TY  - JOUR
AU  - Ušjak, Ljuboš
AU  - Sofrenić, I
AU  - Tešević, Vele
AU  - Drobac, Milica
AU  - Niketić, Marjan
AU  - Petrović, Silvana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3281
AB  - Fatty acids (FAs), sterols, and triterpenes of dichloromethane extracts of the fruits of 8 Heracleum L. taxa (Apiaceae) from southeastern Europe were investigated by gas chromatography with flame ionization detector and gas chromatography with mass spectrometry. In order to analyze the FAs, their volatile methyl esters were obtained by saponification and subsequent esterification of oily supernatants of the fruit extracts. Dominant was petroselinic acid (42.8%-56.5%), followed by linoleic (20.3%-33.3%) and oleic acids (12.3%-13.7%). Sterols and triterpenes were analyzed as volatile derivatives obtained by the silanization of residual unsaponifiable fractions. Among them, the most abundant was β-sitosterol (44.9%-56.9%), followed by stigmasterol (15.7%-25.0%), Δ7-stigmastenol (6.6%-12.5%), and campesterol (5.2%-8.1%). The quantity of petroselinic acid was also determined by the external standard method (298.8-433.4 mg/g of oily supernatant). The obtained results show that the investigated plants are potential valuable sources of the compounds utilized in different industries.
PB  - Natural Product Incorporation
T2  - Natural Product Communications
T1  - Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa
VL  - 14
IS  - 6
DO  - 10.1177/1934578X19856788
ER  - 

@article{
author = "Ušjak, Ljuboš and Sofrenić, I and Tešević, Vele and Drobac, Milica and Niketić, Marjan and Petrović, Silvana",
year = "2019",
abstract = "Fatty acids (FAs), sterols, and triterpenes of dichloromethane extracts of the fruits of 8 Heracleum L. taxa (Apiaceae) from southeastern Europe were investigated by gas chromatography with flame ionization detector and gas chromatography with mass spectrometry. In order to analyze the FAs, their volatile methyl esters were obtained by saponification and subsequent esterification of oily supernatants of the fruit extracts. Dominant was petroselinic acid (42.8%-56.5%), followed by linoleic (20.3%-33.3%) and oleic acids (12.3%-13.7%). Sterols and triterpenes were analyzed as volatile derivatives obtained by the silanization of residual unsaponifiable fractions. Among them, the most abundant was β-sitosterol (44.9%-56.9%), followed by stigmasterol (15.7%-25.0%), Δ7-stigmastenol (6.6%-12.5%), and campesterol (5.2%-8.1%). The quantity of petroselinic acid was also determined by the external standard method (298.8-433.4 mg/g of oily supernatant). The obtained results show that the investigated plants are potential valuable sources of the compounds utilized in different industries.",
publisher = "Natural Product Incorporation",
journal = "Natural Product Communications",
title = "Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa",
volume = "14",
number = "6",
doi = "10.1177/1934578X19856788"
}

Ušjak, L., Sofrenić, I., Tešević, V., Drobac, M., Niketić, M.,& Petrović, S.. (2019). Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa. in Natural Product Communications
Natural Product Incorporation., 14(6).
https://doi.org/10.1177/1934578X19856788

Ušjak L, Sofrenić I, Tešević V, Drobac M, Niketić M, Petrović S. Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa. in Natural Product Communications. 2019;14(6).
doi:10.1177/1934578X19856788 .

Ušjak, Ljuboš, Sofrenić, I, Tešević, Vele, Drobac, Milica, Niketić, Marjan, Petrović, Silvana, "Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa" in Natural Product Communications, 14, no. 6 (2019),
https://doi.org/10.1177/1934578X19856788 . .

TY  - CONF
AU  - Ušjak, Ljuboš
AU  - Sofrenić, Ivana
AU  - Tešević, Vele
AU  - Drobac, Milica
AU  - Niketić, Marjan
AU  - Petrović, Silvana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5241
AB  - Taksoni roda Heracleum L. su rasprostranjeni predstavnici familije Apiaceae, koji bi mogli biti od značaja u raznim granama industrije. Predmet ovog ispitivanja su masne kiseline, steroli i triterpeni masnih ulja plodova H. sphondylium L., H. sibiricum L., H. montanum Schleich. ex Gaudin, H. ternatum Velen., H. pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti, H. pyrenaicum subsp. orsinii (Guss.) F. Pedrotti & Pignatti, H. verticillatum Pančić i H. orphanidis Boiss., sakupljenih u Srbiji, Makedoniji, Crnoj Gori i Sloveniji. Osušeni i samleveni plodovi ekstrahovani su dihlormetanom postupkom bimaceracije na sobnoj temperaturi. Rastvarač je uklonjen pod sniženim pritiskom, ekstrakti filtrirani i dobijeni supernatanti podvrgnuti postupku saponifikacije. Saponifikovane frakcije, bogate masnim kiselinama, su metilovane, a nesaponifikovane frakcije, koje prvenstveno sadrže sterole i triterpene, silanizovane, u cilju dobijanja isparljivih derivata, koji su analizirani gasnom hromatografijom (GC‐FID i GC‐MS). Komponente su identifikovane pomoću komercijalnih standarda i biblioteka masenih spektara. Šesnaest od ukupno osamnaest identifikovanih masnih kiselina su detektovane u svim saponifikovanim frakcijama, a dominantne su bile petroselinska (42,8‐56,5 %), linolna (20,3‐33,3 %) i oleinska (12,3‐13,7 %) kiselina. U svakoj nesaponifikovanoj frakciji identifikovani su triterpen α‐amirin (0,8‐6,0 %) i devet istih sterola, od kojih je najzastupljeniji bio β‐sitosterol (44,9‐56,9 %), a sledili su ga po količini stigmasterol (15,7‐25,0 %), Δ7‐stigmastenol (6,6‐12,5 %) i kampesterol (5,2‐8,1 %). Kao najznačajnije može se istaći prisustvo petroselinske kiseline, potencijalno važne sirovine za farmaceutsku, kozmetičku, prehrambenu i hemijsku industriju. U ovom radu, masne kiseline, steroli i triterpeni masnih ulja plodova H. ternatum, H. pyrenaicum subsp. pollinianum, H. verticillatum i H. orphanidis ispitivani su po prvi put, a u slučaju H. sphondylium, H. sibiricum, H. montanum i H. pyrenaicum subsp. orsinii, postojeći podaci o ovim sastojcima masnih ulja su značajno dopunjeni. Dobijeni rezultati pružaju dobru osnovu za dalja istraživanja, u cilju primene ovih biljaka kao potencijalnih novih izvora industrijski značajnih masnih ulja.
AB  - Heracleum L. taxa are widespread members of Apiaceae family, with potential application in different industries. Focus of this study was on fatty acids, sterols and triterpenes of the fruit fatty oils of H. sphondylium L., H. sibiricum L., H. montanum Schleich. ex Gaudin, H. ternatum Velen., H. pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti, H. pyrenaicum subsp. orsinii (Guss.) F. Pedrotti & Pignatti, H. verticillatum Pančić and H. orphanidis Boiss., collected in Serbia, Macedonia, Montenegro and Slovenia. Air‐dried and powdered fruits were bimacerated with dichloromethane at room temperature. Solvent was evaporated under reduced pressure, extracts were filtered and obtained oily residues were subjected to saponification. Saponifiable fractions, rich in fatty acids, were further subjected to methylation, and unsaponifiable fractions, mostly containing sterols and triterpenes, to silanization, to obtain volatile derivatives that were analyzed by GC‐FID and GC‐MS. Compounds were identified using commercial standards and mass spectra libraries. Sixteen of the total of eighteen identified fatty acids were detected in all saponifiable fractions, with petroselinic (42.8‐56.5 %), linoleic (20.3‐33.3 %) and oleic (12.3‐13.7 %) acids being the most abundant. In every unsaponifiable fraction, a triterpene α‐amyrin (0.8‐6.0 %) and the same nine sterols, predominantly β‐sitosterol (44.9‐56.9 %), followed by stigmasterol (15.7‐25.0 %), Δ7‐stigmastenol (6.6‐12.5 %) and campesterol (5.2‐8.1 %), were identified. The most notably, petroselinic acid can be utilized in pharmaceutical, cosmetic, food and chemical industries. In this research, fatty acids, sterols and triterpenes of the fruit fatty oils of H. ternatum, H. pyrenaicum subsp. pollinianum, H. verticillatum and H. orphanidis were investigated for the first time, while in the case of H. sphondylium, H. sibiricum, H. montanum and H. pyrenaicum subsp. orsinii, the knowledge about their fatty oils constituents was enhanced. Obtained results provide a good basis for further investigations, aiming to establish these plants as potential sources of valuable novel raw materials.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Masne kiseline, steroli i triterpeni masnih ulja plodova osam taksona roda Heracleum L. iz jugoistočne Evrope
T1  - Fatty acids, sterols and triterpenes of the fruit fatty oils of eight Heracleum L. taxa from Southeastern Europe
VL  - 68
IS  - 3
SP  - 700
EP  - 701
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5241
ER  - 

@conference{
author = "Ušjak, Ljuboš and Sofrenić, Ivana and Tešević, Vele and Drobac, Milica and Niketić, Marjan and Petrović, Silvana",
year = "2018",
abstract = "Taksoni roda Heracleum L. su rasprostranjeni predstavnici familije Apiaceae, koji bi mogli biti od značaja u raznim granama industrije. Predmet ovog ispitivanja su masne kiseline, steroli i triterpeni masnih ulja plodova H. sphondylium L., H. sibiricum L., H. montanum Schleich. ex Gaudin, H. ternatum Velen., H. pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti, H. pyrenaicum subsp. orsinii (Guss.) F. Pedrotti & Pignatti, H. verticillatum Pančić i H. orphanidis Boiss., sakupljenih u Srbiji, Makedoniji, Crnoj Gori i Sloveniji. Osušeni i samleveni plodovi ekstrahovani su dihlormetanom postupkom bimaceracije na sobnoj temperaturi. Rastvarač je uklonjen pod sniženim pritiskom, ekstrakti filtrirani i dobijeni supernatanti podvrgnuti postupku saponifikacije. Saponifikovane frakcije, bogate masnim kiselinama, su metilovane, a nesaponifikovane frakcije, koje prvenstveno sadrže sterole i triterpene, silanizovane, u cilju dobijanja isparljivih derivata, koji su analizirani gasnom hromatografijom (GC‐FID i GC‐MS). Komponente su identifikovane pomoću komercijalnih standarda i biblioteka masenih spektara. Šesnaest od ukupno osamnaest identifikovanih masnih kiselina su detektovane u svim saponifikovanim frakcijama, a dominantne su bile petroselinska (42,8‐56,5 %), linolna (20,3‐33,3 %) i oleinska (12,3‐13,7 %) kiselina. U svakoj nesaponifikovanoj frakciji identifikovani su triterpen α‐amirin (0,8‐6,0 %) i devet istih sterola, od kojih je najzastupljeniji bio β‐sitosterol (44,9‐56,9 %), a sledili su ga po količini stigmasterol (15,7‐25,0 %), Δ7‐stigmastenol (6,6‐12,5 %) i kampesterol (5,2‐8,1 %). Kao najznačajnije može se istaći prisustvo petroselinske kiseline, potencijalno važne sirovine za farmaceutsku, kozmetičku, prehrambenu i hemijsku industriju. U ovom radu, masne kiseline, steroli i triterpeni masnih ulja plodova H. ternatum, H. pyrenaicum subsp. pollinianum, H. verticillatum i H. orphanidis ispitivani su po prvi put, a u slučaju H. sphondylium, H. sibiricum, H. montanum i H. pyrenaicum subsp. orsinii, postojeći podaci o ovim sastojcima masnih ulja su značajno dopunjeni. Dobijeni rezultati pružaju dobru osnovu za dalja istraživanja, u cilju primene ovih biljaka kao potencijalnih novih izvora industrijski značajnih masnih ulja., Heracleum L. taxa are widespread members of Apiaceae family, with potential application in different industries. Focus of this study was on fatty acids, sterols and triterpenes of the fruit fatty oils of H. sphondylium L., H. sibiricum L., H. montanum Schleich. ex Gaudin, H. ternatum Velen., H. pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti, H. pyrenaicum subsp. orsinii (Guss.) F. Pedrotti & Pignatti, H. verticillatum Pančić and H. orphanidis Boiss., collected in Serbia, Macedonia, Montenegro and Slovenia. Air‐dried and powdered fruits were bimacerated with dichloromethane at room temperature. Solvent was evaporated under reduced pressure, extracts were filtered and obtained oily residues were subjected to saponification. Saponifiable fractions, rich in fatty acids, were further subjected to methylation, and unsaponifiable fractions, mostly containing sterols and triterpenes, to silanization, to obtain volatile derivatives that were analyzed by GC‐FID and GC‐MS. Compounds were identified using commercial standards and mass spectra libraries. Sixteen of the total of eighteen identified fatty acids were detected in all saponifiable fractions, with petroselinic (42.8‐56.5 %), linoleic (20.3‐33.3 %) and oleic (12.3‐13.7 %) acids being the most abundant. In every unsaponifiable fraction, a triterpene α‐amyrin (0.8‐6.0 %) and the same nine sterols, predominantly β‐sitosterol (44.9‐56.9 %), followed by stigmasterol (15.7‐25.0 %), Δ7‐stigmastenol (6.6‐12.5 %) and campesterol (5.2‐8.1 %), were identified. The most notably, petroselinic acid can be utilized in pharmaceutical, cosmetic, food and chemical industries. In this research, fatty acids, sterols and triterpenes of the fruit fatty oils of H. ternatum, H. pyrenaicum subsp. pollinianum, H. verticillatum and H. orphanidis were investigated for the first time, while in the case of H. sphondylium, H. sibiricum, H. montanum and H. pyrenaicum subsp. orsinii, the knowledge about their fatty oils constituents was enhanced. Obtained results provide a good basis for further investigations, aiming to establish these plants as potential sources of valuable novel raw materials.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Masne kiseline, steroli i triterpeni masnih ulja plodova osam taksona roda Heracleum L. iz jugoistočne Evrope, Fatty acids, sterols and triterpenes of the fruit fatty oils of eight Heracleum L. taxa from Southeastern Europe",
volume = "68",
number = "3",
pages = "700-701",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5241"
}

Ušjak, L., Sofrenić, I., Tešević, V., Drobac, M., Niketić, M.,& Petrović, S.. (2018). Masne kiseline, steroli i triterpeni masnih ulja plodova osam taksona roda Heracleum L. iz jugoistočne Evrope. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 68(3), 700-701.
https://hdl.handle.net/21.15107/rcub_farfar_5241

Ušjak L, Sofrenić I, Tešević V, Drobac M, Niketić M, Petrović S. Masne kiseline, steroli i triterpeni masnih ulja plodova osam taksona roda Heracleum L. iz jugoistočne Evrope. in Arhiv za farmaciju. 2018;68(3):700-701.
https://hdl.handle.net/21.15107/rcub_farfar_5241 .

Ušjak, Ljuboš, Sofrenić, Ivana, Tešević, Vele, Drobac, Milica, Niketić, Marjan, Petrović, Silvana, "Masne kiseline, steroli i triterpeni masnih ulja plodova osam taksona roda Heracleum L. iz jugoistočne Evrope" in Arhiv za farmaciju, 68, no. 3 (2018):700-701,
https://hdl.handle.net/21.15107/rcub_farfar_5241 .

TY  - JOUR
AU  - Mandić, Boris M.
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana
AU  - Simić, Milena
AU  - Vujisić, Ljubodrag V.
AU  - Vucković, Ivan M.
AU  - Novaković, Miroslav
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2412
AB  - Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge
VL  - 29
IS  - 9
SP  - 887
EP  - 890
DO  - 10.1080/14786419.2014.991929
ER  - 

@article{
author = "Mandić, Boris M. and Vlajić, Marina D. and Trifunović, Snežana and Simić, Milena and Vujisić, Ljubodrag V. and Vucković, Ivan M. and Novaković, Miroslav and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2015",
abstract = "Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge",
volume = "29",
number = "9",
pages = "887-890",
doi = "10.1080/14786419.2014.991929"
}

Mandić, B. M., Vlajić, M. D., Trifunović, S., Simić, M., Vujisić, L. V., Vucković, I. M., Novaković, M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(9), 887-890.
https://doi.org/10.1080/14786419.2014.991929

Mandić BM, Vlajić MD, Trifunović S, Simić M, Vujisić LV, Vucković IM, Novaković M, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević S. Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research. 2015;29(9):887-890.
doi:10.1080/14786419.2014.991929 .

Mandić, Boris M., Vlajić, Marina D., Trifunović, Snežana, Simić, Milena, Vujisić, Ljubodrag V., Vucković, Ivan M., Novaković, Miroslav, Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge" in Natural Product Research, 29, no. 9 (2015):887-890,
https://doi.org/10.1080/14786419.2014.991929 . .

TY  - JOUR
AU  - Mandić, Boris M.
AU  - Simić, Milena
AU  - Vucković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, Miroslav
AU  - Trifunović, Snežana
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1894
AB  - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
PB  - MDPI, Basel
T2  - Molecules
T1  - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
VL  - 18
IS  - 9
SP  - 10694
EP  - 10706
DO  - 10.3390/molecules180910694
ER  - 

@article{
author = "Mandić, Boris M. and Simić, Milena and Vucković, Ivan M. and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2013",
abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.",
publisher = "MDPI, Basel",
journal = "Molecules",
title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization",
volume = "18",
number = "9",
pages = "10694-10706",
doi = "10.3390/molecules180910694"
}

Mandić, B. M., Simić, M., Vucković, I. M., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules
MDPI, Basel., 18(9), 10694-10706.
https://doi.org/10.3390/molecules180910694

Mandić BM, Simić M, Vucković IM, Vujisić LV, Novaković M, Trifunović S, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706.
doi:10.3390/molecules180910694 .

Mandić, Boris M., Simić, Milena, Vucković, Ivan M., Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706,
https://doi.org/10.3390/molecules180910694 . .