Ministry of Science, Technologies and development of Republic of Serbia (Project No. 1458)

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Ministry of Science, Technologies and development of Republic of Serbia (Project No. 1458)

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Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine

Aleksić, Mara; Ilić, Miloš; Kapetanović, Vera

(Elsevier B.V., 2004)

TY  - JOUR
AU  - Aleksić, Mara
AU  - Ilić, Miloš
AU  - Kapetanović, Vera
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5467
AB  - Abstract
It was found that the reduction of the cefpodoxime proxetil (CP) molecule is strongly influenced by the adsorption. The adsorptive
properties of CP were investigated in order to achieve an increase sensitivity of its determination. Validated adsorptive stripping differential
pulse voltammetry is applied for the determination of low concentration of CP at pH 3.5 and 9.0 where the best pronounced adsorption effects
were observed. The linearity of the calibration curves were achieved from 1 × 10−8 to 1 × 10−7 M with limit of detection (LOD) of 6.3×10−9
and 7.1 × 10−9 M, and limit of quantification (LOQ) of 2.1 × 10−8 and 2.3 × 10−8 M, at pH 3.5 and 9.0, respectively. The proposed method
was tested for CP determination in spiked urine samples, enabling determination of low concentrations of CP.
PB  - Elsevier B.V.
T2  - Journal of Pharmaceutical and Biomedical  Analysis
T1  - Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine
VL  - 36
IS  - 4
SP  - 899
EP  - 993
DO  - 10.1016/j.jpba.2004.08.035
ER  - 
@article{
author = "Aleksić, Mara and Ilić, Miloš and Kapetanović, Vera",
year = "2004",
abstract = "Abstract
It was found that the reduction of the cefpodoxime proxetil (CP) molecule is strongly influenced by the adsorption. The adsorptive
properties of CP were investigated in order to achieve an increase sensitivity of its determination. Validated adsorptive stripping differential
pulse voltammetry is applied for the determination of low concentration of CP at pH 3.5 and 9.0 where the best pronounced adsorption effects
were observed. The linearity of the calibration curves were achieved from 1 × 10−8 to 1 × 10−7 M with limit of detection (LOD) of 6.3×10−9
and 7.1 × 10−9 M, and limit of quantification (LOQ) of 2.1 × 10−8 and 2.3 × 10−8 M, at pH 3.5 and 9.0, respectively. The proposed method
was tested for CP determination in spiked urine samples, enabling determination of low concentrations of CP.",
publisher = "Elsevier B.V.",
journal = "Journal of Pharmaceutical and Biomedical  Analysis",
title = "Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine",
volume = "36",
number = "4",
pages = "899-993",
doi = "10.1016/j.jpba.2004.08.035"
}
Aleksić, M., Ilić, M.,& Kapetanović, V.. (2004). Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine. in Journal of Pharmaceutical and Biomedical  Analysis
Elsevier B.V.., 36(4), 899-993.
https://doi.org/10.1016/j.jpba.2004.08.035
Aleksić M, Ilić M, Kapetanović V. Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine. in Journal of Pharmaceutical and Biomedical  Analysis. 2004;36(4):899-993.
doi:10.1016/j.jpba.2004.08.035 .
Aleksić, Mara, Ilić, Miloš, Kapetanović, Vera, "Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine" in Journal of Pharmaceutical and Biomedical  Analysis, 36, no. 4 (2004):899-993,
https://doi.org/10.1016/j.jpba.2004.08.035 . .
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