TY  - JOUR
AU  - Đukanović, Ljubica
AU  - Lezaić, Višnja
AU  - Bukvić, Danica
AU  - Mirković, Duško
AU  - Marić, Ivko
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3247
AB  - Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons. The aim of the study was to assess whether tubular creatinine secretion affects Ccr in early stages of BEN and to check the applicability of serum creatinine-based glomerular filtration rate (GFR) equations in these patients. Methods: The study involved 21 BEN patients with estimated GFR (eGFR) above 60 mL/min/1.73 m(2), excluding any conditions that could affect GFR or tubular creatinine secretion, and 15 healthy controls. In all participants Ccr with and without cimetidine and iohexol clearance (mGFR) were measured and eGFR calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations. Glomerular hyperfiltration cutoff (GFR-HF) was calculated. Results: There was no significant difference between the groups in Ccr before and after cimetidine or for eGFR, but mGFR was significantly higher in BEN patients than in controls (122.02 +/- 28.03 mL/min/1.73 m(2) vs. 101.15 +/- 27.32 mL/min/1.73 m(2); p = 0.032). Cimetidine administration reduced Ccr by 10% in both groups. The ratio of Ccr to mGFR was significantly above one in seven BEN patients and five controls and their mGFR values were similar. Seven other patients and eight controls had this ratio equal to one, while values below one were recorded for seven more patients and two controls. mGFR of all these 14 patients was significantly higher than that of healthy controls (129.88 +/- 27.52 mL/min/1.73 m(2) vs. 107.43 +/- 19.51 mL/min/1.73 m(2); p = 0.009). Mean GFR-HF was significantly higher than mGFR in controls, but these two values were similar in BEN patients. eGFR underestimated mGFR in both BEN patients and controls. Conclusion: The ratio of Ccr to mGFR and mGFR to GFR-HF indicated that elevated mGFR in early stages of BEN could be explained by increased glomerular filtration, but tubular creatinine secretion augmented Ccr in a smaller proportion of patients, who did not differ from healthy subjects.
PB  - MDPI, Basel
T2  - Medicina-Lithuania
T1  - Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy
VL  - 55
IS  - 5
DO  - 10.3390/medicina55050155
ER  - 

@article{
author = "Đukanović, Ljubica and Lezaić, Višnja and Bukvić, Danica and Mirković, Duško and Marić, Ivko",
year = "2019",
abstract = "Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons. The aim of the study was to assess whether tubular creatinine secretion affects Ccr in early stages of BEN and to check the applicability of serum creatinine-based glomerular filtration rate (GFR) equations in these patients. Methods: The study involved 21 BEN patients with estimated GFR (eGFR) above 60 mL/min/1.73 m(2), excluding any conditions that could affect GFR or tubular creatinine secretion, and 15 healthy controls. In all participants Ccr with and without cimetidine and iohexol clearance (mGFR) were measured and eGFR calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations. Glomerular hyperfiltration cutoff (GFR-HF) was calculated. Results: There was no significant difference between the groups in Ccr before and after cimetidine or for eGFR, but mGFR was significantly higher in BEN patients than in controls (122.02 +/- 28.03 mL/min/1.73 m(2) vs. 101.15 +/- 27.32 mL/min/1.73 m(2); p = 0.032). Cimetidine administration reduced Ccr by 10% in both groups. The ratio of Ccr to mGFR was significantly above one in seven BEN patients and five controls and their mGFR values were similar. Seven other patients and eight controls had this ratio equal to one, while values below one were recorded for seven more patients and two controls. mGFR of all these 14 patients was significantly higher than that of healthy controls (129.88 +/- 27.52 mL/min/1.73 m(2) vs. 107.43 +/- 19.51 mL/min/1.73 m(2); p = 0.009). Mean GFR-HF was significantly higher than mGFR in controls, but these two values were similar in BEN patients. eGFR underestimated mGFR in both BEN patients and controls. Conclusion: The ratio of Ccr to mGFR and mGFR to GFR-HF indicated that elevated mGFR in early stages of BEN could be explained by increased glomerular filtration, but tubular creatinine secretion augmented Ccr in a smaller proportion of patients, who did not differ from healthy subjects.",
publisher = "MDPI, Basel",
journal = "Medicina-Lithuania",
title = "Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy",
volume = "55",
number = "5",
doi = "10.3390/medicina55050155"
}

Đukanović, L., Lezaić, V., Bukvić, D., Mirković, D.,& Marić, I.. (2019). Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy. in Medicina-Lithuania
MDPI, Basel., 55(5).
https://doi.org/10.3390/medicina55050155

Đukanović L, Lezaić V, Bukvić D, Mirković D, Marić I. Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy. in Medicina-Lithuania. 2019;55(5).
doi:10.3390/medicina55050155 .

Đukanović, Ljubica, Lezaić, Višnja, Bukvić, Danica, Mirković, Duško, Marić, Ivko, "Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy" in Medicina-Lithuania, 55, no. 5 (2019),
https://doi.org/10.3390/medicina55050155 . .

TY  - JOUR
AU  - Radović, Mina
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Lezaić, Višnja
AU  - Milicić, Biljana
AU  - Velinović, Miloš
AU  - Karan, Radmila
AU  - Simić-Ogrizović, Sanja
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3311
AB  - Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients
VL  - 38
IS  - 2
SP  - 118
EP  - 125
DO  - 10.2478/jomb-2018-0018
ER  - 

@article{
author = "Radović, Mina and Bojić, Suzana and Kotur-Stevuljević, Jelena and Lezaić, Višnja and Milicić, Biljana and Velinović, Miloš and Karan, Radmila and Simić-Ogrizović, Sanja",
year = "2019",
abstract = "Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients",
volume = "38",
number = "2",
pages = "118-125",
doi = "10.2478/jomb-2018-0018"
}

Radović, M., Bojić, S., Kotur-Stevuljević, J., Lezaić, V., Milicić, B., Velinović, M., Karan, R.,& Simić-Ogrizović, S.. (2019). Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(2), 118-125.
https://doi.org/10.2478/jomb-2018-0018

Radović M, Bojić S, Kotur-Stevuljević J, Lezaić V, Milicić B, Velinović M, Karan R, Simić-Ogrizović S. Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry. 2019;38(2):118-125.
doi:10.2478/jomb-2018-0018 .

Radović, Mina, Bojić, Suzana, Kotur-Stevuljević, Jelena, Lezaić, Višnja, Milicić, Biljana, Velinović, Miloš, Karan, Radmila, Simić-Ogrizović, Sanja, "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients" in Journal of Medical Biochemistry, 38, no. 2 (2019):118-125,
https://doi.org/10.2478/jomb-2018-0018 . .

TY  - JOUR
AU  - Lezaić, Višnja
AU  - Petković, Nenad
AU  - Marić, Ivko
AU  - Miljković, Branislava
AU  - Vučićević, Katarina
AU  - Simić-Ogrizović, Sanja
AU  - Pejović, Vesna
AU  - Đukanović, Ljubica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1882
AB  - Background: Balkan endemic nephropathy (BEN) hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Objectives: Comparison of the pharmacokinetics of beta-erythropoietin given subcutaneously to hemodialysis patients with BEN or other kidney diseases (non-BEN). Methods: Recombinant human erythropoietin (75U/kg) was administered subcutaneously to 10 BEN and 14 non-BEN hemodialysis patients. The predose plasma level of erythropoietin (Epo) was subtracted from all postdose levels. The relevant pharmacokinetic parameters were calculated after noncompartmental pharmacokinetic analysis using Kinetica software (Thermo Scientific, ver.5.0). Results: Although basal plasma Epo concentration was similar in BEN (20.1 +/- 10.3U/L) and non-BEN (15.1 +/- 8.1U/L; p=.1964) patients, there were significant differences between the groups for elimination rate constant (0.016 +/- 0.006 vs 0.026 +/- 0.011 hr(-1); p=.020) and elimination half-life (50.24 +/- 19.12 vs 33.79 +/- 18.91 hr, p=.048). These differences remained significant after adjustment for patient characteristics (age, sex, hennodialysis duration, ferritin, PTH and ACEI use). No significant differences between groups were found in maximal Epo concentration, time to maximum Epo concentration, area under the curve from time of dosing extrapolated to infinity, clearance, mean residence time of Epo between groups both before and after adjustment. Conclusion: Pharmacokinetic analysis of beta-erythropoietin detected a significantly longer elimination half-life in BEN than in non BEN patients. This finding needs to be confirmed in a well-controlled study with a larger sample size.
PB  - Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid
T2  - Nefrologia
T1  - The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients
VL  - 33
IS  - 4
SP  - 478
EP  - 485
DO  - 10.3265/Nefrologia.pre2013.Apr.11800
ER  - 

@article{
author = "Lezaić, Višnja and Petković, Nenad and Marić, Ivko and Miljković, Branislava and Vučićević, Katarina and Simić-Ogrizović, Sanja and Pejović, Vesna and Đukanović, Ljubica",
year = "2013",
abstract = "Background: Balkan endemic nephropathy (BEN) hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Objectives: Comparison of the pharmacokinetics of beta-erythropoietin given subcutaneously to hemodialysis patients with BEN or other kidney diseases (non-BEN). Methods: Recombinant human erythropoietin (75U/kg) was administered subcutaneously to 10 BEN and 14 non-BEN hemodialysis patients. The predose plasma level of erythropoietin (Epo) was subtracted from all postdose levels. The relevant pharmacokinetic parameters were calculated after noncompartmental pharmacokinetic analysis using Kinetica software (Thermo Scientific, ver.5.0). Results: Although basal plasma Epo concentration was similar in BEN (20.1 +/- 10.3U/L) and non-BEN (15.1 +/- 8.1U/L; p=.1964) patients, there were significant differences between the groups for elimination rate constant (0.016 +/- 0.006 vs 0.026 +/- 0.011 hr(-1); p=.020) and elimination half-life (50.24 +/- 19.12 vs 33.79 +/- 18.91 hr, p=.048). These differences remained significant after adjustment for patient characteristics (age, sex, hennodialysis duration, ferritin, PTH and ACEI use). No significant differences between groups were found in maximal Epo concentration, time to maximum Epo concentration, area under the curve from time of dosing extrapolated to infinity, clearance, mean residence time of Epo between groups both before and after adjustment. Conclusion: Pharmacokinetic analysis of beta-erythropoietin detected a significantly longer elimination half-life in BEN than in non BEN patients. This finding needs to be confirmed in a well-controlled study with a larger sample size.",
publisher = "Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid",
journal = "Nefrologia",
title = "The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients",
volume = "33",
number = "4",
pages = "478-485",
doi = "10.3265/Nefrologia.pre2013.Apr.11800"
}

Lezaić, V., Petković, N., Marić, I., Miljković, B., Vučićević, K., Simić-Ogrizović, S., Pejović, V.,& Đukanović, L.. (2013). The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients. in Nefrologia
Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid., 33(4), 478-485.
https://doi.org/10.3265/Nefrologia.pre2013.Apr.11800

Lezaić V, Petković N, Marić I, Miljković B, Vučićević K, Simić-Ogrizović S, Pejović V, Đukanović L. The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients. in Nefrologia. 2013;33(4):478-485.
doi:10.3265/Nefrologia.pre2013.Apr.11800 .

Lezaić, Višnja, Petković, Nenad, Marić, Ivko, Miljković, Branislava, Vučićević, Katarina, Simić-Ogrizović, Sanja, Pejović, Vesna, Đukanović, Ljubica, "The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients" in Nefrologia, 33, no. 4 (2013):478-485,
https://doi.org/10.3265/Nefrologia.pre2013.Apr.11800 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bojić, Suzana
AU  - Basta-Jovanović, Gordana
AU  - Radojević, Sanja
AU  - Pavlović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Violeta
AU  - Naumović, Radomir
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1842
AB  - Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
PB  - Hindawi Publishing Corporation, New York
T2  - Disease Markers
T1  - Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
SP  - 567
EP  - 572
DO  - 10.1155/2013/183246
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bojić, Suzana and Basta-Jovanović, Gordana and Radojević, Sanja and Pavlović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Naumović, Radomir",
year = "2013",
abstract = "Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Disease Markers",
title = "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy",
pages = "567-572",
doi = "10.1155/2013/183246"
}

Simić-Ogrizović, S., Bojić, S., Basta-Jovanović, G., Radojević, S., Pavlović, J., Kotur-Stevuljević, J., Dopsaj, V.,& Naumović, R.. (2013). Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers
Hindawi Publishing Corporation, New York., 567-572.
https://doi.org/10.1155/2013/183246

Simić-Ogrizović S, Bojić S, Basta-Jovanović G, Radojević S, Pavlović J, Kotur-Stevuljević J, Dopsaj V, Naumović R. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers. 2013;:567-572.
doi:10.1155/2013/183246 .

Simić-Ogrizović, Sanja, Bojić, Suzana, Basta-Jovanović, Gordana, Radojević, Sanja, Pavlović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Naumović, Radomir, "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy" in Disease Markers (2013):567-572,
https://doi.org/10.1155/2013/183246 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Vucković, Maja
AU  - Dopsaj, Violeta
AU  - Giga, Vojislav
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1719
AB  - The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation
VL  - 226
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1620/tjem.226.137
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Vucković, Maja and Dopsaj, Violeta and Giga, Vojislav and Kravljaca, Milica and Stošović, Milan and Lezaić, Višnja",
year = "2012",
abstract = "The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation",
volume = "226",
number = "2",
pages = "137-144",
doi = "10.1620/tjem.226.137"
}

Simić-Ogrizović, S., Bogavac-Stanojević, N., Vucković, M., Dopsaj, V., Giga, V., Kravljaca, M., Stošović, M.,& Lezaić, V.. (2012). Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 226(2), 137-144.
https://doi.org/10.1620/tjem.226.137

Simić-Ogrizović S, Bogavac-Stanojević N, Vucković M, Dopsaj V, Giga V, Kravljaca M, Stošović M, Lezaić V. Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry. 2012;226(2):137-144.
doi:10.1620/tjem.226.137 .

Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Vucković, Maja, Dopsaj, Violeta, Giga, Vojislav, Kravljaca, Milica, Stošović, Milan, Lezaić, Višnja, "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation" in Toxicological and Environmental Chemistry, 226, no. 2 (2012):137-144,
https://doi.org/10.1620/tjem.226.137 . .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Bontić, Ana
AU  - Ignjatović, Svetlana
AU  - Pavlović, Jelena
AU  - Majkić-Singh, Nada
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1747
AB  - Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients
VL  - 140
IS  - 3-4
SP  - 173
EP  - 178
DO  - 10.2298/SARH1204173D
ER  - 

@article{
author = "Dajak, Marijana and Bontić, Ana and Ignjatović, Svetlana and Pavlović, Jelena and Majkić-Singh, Nada and Lezaić, Višnja",
year = "2012",
abstract = "Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients",
volume = "140",
number = "3-4",
pages = "173-178",
doi = "10.2298/SARH1204173D"
}

Dajak, M., Bontić, A., Ignjatović, S., Pavlović, J., Majkić-Singh, N.,& Lezaić, V.. (2012). Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(3-4), 173-178.
https://doi.org/10.2298/SARH1204173D

Dajak M, Bontić A, Ignjatović S, Pavlović J, Majkić-Singh N, Lezaić V. Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo. 2012;140(3-4):173-178.
doi:10.2298/SARH1204173D .

Dajak, Marijana, Bontić, Ana, Ignjatović, Svetlana, Pavlović, Jelena, Majkić-Singh, Nada, Lezaić, Višnja, "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients" in Srpski arhiv za celokupno lekarstvo, 140, no. 3-4 (2012):173-178,
https://doi.org/10.2298/SARH1204173D . .