Design and methods: The effectiveness of apolipoproteins, lipoproteins and high sensitivity C-reactive protein (hs-CRP) supplementary to Framingham scoring data within a CAD risk assessment procedure was established in 221 CAD patients and 289 controls. The total costs of diagnostic procedures were calculated and incremental cost-effectiveness analysis was applied. Results: A diagnostic strategy employing Framingham calculation followed by apolipoprotein A-I (apoA-I) had the lowest cost per additional successfully diagnosed patient than the same strategy followed by hs-CRP in the low (2.63 vs. 24.47 euros) and intermediate-risk groups (2.96 vs. 122.85 euros). in the high-risk group the diagnostic strategy employing apoA-I saved 9.14 euros in comparison to the strategy employing hs-CRP. Conclusion: Cost-effectiveness analysis of different diagnostic markers results in improved identification of at-risk patients at a lower health cost for society.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers
VL  - 40
IS  - 16-17
SP  - 1180
EP  - 1187
DO  - 10.1016/j.clinbiochem.2007.07.004
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Petrova, Guenka and Jelić-Ivanović, Zorana and Memon, Lidija and Spasić, Slavica",
year = "2007",
abstract = "Objectives: The aim of our study was to determine the cost-effectiveness of coronary artery disease (CAD) diagnostic parameters in a clinical laboratory setting. Design and methods: The effectiveness of apolipoproteins, lipoproteins and high sensitivity C-reactive protein (hs-CRP) supplementary to Framingham scoring data within a CAD risk assessment procedure was established in 221 CAD patients and 289 controls. The total costs of diagnostic procedures were calculated and incremental cost-effectiveness analysis was applied. Results: A diagnostic strategy employing Framingham calculation followed by apolipoprotein A-I (apoA-I) had the lowest cost per additional successfully diagnosed patient than the same strategy followed by hs-CRP in the low (2.63 vs. 24.47 euros) and intermediate-risk groups (2.96 vs. 122.85 euros). in the high-risk group the diagnostic strategy employing apoA-I saved 9.14 euros in comparison to the strategy employing hs-CRP. Conclusion: Cost-effectiveness analysis of different diagnostic markers results in improved identification of at-risk patients at a lower health cost for society.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers",
volume = "40",
number = "16-17",
pages = "1180-1187",
doi = "10.1016/j.clinbiochem.2007.07.004"
}

Bogavac-Stanojević, N., Petrova, G., Jelić-Ivanović, Z., Memon, L.,& Spasić, S.. (2007). Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(16-17), 1180-1187.
https://doi.org/10.1016/j.clinbiochem.2007.07.004

Bogavac-Stanojević N, Petrova G, Jelić-Ivanović Z, Memon L, Spasić S. Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers. in Clinical Biochemistry. 2007;40(16-17):1180-1187.
doi:10.1016/j.clinbiochem.2007.07.004 .

Bogavac-Stanojević, Nataša, Petrova, Guenka, Jelić-Ivanović, Zorana, Memon, Lidija, Spasić, Slavica, "Cost-effectiveness analysis in diagnosis of coronary artery disease: Choice of laboratory markers" in Clinical Biochemistry, 40, no. 16-17 (2007):1180-1187,
https://doi.org/10.1016/j.clinbiochem.2007.07.004 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, S.
AU  - Spasojević-Kalimanovska, Vesna
AU  - Topić, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Stefanović, A.
AU  - Zunić, G.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/979
AB  - Background Alterations in plasma lipoprotein subclass distributions affect atherosclerosis risk. Smaller, denser low-density lipoprotein (LDL) particles (sdLDL) are more susceptible to oxidation. In contrast, most of the protective effects of high-density lipoproteins (HDL) are attributable to larger particles. This study investigates the connection between LDL and HDL particle heterogeneity and oxidative stress, antioxidative defence (AOD) and paraoxonase (PON1) status in a healthy middle-aged Serbian population. Materials and methods LDL and HDL particle sizes and subclass distributions were measured by gradient gel electrophoresis in 104 men and 103 women, aged 53 +/- 9.4 years. PON1 activities and PON1(Q192R) phenotypes were determined with paraoxon and diazoxon as substrates. The oxidative stress/AOD status was estimated by measuring malondialdehyde (MDA) and superoxide-anion (O-2(.-)) levels and superoxide-dismutase (SOD) activity. Results Subjects with sdLDL had significantly higher MDA (P  lt  0.001) and O-2(.-) (P  lt  0.05) levels and greater diazoxonase (DZOase) activity (P  lt  0.05) compared to subjects with larger LDL particles. A high MDA concentration was a significant predictor of the sdLDL phenotype (P  lt  0.005). Increased levels of O-2(.-) and MDA were associated with smaller HDL3 subclass abundance. Reduced HDL particle size was associated with lower DZOase activity (P  lt  0.01). Conclusions Even in the absence of symptoms of atherosclerosis, sdLDL particles are associated with increased oxidative stress, which may stimulate a compensatory rise in PON1 DZOase activity. Elevated oxidative stress may significantly affect HDL subclass distribution, resulting in the accumulation of smaller, denser HDL particles with diminished antioxidative capacity.
PB  - Wiley, Hoboken
T2  - European Journal of Clinical Investigation
T1  - Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
VL  - 37
IS  - 9
SP  - 715
EP  - 723
DO  - 10.1111/j.1365-2362.2007.01849.x
ER  - 

@article{
author = "Vekić, Jelena and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana and Spasić, S. and Spasojević-Kalimanovska, Vesna and Topić, Aleksandra and Zeljković, Aleksandra and Stefanović, A. and Zunić, G.",
year = "2007",
abstract = "Background Alterations in plasma lipoprotein subclass distributions affect atherosclerosis risk. Smaller, denser low-density lipoprotein (LDL) particles (sdLDL) are more susceptible to oxidation. In contrast, most of the protective effects of high-density lipoproteins (HDL) are attributable to larger particles. This study investigates the connection between LDL and HDL particle heterogeneity and oxidative stress, antioxidative defence (AOD) and paraoxonase (PON1) status in a healthy middle-aged Serbian population. Materials and methods LDL and HDL particle sizes and subclass distributions were measured by gradient gel electrophoresis in 104 men and 103 women, aged 53 +/- 9.4 years. PON1 activities and PON1(Q192R) phenotypes were determined with paraoxon and diazoxon as substrates. The oxidative stress/AOD status was estimated by measuring malondialdehyde (MDA) and superoxide-anion (O-2(.-)) levels and superoxide-dismutase (SOD) activity. Results Subjects with sdLDL had significantly higher MDA (P  lt  0.001) and O-2(.-) (P  lt  0.05) levels and greater diazoxonase (DZOase) activity (P  lt  0.05) compared to subjects with larger LDL particles. A high MDA concentration was a significant predictor of the sdLDL phenotype (P  lt  0.005). Increased levels of O-2(.-) and MDA were associated with smaller HDL3 subclass abundance. Reduced HDL particle size was associated with lower DZOase activity (P  lt  0.01). Conclusions Even in the absence of symptoms of atherosclerosis, sdLDL particles are associated with increased oxidative stress, which may stimulate a compensatory rise in PON1 DZOase activity. Elevated oxidative stress may significantly affect HDL subclass distribution, resulting in the accumulation of smaller, denser HDL particles with diminished antioxidative capacity.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Clinical Investigation",
title = "Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects",
volume = "37",
number = "9",
pages = "715-723",
doi = "10.1111/j.1365-2362.2007.01849.x"
}

Vekić, J., Kotur-Stevuljević, J., Jelić-Ivanović, Z., Spasić, S., Spasojević-Kalimanovska, V., Topić, A., Zeljković, A., Stefanović, A.,& Zunić, G.. (2007). Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects. in European Journal of Clinical Investigation
Wiley, Hoboken., 37(9), 715-723.
https://doi.org/10.1111/j.1365-2362.2007.01849.x

Vekić J, Kotur-Stevuljević J, Jelić-Ivanović Z, Spasić S, Spasojević-Kalimanovska V, Topić A, Zeljković A, Stefanović A, Zunić G. Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects. in European Journal of Clinical Investigation. 2007;37(9):715-723.
doi:10.1111/j.1365-2362.2007.01849.x .

Vekić, Jelena, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, Spasić, S., Spasojević-Kalimanovska, Vesna, Topić, Aleksandra, Zeljković, Aleksandra, Stefanović, A., Zunić, G., "Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects" in European Journal of Clinical Investigation, 37, no. 9 (2007):715-723,
https://doi.org/10.1111/j.1365-2362.2007.01849.x . .

TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/969
AB  - Background: Many studies have investigated the clinical accuracy of single lipid and inflammatory markers. in contrast, few have evaluated their potential for the detection of CAD using a multi-marker approach. Methods: The concentrations of lipid, lipoproteins, apolipoproteins, high sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured by standard laboratory methods. Apolipoprotein (a) [apo(a)] phenotyping was performed by sodium dodecylsulphate-gel electrophoresis and immunoblotting. The lipid tetrad index (LTI) and the lipid pentad index (LPI) were calculated. Clinical accuracy of the examined parameters, indexes and a logistic regression model was assessed using receiving operative characteristic (ROC) curve analysis. Results: Logistic regression analysis indicated that non-HDL-c, hs-CRP, HDL-c and Lp(a) were significant independent predictors for CAD. The AUC for this model (0.802) was higher than AUCs for any single marker or index tested. Conclusions: We conclude that the performance of a logistic regression model for CAD prediction warrants its use in clinical practice.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach
VL  - 40
IS  - 13-14
SP  - 1000
EP  - 1006
DO  - 10.1016/j.clinbiochem.2007.05.012
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Kalimanovska-Oštrić, Dimitra",
year = "2007",
abstract = "Background: Many studies have investigated the clinical accuracy of single lipid and inflammatory markers. in contrast, few have evaluated their potential for the detection of CAD using a multi-marker approach. Methods: The concentrations of lipid, lipoproteins, apolipoproteins, high sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured by standard laboratory methods. Apolipoprotein (a) [apo(a)] phenotyping was performed by sodium dodecylsulphate-gel electrophoresis and immunoblotting. The lipid tetrad index (LTI) and the lipid pentad index (LPI) were calculated. Clinical accuracy of the examined parameters, indexes and a logistic regression model was assessed using receiving operative characteristic (ROC) curve analysis. Results: Logistic regression analysis indicated that non-HDL-c, hs-CRP, HDL-c and Lp(a) were significant independent predictors for CAD. The AUC for this model (0.802) was higher than AUCs for any single marker or index tested. Conclusions: We conclude that the performance of a logistic regression model for CAD prediction warrants its use in clinical practice.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach",
volume = "40",
number = "13-14",
pages = "1000-1006",
doi = "10.1016/j.clinbiochem.2007.05.012"
}

Bogavac-Stanojević, N., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S.,& Kalimanovska-Oštrić, D.. (2007). Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(13-14), 1000-1006.
https://doi.org/10.1016/j.clinbiochem.2007.05.012

Bogavac-Stanojević N, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Kalimanovska-Oštrić D. Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach. in Clinical Biochemistry. 2007;40(13-14):1000-1006.
doi:10.1016/j.clinbiochem.2007.05.012 .

Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Kalimanovska-Oštrić, Dimitra, "Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach" in Clinical Biochemistry, 40, no. 13-14 (2007):1000-1006,
https://doi.org/10.1016/j.clinbiochem.2007.05.012 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Topić, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/955
AB  - Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P  lt  0.001, and P  lt  0.05, respectively), higher frequency of LDL B phenotype (P  lt  0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P  lt  0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P  lt  0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population
VL  - 40
IS  - 5-6
SP  - 310
EP  - 316
DO  - 10.1016/j.clinbiochem.2006.11.013
ER  - 

@article{
author = "Vekić, Jelena and Topić, Aleksandra and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna",
year = "2007",
abstract = "Objectives: Small, dense LDL particles are associated with an increased risk of coronary heart disease (CHD), and there is growing evidence that small HDL subclasses are less protective than the larger ones. Very limited information is available about the lipoprotein subclasses among populations living in South-East European region, and none for Serbia. Design and methods: We analyzed the distributions of LDL and HDL subclasses and their relationships with Framingham risk scores (FRS) in 229 Serbian middle-aged asymptomatic individuals. By use of non-denaturing gradient gel electrophoresis, we determined the diameters of LDL and HDL subtractions in a single run. Results: Comparing to women, men had smaller LDL and HDL particles (P  lt  0.001, and P  lt  0.05, respectively), higher frequency of LDL B phenotype (P  lt  0.005), and significant reduction of HDL2b in favor of HDL2a subclasses (P  lt  0.05). The observed gender-related differences disappeared after the age of 60. We found a significant association of the small LDL particles with high FRS values (P  lt  0.005). A notable incidence of risk lipoprotein phenotypes (LDL B-9.2%; small-sized HDL-9.9%) was found among subjects that were categorized as "low-risk", requiring no further intervention, according to FRS. Conclusion: Measurement of LDL, and possibly HDL particle size could provide further insight into individual CHD risk, and enable them to benefit from targeted preventive measures.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population",
volume = "40",
number = "5-6",
pages = "310-316",
doi = "10.1016/j.clinbiochem.2006.11.013"
}

Vekić, J., Topić, A., Zeljković, A., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2007). LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(5-6), 310-316.
https://doi.org/10.1016/j.clinbiochem.2006.11.013

Vekić J, Topić A, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V. LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population. in Clinical Biochemistry. 2007;40(5-6):310-316.
doi:10.1016/j.clinbiochem.2006.11.013 .

Vekić, Jelena, Topić, Aleksandra, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "LDL and HDL subclasses and their relationship with Framingham risk score in middle-aged Serbian population" in Clinical Biochemistry, 40, no. 5-6 (2007):310-316,
https://doi.org/10.1016/j.clinbiochem.2006.11.013 . .