TY  - JOUR
AU  - Dudašova Petrovičova, Olina
AU  - Stanković, Ivan
AU  - Đorđević, Brižita
AU  - Dopsaj, Violeta
AU  - Milinković, Neda
AU  - Dopsaj, Milivoj
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5409
AB  - A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group (n = 15) and a control group (n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS (p = 0.010) and OSI (p = 0.004), a lower MDA (p = 0.001) and a higher level of SH groups (p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group (p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes.
PB  - MDPI
T2  - Metabolites
T1  - How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress
VL  - 13
IS  - 12
DO  - 10.3390/metabo13121200
ER  - 

@article{
author = "Dudašova Petrovičova, Olina and Stanković, Ivan and Đorđević, Brižita and Dopsaj, Violeta and Milinković, Neda and Dopsaj, Milivoj",
year = "2023",
abstract = "A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group (n = 15) and a control group (n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS (p = 0.010) and OSI (p = 0.004), a lower MDA (p = 0.001) and a higher level of SH groups (p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group (p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes.",
publisher = "MDPI",
journal = "Metabolites",
title = "How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress",
volume = "13",
number = "12",
doi = "10.3390/metabo13121200"
}

Dudašova Petrovičova, O., Stanković, I., Đorđević, B., Dopsaj, V., Milinković, N.,& Dopsaj, M.. (2023). How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress. in Metabolites
MDPI., 13(12).
https://doi.org/10.3390/metabo13121200

Dudašova Petrovičova O, Stanković I, Đorđević B, Dopsaj V, Milinković N, Dopsaj M. How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress. in Metabolites. 2023;13(12).
doi:10.3390/metabo13121200 .

Dudašova Petrovičova, Olina, Stanković, Ivan, Đorđević, Brižita, Dopsaj, Violeta, Milinković, Neda, Dopsaj, Milivoj, "How Supplementation with SOD-Rich Plant Extract, Combined with Gliadin, Can Affect Oxidative Stress Markers and Zonulin Levels in Exercise-Induced Oxidative Stress" in Metabolites, 13, no. 12 (2023),
https://doi.org/10.3390/metabo13121200 . .