TY  - JOUR
AU  - Savić, Miroslav
AU  - Kukić-Marković, Jelena
AU  - Grayer, Renee J.
AU  - Milinković, Marija M.
AU  - Marin, Petar
AU  - Divljaković, Jovana
AU  - van Linn, Michael
AU  - Cook, James M.
AU  - Petrović, Silvana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1336
AB  - We performed a basic behavioral characterization of methanol extracts of four Balkan endemic Stachys taxa: S. anisochila (SA), S. beckeana (SB), S. plumosa (SP) and S. alpina subsp. dinarica (SAD). The behavioral activity of extracts dosed intraperitoneally in the range 100-400 mg/kg was examined in adult male Wistar rats, in the elevated plus maze, spontaneous locomotor activity, and grip strength tests, mainly predictive of anxiolytic, sedative and myorelaxant actions, respectively. All investigated Stachys extracts lacked anxiolytic or myorelaxant activities, while SB at 400 mg/kg exerted an anxiogenic-like effect. The study with the selective antagonist beta-CCt showed that the sedative effect of SAD was only partially mediated by GABAA receptors containing the alpha 1-subunit. While discernible, the behavioral effects of SA and SP were not distinct. In all extracts, chlorogenic acid and verbascoside were identified. In SA, SB, and SAD the flavonoid fraction was constituted of isoscutellarein and hypolaetine glycosides, while in SP chrysoeriol and apigenin glycosides were present. The results reveal the psychotropic potential of four endemic Stachys taxa, of which SAD appeared most promising as a natural sedative. Copyright
PB  - Wiley-Blackwell, Malden
T2  - Phytotherapy Research
T1  - Behavioural Characterization of Four Endemic Stachys Taxa
VL  - 24
IS  - 9
SP  - 1309
EP  - 1316
DO  - 10.1002/ptr.3106
ER  - 

@article{
author = "Savić, Miroslav and Kukić-Marković, Jelena and Grayer, Renee J. and Milinković, Marija M. and Marin, Petar and Divljaković, Jovana and van Linn, Michael and Cook, James M. and Petrović, Silvana",
year = "2010",
abstract = "We performed a basic behavioral characterization of methanol extracts of four Balkan endemic Stachys taxa: S. anisochila (SA), S. beckeana (SB), S. plumosa (SP) and S. alpina subsp. dinarica (SAD). The behavioral activity of extracts dosed intraperitoneally in the range 100-400 mg/kg was examined in adult male Wistar rats, in the elevated plus maze, spontaneous locomotor activity, and grip strength tests, mainly predictive of anxiolytic, sedative and myorelaxant actions, respectively. All investigated Stachys extracts lacked anxiolytic or myorelaxant activities, while SB at 400 mg/kg exerted an anxiogenic-like effect. The study with the selective antagonist beta-CCt showed that the sedative effect of SAD was only partially mediated by GABAA receptors containing the alpha 1-subunit. While discernible, the behavioral effects of SA and SP were not distinct. In all extracts, chlorogenic acid and verbascoside were identified. In SA, SB, and SAD the flavonoid fraction was constituted of isoscutellarein and hypolaetine glycosides, while in SP chrysoeriol and apigenin glycosides were present. The results reveal the psychotropic potential of four endemic Stachys taxa, of which SAD appeared most promising as a natural sedative. Copyright",
publisher = "Wiley-Blackwell, Malden",
journal = "Phytotherapy Research",
title = "Behavioural Characterization of Four Endemic Stachys Taxa",
volume = "24",
number = "9",
pages = "1309-1316",
doi = "10.1002/ptr.3106"
}

Savić, M., Kukić-Marković, J., Grayer, R. J., Milinković, M. M., Marin, P., Divljaković, J., van Linn, M., Cook, J. M.,& Petrović, S.. (2010). Behavioural Characterization of Four Endemic Stachys Taxa. in Phytotherapy Research
Wiley-Blackwell, Malden., 24(9), 1309-1316.
https://doi.org/10.1002/ptr.3106

Savić M, Kukić-Marković J, Grayer RJ, Milinković MM, Marin P, Divljaković J, van Linn M, Cook JM, Petrović S. Behavioural Characterization of Four Endemic Stachys Taxa. in Phytotherapy Research. 2010;24(9):1309-1316.
doi:10.1002/ptr.3106 .

Savić, Miroslav, Kukić-Marković, Jelena, Grayer, Renee J., Milinković, Marija M., Marin, Petar, Divljaković, Jovana, van Linn, Michael, Cook, James M., Petrović, Silvana, "Behavioural Characterization of Four Endemic Stachys Taxa" in Phytotherapy Research, 24, no. 9 (2010):1309-1316,
https://doi.org/10.1002/ptr.3106 . .