TY  - JOUR
AU  - Gopčević, Kristina
AU  - Grujić, Slavica
AU  - Arsenijević, Jelena
AU  - Džamić, Ana
AU  - Veličković, Ivona
AU  - Izrael-Živković, Lidija
AU  - Medić, Ana
AU  - Mudrić, Jelena
AU  - Soković, Marina
AU  - Đurić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4342
AB  - The aim of the study was to investigate the biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains of Bacillus cereus and Micrococcus flavus (MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.
PB  - Nature Research
T2  - Scientific Reports
T1  - Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction
VL  - 12
IS  - 1
DO  - 10.1038/s41598-022-25668-3
ER  - 

@article{
author = "Gopčević, Kristina and Grujić, Slavica and Arsenijević, Jelena and Džamić, Ana and Veličković, Ivona and Izrael-Živković, Lidija and Medić, Ana and Mudrić, Jelena and Soković, Marina and Đurić, Ana",
year = "2022",
abstract = "The aim of the study was to investigate the biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains of Bacillus cereus and Micrococcus flavus (MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient against Aspergillus ochraceus (MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction",
volume = "12",
number = "1",
doi = "10.1038/s41598-022-25668-3"
}

Gopčević, K., Grujić, S., Arsenijević, J., Džamić, A., Veličković, I., Izrael-Živković, L., Medić, A., Mudrić, J., Soković, M.,& Đurić, A.. (2022). Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction. in Scientific Reports
Nature Research., 12(1).
https://doi.org/10.1038/s41598-022-25668-3

Gopčević K, Grujić S, Arsenijević J, Džamić A, Veličković I, Izrael-Živković L, Medić A, Mudrić J, Soković M, Đurić A. Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction. in Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-25668-3 .

Gopčević, Kristina, Grujić, Slavica, Arsenijević, Jelena, Džamić, Ana, Veličković, Ivona, Izrael-Živković, Lidija, Medić, Ana, Mudrić, Jelena, Soković, Marina, Đurić, Ana, "Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction" in Scientific Reports, 12, no. 1 (2022),
https://doi.org/10.1038/s41598-022-25668-3 . .