TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Šavikin, Katarina
AU  - Novaković, Miroslav
AU  - Milosavljević, Slobodan
AU  - Petrović, Silvana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1542
AB  - The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl3, n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS root+ scavenging assays and inhibition of lipid peroxidation. The EtOAc extract of H. richeri was the most potent antioxidant in all experiments. Free radical scavenging compounds were identified by HPLC-DPPH root (high-performance liquid chromatography-2,2-diphenyl-1-picrylhydrazyl) post-column derivatisation method, where all phenolic compounds except I3,II8-biapigenin exhibited radical scavenging properties. This is the first report of the presence of myricetin-3-O-rutinoside, myricetin-3-O-galactoside, myricetin-3-O-glucoside, 5-O-caffeoylquinic acid and I3,II8-biapigenin in H. richeri.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity
VL  - 25
IS  - 3
SP  - 175
EP  - 187
DO  - 10.1080/14786410802401390
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Šavikin, Katarina and Novaković, Miroslav and Milosavljević, Slobodan and Petrović, Silvana",
year = "2011",
abstract = "The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl3, n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS root+ scavenging assays and inhibition of lipid peroxidation. The EtOAc extract of H. richeri was the most potent antioxidant in all experiments. Free radical scavenging compounds were identified by HPLC-DPPH root (high-performance liquid chromatography-2,2-diphenyl-1-picrylhydrazyl) post-column derivatisation method, where all phenolic compounds except I3,II8-biapigenin exhibited radical scavenging properties. This is the first report of the presence of myricetin-3-O-rutinoside, myricetin-3-O-galactoside, myricetin-3-O-glucoside, 5-O-caffeoylquinic acid and I3,II8-biapigenin in H. richeri.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity",
volume = "25",
number = "3",
pages = "175-187",
doi = "10.1080/14786410802401390"
}

Zdunić, G., Gođevac, D., Šavikin, K., Novaković, M., Milosavljević, S.,& Petrović, S.. (2011). Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 25(3), 175-187.
https://doi.org/10.1080/14786410802401390

Zdunić G, Gođevac D, Šavikin K, Novaković M, Milosavljević S, Petrović S. Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. in Natural Product Research. 2011;25(3):175-187.
doi:10.1080/14786410802401390 .

Zdunić, Gordana, Gođevac, Dejan, Šavikin, Katarina, Novaković, Miroslav, Milosavljević, Slobodan, Petrović, Silvana, "Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity" in Natural Product Research, 25, no. 3 (2011):175-187,
https://doi.org/10.1080/14786410802401390 . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Milenković, Marina
AU  - Šavikin, Katarina
AU  - Menković, Nebojša
AU  - Petrović, Silvana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1343
AB  - Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts
VL  - 5
IS  - 8
SP  - 1215
EP  - 1218
DO  - 10.1177/1934578X1000500814
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1343
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Šavikin, Katarina and Menković, Nebojša and Petrović, Silvana",
year = "2010",
abstract = "Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts",
volume = "5",
number = "8",
pages = "1215-1218",
doi = "10.1177/1934578X1000500814",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1343"
}

Zdunić, G., Gođevac, D., Milenković, M., Šavikin, K., Menković, N.,& Petrović, S.. (2010). Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications
Natural Products Inc, Westerville., 5(8), 1215-1218.
https://doi.org/10.1177/1934578X1000500814
https://hdl.handle.net/21.15107/rcub_farfar_1343

Zdunić G, Gođevac D, Milenković M, Šavikin K, Menković N, Petrović S. Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications. 2010;5(8):1215-1218.
doi:10.1177/1934578X1000500814
https://hdl.handle.net/21.15107/rcub_farfar_1343 .

Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Šavikin, Katarina, Menković, Nebojša, Petrović, Silvana, "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts" in Natural Product Communications, 5, no. 8 (2010):1215-1218,
https://doi.org/10.1177/1934578X1000500814 .,
https://hdl.handle.net/21.15107/rcub_farfar_1343 .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Milenković, Marina
AU  - Vučićević, Dragana
AU  - Šavikin, Katarina
AU  - Menković, Nebojša
AU  - Petrović, Silvana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1206
AB  - Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats
VL  - 23
IS  - 11
SP  - 1559
EP  - 1564
DO  - 10.1002/ptr.2809
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Vučićević, Dragana and Šavikin, Katarina and Menković, Nebojša and Petrović, Silvana",
year = "2009",
abstract = "Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats",
volume = "23",
number = "11",
pages = "1559-1564",
doi = "10.1002/ptr.2809"
}

Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N.,& Petrović, S.. (2009). Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats. in Phytotherapy Research
John Wiley & Sons Ltd, Chichester., 23(11), 1559-1564.
https://doi.org/10.1002/ptr.2809

Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, Petrović S. Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats. in Phytotherapy Research. 2009;23(11):1559-1564.
doi:10.1002/ptr.2809 .

Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Vučićević, Dragana, Šavikin, Katarina, Menković, Nebojša, Petrović, Silvana, "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats" in Phytotherapy Research, 23, no. 11 (2009):1559-1564,
https://doi.org/10.1002/ptr.2809 . .