TY  - JOUR
AU  - Ninković, Milica
AU  - Maliević, Ivorad M.
AU  - Jelenković, Ankica V.
AU  - Đukić, Mirjana
AU  - Jovanović, Marina
AU  - Stevanović, Ivana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1169
AB  - Oxidative stress development in different brain structures and the influence of nitric oxide (NO) overproduction during sepsis was investigated using male Wistar rats. Rats were subjected to cecal ligation and puncture (CLP) or were sham-operated. To evaluate the source of NO production, 30 min before the operation septic and control animals were treated with single intraperitoneal doses of NO synthase (NOS) inhibitors: L-NAME and aminoguanidine (AG) (10, 30 or 90 mg/kg) and 7-nitroindazole (7-NI) (30 mg/kg). The concentration of GSH in the cortex, brain stem, cerebellum, striatum and hippocampus significantly decreased post CLP at both early and late stage sepsis. Lipid peroxidation also occurred in the cortex and cerebellum in late stage sepsis. Pre-treatment with a non-selective NOS inhibitor (L-NAME) and with selective inducible and neuronal NOS inhibitors (AG and 7-NI) revealed benefit effects on the GSH concentrations. Unexpectedly, NOS inhibition resulted in diverse effects on TBARS concentrations, suggesting the importance of specific quantities of NO in specific brain structures during sepsis.
PB  - General Physiol And Biophysics, Bratislava
T2  - General Physiology and Biophysics
T1  - Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture
VL  - 28
SP  - 243
EP  - 250
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1476
ER  - 

@article{
author = "Ninković, Milica and Maliević, Ivorad M. and Jelenković, Ankica V. and Đukić, Mirjana and Jovanović, Marina and Stevanović, Ivana",
year = "2009",
abstract = "Oxidative stress development in different brain structures and the influence of nitric oxide (NO) overproduction during sepsis was investigated using male Wistar rats. Rats were subjected to cecal ligation and puncture (CLP) or were sham-operated. To evaluate the source of NO production, 30 min before the operation septic and control animals were treated with single intraperitoneal doses of NO synthase (NOS) inhibitors: L-NAME and aminoguanidine (AG) (10, 30 or 90 mg/kg) and 7-nitroindazole (7-NI) (30 mg/kg). The concentration of GSH in the cortex, brain stem, cerebellum, striatum and hippocampus significantly decreased post CLP at both early and late stage sepsis. Lipid peroxidation also occurred in the cortex and cerebellum in late stage sepsis. Pre-treatment with a non-selective NOS inhibitor (L-NAME) and with selective inducible and neuronal NOS inhibitors (AG and 7-NI) revealed benefit effects on the GSH concentrations. Unexpectedly, NOS inhibition resulted in diverse effects on TBARS concentrations, suggesting the importance of specific quantities of NO in specific brain structures during sepsis.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture",
volume = "28",
pages = "243-250",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1476"
}

Ninković, M., Maliević, I. M., Jelenković, A. V., Đukić, M., Jovanović, M.,& Stevanović, I.. (2009). Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 28, 243-250.
https://hdl.handle.net/21.15107/rcub_ibiss_1476

Ninković M, Maliević IM, Jelenković AV, Đukić M, Jovanović M, Stevanović I. Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture. in General Physiology and Biophysics. 2009;28:243-250.
https://hdl.handle.net/21.15107/rcub_ibiss_1476 .

Ninković, Milica, Maliević, Ivorad M., Jelenković, Ankica V., Đukić, Mirjana, Jovanović, Marina, Stevanović, Ivana, "Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture" in General Physiology and Biophysics, 28 (2009):243-250,
https://hdl.handle.net/21.15107/rcub_ibiss_1476 .