TY  - JOUR
AU  - Koss-Mikołajczyk, Izabela
AU  - Todorović, Vanja
AU  - Šobajić, Slađana
AU  - Mahajna, Jamal
AU  - Gerić, Marko
AU  - Tur, Josep A.
AU  - Bartoszek, Agnieszka
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3971
AB  - Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review
VL  - 22
IS  - 18
DO  - 10.3390/ijms221810037
ER  - 

@article{
author = "Koss-Mikołajczyk, Izabela and Todorović, Vanja and Šobajić, Slađana and Mahajna, Jamal and Gerić, Marko and Tur, Josep A. and Bartoszek, Agnieszka",
year = "2021",
abstract = "Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review",
volume = "22",
number = "18",
doi = "10.3390/ijms221810037"
}

Koss-Mikołajczyk, I., Todorović, V., Šobajić, S., Mahajna, J., Gerić, M., Tur, J. A.,& Bartoszek, A.. (2021). Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences
MDPI., 22(18).
https://doi.org/10.3390/ijms221810037

Koss-Mikołajczyk I, Todorović V, Šobajić S, Mahajna J, Gerić M, Tur JA, Bartoszek A. Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences. 2021;22(18).
doi:10.3390/ijms221810037 .

Koss-Mikołajczyk, Izabela, Todorović, Vanja, Šobajić, Slađana, Mahajna, Jamal, Gerić, Marko, Tur, Josep A., Bartoszek, Agnieszka, "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review" in International Journal of Molecular Sciences, 22, no. 18 (2021),
https://doi.org/10.3390/ijms221810037 . .