TY  - JOUR
AU  - Perišić, Milica
AU  - Stojić-Vukanić, Zorica
AU  - Pilipović, Ivan
AU  - Kosec, Duško
AU  - Nacka-Aleksić, Mirjana
AU  - Đikić, Jasmina
AU  - Arsenović-Ranin, Nevena
AU  - Leposavić, Gordana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1915
AB  - The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Immunobiology
T1  - Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery
VL  - 218
IS  - 3
SP  - 353
EP  - 367
DO  - 10.1016/j.imbio.2012.05.009
ER  - 

@article{
author = "Perišić, Milica and Stojić-Vukanić, Zorica and Pilipović, Ivan and Kosec, Duško and Nacka-Aleksić, Mirjana and Đikić, Jasmina and Arsenović-Ranin, Nevena and Leposavić, Gordana",
year = "2013",
abstract = "The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Immunobiology",
title = "Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery",
volume = "218",
number = "3",
pages = "353-367",
doi = "10.1016/j.imbio.2012.05.009"
}

Perišić, M., Stojić-Vukanić, Z., Pilipović, I., Kosec, D., Nacka-Aleksić, M., Đikić, J., Arsenović-Ranin, N.,& Leposavić, G.. (2013). Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery. in Immunobiology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 218(3), 353-367.
https://doi.org/10.1016/j.imbio.2012.05.009

Perišić M, Stojić-Vukanić Z, Pilipović I, Kosec D, Nacka-Aleksić M, Đikić J, Arsenović-Ranin N, Leposavić G. Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery. in Immunobiology. 2013;218(3):353-367.
doi:10.1016/j.imbio.2012.05.009 .

Perišić, Milica, Stojić-Vukanić, Zorica, Pilipović, Ivan, Kosec, Duško, Nacka-Aleksić, Mirjana, Đikić, Jasmina, Arsenović-Ranin, Nevena, Leposavić, Gordana, "Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery" in Immunobiology, 218, no. 3 (2013):353-367,
https://doi.org/10.1016/j.imbio.2012.05.009 . .