TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4410
AB  - In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for
semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the
obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by
lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug
kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has
shown good thermal stability, mechanical properties, and prolonged release of IBU following the
Fickian diffusion process.
AB  - Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery
T1  - 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu
VL  - 72
IS  - 6
SP  - 661
EP  - 673
DO  - 10.5937/arhfarm72-40262
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2022",
abstract = "In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for
semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the
obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by
lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug
kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has
shown good thermal stability, mechanical properties, and prolonged release of IBU following the
Fickian diffusion process., Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery, 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu",
volume = "72",
number = "6",
pages = "661-673",
doi = "10.5937/arhfarm72-40262"
}

Jovanović, M., Petrović, M., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2022). Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 661-673.
https://doi.org/10.5937/arhfarm72-40262

Jovanović M, Petrović M, Stojanović D, Ibrić S, Uskoković P. Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za farmaciju. 2022;72(6):661-673.
doi:10.5937/arhfarm72-40262 .

Jovanović, Marija, Petrović, Miloš, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery" in Arhiv za farmaciju, 72, no. 6 (2022):661-673,
https://doi.org/10.5937/arhfarm72-40262 . .