TY  - JOUR
AU  - Radojcić, Maja R.
AU  - El Marroun, Hanan
AU  - Miljković, Branislava
AU  - Stricker, Bruno H. C.
AU  - Jaddoe, Vincent W. V.
AU  - Verhulst, Frank C.
AU  - White, Tonya
AU  - Tiemeier, Henning
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2982
AB  - Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children. At child age, 6 years, Oppositional Defiant Disorder (ODD), Aggressive Behavior and Anxiety Problems were assessed by the Child Behavior Checklist (CBCL) reported by the mother and the Teacher Report Form (TRF). Children prenatally exposed to BBRM had higher scores of ODD and aggressive behavior, but not of anxiety. However, these associations were explained by maternal anxiety symptoms during pregnancy. Moreover, prenatal exposure to anxiety (without exposure to BBRM) was associated with increased scores of child ODD, aggressive behavior, and anxiety. In conclusion, the current study demonstrates that prenatal BBRM exposure was not independently associated with ODD and aggressive behavior in childhood when prenatal anxiety symptoms were taken into account.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Neurotoxicology and Teratology
T1  - Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study
VL  - 61
SP  - 58
EP  - 65
DO  - 10.1016/j.ntt.2017.02.005
ER  - 

@article{
author = "Radojcić, Maja R. and El Marroun, Hanan and Miljković, Branislava and Stricker, Bruno H. C. and Jaddoe, Vincent W. V. and Verhulst, Frank C. and White, Tonya and Tiemeier, Henning",
year = "2017",
abstract = "Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children. At child age, 6 years, Oppositional Defiant Disorder (ODD), Aggressive Behavior and Anxiety Problems were assessed by the Child Behavior Checklist (CBCL) reported by the mother and the Teacher Report Form (TRF). Children prenatally exposed to BBRM had higher scores of ODD and aggressive behavior, but not of anxiety. However, these associations were explained by maternal anxiety symptoms during pregnancy. Moreover, prenatal exposure to anxiety (without exposure to BBRM) was associated with increased scores of child ODD, aggressive behavior, and anxiety. In conclusion, the current study demonstrates that prenatal BBRM exposure was not independently associated with ODD and aggressive behavior in childhood when prenatal anxiety symptoms were taken into account.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Neurotoxicology and Teratology",
title = "Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study",
volume = "61",
pages = "58-65",
doi = "10.1016/j.ntt.2017.02.005"
}

Radojcić, M. R., El Marroun, H., Miljković, B., Stricker, B. H. C., Jaddoe, V. W. V., Verhulst, F. C., White, T.,& Tiemeier, H.. (2017). Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study. in Neurotoxicology and Teratology
Pergamon-Elsevier Science Ltd, Oxford., 61, 58-65.
https://doi.org/10.1016/j.ntt.2017.02.005

Radojcić MR, El Marroun H, Miljković B, Stricker BHC, Jaddoe VWV, Verhulst FC, White T, Tiemeier H. Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study. in Neurotoxicology and Teratology. 2017;61:58-65.
doi:10.1016/j.ntt.2017.02.005 .

Radojcić, Maja R., El Marroun, Hanan, Miljković, Branislava, Stricker, Bruno H. C., Jaddoe, Vincent W. V., Verhulst, Frank C., White, Tonya, Tiemeier, Henning, "Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study" in Neurotoxicology and Teratology, 61 (2017):58-65,
https://doi.org/10.1016/j.ntt.2017.02.005 . .