Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200134 (University of Novi Sad, Faculty of Technology)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200134 (University of Novi Sad, Faculty of Technology) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200134 (Univerzitet u Novom Sadu, Tehnološki fakultet) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200134 (Универзитет у Новом Саду, Технолошки факултет) (sr)
Authors

Publications

Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices

Petronijević, M.; Ražić, Slavica; Tubić, A.; Molnar Jazić, J.; Watson, M.; Dalmacija, B.; Agbaba, J.

(Institute for Ionics, 2023)

TY  - JOUR
AU  - Petronijević, M.
AU  - Ražić, Slavica
AU  - Tubić, A.
AU  - Molnar Jazić, J.
AU  - Watson, M.
AU  - Dalmacija, B.
AU  - Agbaba, J.
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4552
AB  - The aim of this study was to investigate the influence of UV/H2O2 advanced oxidation process on the natural organic matter content and disinfection by-products formation potential of different water matrices. Three water matrices (two natural waters and a synthetic humic acid solution) with different natural organic matter characteristics and concentrations were analysed. The carbonaceous disinfection by-products: trihalomethanes, haloacetic acids and haloketones, as well as nitrogenous disinfection by-products: haloacetonitriles and chloropicrin were investigated after chlorination. The UV/H2O2 treatment resulted in significant trihalomethane and haloacetic acids precursors removal (up to 53% and 30%, respectively) in humic acid solution in conditions ≥ 1.0 mg H2O2/mg DOC, in combination with a dose of UV irradiation ≥ 3000 mJ/cm2. Under the same reaction conditions, in natural groundwater rich in hydrophobic natural organic matter, the advanced process was less effective in DBP precursors removal. On the other hand, the advanced process was very effective in trihalomethaneprecursors removal (up to 76%) in groundwater with hydrophyilic natural organic matter. Haloketones were formed after treatment in very low concentrations. Nitrogenous disinfection by-products were only formed in the natural water containing hydrophilic organic matter, during the advanced process at 3.0 mg H2O2/mg DOC. The UV/H2O2 process resulted in negligible organic matter mineralization, but increased the brominated disinfection by-products formation in waters with low to medium bromide contents. It was concluded that under the same advanced oxidation process reaction conditions different natural organic matter structures showed different reactivities with chlorine toward the formation of the investigated disinfection by-products.
PB  - Institute for Ionics
T2  - International Journal of Environmental Science and Technology
T1  - Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices
DO  - 10.1007/s13762-023-04862-4
ER  - 
@article{
author = "Petronijević, M. and Ražić, Slavica and Tubić, A. and Molnar Jazić, J. and Watson, M. and Dalmacija, B. and Agbaba, J.",
year = "2023",
abstract = "The aim of this study was to investigate the influence of UV/H2O2 advanced oxidation process on the natural organic matter content and disinfection by-products formation potential of different water matrices. Three water matrices (two natural waters and a synthetic humic acid solution) with different natural organic matter characteristics and concentrations were analysed. The carbonaceous disinfection by-products: trihalomethanes, haloacetic acids and haloketones, as well as nitrogenous disinfection by-products: haloacetonitriles and chloropicrin were investigated after chlorination. The UV/H2O2 treatment resulted in significant trihalomethane and haloacetic acids precursors removal (up to 53% and 30%, respectively) in humic acid solution in conditions ≥ 1.0 mg H2O2/mg DOC, in combination with a dose of UV irradiation ≥ 3000 mJ/cm2. Under the same reaction conditions, in natural groundwater rich in hydrophobic natural organic matter, the advanced process was less effective in DBP precursors removal. On the other hand, the advanced process was very effective in trihalomethaneprecursors removal (up to 76%) in groundwater with hydrophyilic natural organic matter. Haloketones were formed after treatment in very low concentrations. Nitrogenous disinfection by-products were only formed in the natural water containing hydrophilic organic matter, during the advanced process at 3.0 mg H2O2/mg DOC. The UV/H2O2 process resulted in negligible organic matter mineralization, but increased the brominated disinfection by-products formation in waters with low to medium bromide contents. It was concluded that under the same advanced oxidation process reaction conditions different natural organic matter structures showed different reactivities with chlorine toward the formation of the investigated disinfection by-products.",
publisher = "Institute for Ionics",
journal = "International Journal of Environmental Science and Technology",
title = "Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices",
doi = "10.1007/s13762-023-04862-4"
}
Petronijević, M., Ražić, S., Tubić, A., Molnar Jazić, J., Watson, M., Dalmacija, B.,& Agbaba, J.. (2023). Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices. in International Journal of Environmental Science and Technology
Institute for Ionics..
https://doi.org/10.1007/s13762-023-04862-4
Petronijević M, Ražić S, Tubić A, Molnar Jazić J, Watson M, Dalmacija B, Agbaba J. Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices. in International Journal of Environmental Science and Technology. 2023;.
doi:10.1007/s13762-023-04862-4 .
Petronijević, M., Ražić, Slavica, Tubić, A., Molnar Jazić, J., Watson, M., Dalmacija, B., Agbaba, J., "Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices" in International Journal of Environmental Science and Technology (2023),
https://doi.org/10.1007/s13762-023-04862-4 . .

Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant

Milinković Budinčić, Jelena; Petrović, Lidija; Đekić, Ljiljana; Aleksić, Milijana; Fraj, Jadranka; Popović, Senka; Bučko, Sandra; Katona, Jaroslav; Spasojević, Ljiljana; Škrbić, Jelena; Malenović, Anđelija

(MDPI, 2021)

TY  - JOUR
AU  - Milinković Budinčić, Jelena
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Aleksić, Milijana
AU  - Fraj, Jadranka
AU  - Popović, Senka
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
AU  - Spasojević, Ljiljana
AU  - Škrbić, Jelena
AU  - Malenović, Anđelija
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4021
AB  - Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant
VL  - 15
IS  - 1
DO  - 10.3390/ph15010054
ER  - 
@article{
author = "Milinković Budinčić, Jelena and Petrović, Lidija and Đekić, Ljiljana and Aleksić, Milijana and Fraj, Jadranka and Popović, Senka and Bučko, Sandra and Katona, Jaroslav and Spasojević, Ljiljana and Škrbić, Jelena and Malenović, Anđelija",
year = "2021",
abstract = "Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant",
volume = "15",
number = "1",
doi = "10.3390/ph15010054"
}
Milinković Budinčić, J., Petrović, L., Đekić, L., Aleksić, M., Fraj, J., Popović, S., Bučko, S., Katona, J., Spasojević, L., Škrbić, J.,& Malenović, A.. (2021). Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant. in Pharmaceuticals
MDPI., 15(1).
https://doi.org/10.3390/ph15010054
Milinković Budinčić J, Petrović L, Đekić L, Aleksić M, Fraj J, Popović S, Bučko S, Katona J, Spasojević L, Škrbić J, Malenović A. Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant. in Pharmaceuticals. 2021;15(1).
doi:10.3390/ph15010054 .
Milinković Budinčić, Jelena, Petrović, Lidija, Đekić, Ljiljana, Aleksić, Milijana, Fraj, Jadranka, Popović, Senka, Bučko, Sandra, Katona, Jaroslav, Spasojević, Ljiljana, Škrbić, Jelena, Malenović, Anđelija, "Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant" in Pharmaceuticals, 15, no. 1 (2021),
https://doi.org/10.3390/ph15010054 . .
1
9
10

Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules

Milinković Budinčić, Jelena; Petrović, Lidija; Đekić, Ljiljana; Fraj, Jadranka; Bučko, Sandra; Katona, Jaroslav; Spasojević, Ljiljana

(Elsevier Ltd, 2021)

TY  - JOUR
AU  - Milinković Budinčić, Jelena
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Fraj, Jadranka
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
AU  - Spasojević, Ljiljana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3774
AB  - Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 ± 0.213 μm), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 ± 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.
PB  - Elsevier Ltd
T2  - Carbohydrate Polymers
T1  - Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules
VL  - 251
DO  - 10.1016/j.carbpol.2020.116988
ER  - 
@article{
author = "Milinković Budinčić, Jelena and Petrović, Lidija and Đekić, Ljiljana and Fraj, Jadranka and Bučko, Sandra and Katona, Jaroslav and Spasojević, Ljiljana",
year = "2021",
abstract = "Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 ± 0.213 μm), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 ± 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.",
publisher = "Elsevier Ltd",
journal = "Carbohydrate Polymers",
title = "Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules",
volume = "251",
doi = "10.1016/j.carbpol.2020.116988"
}
Milinković Budinčić, J., Petrović, L., Đekić, L., Fraj, J., Bučko, S., Katona, J.,& Spasojević, L.. (2021). Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules. in Carbohydrate Polymers
Elsevier Ltd., 251.
https://doi.org/10.1016/j.carbpol.2020.116988
Milinković Budinčić J, Petrović L, Đekić L, Fraj J, Bučko S, Katona J, Spasojević L. Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules. in Carbohydrate Polymers. 2021;251.
doi:10.1016/j.carbpol.2020.116988 .
Milinković Budinčić, Jelena, Petrović, Lidija, Đekić, Ljiljana, Fraj, Jadranka, Bučko, Sandra, Katona, Jaroslav, Spasojević, Ljiljana, "Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules" in Carbohydrate Polymers, 251 (2021),
https://doi.org/10.1016/j.carbpol.2020.116988 . .
55
20
49

Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system

Fraj, Jadranka; Petrović, Lidija; Đekić, Ljiljana; Milinković Budinčić, Jelena; Bučko, Sandra; Katona, Jaroslav

(Elsevier Ltd, 2021)

TY  - JOUR
AU  - Fraj, Jadranka
AU  - Petrović, Lidija
AU  - Đekić, Ljiljana
AU  - Milinković Budinčić, Jelena
AU  - Bučko, Sandra
AU  - Katona, Jaroslav
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3695
AB  - The objective of this study was to produce and characterize microcapsules for simultaneous encapsulation hydrophilic and lipophilic active substances. For this purpose, double emulsification process was employed, followed by complex coacervation in the system of two oppositely charged biopolymers, gelatin and sodium caseinate (NaCAS). Properties of the microcapsules wall have been regulated by cross-linking of the gelatin/NaCAS complex at the interface with genipin. Vitamins C and E were selected as model hydrophilic and lipophilic bioactive compounds for this study. Investigations of surface morphology, encapsulation efficiency (EE) and kinetic of vitamin C release have shown that genipin concentration as well as interaction in gelatin/NaCAS system make an influence on microcapsules properties. Genipin concentration of 2 mmol/g, was chosen as the optimal and the highest EE of the vitamins were obtained at proteins mass ratio of 2:1. The results of release kinetic determination of the vitamins showed that release mechanism is simple diffusion.
PB  - Elsevier Ltd
T2  - Journal of Food Engineering
T1  - Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system
VL  - 292
DO  - 10.1016/j.jfoodeng.2020.110353
ER  - 
@article{
author = "Fraj, Jadranka and Petrović, Lidija and Đekić, Ljiljana and Milinković Budinčić, Jelena and Bučko, Sandra and Katona, Jaroslav",
year = "2021",
abstract = "The objective of this study was to produce and characterize microcapsules for simultaneous encapsulation hydrophilic and lipophilic active substances. For this purpose, double emulsification process was employed, followed by complex coacervation in the system of two oppositely charged biopolymers, gelatin and sodium caseinate (NaCAS). Properties of the microcapsules wall have been regulated by cross-linking of the gelatin/NaCAS complex at the interface with genipin. Vitamins C and E were selected as model hydrophilic and lipophilic bioactive compounds for this study. Investigations of surface morphology, encapsulation efficiency (EE) and kinetic of vitamin C release have shown that genipin concentration as well as interaction in gelatin/NaCAS system make an influence on microcapsules properties. Genipin concentration of 2 mmol/g, was chosen as the optimal and the highest EE of the vitamins were obtained at proteins mass ratio of 2:1. The results of release kinetic determination of the vitamins showed that release mechanism is simple diffusion.",
publisher = "Elsevier Ltd",
journal = "Journal of Food Engineering",
title = "Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system",
volume = "292",
doi = "10.1016/j.jfoodeng.2020.110353"
}
Fraj, J., Petrović, L., Đekić, L., Milinković Budinčić, J., Bučko, S.,& Katona, J.. (2021). Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system. in Journal of Food Engineering
Elsevier Ltd., 292.
https://doi.org/10.1016/j.jfoodeng.2020.110353
Fraj J, Petrović L, Đekić L, Milinković Budinčić J, Bučko S, Katona J. Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system. in Journal of Food Engineering. 2021;292.
doi:10.1016/j.jfoodeng.2020.110353 .
Fraj, Jadranka, Petrović, Lidija, Đekić, Ljiljana, Milinković Budinčić, Jelena, Bučko, Sandra, Katona, Jaroslav, "Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system" in Journal of Food Engineering, 292 (2021),
https://doi.org/10.1016/j.jfoodeng.2020.110353 . .
30
6
24

From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry

Ražić, Slavica; Cvetanović, Aleksandra; Arsenijević, Jelena

(University of Alicante, 2021)

TY  - CONF
AU  - Ražić, Slavica
AU  - Cvetanović, Aleksandra
AU  - Arsenijević, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5157
PB  - University of Alicante
C3  - 23rd International Symposium on Advances in Extraction Technologies, Book of abstracts
T1  - From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry
SP  - 108
EP  - 108
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5157
ER  - 
@conference{
author = "Ražić, Slavica and Cvetanović, Aleksandra and Arsenijević, Jelena",
year = "2021",
publisher = "University of Alicante",
journal = "23rd International Symposium on Advances in Extraction Technologies, Book of abstracts",
title = "From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry",
pages = "108-108",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5157"
}
Ražić, S., Cvetanović, A.,& Arsenijević, J.. (2021). From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry. in 23rd International Symposium on Advances in Extraction Technologies, Book of abstracts
University of Alicante., 108-108.
https://hdl.handle.net/21.15107/rcub_farfar_5157
Ražić S, Cvetanović A, Arsenijević J. From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry. in 23rd International Symposium on Advances in Extraction Technologies, Book of abstracts. 2021;:108-108.
https://hdl.handle.net/21.15107/rcub_farfar_5157 .
Ražić, Slavica, Cvetanović, Aleksandra, Arsenijević, Jelena, "From plants samples to analysis of biologically active compounds – toward green(er) analytical chemistry" in 23rd International Symposium on Advances in Extraction Technologies, Book of abstracts (2021):108-108,
https://hdl.handle.net/21.15107/rcub_farfar_5157 .

Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents

Kovačević, Strahinja; Karadžić Banjac, Milica; Milošević, Nataša; Ćurčić, Jelena; Marjanović, Dunja; Todorović, Nemanja; Krmar, Jovana; Podunavac-Kuzmanović, Sanja; Banjac, Nebojša; Ušćumlić, Gordana

(Elsevier B.V., 2020)

TY  - JOUR
AU  - Kovačević, Strahinja
AU  - Karadžić Banjac, Milica
AU  - Milošević, Nataša
AU  - Ćurčić, Jelena
AU  - Marjanović, Dunja
AU  - Todorović, Nemanja
AU  - Krmar, Jovana
AU  - Podunavac-Kuzmanović, Sanja
AU  - Banjac, Nebojša
AU  - Ušćumlić, Gordana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3645
AB  - Numerous structurally different amides and imides including succinimide derivatives exhibit diverse bioactive potential. The development of new compounds requires rationalization in the design in or- der to provide structural changes that guarantee favorable physico-chemical properties, pharmacological activity and safety. In the present research, a comprehensive study with comparison of the chromato- graphic lipophilicity and other physico-chemical properties of five groups of 1-arylsuccinimide derivatives was conducted. The chemometric analysis of their physico-chemical properties was carried out by us- ing unsupervised (hierarchical cluster analysis and principal component analysis) and supervised pattern recognition methods (linear discriminant analysis), while the correlations between the in silico molecular features and chromatographic lipophilicity were examined applying linear and non-linear Quantitative Structure–Retention Relationship (QSRR) approaches. The main aim of the conducted research was to determine similarities and dissimilarities among the studied 1-arylsuccinimides, to point out the molec- ular features which have significant influence on their lipophilicity, as well as to establish high-quality QSRR models which can be used in prediction of chromatographic lipophilicity of structurally similar 1-arylsuccinimides. This study is a continuation of analysis and determination of the physico-chemical properties of 1-arylsuccinimides which could be important guidelines in further in vitro and eventually in vivo studies of their biological potential.
PB  - Elsevier B.V.
T2  - Journal of Chromatography A
T1  - Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents
VL  - 1628
DO  - 10.1016/j.chroma.2020.461439
ER  - 
@article{
author = "Kovačević, Strahinja and Karadžić Banjac, Milica and Milošević, Nataša and Ćurčić, Jelena and Marjanović, Dunja and Todorović, Nemanja and Krmar, Jovana and Podunavac-Kuzmanović, Sanja and Banjac, Nebojša and Ušćumlić, Gordana",
year = "2020",
abstract = "Numerous structurally different amides and imides including succinimide derivatives exhibit diverse bioactive potential. The development of new compounds requires rationalization in the design in or- der to provide structural changes that guarantee favorable physico-chemical properties, pharmacological activity and safety. In the present research, a comprehensive study with comparison of the chromato- graphic lipophilicity and other physico-chemical properties of five groups of 1-arylsuccinimide derivatives was conducted. The chemometric analysis of their physico-chemical properties was carried out by us- ing unsupervised (hierarchical cluster analysis and principal component analysis) and supervised pattern recognition methods (linear discriminant analysis), while the correlations between the in silico molecular features and chromatographic lipophilicity were examined applying linear and non-linear Quantitative Structure–Retention Relationship (QSRR) approaches. The main aim of the conducted research was to determine similarities and dissimilarities among the studied 1-arylsuccinimides, to point out the molec- ular features which have significant influence on their lipophilicity, as well as to establish high-quality QSRR models which can be used in prediction of chromatographic lipophilicity of structurally similar 1-arylsuccinimides. This study is a continuation of analysis and determination of the physico-chemical properties of 1-arylsuccinimides which could be important guidelines in further in vitro and eventually in vivo studies of their biological potential.",
publisher = "Elsevier B.V.",
journal = "Journal of Chromatography A",
title = "Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents",
volume = "1628",
doi = "10.1016/j.chroma.2020.461439"
}
Kovačević, S., Karadžić Banjac, M., Milošević, N., Ćurčić, J., Marjanović, D., Todorović, N., Krmar, J., Podunavac-Kuzmanović, S., Banjac, N.,& Ušćumlić, G.. (2020). Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents. in Journal of Chromatography A
Elsevier B.V.., 1628.
https://doi.org/10.1016/j.chroma.2020.461439
Kovačević S, Karadžić Banjac M, Milošević N, Ćurčić J, Marjanović D, Todorović N, Krmar J, Podunavac-Kuzmanović S, Banjac N, Ušćumlić G. Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents. in Journal of Chromatography A. 2020;1628.
doi:10.1016/j.chroma.2020.461439 .
Kovačević, Strahinja, Karadžić Banjac, Milica, Milošević, Nataša, Ćurčić, Jelena, Marjanović, Dunja, Todorović, Nemanja, Krmar, Jovana, Podunavac-Kuzmanović, Sanja, Banjac, Nebojša, Ušćumlić, Gordana, "Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents" in Journal of Chromatography A, 1628 (2020),
https://doi.org/10.1016/j.chroma.2020.461439 . .
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