TY  - JOUR
AU  - Solomun, Ljiljana
AU  - Ibrić, Svetlana
AU  - Vajs, Vlatka
AU  - Vucković, Ivan M.
AU  - Vujić, Zorica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1426
AB  - In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections, was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylprednisolone esters (17-hydrogen succinate and 21-hydrogen succinate) and free methylprednisolone. The HPLC method was used for stability evaluation of the active substance and determination of related substances. Four main degradation products were registered. Temperature has a major impact on the degradation process with the appearance of 3 degradation products (impurities B, C and D), while the presence of light caused an increasing content of impurity A. Identification of impurity B, C and D has been realized using mass and NMR spectroscopy. All three substances are substances related to methylprednisolone.
AB  - U ovom radu ispitivane su osobine farmakološki aktivne supstance metilprednizolona (u obliku metilprednizolon-natrijum-sukcinata) u gotovom proizvodu - liofilizatu za rastvor za injekcije. Cilj rada je ispitivanje hemijske stabilnosti metilpredni-zolon-natrijum-sukcinata u dvokomornoj bočici, kao specifičnom sistemu kontaktnog pakovanja. Ispitan je efekat različitih parametara: temperature, vlage i svetlosti. Za određivanje koncentracije metilprednizolona, kao zbirne koncentracije metilprednizolon estara (17-hidrogen-sukcinata i 21-hidrogen-sukcinata) i slobodnog metilprednizolona, korišćena je metoda opisana u Američkoj farmakopeji. Za ispitivanje srodnih supstanci primenjena je HPLC metoda. Uočena su 4 degradaciona proizvoda. Dokazano je da povećanje temperature ima najveći značaj na proces degradacije i utiče na povećanje sadržaja nečistoća B, C i D, dok prisustvo svetlosti dovodi do povećanja sadržaja nečistoće A. Nečistoće B, C i D su identifikovane primenom masene i NMR spektroskopije. Sve tri nečistoće su identifikovane kao srodne supstance metilprednizolona.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Methylprednisolone and its related substances in freeze-dried powders for injections
T1  - Metilprednizolon i njegove srodne supstance u liofilizatu za rastvor za injekcije
VL  - 75
IS  - 10
SP  - 1441
EP  - 1452
DO  - 10.2298/JSC100115087S
ER  - 

@article{
author = "Solomun, Ljiljana and Ibrić, Svetlana and Vajs, Vlatka and Vucković, Ivan M. and Vujić, Zorica",
year = "2010",
abstract = "In this work, the behavior of the active pharmaceutical substances methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form, i.e., freeze-dried powder for injections, was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in a dual chamber vial, as a specific container closure system. The effect of different parameters: temperature, moisture and light were monitored. The method proposed by United States Pharmacopeia was used to determine concentrations of methylprednisolone, as the sum of the concentration of methylprednisolone esters (17-hydrogen succinate and 21-hydrogen succinate) and free methylprednisolone. The HPLC method was used for stability evaluation of the active substance and determination of related substances. Four main degradation products were registered. Temperature has a major impact on the degradation process with the appearance of 3 degradation products (impurities B, C and D), while the presence of light caused an increasing content of impurity A. Identification of impurity B, C and D has been realized using mass and NMR spectroscopy. All three substances are substances related to methylprednisolone., U ovom radu ispitivane su osobine farmakološki aktivne supstance metilprednizolona (u obliku metilprednizolon-natrijum-sukcinata) u gotovom proizvodu - liofilizatu za rastvor za injekcije. Cilj rada je ispitivanje hemijske stabilnosti metilpredni-zolon-natrijum-sukcinata u dvokomornoj bočici, kao specifičnom sistemu kontaktnog pakovanja. Ispitan je efekat različitih parametara: temperature, vlage i svetlosti. Za određivanje koncentracije metilprednizolona, kao zbirne koncentracije metilprednizolon estara (17-hidrogen-sukcinata i 21-hidrogen-sukcinata) i slobodnog metilprednizolona, korišćena je metoda opisana u Američkoj farmakopeji. Za ispitivanje srodnih supstanci primenjena je HPLC metoda. Uočena su 4 degradaciona proizvoda. Dokazano je da povećanje temperature ima najveći značaj na proces degradacije i utiče na povećanje sadržaja nečistoća B, C i D, dok prisustvo svetlosti dovodi do povećanja sadržaja nečistoće A. Nečistoće B, C i D su identifikovane primenom masene i NMR spektroskopije. Sve tri nečistoće su identifikovane kao srodne supstance metilprednizolona.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Methylprednisolone and its related substances in freeze-dried powders for injections, Metilprednizolon i njegove srodne supstance u liofilizatu za rastvor za injekcije",
volume = "75",
number = "10",
pages = "1441-1452",
doi = "10.2298/JSC100115087S"
}

Solomun, L., Ibrić, S., Vajs, V., Vucković, I. M.,& Vujić, Z.. (2010). Methylprednisolone and its related substances in freeze-dried powders for injections. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(10), 1441-1452.
https://doi.org/10.2298/JSC100115087S

Solomun L, Ibrić S, Vajs V, Vucković IM, Vujić Z. Methylprednisolone and its related substances in freeze-dried powders for injections. in Journal of the Serbian Chemical Society. 2010;75(10):1441-1452.
doi:10.2298/JSC100115087S .

Solomun, Ljiljana, Ibrić, Svetlana, Vajs, Vlatka, Vucković, Ivan M., Vujić, Zorica, "Methylprednisolone and its related substances in freeze-dried powders for injections" in Journal of the Serbian Chemical Society, 75, no. 10 (2010):1441-1452,
https://doi.org/10.2298/JSC100115087S . .

TY  - JOUR
AU  - Grigg, Ronald
AU  - Husinec, Suren
AU  - Savić, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1417
AB  - Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated.
AB  - Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes
T1  - Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima
VL  - 75
IS  - 1
SP  - 1
EP  - 9
DO  - 10.2298/JSC1001001G
ER  - 

@article{
author = "Grigg, Ronald and Husinec, Suren and Savić, Vladimir",
year = "2010",
abstract = "Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimized conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71% e.e. The effects of various reaction variables on the stereoselectivity were also investigated., Proučavane su stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane kompleksima srebra i bisfosfinskog liganda generisanih in situ. Pirolidinski derivati izolovani su u dobrim prinosima i sa enantioselektivnošću do 71%. Proučavani su takođe i efekti reakcionih uslova na stereoselektivnost ovih reakcija.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes, Stereoselektivne cikloadicione reakcije azometinskih ilida katalizovane in situ generisanim Ag(I)/bisfosfinskim kompleksima",
volume = "75",
number = "1",
pages = "1-9",
doi = "10.2298/JSC1001001G"
}

Grigg, R., Husinec, S.,& Savić, V.. (2010). Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 75(1), 1-9.
https://doi.org/10.2298/JSC1001001G

Grigg R, Husinec S, Savić V. Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes. in Journal of the Serbian Chemical Society. 2010;75(1):1-9.
doi:10.2298/JSC1001001G .

Grigg, Ronald, Husinec, Suren, Savić, Vladimir, "Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes" in Journal of the Serbian Chemical Society, 75, no. 1 (2010):1-9,
https://doi.org/10.2298/JSC1001001G . .

TY  - JOUR
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Savić, Vladimir
AU  - Karljiković-Rajić, Katarina
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1388
AB  - A novel topical corticosteroid FA-21-PhP, 2-phenoxypropionate ester of fluocinolone acetonide, has been synthesized in order to investigate the possibility of decreasing systemic side effects. In this study model system for in vitro solvolytic reaction of FA-21-PhP has been analyzed in ethanol/water (90:10, v/v) with excess of sodium hydrogen carbonate. The selected conditions have been used as in vitro model for activation of corticosteroid C-21 ester prodrug. The second-order derivative spectrophotometric method (DS) using zero-crossing technique was developed for monitoring ternary mixture of solvolysis. Fluocinolone acetonide (FA) as a solvolyte was determined in the mixture in the concentration range 0.062-0.312 mM using amplitude (2)D(274.9G). Experimentally determined LOD value was 0.0295 mM. The accuracy of proposed DS method was confirmed with HPLC referent method. Peak area of parent ester FA-21-PhP was used for solvolysis monitoring to ensure the initial stage of changes. Linear relationship in HPLC assay for parent ester was obtained in the concentration range 0.054-0.54 mM, with experimentally determined LOD value of 0.0041 mM. Investigated solvolytic reaction in the presence of excess of NaHCO(3) proceeded via a pseudo-first-order kinetic with significant correlation coefficients 0.9891 and 0.9997 for DS and HPLC, respectively. The values of solvolysis rate constant calculated according to DS and HPLC methods are in good accordance 0.038 and 0.043 h(-1), respectively.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Spectroscopy Letters
T1  - An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester
VL  - 75
IS  - 2
SP  - 930
EP  - 935
DO  - 10.1016/j.saa.2009.12.043
ER  - 

@article{
author = "Marković, Bojan and Vladimirov, Sote and Čudina, Olivera and Savić, Vladimir and Karljiković-Rajić, Katarina",
year = "2010",
abstract = "A novel topical corticosteroid FA-21-PhP, 2-phenoxypropionate ester of fluocinolone acetonide, has been synthesized in order to investigate the possibility of decreasing systemic side effects. In this study model system for in vitro solvolytic reaction of FA-21-PhP has been analyzed in ethanol/water (90:10, v/v) with excess of sodium hydrogen carbonate. The selected conditions have been used as in vitro model for activation of corticosteroid C-21 ester prodrug. The second-order derivative spectrophotometric method (DS) using zero-crossing technique was developed for monitoring ternary mixture of solvolysis. Fluocinolone acetonide (FA) as a solvolyte was determined in the mixture in the concentration range 0.062-0.312 mM using amplitude (2)D(274.9G). Experimentally determined LOD value was 0.0295 mM. The accuracy of proposed DS method was confirmed with HPLC referent method. Peak area of parent ester FA-21-PhP was used for solvolysis monitoring to ensure the initial stage of changes. Linear relationship in HPLC assay for parent ester was obtained in the concentration range 0.054-0.54 mM, with experimentally determined LOD value of 0.0041 mM. Investigated solvolytic reaction in the presence of excess of NaHCO(3) proceeded via a pseudo-first-order kinetic with significant correlation coefficients 0.9891 and 0.9997 for DS and HPLC, respectively. The values of solvolysis rate constant calculated according to DS and HPLC methods are in good accordance 0.038 and 0.043 h(-1), respectively.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Spectroscopy Letters",
title = "An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester",
volume = "75",
number = "2",
pages = "930-935",
doi = "10.1016/j.saa.2009.12.043"
}

Marković, B., Vladimirov, S., Čudina, O., Savić, V.,& Karljiković-Rajić, K.. (2010). An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester. in Spectroscopy Letters
Pergamon-Elsevier Science Ltd, Oxford., 75(2), 930-935.
https://doi.org/10.1016/j.saa.2009.12.043

Marković B, Vladimirov S, Čudina O, Savić V, Karljiković-Rajić K. An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester. in Spectroscopy Letters. 2010;75(2):930-935.
doi:10.1016/j.saa.2009.12.043 .

Marković, Bojan, Vladimirov, Sote, Čudina, Olivera, Savić, Vladimir, Karljiković-Rajić, Katarina, "An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester" in Spectroscopy Letters, 75, no. 2 (2010):930-935,
https://doi.org/10.1016/j.saa.2009.12.043 . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Matić, Silvana
AU  - Kuntić, Vesna
AU  - Vladimirov, Sote
AU  - Uskoković-Marković, Snežana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1339
AB  - A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
VL  - 72
IS  - 5-6
SP  - 581
EP  - 584
DO  - 10.1365/s10337-010-1684-9
ER  - 

@article{
author = "Vujić, Zorica and Matić, Silvana and Kuntić, Vesna and Vladimirov, Sote and Uskoković-Marković, Snežana",
year = "2010",
abstract = "A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products",
volume = "72",
number = "5-6",
pages = "581-584",
doi = "10.1365/s10337-010-1684-9"
}

Vujić, Z., Matić, S., Kuntić, V., Vladimirov, S.,& Uskoković-Marković, S.. (2010). GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia
Springer Heidelberg, Heidelberg., 72(5-6), 581-584.
https://doi.org/10.1365/s10337-010-1684-9

Vujić Z, Matić S, Kuntić V, Vladimirov S, Uskoković-Marković S. GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia. 2010;72(5-6):581-584.
doi:10.1365/s10337-010-1684-9 .

Vujić, Zorica, Matić, Silvana, Kuntić, Vesna, Vladimirov, Sote, Uskoković-Marković, Snežana, "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products" in Chromatographia, 72, no. 5-6 (2010):581-584,
https://doi.org/10.1365/s10337-010-1684-9 . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Crevar, Milkica
AU  - Obradović, Vladimir
AU  - Kuntić, Vesna
AU  - Uskoković-Marković, Snežana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1160
AB  - A rapid and simple liquid chromatographic method with UV detection has been developed for the determination of hydrochlorothiazide (HCTZ), cilazapril (CL) and its active metabolite cilazaprilat (CLT) in urine. Sample preparation for urine consisted of solid-phase extraction using styrene-divinylbenzene (SDB-2) cartridges. The chromatographic system was a Zorbax Eclipse XDB-C-18 column with a mixture of methanol and 10 mM phosphate buffer, pH 2.3 with gradient (20 to 60% of methanol) as mobile phase at a flow rate of 1.0 mL min(-1). The detection was performed at the wavelength of 206 nm. Enalapril maleat was used as an internal standard. The detector response was linear in the range of 2.4-30.0, 1.6-15.0 and 1.8-20.0 mu g mL(-1) for HCTZ, CL and CLT, respectively. LOQ was determined to be 2.4, 1.6 and 1.8 mu g mL(-1) for HCTZ, CL and CLT, respectively. Both intra- and inter-day precision were within acceptable limits. The method has been applied to urine samples obtained from three hypertensive patients after intake of HCTZ and CL therapeutic dose.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC
VL  - 70
IS  - 7-8
SP  - 1221
EP  - 1225
DO  - 10.1365/s10337-009-1286-6
ER  - 

@article{
author = "Vujić, Zorica and Crevar, Milkica and Obradović, Vladimir and Kuntić, Vesna and Uskoković-Marković, Snežana",
year = "2009",
abstract = "A rapid and simple liquid chromatographic method with UV detection has been developed for the determination of hydrochlorothiazide (HCTZ), cilazapril (CL) and its active metabolite cilazaprilat (CLT) in urine. Sample preparation for urine consisted of solid-phase extraction using styrene-divinylbenzene (SDB-2) cartridges. The chromatographic system was a Zorbax Eclipse XDB-C-18 column with a mixture of methanol and 10 mM phosphate buffer, pH 2.3 with gradient (20 to 60% of methanol) as mobile phase at a flow rate of 1.0 mL min(-1). The detection was performed at the wavelength of 206 nm. Enalapril maleat was used as an internal standard. The detector response was linear in the range of 2.4-30.0, 1.6-15.0 and 1.8-20.0 mu g mL(-1) for HCTZ, CL and CLT, respectively. LOQ was determined to be 2.4, 1.6 and 1.8 mu g mL(-1) for HCTZ, CL and CLT, respectively. Both intra- and inter-day precision were within acceptable limits. The method has been applied to urine samples obtained from three hypertensive patients after intake of HCTZ and CL therapeutic dose.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC",
volume = "70",
number = "7-8",
pages = "1221-1225",
doi = "10.1365/s10337-009-1286-6"
}

Vujić, Z., Crevar, M., Obradović, V., Kuntić, V.,& Uskoković-Marković, S.. (2009). Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC. in Chromatographia
Springer Heidelberg, Heidelberg., 70(7-8), 1221-1225.
https://doi.org/10.1365/s10337-009-1286-6

Vujić Z, Crevar M, Obradović V, Kuntić V, Uskoković-Marković S. Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC. in Chromatographia. 2009;70(7-8):1221-1225.
doi:10.1365/s10337-009-1286-6 .

Vujić, Zorica, Crevar, Milkica, Obradović, Vladimir, Kuntić, Vesna, Uskoković-Marković, Snežana, "Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC" in Chromatographia, 70, no. 7-8 (2009):1221-1225,
https://doi.org/10.1365/s10337-009-1286-6 . .

TY  - CONF
AU  - Marković, Bojan
AU  - Vladimirov, S.
AU  - Pitić, D.
AU  - Savić, Vladimir
AU  - Jaćević, Vesna
AU  - Dobrić, Silva
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1196
AB  - In this study it was described synthesis of new C-21 esters of fluocinolone acetonide with alpha-alkoxyalcanoic and alpha-aryloxyalkanoic acids. Esterification with these branched oxyacids has to improve benefit-risk ratio. All synthesized compound were shown some topical anti-inflammatory activity.
PB  - Medimond S R L, 40128 Bologna
C3  - Joint Meeting on Medical Chemistry
T1  - Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide
SP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1196
ER  - 

@conference{
author = "Marković, Bojan and Vladimirov, S. and Pitić, D. and Savić, Vladimir and Jaćević, Vesna and Dobrić, Silva",
year = "2009",
abstract = "In this study it was described synthesis of new C-21 esters of fluocinolone acetonide with alpha-alkoxyalcanoic and alpha-aryloxyalkanoic acids. Esterification with these branched oxyacids has to improve benefit-risk ratio. All synthesized compound were shown some topical anti-inflammatory activity.",
publisher = "Medimond S R L, 40128 Bologna",
journal = "Joint Meeting on Medical Chemistry",
title = "Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide",
pages = "41",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1196"
}

Marković, B., Vladimirov, S., Pitić, D., Savić, V., Jaćević, V.,& Dobrić, S.. (2009). Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide. in Joint Meeting on Medical Chemistry
Medimond S R L, 40128 Bologna., 41.
https://hdl.handle.net/21.15107/rcub_farfar_1196

Marković B, Vladimirov S, Pitić D, Savić V, Jaćević V, Dobrić S. Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide. in Joint Meeting on Medical Chemistry. 2009;:41.
https://hdl.handle.net/21.15107/rcub_farfar_1196 .

Marković, Bojan, Vladimirov, S., Pitić, D., Savić, Vladimir, Jaćević, Vesna, Dobrić, Silva, "Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide" in Joint Meeting on Medical Chemistry (2009):41,
https://hdl.handle.net/21.15107/rcub_farfar_1196 .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Uskoković-Marković, Snežana
AU  - Kuntić, Vesna
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1266
AB  - A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Analytical Letters
T1  - Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization
VL  - 42
IS  - 13
SP  - 2060
EP  - 2070
DO  - 10.1080/00032710903082747
ER  - 

@article{
author = "Vujić, Zorica and Uskoković-Marković, Snežana and Kuntić, Vesna",
year = "2009",
abstract = "A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization",
volume = "42",
number = "13",
pages = "2060-2070",
doi = "10.1080/00032710903082747"
}

Vujić, Z., Uskoković-Marković, S.,& Kuntić, V.. (2009). Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 42(13), 2060-2070.
https://doi.org/10.1080/00032710903082747

Vujić Z, Uskoković-Marković S, Kuntić V. Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters. 2009;42(13):2060-2070.
doi:10.1080/00032710903082747 .

Vujić, Zorica, Uskoković-Marković, Snežana, Kuntić, Vesna, "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization" in Analytical Letters, 42, no. 13 (2009):2060-2070,
https://doi.org/10.1080/00032710903082747 . .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, I.
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirova, S.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1090
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, I. and Karljiković-Rajić, Katarina and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I., Karljiković-Rajić, K.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković I, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, I., Karljiković-Rajić, Katarina, Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .

TY  - JOUR
AU  - Crevar, Milkica
AU  - Ivković, Branka
AU  - Vladimirov, Sote
AU  - Kuntić, Vesna
AU  - Vujić, Zorica
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1064
AB  - Paracetamol, analgoantipyretic and anti-inflammatory drug, is available in numerous pharmaceutical formulations in common combination with caffeine and some other drug substances. p-aminophenol is paracatamol's process-related impurity that also may be present in formulations containing paracetamol. This paper presents a RP-HPLC method for simultaneous determination of caffeine, paracetamol and p-aminophenol, using chromatographic system Hewlett Packard 1100 series. In defining optimal RP-HPLC chromatographic conditions for the separation of these three compounds, experimental design was applied. Completely separation was achieved using Zorbax Extend C18 column (150 mm x 4.6 mm, 5 mu m), with mobile phase consisting of methanol-phosphate buffer pH 6 (20:80 v/v), flow rate of 1 ml/min, and column temperature of 30 degrees C. UV detection was performed at 230 nm.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol
VL  - 55
IS  - 3
SP  - 665
EP  - 670
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1064
ER  - 

@article{
author = "Crevar, Milkica and Ivković, Branka and Vladimirov, Sote and Kuntić, Vesna and Vujić, Zorica",
year = "2008",
abstract = "Paracetamol, analgoantipyretic and anti-inflammatory drug, is available in numerous pharmaceutical formulations in common combination with caffeine and some other drug substances. p-aminophenol is paracatamol's process-related impurity that also may be present in formulations containing paracetamol. This paper presents a RP-HPLC method for simultaneous determination of caffeine, paracetamol and p-aminophenol, using chromatographic system Hewlett Packard 1100 series. In defining optimal RP-HPLC chromatographic conditions for the separation of these three compounds, experimental design was applied. Completely separation was achieved using Zorbax Extend C18 column (150 mm x 4.6 mm, 5 mu m), with mobile phase consisting of methanol-phosphate buffer pH 6 (20:80 v/v), flow rate of 1 ml/min, and column temperature of 30 degrees C. UV detection was performed at 230 nm.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol",
volume = "55",
number = "3",
pages = "665-670",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1064"
}

Crevar, M., Ivković, B., Vladimirov, S., Kuntić, V.,& Vujić, Z.. (2008). Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 55(3), 665-670.
https://hdl.handle.net/21.15107/rcub_farfar_1064

Crevar M, Ivković B, Vladimirov S, Kuntić V, Vujić Z. Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol. in Acta Chimica Slovenica. 2008;55(3):665-670.
https://hdl.handle.net/21.15107/rcub_farfar_1064 .

Crevar, Milkica, Ivković, Branka, Vladimirov, Sote, Kuntić, Vesna, Vujić, Zorica, "Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol" in Acta Chimica Slovenica, 55, no. 3 (2008):665-670,
https://hdl.handle.net/21.15107/rcub_farfar_1064 .

TY  - JOUR
AU  - Injac, Rade
AU  - Mlinarić, Ales
AU  - Đorđević-Milić, Vukosava
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1103
AB  - A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmoll(-1) borate, 20 mmoll(-1) phosphate, pH 8.4, containing 20 mmoll(-1) sodium dodecylsulphate and 10% (v/v) methanol. MEKC was performed at 25C; the applied voltage was 25 kV with a running pressure of 10 mbar. Simultaneous UV detection for all analytes was at 215 nm. The method was validated for specificity, accuracy, linearity, precision and robustness. It was shown to be specific, accurate (recoveries were 99.7 +/- 0.3, 99.9 +/- 0.9, 99.8 +/- 1.0 and 99.5 +/- 0.4, respectively, for oxytetracycline-, sulfacetamide-, polymyxin B- and zinc bacitracin-spiked samples of feed for cow, pigs, chicken and cattle), linear over the tested range (correlation coefficients >= 0.9987) and precise (RSDs below 1.8% for each analyte). The method was applied to determine zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide as additives in animal feed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Food Additives and Contaminants Part A: Chemistry Analysis Control Exposure & Risk Assessment
T1  - Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography
VL  - 25
IS  - 4
SP  - 424
EP  - 431
DO  - 10.1080/02652030701584058
ER  - 

@article{
author = "Injac, Rade and Mlinarić, Ales and Đorđević-Milić, Vukosava and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
abstract = "A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmoll(-1) borate, 20 mmoll(-1) phosphate, pH 8.4, containing 20 mmoll(-1) sodium dodecylsulphate and 10% (v/v) methanol. MEKC was performed at 25C; the applied voltage was 25 kV with a running pressure of 10 mbar. Simultaneous UV detection for all analytes was at 215 nm. The method was validated for specificity, accuracy, linearity, precision and robustness. It was shown to be specific, accurate (recoveries were 99.7 +/- 0.3, 99.9 +/- 0.9, 99.8 +/- 1.0 and 99.5 +/- 0.4, respectively, for oxytetracycline-, sulfacetamide-, polymyxin B- and zinc bacitracin-spiked samples of feed for cow, pigs, chicken and cattle), linear over the tested range (correlation coefficients >= 0.9987) and precise (RSDs below 1.8% for each analyte). The method was applied to determine zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide as additives in animal feed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Food Additives and Contaminants Part A: Chemistry Analysis Control Exposure & Risk Assessment",
title = "Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography",
volume = "25",
number = "4",
pages = "424-431",
doi = "10.1080/02652030701584058"
}

Injac, R., Mlinarić, A., Đorđević-Milić, V., Karljiković-Rajić, K.,& Štrukelj, B.. (2008). Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography. in Food Additives and Contaminants Part A: Chemistry Analysis Control Exposure & Risk Assessment
Taylor & Francis Ltd, Abingdon., 25(4), 424-431.
https://doi.org/10.1080/02652030701584058

Injac R, Mlinarić A, Đorđević-Milić V, Karljiković-Rajić K, Štrukelj B. Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography. in Food Additives and Contaminants Part A: Chemistry Analysis Control Exposure & Risk Assessment. 2008;25(4):424-431.
doi:10.1080/02652030701584058 .

Injac, Rade, Mlinarić, Ales, Đorđević-Milić, Vukosava, Karljiković-Rajić, Katarina, Štrukelj, Borut, "Optimal conditions for determination of zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feed by micellar electrokinetic capillary chromatography" in Food Additives and Contaminants Part A: Chemistry Analysis Control Exposure & Risk Assessment, 25, no. 4 (2008):424-431,
https://doi.org/10.1080/02652030701584058 . .

TY  - JOUR
AU  - Dilber, Sanda
AU  - Dobrić, Silva
AU  - Juranić, Zorica
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Juranić, Ivan O.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1101
AB  - The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.
PB  - Molecular Diversity Preservation Int, Basel
T2  - Molecules
T1  - Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids
VL  - 13
IS  - 3
SP  - 603
EP  - 615
DO  - 10.3390/molecules13030603
ER  - 

@article{
author = "Dilber, Sanda and Dobrić, Silva and Juranić, Zorica and Marković, Bojan and Vladimirov, Sote and Juranić, Ivan O.",
year = "2008",
abstract = "The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.",
publisher = "Molecular Diversity Preservation Int, Basel",
journal = "Molecules",
title = "Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids",
volume = "13",
number = "3",
pages = "603-615",
doi = "10.3390/molecules13030603"
}

Dilber, S., Dobrić, S., Juranić, Z., Marković, B., Vladimirov, S.,& Juranić, I. O.. (2008). Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules
Molecular Diversity Preservation Int, Basel., 13(3), 603-615.
https://doi.org/10.3390/molecules13030603

Dilber S, Dobrić S, Juranić Z, Marković B, Vladimirov S, Juranić IO. Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules. 2008;13(3):603-615.
doi:10.3390/molecules13030603 .

Dilber, Sanda, Dobrić, Silva, Juranić, Zorica, Marković, Bojan, Vladimirov, Sote, Juranić, Ivan O., "Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids" in Molecules, 13, no. 3 (2008):603-615,
https://doi.org/10.3390/molecules13030603 . .

TY  - JOUR
AU  - Vujić, Zorica
AU  - Kuntić, Vesna
AU  - Ivković, Branka
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1059
AB  - A method of Capillary Zone Electrophoresis (CZE) for separation of three most-frequently prescribed antidepressants in the market: maprotiline, desipramine, and moclobemide was developed. The proposed method is fully validated for a ternary laboratory mixture but it is also suitable for individual determination of the investigated components in pharmaceutical dosage forms. Since the preliminary investigations did not show complete separation because of close migration time of desipramine and maprotiline, a complete set, 2(3) experimental design was applied. All the factors that affect separation as well as their mutual interactions were investigated. Voltage, temperature of capillary and the pH of phosphate buffer were independent variables or factors to be investigated in two levels. Applying response surface methodology, from experimental points the appropriate graphs were constructed and optimal chromatographic conditions for the separation were defined. The optimum conditions were: running voltage of 20kV, phosphate buffer (pH = 2.35), temperature 25 degrees C, and UV detection at 200nm. An uncoated (fused silica) capillary (50 mu m i.d.) with a total length of 50cm and a distance of 47cm between the injection and detection points was used.
PB  - Springer Wien, Wien
T2  - Monatshefte für Chemie Chemical Monthly
T1  - Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis
VL  - 139
IS  - 2
SP  - 81
EP  - 87
DO  - 10.1007/s00706-007-0686-2
ER  - 

@article{
author = "Vujić, Zorica and Kuntić, Vesna and Ivković, Branka",
year = "2008",
abstract = "A method of Capillary Zone Electrophoresis (CZE) for separation of three most-frequently prescribed antidepressants in the market: maprotiline, desipramine, and moclobemide was developed. The proposed method is fully validated for a ternary laboratory mixture but it is also suitable for individual determination of the investigated components in pharmaceutical dosage forms. Since the preliminary investigations did not show complete separation because of close migration time of desipramine and maprotiline, a complete set, 2(3) experimental design was applied. All the factors that affect separation as well as their mutual interactions were investigated. Voltage, temperature of capillary and the pH of phosphate buffer were independent variables or factors to be investigated in two levels. Applying response surface methodology, from experimental points the appropriate graphs were constructed and optimal chromatographic conditions for the separation were defined. The optimum conditions were: running voltage of 20kV, phosphate buffer (pH = 2.35), temperature 25 degrees C, and UV detection at 200nm. An uncoated (fused silica) capillary (50 mu m i.d.) with a total length of 50cm and a distance of 47cm between the injection and detection points was used.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis",
volume = "139",
number = "2",
pages = "81-87",
doi = "10.1007/s00706-007-0686-2"
}

Vujić, Z., Kuntić, V.,& Ivković, B.. (2008). Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis. in Monatshefte für Chemie Chemical Monthly
Springer Wien, Wien., 139(2), 81-87.
https://doi.org/10.1007/s00706-007-0686-2

Vujić Z, Kuntić V, Ivković B. Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis. in Monatshefte für Chemie Chemical Monthly. 2008;139(2):81-87.
doi:10.1007/s00706-007-0686-2 .

Vujić, Zorica, Kuntić, Vesna, Ivković, Branka, "Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis" in Monatshefte für Chemie Chemical Monthly, 139, no. 2 (2008):81-87,
https://doi.org/10.1007/s00706-007-0686-2 . .

TY  - JOUR
AU  - Injac, Rade
AU  - Srđenović, Branislava
AU  - Prijatelj, Matevz
AU  - Bošković, Marija
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1053
PB  - Preston Publ Inc, Niles
T2  - Journal of Chromatographic Science
T1  - Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography
VL  - 46
IS  - 2
SP  - 137
EP  - 143
DO  - 10.1093/chromsci/46.2.137
ER  - 

@article{
author = "Injac, Rade and Srđenović, Branislava and Prijatelj, Matevz and Bošković, Marija and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
publisher = "Preston Publ Inc, Niles",
journal = "Journal of Chromatographic Science",
title = "Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography",
volume = "46",
number = "2",
pages = "137-143",
doi = "10.1093/chromsci/46.2.137"
}

Injac, R., Srđenović, B., Prijatelj, M., Bošković, M., Karljiković-Rajić, K.,& Štrukelj, B.. (2008). Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. in Journal of Chromatographic Science
Preston Publ Inc, Niles., 46(2), 137-143.
https://doi.org/10.1093/chromsci/46.2.137

Injac R, Srđenović B, Prijatelj M, Bošković M, Karljiković-Rajić K, Štrukelj B. Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography. in Journal of Chromatographic Science. 2008;46(2):137-143.
doi:10.1093/chromsci/46.2.137 .

Injac, Rade, Srđenović, Branislava, Prijatelj, Matevz, Bošković, Marija, Karljiković-Rajić, Katarina, Štrukelj, Borut, "Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography" in Journal of Chromatographic Science, 46, no. 2 (2008):137-143,
https://doi.org/10.1093/chromsci/46.2.137 . .

TY  - JOUR
AU  - Injac, Rade
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1134
AB  - Micellar electrokinetic capillary chromatography (MEKC) has become a popular mode among the several capillary electro-migration techniques. Most drug analysis can be performed by using MEKC because of its wide applicability. Separation of very complex mixtures, determination of drugs in the biological materials, etc., can be successfully achieved by MEKC. This review surveys typical applications of MEKC analysis. Recent advances in MEKC, especially with solid-phase extraction and large-volume sample stacking, are described. Modes of electrokinetic chromatography including MEKC, a separation theory of MEKC, environmental friendly analysis, and selectivity manipulation in MEKC are also briefly mentioned.
AB  - Micelama elektrokinetička kapilarna hromatografija (MEKC) postala je najpopularnija kapilarna elektromigraciona metoda. Na osnovu veoma široke upotrebe metode, većina analiza lekova moguća je uz MEKC. Separacija veoma kompleksnih smeša, određivanje lekova u biološkom materijalu, i analize drugih uzoraka, mogu biti veoma uspešno izvedene upotrebom MEKC tehnike. U okviru ovog preglednog rada prikazana je aplikacija tipičnih MEKC metoda. Noviji pristupi u kombinaciji sa čvrsto-faznom ekstrakcijom i visoko-volumskim injektovanjem su takođe opisani. Teorijski i ekološki pristup, kao i prednosti i nedostatci same metode, prikazani su teorijski i kroz praktične primere.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Application of micellar electrokinetic capillary chromatography for routine analysis of different materials
T1  - Upotreba micelarne elektrokinetičke kapilarne hromatografije u rutinskoj analizi različitih uzoraka
VL  - 62
IS  - 3
SP  - 181
EP  - 190
DO  - 10.2298/HEMIND0803181I
ER  - 

@article{
author = "Injac, Rade and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
abstract = "Micellar electrokinetic capillary chromatography (MEKC) has become a popular mode among the several capillary electro-migration techniques. Most drug analysis can be performed by using MEKC because of its wide applicability. Separation of very complex mixtures, determination of drugs in the biological materials, etc., can be successfully achieved by MEKC. This review surveys typical applications of MEKC analysis. Recent advances in MEKC, especially with solid-phase extraction and large-volume sample stacking, are described. Modes of electrokinetic chromatography including MEKC, a separation theory of MEKC, environmental friendly analysis, and selectivity manipulation in MEKC are also briefly mentioned., Micelama elektrokinetička kapilarna hromatografija (MEKC) postala je najpopularnija kapilarna elektromigraciona metoda. Na osnovu veoma široke upotrebe metode, većina analiza lekova moguća je uz MEKC. Separacija veoma kompleksnih smeša, određivanje lekova u biološkom materijalu, i analize drugih uzoraka, mogu biti veoma uspešno izvedene upotrebom MEKC tehnike. U okviru ovog preglednog rada prikazana je aplikacija tipičnih MEKC metoda. Noviji pristupi u kombinaciji sa čvrsto-faznom ekstrakcijom i visoko-volumskim injektovanjem su takođe opisani. Teorijski i ekološki pristup, kao i prednosti i nedostatci same metode, prikazani su teorijski i kroz praktične primere.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Application of micellar electrokinetic capillary chromatography for routine analysis of different materials, Upotreba micelarne elektrokinetičke kapilarne hromatografije u rutinskoj analizi različitih uzoraka",
volume = "62",
number = "3",
pages = "181-190",
doi = "10.2298/HEMIND0803181I"
}

Injac, R., Karljiković-Rajić, K.,& Štrukelj, B.. (2008). Application of micellar electrokinetic capillary chromatography for routine analysis of different materials. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 62(3), 181-190.
https://doi.org/10.2298/HEMIND0803181I

Injac R, Karljiković-Rajić K, Štrukelj B. Application of micellar electrokinetic capillary chromatography for routine analysis of different materials. in Hemijska industrija. 2008;62(3):181-190.
doi:10.2298/HEMIND0803181I .

Injac, Rade, Karljiković-Rajić, Katarina, Štrukelj, Borut, "Application of micellar electrokinetic capillary chromatography for routine analysis of different materials" in Hemijska industrija, 62, no. 3 (2008):181-190,
https://doi.org/10.2298/HEMIND0803181I . .

TY  - JOUR
AU  - Marković, Bojan
AU  - Vladimirov, Sote
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1142
AB  - Topical anti-inflammatory corticosteroids are "drug of choice" in treatment of many inflammatory and allergic diseases in dermatology, pulmology, ophthalmology rheumatology and gastroenterology. Their using is limited because some serious systematic effects have been noted by longtime using of these drugs. In this manuscript, it was made a review of the relationship of structural changes on molecules of corticosteroids and intensity and specificity of their activity. Some of recently trends in design of newly anti-inflammatory steroids are based on retrometabolic design of "soft drugs", which are biotransformed to the inactive metabolits in body of patient after their applications. In manuscript, design and synthesis of new diastereoisomeric esters of steroid, as potentional antiinflammatory agents, was shown.
AB  - Lokalni antiinflamatorni steroidi su "lekovi izbora" u lečenju raznih inflamatornih i alergijskih oboljenja u dermatologiji, pulmologiji, oftalmologiji, reumatologiji, gastroenterologiji. Dugotrajnom primenom ovih lekova mogu nastati veoma ozbiljni sistemski neželjeni efekti koji ograničavaju njihovu upotrebu. U ovom radu, dat je pregled uticaja strukturnih promena, u molekulama lokalnih antiinflamatornih steroida, na jačinu i specifičnost antiinflamatornog dejstva, a sve u cilju dobijanja novih bezbednijih lekova. Jedan od savremenih trendova u dizajnu antiinflamatornih steroida zasniva se na retrometaboličkom pristupu "soft" lekova, koji se nakon ispoljavanja dejstva, u organizmu pacijenta biotransformišu do neaktivnih i netoksičnih metabolita. U radu je prikazan dizajn i sinteza novih diastereoizomernih estara antiinflamatornih steroida kao potencijalnih lekova u lokalnoj terapiji.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - New trends in design and development of topical anti-inflammatory steroids
T1  - Novine u dizajniranju i razvoju lokalnih antiinflamatornih steroida
VL  - 58
IS  - 2-3
SP  - 137
EP  - 152
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1142
ER  - 

@article{
author = "Marković, Bojan and Vladimirov, Sote",
year = "2008",
abstract = "Topical anti-inflammatory corticosteroids are "drug of choice" in treatment of many inflammatory and allergic diseases in dermatology, pulmology, ophthalmology rheumatology and gastroenterology. Their using is limited because some serious systematic effects have been noted by longtime using of these drugs. In this manuscript, it was made a review of the relationship of structural changes on molecules of corticosteroids and intensity and specificity of their activity. Some of recently trends in design of newly anti-inflammatory steroids are based on retrometabolic design of "soft drugs", which are biotransformed to the inactive metabolits in body of patient after their applications. In manuscript, design and synthesis of new diastereoisomeric esters of steroid, as potentional antiinflammatory agents, was shown., Lokalni antiinflamatorni steroidi su "lekovi izbora" u lečenju raznih inflamatornih i alergijskih oboljenja u dermatologiji, pulmologiji, oftalmologiji, reumatologiji, gastroenterologiji. Dugotrajnom primenom ovih lekova mogu nastati veoma ozbiljni sistemski neželjeni efekti koji ograničavaju njihovu upotrebu. U ovom radu, dat je pregled uticaja strukturnih promena, u molekulama lokalnih antiinflamatornih steroida, na jačinu i specifičnost antiinflamatornog dejstva, a sve u cilju dobijanja novih bezbednijih lekova. Jedan od savremenih trendova u dizajnu antiinflamatornih steroida zasniva se na retrometaboličkom pristupu "soft" lekova, koji se nakon ispoljavanja dejstva, u organizmu pacijenta biotransformišu do neaktivnih i netoksičnih metabolita. U radu je prikazan dizajn i sinteza novih diastereoizomernih estara antiinflamatornih steroida kao potencijalnih lekova u lokalnoj terapiji.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "New trends in design and development of topical anti-inflammatory steroids, Novine u dizajniranju i razvoju lokalnih antiinflamatornih steroida",
volume = "58",
number = "2-3",
pages = "137-152",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1142"
}

Marković, B.,& Vladimirov, S.. (2008). New trends in design and development of topical anti-inflammatory steroids. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 58(2-3), 137-152.
https://hdl.handle.net/21.15107/rcub_farfar_1142

Marković B, Vladimirov S. New trends in design and development of topical anti-inflammatory steroids. in Arhiv za farmaciju. 2008;58(2-3):137-152.
https://hdl.handle.net/21.15107/rcub_farfar_1142 .

Marković, Bojan, Vladimirov, Sote, "New trends in design and development of topical anti-inflammatory steroids" in Arhiv za farmaciju, 58, no. 2-3 (2008):137-152,
https://hdl.handle.net/21.15107/rcub_farfar_1142 .

TY  - JOUR
AU  - Injac, Rade
AU  - Karljiković-Rajić, Katarina
AU  - Štrukelj, Borut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1061
AB  - A novel and simple method has been developed for the determination of doxycycline (DOX) in biological fluids. The method is based on SPE, large-volume sample stacking (LVSS) and MEKC with UV-DAD detection. Six SPE cartridges have been used in investigation for sample clean up and pre-concentration (Supelco (R) LC-8, LC-18, LC-SCX, and LC-WCX, as well as Strata (TM)-X and X-C). DOX was determined on a 56 cm. (effective length 50 cm) x 50 mu m id fused-silica capillary. The BGE was 20 mM borate buffer, pH 9.3, containing 80 mM SDS and 7.5% v/v of methanol (30 s x 50 mbar), and the temperature and voltage were 25 degrees C and 30 kV, respectively. The analytical wavelength was set at 210 nm. Under optimized conditions it is possible to determine DOX in human serum, urine, semen, tears and saliva with recovery of 97.5% (RSD 2.5%). The method was shown to be sensitive (LOD is 1 mu g/L) and precise (intra-day RSD 0.2 and 2.4%; inter-days 0.4 and 3.5% for migration time and peak area, respectively). Results for developed SPE-LVSS-MEKC were compared with LVSS-MEKC method with direct sample injection. The new LVSS-MEKC method is presented as a useful technique for rapid determination without extraction procedure of DOX in human urine and serum, using 80mM of SDS, 10% v/v of methanol and 40 mM borate buffer (pH 9.3; 30 s x 50 mbar; 25 degrees C; 30 kV; 350 nm), but not for the other biological fluids, according to lower sensitivity of the method and because of the sample composition.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Electrophoresis
T1  - SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: Comparison of direct injection to SPE-MEKC
VL  - 29
IS  - 21
SP  - 4431
EP  - 4438
DO  - 10.1002/elps.200800339
ER  - 

@article{
author = "Injac, Rade and Karljiković-Rajić, Katarina and Štrukelj, Borut",
year = "2008",
abstract = "A novel and simple method has been developed for the determination of doxycycline (DOX) in biological fluids. The method is based on SPE, large-volume sample stacking (LVSS) and MEKC with UV-DAD detection. Six SPE cartridges have been used in investigation for sample clean up and pre-concentration (Supelco (R) LC-8, LC-18, LC-SCX, and LC-WCX, as well as Strata (TM)-X and X-C). DOX was determined on a 56 cm. (effective length 50 cm) x 50 mu m id fused-silica capillary. The BGE was 20 mM borate buffer, pH 9.3, containing 80 mM SDS and 7.5% v/v of methanol (30 s x 50 mbar), and the temperature and voltage were 25 degrees C and 30 kV, respectively. The analytical wavelength was set at 210 nm. Under optimized conditions it is possible to determine DOX in human serum, urine, semen, tears and saliva with recovery of 97.5% (RSD 2.5%). The method was shown to be sensitive (LOD is 1 mu g/L) and precise (intra-day RSD 0.2 and 2.4%; inter-days 0.4 and 3.5% for migration time and peak area, respectively). Results for developed SPE-LVSS-MEKC were compared with LVSS-MEKC method with direct sample injection. The new LVSS-MEKC method is presented as a useful technique for rapid determination without extraction procedure of DOX in human urine and serum, using 80mM of SDS, 10% v/v of methanol and 40 mM borate buffer (pH 9.3; 30 s x 50 mbar; 25 degrees C; 30 kV; 350 nm), but not for the other biological fluids, according to lower sensitivity of the method and because of the sample composition.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Electrophoresis",
title = "SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: Comparison of direct injection to SPE-MEKC",
volume = "29",
number = "21",
pages = "4431-4438",
doi = "10.1002/elps.200800339"
}

Injac, R., Karljiković-Rajić, K.,& Štrukelj, B.. (2008). SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: Comparison of direct injection to SPE-MEKC. in Electrophoresis
Wiley-VCH Verlag GMBH, Weinheim., 29(21), 4431-4438.
https://doi.org/10.1002/elps.200800339

Injac R, Karljiković-Rajić K, Štrukelj B. SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: Comparison of direct injection to SPE-MEKC. in Electrophoresis. 2008;29(21):4431-4438.
doi:10.1002/elps.200800339 .

Injac, Rade, Karljiković-Rajić, Katarina, Štrukelj, Borut, "SPE and large-volume sample stacking in MEKC for determination of doxycycline in biological fluids: Comparison of direct injection to SPE-MEKC" in Electrophoresis, 29, no. 21 (2008):4431-4438,
https://doi.org/10.1002/elps.200800339 . .

TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Agbaba, Danica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/905
AB  - Simple, rapid, and precise densitometric TLC methods have been established for simultaneous determination of loratadine and preservatives in loratadine-sodium benzoate and loratadine-methylparaben-propylparaben mixtures. Chromatography was performed on aluminium plates precoated with silica gel 60 F-254. The mobile phases were n-butyl acetate-carbon tetrachloride-acetic acid-acetonitrile 3:6:0.2:3 (v/v) for loratadine-sodium benzoate mixtures and ethyl acetate-n-hexane-methanol-ammonia-diethylamine 1:4:0.8:0.4:2 (v/v) for loratadine-methylparaben-propylparaben mixtures. Chromatographic zones were scanned in reflectance-absorbance mode at 240 nm for the former mixture and 275 mu for the latter. Relationships between peak areas and amounts of the compounds were evaluated by linear regression analysis in the concentration ranges 0.3-0.7 mu g per band for loratadine, methylparaben, and sodium benzoate and 0.03-0.07 mu g per band for propylparaben. Mean recovery for all the compounds varied from 98.3 to 102.5 %. Detection and quantification limits ranged from 0.004 to 0.03 and from 0.01 to 0.1 mu g per band, respectively. The proposed method was used for simultaneous determination of loratadine. and the preservatives in commercial medicinal syrups.
PB  - Univ Silesia, Inst Chemistry, Katowice
T2  - Acta Chromatographica
T1  - Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography
VL  - 19
SP  - 161
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_farfar_905
ER  - 

@article{
author = "Popović, Gordana and Čakar, Mira and Agbaba, Danica",
year = "2007",
abstract = "Simple, rapid, and precise densitometric TLC methods have been established for simultaneous determination of loratadine and preservatives in loratadine-sodium benzoate and loratadine-methylparaben-propylparaben mixtures. Chromatography was performed on aluminium plates precoated with silica gel 60 F-254. The mobile phases were n-butyl acetate-carbon tetrachloride-acetic acid-acetonitrile 3:6:0.2:3 (v/v) for loratadine-sodium benzoate mixtures and ethyl acetate-n-hexane-methanol-ammonia-diethylamine 1:4:0.8:0.4:2 (v/v) for loratadine-methylparaben-propylparaben mixtures. Chromatographic zones were scanned in reflectance-absorbance mode at 240 nm for the former mixture and 275 mu for the latter. Relationships between peak areas and amounts of the compounds were evaluated by linear regression analysis in the concentration ranges 0.3-0.7 mu g per band for loratadine, methylparaben, and sodium benzoate and 0.03-0.07 mu g per band for propylparaben. Mean recovery for all the compounds varied from 98.3 to 102.5 %. Detection and quantification limits ranged from 0.004 to 0.03 and from 0.01 to 0.1 mu g per band, respectively. The proposed method was used for simultaneous determination of loratadine. and the preservatives in commercial medicinal syrups.",
publisher = "Univ Silesia, Inst Chemistry, Katowice",
journal = "Acta Chromatographica",
title = "Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography",
volume = "19",
pages = "161-169",
url = "https://hdl.handle.net/21.15107/rcub_farfar_905"
}

Popović, G., Čakar, M.,& Agbaba, D.. (2007). Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography. in Acta Chromatographica
Univ Silesia, Inst Chemistry, Katowice., 19, 161-169.
https://hdl.handle.net/21.15107/rcub_farfar_905

Popović G, Čakar M, Agbaba D. Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography. in Acta Chromatographica. 2007;19:161-169.
https://hdl.handle.net/21.15107/rcub_farfar_905 .

Popović, Gordana, Čakar, Mira, Agbaba, Danica, "Simultaneous determination of loratadine and preservatives in syrups by thin-layer chromatography" in Acta Chromatographica, 19 (2007):161-169,
https://hdl.handle.net/21.15107/rcub_farfar_905 .

TY  - JOUR
AU  - Tubić, Biljana
AU  - Ivković, Branka
AU  - Zečević, Mira
AU  - Vladimirov, S.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/992
AB  - A simple, rapid and reproducible reversed-phase high-performance liquid chromatography method for the analysis of nimesulide and its impurities both in the bulk drug and pharmaceutical formulations is reported. The method is suitable for monitoring the stability of nimesulide. The presence of nimesulide impurities C (2- phenoxyaniline) and D (2- phenoxy4- nitroaniline) was observed. The best separation was achieved using an Agilent Zorbax Extend C-18 column ( 150 x 4.6 mm, particle size 5 mu m) at 40 C and flow rate of 1.0 mLmin(-1). The analytes were monitored at 230 nm. The mobile phase consisted of acetonitrile - triethylamine (TEA) - water (45:0.5:54.5 v/v/v), adjusted to pH 5.2 with formic acid. Under these conditions the retention times were of 7.11, 7.98 and 8.66 min for nimesulide, D and C, respectively. The resolution of nimesulide and impurity D was 3.20 and that of impurity D and impurity C 2.40, indicating that the compounds were well separated. Evaluation of linearity, accuracy, precision, selectivity, sensitivity and robustness of the method produced satisfactory results. The developed method was successfully applied to assay nimesulide in different solid pharmaceutical formulations.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - Simulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography
VL  - 54
IS  - 3
SP  - 583
EP  - 590
UR  - https://hdl.handle.net/21.15107/rcub_farfar_992
ER  - 

@article{
author = "Tubić, Biljana and Ivković, Branka and Zečević, Mira and Vladimirov, S.",
year = "2007",
abstract = "A simple, rapid and reproducible reversed-phase high-performance liquid chromatography method for the analysis of nimesulide and its impurities both in the bulk drug and pharmaceutical formulations is reported. The method is suitable for monitoring the stability of nimesulide. The presence of nimesulide impurities C (2- phenoxyaniline) and D (2- phenoxy4- nitroaniline) was observed. The best separation was achieved using an Agilent Zorbax Extend C-18 column ( 150 x 4.6 mm, particle size 5 mu m) at 40 C and flow rate of 1.0 mLmin(-1). The analytes were monitored at 230 nm. The mobile phase consisted of acetonitrile - triethylamine (TEA) - water (45:0.5:54.5 v/v/v), adjusted to pH 5.2 with formic acid. Under these conditions the retention times were of 7.11, 7.98 and 8.66 min for nimesulide, D and C, respectively. The resolution of nimesulide and impurity D was 3.20 and that of impurity D and impurity C 2.40, indicating that the compounds were well separated. Evaluation of linearity, accuracy, precision, selectivity, sensitivity and robustness of the method produced satisfactory results. The developed method was successfully applied to assay nimesulide in different solid pharmaceutical formulations.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "Simulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography",
volume = "54",
number = "3",
pages = "583-590",
url = "https://hdl.handle.net/21.15107/rcub_farfar_992"
}

Tubić, B., Ivković, B., Zečević, M.,& Vladimirov, S.. (2007). Simulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 54(3), 583-590.
https://hdl.handle.net/21.15107/rcub_farfar_992

Tubić B, Ivković B, Zečević M, Vladimirov S. Simulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography. in Acta Chimica Slovenica. 2007;54(3):583-590.
https://hdl.handle.net/21.15107/rcub_farfar_992 .

Tubić, Biljana, Ivković, Branka, Zečević, Mira, Vladimirov, S., "Simulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography" in Acta Chimica Slovenica, 54, no. 3 (2007):583-590,
https://hdl.handle.net/21.15107/rcub_farfar_992 .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Stanojević, Maja
AU  - Holclajtner-Antunović, Ivanka
AU  - Uskoković-Marković, Snežana
AU  - Mioč, Ubavka B.
AU  - Todorović, Marija R.
AU  - Jovanović, Tanja
AU  - Vukojević, Vladana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/837
AB  - Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
PB  - Springer Wien, Wien
T2  - Monatshefte für Chemie Chemical Monthly
T1  - Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid
VL  - 137
IS  - 6
SP  - 803
EP  - 810
DO  - 10.1007/s00706-006-0467-3
ER  - 

@article{
author = "Kuntić, Vesna and Stanojević, Maja and Holclajtner-Antunović, Ivanka and Uskoković-Marković, Snežana and Mioč, Ubavka B. and Todorović, Marija R. and Jovanović, Tanja and Vukojević, Vladana",
year = "2006",
abstract = "Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid",
volume = "137",
number = "6",
pages = "803-810",
doi = "10.1007/s00706-006-0467-3"
}

Kuntić, V., Stanojević, M., Holclajtner-Antunović, I., Uskoković-Marković, S., Mioč, U. B., Todorović, M. R., Jovanović, T.,& Vukojević, V.. (2006). Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly
Springer Wien, Wien., 137(6), 803-810.
https://doi.org/10.1007/s00706-006-0467-3

Kuntić V, Stanojević M, Holclajtner-Antunović I, Uskoković-Marković S, Mioč UB, Todorović MR, Jovanović T, Vukojević V. Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly. 2006;137(6):803-810.
doi:10.1007/s00706-006-0467-3 .

Kuntić, Vesna, Stanojević, Maja, Holclajtner-Antunović, Ivanka, Uskoković-Marković, Snežana, Mioč, Ubavka B., Todorović, Marija R., Jovanović, Tanja, Vukojević, Vladana, "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid" in Monatshefte für Chemie Chemical Monthly, 137, no. 6 (2006):803-810,
https://doi.org/10.1007/s00706-006-0467-3 . .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Janković, Ivana
AU  - Comor, Mirjana
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/712
AB  - In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Colloid and Interface Science
T1  - Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide
VL  - 301
IS  - 2
SP  - 692
EP  - 696
DO  - 10.1016/j.jcis.2006.05.025
ER  - 

@article{
author = "Čudina, Olivera and Janković, Ivana and Comor, Mirjana and Vladimirov, Sote",
year = "2006",
abstract = "In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Colloid and Interface Science",
title = "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "301",
number = "2",
pages = "692-696",
doi = "10.1016/j.jcis.2006.05.025"
}

Čudina, O., Janković, I., Comor, M.,& Vladimirov, S.. (2006). Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science
Academic Press Inc Elsevier Science, San Diego., 301(2), 692-696.
https://doi.org/10.1016/j.jcis.2006.05.025

Čudina O, Janković I, Comor M, Vladimirov S. Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science. 2006;301(2):692-696.
doi:10.1016/j.jcis.2006.05.025 .

Čudina, Olivera, Janković, Ivana, Comor, Mirjana, Vladimirov, Sote, "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide" in Journal of Colloid and Interface Science, 301, no. 2 (2006):692-696,
https://doi.org/10.1016/j.jcis.2006.05.025 . .