PHS HHS - 46851

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PHS HHS - 46851

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Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence

Savić, Miroslav; Obradović, Dragan I.; Ugrešić, Nenad; Cook, James M.; Yin, Wenyuan; van Linn, Michael; Bokonjić, Dubravko

(Pergamon-Elsevier Science Ltd, Oxford, 2006)

TY  - JOUR
AU  - Savić, Miroslav
AU  - Obradović, Dragan I.
AU  - Ugrešić, Nenad
AU  - Cook, James M.
AU  - Yin, Wenyuan
AU  - van Linn, Michael
AU  - Bokonjić, Dubravko
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/828
AB  - Benzodiazepine site inverse agonists may increase or decrease locomotor activity in rodents, depending on the experimental settings. We have compared the behavioral responses to environmental novelty of rats treated with the non-selective inverse agonist DMCM (2 mg/kg) and the alpha(1)-subunit affinity-selective inverse agonist 3-EBC (15 mg/kg). The behavior in spontaneous locomotor assay (during 45 min) and elevated plus maze (EPM) was automatically recorded. In the EPM, general activity-related parameters were similarly decreased, whereas only DMCM inhibited open-arm activity. In the locomotor assay, both compounds depressed locomotion in the first 15 min and activity in the central zone of the chamber. However, the influence of 3-EBC was less pronounced. The alpha(1)-subunit selective antagonist beta-CCt (15 mg/kg) attenuated locomotor depression, but not the central-zone avoidance elicited by DMCM. When habituated to the chamber, DMCM-treated animals emitted a plateau phase of activity, which disappeared by adding beta-CCt. Hence, inhibition of activity in exposed areas may be mediated by non-alpha(1)-subunits, whereas both alpha(1) and non-alpha(1)-subunits may participate in suppression of activity in more protective areas of an apparatus. Hyperlocomotion in habituated animals may depend primarily on the alpha(1)-subunit. Moreover, the bimodal influence of inverse agonists on locomotion can be biphasic, observable in the same experiment.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Pharmacology Biochemistry and Behavior
T1  - Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence
VL  - 84
IS  - 1
SP  - 35
EP  - 42
DO  - 10.1016/j.pbb.2006.04.001
ER  - 
@article{
author = "Savić, Miroslav and Obradović, Dragan I. and Ugrešić, Nenad and Cook, James M. and Yin, Wenyuan and van Linn, Michael and Bokonjić, Dubravko",
year = "2006",
abstract = "Benzodiazepine site inverse agonists may increase or decrease locomotor activity in rodents, depending on the experimental settings. We have compared the behavioral responses to environmental novelty of rats treated with the non-selective inverse agonist DMCM (2 mg/kg) and the alpha(1)-subunit affinity-selective inverse agonist 3-EBC (15 mg/kg). The behavior in spontaneous locomotor assay (during 45 min) and elevated plus maze (EPM) was automatically recorded. In the EPM, general activity-related parameters were similarly decreased, whereas only DMCM inhibited open-arm activity. In the locomotor assay, both compounds depressed locomotion in the first 15 min and activity in the central zone of the chamber. However, the influence of 3-EBC was less pronounced. The alpha(1)-subunit selective antagonist beta-CCt (15 mg/kg) attenuated locomotor depression, but not the central-zone avoidance elicited by DMCM. When habituated to the chamber, DMCM-treated animals emitted a plateau phase of activity, which disappeared by adding beta-CCt. Hence, inhibition of activity in exposed areas may be mediated by non-alpha(1)-subunits, whereas both alpha(1) and non-alpha(1)-subunits may participate in suppression of activity in more protective areas of an apparatus. Hyperlocomotion in habituated animals may depend primarily on the alpha(1)-subunit. Moreover, the bimodal influence of inverse agonists on locomotion can be biphasic, observable in the same experiment.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Pharmacology Biochemistry and Behavior",
title = "Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence",
volume = "84",
number = "1",
pages = "35-42",
doi = "10.1016/j.pbb.2006.04.001"
}
Savić, M., Obradović, D. I., Ugrešić, N., Cook, J. M., Yin, W., van Linn, M.,& Bokonjić, D.. (2006). Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence. in Pharmacology Biochemistry and Behavior
Pergamon-Elsevier Science Ltd, Oxford., 84(1), 35-42.
https://doi.org/10.1016/j.pbb.2006.04.001
Savić M, Obradović DI, Ugrešić N, Cook JM, Yin W, van Linn M, Bokonjić D. Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence. in Pharmacology Biochemistry and Behavior. 2006;84(1):35-42.
doi:10.1016/j.pbb.2006.04.001 .
Savić, Miroslav, Obradović, Dragan I., Ugrešić, Nenad, Cook, James M., Yin, Wenyuan, van Linn, Michael, Bokonjić, Dubravko, "Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence" in Pharmacology Biochemistry and Behavior, 84, no. 1 (2006):35-42,
https://doi.org/10.1016/j.pbb.2006.04.001 . .
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