TY  - JOUR
AU  - Đuričić, Ivana
AU  - Gojković, Tamara
AU  - Antonijević, Biljana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4060
AB  - Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view.
AB  - Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia
T1  - Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije
VL  - 79
IS  - 1
SP  - 8
EP  - 16
DO  - 10.2298/VSP200212054D
ER  - 

@article{
author = "Đuričić, Ivana and Gojković, Tamara and Antonijević, Biljana and Šobajić, Slađana",
year = "2022",
abstract = "Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view., Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia, Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije",
volume = "79",
number = "1",
pages = "8-16",
doi = "10.2298/VSP200212054D"
}

Đuričić, I., Gojković, T., Antonijević, B.,& Šobajić, S.. (2022). Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 79(1), 8-16.
https://doi.org/10.2298/VSP200212054D

Đuričić I, Gojković T, Antonijević B, Šobajić S. Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled. 2022;79(1):8-16.
doi:10.2298/VSP200212054D .

Đuričić, Ivana, Gojković, Tamara, Antonijević, Biljana, Šobajić, Slađana, "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia" in Vojnosanitetski pregled, 79, no. 1 (2022):8-16,
https://doi.org/10.2298/VSP200212054D . .

TY  - JOUR
AU  - Radovanović, Jelena
AU  - Antonijević, Biljana
AU  - Kolarević, Stoimir
AU  - Milutinović-Smiljanić, Sanja
AU  - Mandić, Jelena
AU  - Vuković-Gačić, Branka
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Kračun-Kolarević, Margareta
AU  - Sunjog, Karolina
AU  - Kostić-Vuković, Jovana
AU  - Jovanović Marić, Jovana
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Mandinić, Zoran
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3761
AB  - The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.
PB  - Elsevier Ltd
T2  - Chemosphere
T1  - Genotoxicity of fluoride subacute exposure in rats and selenium intervention
VL  - 266
DO  - 10.1016/j.chemosphere.2020.128978
ER  - 

@article{
author = "Radovanović, Jelena and Antonijević, Biljana and Kolarević, Stoimir and Milutinović-Smiljanić, Sanja and Mandić, Jelena and Vuković-Gačić, Branka and Bulat, Zorica and Ćurčić, Marijana and Kračun-Kolarević, Margareta and Sunjog, Karolina and Kostić-Vuković, Jovana and Jovanović Marić, Jovana and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Mandinić, Zoran",
year = "2021",
abstract = "The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.",
publisher = "Elsevier Ltd",
journal = "Chemosphere",
title = "Genotoxicity of fluoride subacute exposure in rats and selenium intervention",
volume = "266",
doi = "10.1016/j.chemosphere.2020.128978"
}

Radovanović, J., Antonijević, B., Kolarević, S., Milutinović-Smiljanić, S., Mandić, J., Vuković-Gačić, B., Bulat, Z., Ćurčić, M., Kračun-Kolarević, M., Sunjog, K., Kostić-Vuković, J., Jovanović Marić, J., Antonijević-Miljaković, E., Đukić-Ćosić, D., Buha-Đorđević, A., Javorac, D., Baralić, K.,& Mandinić, Z.. (2021). Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere
Elsevier Ltd., 266.
https://doi.org/10.1016/j.chemosphere.2020.128978

Radovanović J, Antonijević B, Kolarević S, Milutinović-Smiljanić S, Mandić J, Vuković-Gačić B, Bulat Z, Ćurčić M, Kračun-Kolarević M, Sunjog K, Kostić-Vuković J, Jovanović Marić J, Antonijević-Miljaković E, Đukić-Ćosić D, Buha-Đorđević A, Javorac D, Baralić K, Mandinić Z. Genotoxicity of fluoride subacute exposure in rats and selenium intervention. in Chemosphere. 2021;266.
doi:10.1016/j.chemosphere.2020.128978 .

Radovanović, Jelena, Antonijević, Biljana, Kolarević, Stoimir, Milutinović-Smiljanić, Sanja, Mandić, Jelena, Vuković-Gačić, Branka, Bulat, Zorica, Ćurčić, Marijana, Kračun-Kolarević, Margareta, Sunjog, Karolina, Kostić-Vuković, Jovana, Jovanović Marić, Jovana, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Mandinić, Zoran, "Genotoxicity of fluoride subacute exposure in rats and selenium intervention" in Chemosphere, 266 (2021),
https://doi.org/10.1016/j.chemosphere.2020.128978 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Tatović, Simona
AU  - Baralić, Katarina
AU  - Antonijević, Evica
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3715
AB  - Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.
AB  - Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.
PB  - Sciendo
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture
T1  - Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova
VL  - 71
IS  - 3
SP  - 197
EP  - 204
DO  - 10.2478/aiht-2020-71-3425
ER  - 

@article{
author = "Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Tatović, Simona and Baralić, Katarina and Antonijević, Evica and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2020",
abstract = "Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity., Dosadašnji podatci o neurotoksičnosti olova (Pb) i kadmija (Cd) uglavnom su opisani nakon izloženosti pojedinačnim
metalima, a podatci o neurotoksičnom djelovanju smjese tih dvaju metala prilično su oskudni. Cilj ovoga rada bio je
ispitati učinak akutnoga izlaganja smjesi olova i kadmija na parametre oksidacijskoga stresa i status bioelemenata u mozgu
štakora. Životinje su bile podijeljene u pet skupina: Cd15 (15 mg/kg), Cd30 (30 mg/kg), Pb150 (150 mg/kg), Pb150+Cd15
i kontrolna, netretirana skupina. Smjesa olova i kadmija dovela je do značajno viših vrijednosti malondialdehida (MDA)
i drugih produkata u mozgu štakora u usporedbi s kontrolnom skupinom i obama pojedinačnim metalima. To je iznimno
važno, imajući u vidu da je prisutnost MDA-a u mozgu povezana s mnogim neurodegenerativnim poremećajima. Nije
dobivena statistički značajna razlika između ispitivanih skupina u razinama cinka (Zn), bakra (Cu), mangana (Mn) i
željeza (Fe). Rezultati ovoga istraživanja važan su doprinos budućim istraživanjima smjesa i upućuju na to da istraživanja
toksičnosti u kojima se procjenjuje neurotoksičnost pojedinačnih kemikalija ne pružaju stvarni uvid u neurotoksičnost
njihovih smjesa kojima smo izloženi u stvarnom životu. Dobiveni rezultati otvaraju daljnja pitanja o interakciji i
mehanizmima toksičnosti smjese tih metala.",
publisher = "Sciendo",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture, Redoks status i razine bioelemenata u mozgu štakora akutno izloženih smjesi kadmija i olova",
volume = "71",
number = "3",
pages = "197-204",
doi = "10.2478/aiht-2020-71-3425"
}

Javorac, D., Buha-Đorđević, A., Anđelković, M., Tatović, S., Baralić, K., Antonijević, E., Kotur-Stevuljević, J., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2020). Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Sciendo., 71(3), 197-204.
https://doi.org/10.2478/aiht-2020-71-3425

Javorac D, Buha-Đorđević A, Anđelković M, Tatović S, Baralić K, Antonijević E, Kotur-Stevuljević J, Đukić-Ćosić D, Antonijević B, Bulat Z. Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2020;71(3):197-204.
doi:10.2478/aiht-2020-71-3425 .

Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Tatović, Simona, Baralić, Katarina, Antonijević, Evica, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 71, no. 3 (2020):197-204,
https://doi.org/10.2478/aiht-2020-71-3425 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Jorgovanović, Dragica
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3634
AB  - Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats
VL  - 143
DO  - 10.1016/j.fct.2020.111540
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Jorgovanović, Dragica and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 108 CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats",
volume = "143",
doi = "10.1016/j.fct.2020.111540"
}

Baralić, K., Živančević, K., Javorac, D., Buha-Đorđević, A., Anđelković, M., Jorgovanović, D., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology
Elsevier Ltd., 143.
https://doi.org/10.1016/j.fct.2020.111540

Baralić K, Živančević K, Javorac D, Buha-Đorđević A, Anđelković M, Jorgovanović D, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats. in Food and Chemical Toxicology. 2020;143.
doi:10.1016/j.fct.2020.111540 .

Baralić, Katarina, Živančević, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Jorgovanović, Dragica, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats" in Food and Chemical Toxicology, 143 (2020),
https://doi.org/10.1016/j.fct.2020.111540 . .

TY  - JOUR
AU  - Wallace, David R.
AU  - Taalab, Yasmeen M.
AU  - Heinze, Sarah
AU  - Tariba Lovaković, Sarah
AU  - Pizent, Alica
AU  - Renieri, Elisavit
AU  - Tsatsakis, Aristidis
AU  - Farooqi, Ammad Ahmad
AU  - Javorac, Dragana
AU  - Anđelković, Milena
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3578
AB  - Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).
PB  - MDPI
T2  - Cells
T1  - Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development
VL  - 9
IS  - 4
DO  - 10.3390/cells9040901
ER  - 

@article{
author = "Wallace, David R. and Taalab, Yasmeen M. and Heinze, Sarah and Tariba Lovaković, Sarah and Pizent, Alica and Renieri, Elisavit and Tsatsakis, Aristidis and Farooqi, Ammad Ahmad and Javorac, Dragana and Anđelković, Milena and Bulat, Zorica and Antonijević, Biljana and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)-short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain-a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).",
publisher = "MDPI",
journal = "Cells",
title = "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development",
volume = "9",
number = "4",
doi = "10.3390/cells9040901"
}

Wallace, D. R., Taalab, Y. M., Heinze, S., Tariba Lovaković, S., Pizent, A., Renieri, E., Tsatsakis, A., Farooqi, A. A., Javorac, D., Anđelković, M., Bulat, Z., Antonijević, B.,& Buha-Đorđević, A.. (2020). Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells
MDPI., 9(4).
https://doi.org/10.3390/cells9040901

Wallace DR, Taalab YM, Heinze S, Tariba Lovaković S, Pizent A, Renieri E, Tsatsakis A, Farooqi AA, Javorac D, Anđelković M, Bulat Z, Antonijević B, Buha-Đorđević A. Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development. in Cells. 2020;9(4).
doi:10.3390/cells9040901 .

Wallace, David R., Taalab, Yasmeen M., Heinze, Sarah, Tariba Lovaković, Sarah, Pizent, Alica, Renieri, Elisavit, Tsatsakis, Aristidis, Farooqi, Ammad Ahmad, Javorac, Dragana, Anđelković, Milena, Bulat, Zorica, Antonijević, Biljana, Buha-Đorđević, Aleksandra, "Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development" in Cells, 9, no. 4 (2020),
https://doi.org/10.3390/cells9040901 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Živančević, Katarina
AU  - Antonijević, Evica
AU  - Anđelković, Milena
AU  - Javorac, Dragana
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3499
AB  - Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.
PB  - MDPI
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats
VL  - 17
IS  - 3
DO  - 10.3390/ijerph17030746
ER  - 

@article{
author = "Baralić, Katarina and Buha-Đorđević, Aleksandra and Živančević, Katarina and Antonijević, Evica and Anđelković, Milena and Javorac, Dragana and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2020",
abstract = "Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and aect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through dierent biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.",
publisher = "MDPI",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats",
volume = "17",
number = "3",
doi = "10.3390/ijerph17030746"
}

Baralić, K., Buha-Đorđević, A., Živančević, K., Antonijević, E., Anđelković, M., Javorac, D., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2020). Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health
MDPI., 17(3).
https://doi.org/10.3390/ijerph17030746

Baralić K, Buha-Đorđević A, Živančević K, Antonijević E, Anđelković M, Javorac D, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats. in International Journal of Environmental Research and Public Health. 2020;17(3).
doi:10.3390/ijerph17030746 .

Baralić, Katarina, Buha-Đorđević, Aleksandra, Živančević, Katarina, Antonijević, Evica, Anđelković, Milena, Javorac, Dragana, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats" in International Journal of Environmental Research and Public Health, 17, no. 3 (2020),
https://doi.org/10.3390/ijerph17030746 . .

TY  - JOUR
AU  - Repić, Aleksandra
AU  - Bulat, Petar
AU  - Antonijević, Biljana
AU  - Antunović, Marko
AU  - Džudović, Jelena
AU  - Buha, Aleksandra
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3486
AB  - According to theWorld Health Organization, in 2015, the Serbian population ranked among the highest ones in Europe in terms of smoking habit: 44.3%males and 36.2%females aged 18–64 smoked tobacco. In the last 7 years, 25%of total mortality inmen and 9%in women from Serbia were associated with smoking. Tobacco smoking is one of the most important sources of exposure to many toxic substances in general population. Our study confirmed higher blood levels of two toxic metals, cadmium and lead, in the blood of smokers (3.5 and 1.5 times higher than in non-smokers, respectively). Furthermore, smoking habits, such as number of smoked cigarettes per day, smoking period and cigarette type, along with age, were shown to influence these metals’ blood concentration. Higher blood levels of Cd and Pb were found in smokers consuming more than 10 cigarettes per day for more than 10 years. The present study also highlighted the importance of the controlled tobacco production, since it was shown that consumption of illicit tobacco could manifold the exposure to toxic metals that can subsequently increase the frequency of related diseases as well.
PB  - Springer-Verlag GmbH Germany, part of Springer Nature
T2  - Environmental Science and Pollution Research
T1  - The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people
VL  - 27
SP  - 751
EP  - 760
DO  - 10.1007/s11356-019-06840-1
ER  - 

@article{
author = "Repić, Aleksandra and Bulat, Petar and Antonijević, Biljana and Antunović, Marko and Džudović, Jelena and Buha, Aleksandra and Bulat, Zorica",
year = "2020",
abstract = "According to theWorld Health Organization, in 2015, the Serbian population ranked among the highest ones in Europe in terms of smoking habit: 44.3%males and 36.2%females aged 18–64 smoked tobacco. In the last 7 years, 25%of total mortality inmen and 9%in women from Serbia were associated with smoking. Tobacco smoking is one of the most important sources of exposure to many toxic substances in general population. Our study confirmed higher blood levels of two toxic metals, cadmium and lead, in the blood of smokers (3.5 and 1.5 times higher than in non-smokers, respectively). Furthermore, smoking habits, such as number of smoked cigarettes per day, smoking period and cigarette type, along with age, were shown to influence these metals’ blood concentration. Higher blood levels of Cd and Pb were found in smokers consuming more than 10 cigarettes per day for more than 10 years. The present study also highlighted the importance of the controlled tobacco production, since it was shown that consumption of illicit tobacco could manifold the exposure to toxic metals that can subsequently increase the frequency of related diseases as well.",
publisher = "Springer-Verlag GmbH Germany, part of Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people",
volume = "27",
pages = "751-760",
doi = "10.1007/s11356-019-06840-1"
}

Repić, A., Bulat, P., Antonijević, B., Antunović, M., Džudović, J., Buha, A.,& Bulat, Z.. (2020). The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people. in Environmental Science and Pollution Research
Springer-Verlag GmbH Germany, part of Springer Nature., 27, 751-760.
https://doi.org/10.1007/s11356-019-06840-1

Repić A, Bulat P, Antonijević B, Antunović M, Džudović J, Buha A, Bulat Z. The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people. in Environmental Science and Pollution Research. 2020;27:751-760.
doi:10.1007/s11356-019-06840-1 .

Repić, Aleksandra, Bulat, Petar, Antonijević, Biljana, Antunović, Marko, Džudović, Jelena, Buha, Aleksandra, Bulat, Zorica, "The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people" in Environmental Science and Pollution Research, 27 (2020):751-760,
https://doi.org/10.1007/s11356-019-06840-1 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3511
AB  - Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it is difficult to identify a fine line between these mechanisms of Cd toxicity, making their understanding highly complicated. The most important mechanisms by which Cd manifests its toxic effects include changes in gene expression and inhibition of damaged DNA repair, interference of apoptosis and autophagy, oxidative stress, and interaction with bioelements. In this review, we will give a brief overview of the recent developments and findings on the most relevant general and specific mechanisms and molecular pathways of Cd toxicity.
T2  - Current Opinion in Toxicology
T1  - An overview of molecular mechanisms in cadmium toxicity
VL  - 19
SP  - 56
EP  - 62
DO  - 10.1016/j.cotox.2019.12.002
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Javorac, Dragana and Buha-Đorđević, Aleksandra and Bulat, Zorica",
year = "2020",
abstract = "Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it is difficult to identify a fine line between these mechanisms of Cd toxicity, making their understanding highly complicated. The most important mechanisms by which Cd manifests its toxic effects include changes in gene expression and inhibition of damaged DNA repair, interference of apoptosis and autophagy, oxidative stress, and interaction with bioelements. In this review, we will give a brief overview of the recent developments and findings on the most relevant general and specific mechanisms and molecular pathways of Cd toxicity.",
journal = "Current Opinion in Toxicology",
title = "An overview of molecular mechanisms in cadmium toxicity",
volume = "19",
pages = "56-62",
doi = "10.1016/j.cotox.2019.12.002"
}

Đukić-Ćosić, D., Baralić, K., Javorac, D., Buha-Đorđević, A.,& Bulat, Z.. (2020). An overview of molecular mechanisms in cadmium toxicity. in Current Opinion in Toxicology, 19, 56-62.
https://doi.org/10.1016/j.cotox.2019.12.002

Đukić-Ćosić D, Baralić K, Javorac D, Buha-Đorđević A, Bulat Z. An overview of molecular mechanisms in cadmium toxicity. in Current Opinion in Toxicology. 2020;19:56-62.
doi:10.1016/j.cotox.2019.12.002 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Javorac, Dragana, Buha-Đorđević, Aleksandra, Bulat, Zorica, "An overview of molecular mechanisms in cadmium toxicity" in Current Opinion in Toxicology, 19 (2020):56-62,
https://doi.org/10.1016/j.cotox.2019.12.002 . .

TY  - JOUR
AU  - Moulis, Jean-Marc
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3520
AB  - Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.
PB  - Elsevier
T2  - Current Opinion in Toxicology
T1  - Threshold in the toxicology of metals: Challenges and pitfalls of the concept
VL  - 19
SP  - 28
EP  - 33
DO  - 10.1016/j.cotox.2019.10.004
ER  - 

@article{
author = "Moulis, Jean-Marc and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2020",
abstract = "Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.",
publisher = "Elsevier",
journal = "Current Opinion in Toxicology",
title = "Threshold in the toxicology of metals: Challenges and pitfalls of the concept",
volume = "19",
pages = "28-33",
doi = "10.1016/j.cotox.2019.10.004"
}

Moulis, J., Bulat, Z.,& Buha-Đorđević, A.. (2020). Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology
Elsevier., 19, 28-33.
https://doi.org/10.1016/j.cotox.2019.10.004

Moulis J, Bulat Z, Buha-Đorđević A. Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology. 2020;19:28-33.
doi:10.1016/j.cotox.2019.10.004 .

Moulis, Jean-Marc, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Threshold in the toxicology of metals: Challenges and pitfalls of the concept" in Current Opinion in Toxicology, 19 (2020):28-33,
https://doi.org/10.1016/j.cotox.2019.10.004 . .

TY  - JOUR
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Evica
AU  - Ćurčić, Marijana
AU  - Milovanović, Vesna
AU  - Antonijević, Biljana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3470
AB  - The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
PB  - Elsevier
T2  - Current Opinion in Toxicology
T1  - Endocrine-disrupting mechanisms of polychlorinated biphenyls
VL  - 19
SP  - 42
EP  - 49
DO  - 10.1016/j.cotox.2019.10.006
ER  - 

@article{
author = "Buha-Đorđević, Aleksandra and Antonijević, Evica and Ćurčić, Marijana and Milovanović, Vesna and Antonijević, Biljana",
year = "2020",
abstract = "The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.",
publisher = "Elsevier",
journal = "Current Opinion in Toxicology",
title = "Endocrine-disrupting mechanisms of polychlorinated biphenyls",
volume = "19",
pages = "42-49",
doi = "10.1016/j.cotox.2019.10.006"
}

Buha-Đorđević, A., Antonijević, E., Ćurčić, M., Milovanović, V.,& Antonijević, B.. (2020). Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology
Elsevier., 19, 42-49.
https://doi.org/10.1016/j.cotox.2019.10.006

Buha-Đorđević A, Antonijević E, Ćurčić M, Milovanović V, Antonijević B. Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology. 2020;19:42-49.
doi:10.1016/j.cotox.2019.10.006 .

Buha-Đorđević, Aleksandra, Antonijević, Evica, Ćurčić, Marijana, Milovanović, Vesna, Antonijević, Biljana, "Endocrine-disrupting mechanisms of polychlorinated biphenyls" in Current Opinion in Toxicology, 19 (2020):42-49,
https://doi.org/10.1016/j.cotox.2019.10.006 . .

TY  - JOUR
AU  - Tulić, Lidija
AU  - Ćurčić, Marijana
AU  - Stojnić, Jelena
AU  - Bulat, Zorica
AU  - Protić, Isidora
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3632
AB  - Introduction/Objective The aim was to assess the effect of oxidative stress parameters on sperm count, motility, and morphology of spermatozoa, and the influence of different semen parameters on the outcome of in vitro fertilization (IVF) procedure – the number of fertilized oocytes, fertilization, and pregnancy rate of female partners. Method In 52 male patients superoxide dismutase (SOD), malondialdehyde (MDA), and sulfhydryl (-SH) groups were determined in serum, before beginning the IVF cycle. Semen samples were collected after 2–3 days of sexual abstinence. Results Patients were divided into two groups, the normozoospermic, and those with pathological sperm findings. The second group was divided into oligozoospermic, asthenozoospermic, and teratozoospermic groups. SOD activity was lower, while MDA and-SH groups, while not significantly, was higher in groups with sperm parameter disorders. Fertilization rate was significantly lower in the group of asthenozoospermia and teratozoospermia (p = 0.034), as well as delivery rate (p = 0.020). The group with oligozoospermia had significantly lower delivery rate (p = 0.013). Conclusion Our study found higher fertilization and delivery rate in men with normozoospermia. However, no significant correlation between OS markers and semen parameters was found.
AB  - Увод/Циљ Циљ рада била је процена утицаја параметара оксидативног стреса на број, покретљивост и морфологију сперматозоида, као и утицаја различитих параметара спер-мограма на исход поступка in vitro фертилизације, број фер-тилисаних ооцита, стопе фертилизације и порођаја.Методе Код 52 мушка партнера одређиване су вредности супероксид-дисмутазе, малондиалдехидаи сулфидрила(-SHгрупа) у серуму, пре започињања поступка in vitro ферти-лизације. Узорци семена сакупљани су после два-три дана апстиненције. Резултати Болесници су били подељени у две групе: гру-па са нормозооспермијом и група са патолошким налазом спермограма. Друга група је затим подељена на подгрупе: олигозооспермија, астенозооспермија и тератозооспер-мија. Активност супероксид-дисмутазе била је нижа, док су вредности малондиалдехидаи -SH група биле више у гру-пама са поремећеним параметрима спермограма, али не статистички значајно. Стопа фертилизације била је значајно нижа у групи са астенозооспермијом и тератозооспермијом (p = 0,034), а такође и стопа порођаја (p = 0,020). Група са олигозооспермијом имала је значајно нижу стопу порођаја (p = 0,013).Закључак У овој студији пронађене су више стопе ферти-лизације и порођаја у групи са нормозооспермијом. Није било значајне корелације између параметара оксидативног стреса и спермограма.
PB  - Serbia Medical Society
T2  - Srpski Arhiv za Celokupno Lekarstvo
T1  - Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization
T1  - Корелација маркера оксидативног стреса и параметара спермограма  са исходом вантелесне оплодње
VL  - 148
IS  - 5-6
SP  - 310
EP  - 314
DO  - 10.2298/SARH190409010T
ER  - 

@article{
author = "Tulić, Lidija and Ćurčić, Marijana and Stojnić, Jelena and Bulat, Zorica and Protić, Isidora",
year = "2020",
abstract = "Introduction/Objective The aim was to assess the effect of oxidative stress parameters on sperm count, motility, and morphology of spermatozoa, and the influence of different semen parameters on the outcome of in vitro fertilization (IVF) procedure – the number of fertilized oocytes, fertilization, and pregnancy rate of female partners. Method In 52 male patients superoxide dismutase (SOD), malondialdehyde (MDA), and sulfhydryl (-SH) groups were determined in serum, before beginning the IVF cycle. Semen samples were collected after 2–3 days of sexual abstinence. Results Patients were divided into two groups, the normozoospermic, and those with pathological sperm findings. The second group was divided into oligozoospermic, asthenozoospermic, and teratozoospermic groups. SOD activity was lower, while MDA and-SH groups, while not significantly, was higher in groups with sperm parameter disorders. Fertilization rate was significantly lower in the group of asthenozoospermia and teratozoospermia (p = 0.034), as well as delivery rate (p = 0.020). The group with oligozoospermia had significantly lower delivery rate (p = 0.013). Conclusion Our study found higher fertilization and delivery rate in men with normozoospermia. However, no significant correlation between OS markers and semen parameters was found., Увод/Циљ Циљ рада била је процена утицаја параметара оксидативног стреса на број, покретљивост и морфологију сперматозоида, као и утицаја различитих параметара спер-мограма на исход поступка in vitro фертилизације, број фер-тилисаних ооцита, стопе фертилизације и порођаја.Методе Код 52 мушка партнера одређиване су вредности супероксид-дисмутазе, малондиалдехидаи сулфидрила(-SHгрупа) у серуму, пре започињања поступка in vitro ферти-лизације. Узорци семена сакупљани су после два-три дана апстиненције. Резултати Болесници су били подељени у две групе: гру-па са нормозооспермијом и група са патолошким налазом спермограма. Друга група је затим подељена на подгрупе: олигозооспермија, астенозооспермија и тератозооспер-мија. Активност супероксид-дисмутазе била је нижа, док су вредности малондиалдехидаи -SH група биле више у гру-пама са поремећеним параметрима спермограма, али не статистички значајно. Стопа фертилизације била је значајно нижа у групи са астенозооспермијом и тератозооспермијом (p = 0,034), а такође и стопа порођаја (p = 0,020). Група са олигозооспермијом имала је значајно нижу стопу порођаја (p = 0,013).Закључак У овој студији пронађене су више стопе ферти-лизације и порођаја у групи са нормозооспермијом. Није било значајне корелације између параметара оксидативног стреса и спермограма.",
publisher = "Serbia Medical Society",
journal = "Srpski Arhiv za Celokupno Lekarstvo",
title = "Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization, Корелација маркера оксидативног стреса и параметара спермограма  са исходом вантелесне оплодње",
volume = "148",
number = "5-6",
pages = "310-314",
doi = "10.2298/SARH190409010T"
}

Tulić, L., Ćurčić, M., Stojnić, J., Bulat, Z.,& Protić, I.. (2020). Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization. in Srpski Arhiv za Celokupno Lekarstvo
Serbia Medical Society., 148(5-6), 310-314.
https://doi.org/10.2298/SARH190409010T

Tulić L, Ćurčić M, Stojnić J, Bulat Z, Protić I. Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization. in Srpski Arhiv za Celokupno Lekarstvo. 2020;148(5-6):310-314.
doi:10.2298/SARH190409010T .

Tulić, Lidija, Ćurčić, Marijana, Stojnić, Jelena, Bulat, Zorica, Protić, Isidora, "Correlation of oxidative stress markers and semen parameters with the outcome of in vitro fertilization" in Srpski Arhiv za Celokupno Lekarstvo, 148, no. 5-6 (2020):310-314,
https://doi.org/10.2298/SARH190409010T . .

TY  - JOUR
AU  - Milović, Sanja
AU  - Stanković, Ivan
AU  - Nikolić, Dejan
AU  - Radović, Jelena
AU  - Kolundžić, Marina
AU  - Nikolić, Vesna
AU  - Stanojković, Tatjana
AU  - Petović, Slavica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3468
AB  - Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro
VL  - 16
IS  - 10
SP  - 1
EP  - 11
DO  - 10.1002/cbdv.201900327
ER  - 

@article{
author = "Milović, Sanja and Stanković, Ivan and Nikolić, Dejan and Radović, Jelena and Kolundžić, Marina and Nikolić, Vesna and Stanojković, Tatjana and Petović, Slavica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro",
volume = "16",
number = "10",
pages = "1-11",
doi = "10.1002/cbdv.201900327"
}

Milović, S., Stanković, I., Nikolić, D., Radović, J., Kolundžić, M., Nikolić, V., Stanojković, T., Petović, S.,& Kundaković-Vasović, T.. (2019). Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity
Wiley., 16(10), 1-11.
https://doi.org/10.1002/cbdv.201900327

Milović S, Stanković I, Nikolić D, Radović J, Kolundžić M, Nikolić V, Stanojković T, Petović S, Kundaković-Vasović T. Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity. 2019;16(10):1-11.
doi:10.1002/cbdv.201900327 .

Milović, Sanja, Stanković, Ivan, Nikolić, Dejan, Radović, Jelena, Kolundžić, Marina, Nikolić, Vesna, Stanojković, Tatjana, Petović, Slavica, Kundaković-Vasović, Tatjana, "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro" in Chemistry and Biodiversity, 16, no. 10 (2019):1-11,
https://doi.org/10.1002/cbdv.201900327 . .

TY  - JOUR
AU  - Milović, Sanja
AU  - Stanković, Ivan
AU  - Nikolić, Dejan
AU  - Radović, Jelena
AU  - Kolundžić, Marina
AU  - Nikolić, Vesna
AU  - Stanojković, Tatjana
AU  - Petović, Slavica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3463
AB  - Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro
VL  - 16
IS  - 10
SP  - 1
EP  - 11
DO  - 10.1002/cbdv.201900327
ER  - 

@article{
author = "Milović, Sanja and Stanković, Ivan and Nikolić, Dejan and Radović, Jelena and Kolundžić, Marina and Nikolić, Vesna and Stanojković, Tatjana and Petović, Slavica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro",
volume = "16",
number = "10",
pages = "1-11",
doi = "10.1002/cbdv.201900327"
}

Milović, S., Stanković, I., Nikolić, D., Radović, J., Kolundžić, M., Nikolić, V., Stanojković, T., Petović, S.,& Kundaković-Vasović, T.. (2019). Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity
Wiley., 16(10), 1-11.
https://doi.org/10.1002/cbdv.201900327

Milović S, Stanković I, Nikolić D, Radović J, Kolundžić M, Nikolić V, Stanojković T, Petović S, Kundaković-Vasović T. Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity. 2019;16(10):1-11.
doi:10.1002/cbdv.201900327 .

Milović, Sanja, Stanković, Ivan, Nikolić, Dejan, Radović, Jelena, Kolundžić, Marina, Nikolić, Vesna, Stanojković, Tatjana, Petović, Slavica, Kundaković-Vasović, Tatjana, "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro" in Chemistry and Biodiversity, 16, no. 10 (2019):1-11,
https://doi.org/10.1002/cbdv.201900327 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Evica
AU  - Antonijević, Biljana
AU  - Stanić, Momcilo
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jovanović, Miloš
AU  - Boricić, Novica
AU  - Wallace, David
AU  - Bulat, Zorica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3301
AB  - Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.
PB  - MDPI, Basel
T2  - International Journal of Environmental Research and Public Health
T1  - Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney
VL  - 16
IS  - 2
DO  - 10.3390/ijerph16020274
ER  - 

@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević, Evica and Antonijević, Biljana and Stanić, Momcilo and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Jovanović, Miloš and Boricić, Novica and Wallace, David and Bulat, Zorica",
year = "2019",
abstract = "Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.",
publisher = "MDPI, Basel",
journal = "International Journal of Environmental Research and Public Health",
title = "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney",
volume = "16",
number = "2",
doi = "10.3390/ijerph16020274"
}

Anđelković, M., Buha-Đorđević, A., Antonijević, E., Antonijević, B., Stanić, M., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Jovanović, M., Boricić, N., Wallace, D.,& Bulat, Z.. (2019). Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health
MDPI, Basel., 16(2).
https://doi.org/10.3390/ijerph16020274

Anđelković M, Buha-Đorđević A, Antonijević E, Antonijević B, Stanić M, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Jovanović M, Boricić N, Wallace D, Bulat Z. Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. in International Journal of Environmental Research and Public Health. 2019;16(2).
doi:10.3390/ijerph16020274 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević, Evica, Antonijević, Biljana, Stanić, Momcilo, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Jovanović, Miloš, Boricić, Novica, Wallace, David, Bulat, Zorica, "Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney" in International Journal of Environmental Research and Public Health, 16, no. 2 (2019),
https://doi.org/10.3390/ijerph16020274 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević, Biljana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3249
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
VL  - 308
SP  - 385
EP  - 391
DO  - 10.1016/j.cbi.2019.05.034
ER  - 

@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević, Biljana",
year = "2019",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation",
volume = "308",
pages = "385-391",
doi = "10.1016/j.cbi.2019.05.034"
}

Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Anđelković, M., Buha-Đorđević, A.,& Antonijević, B.. (2019). Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 308, 385-391.
https://doi.org/10.1016/j.cbi.2019.05.034

Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Anđelković M, Buha-Đorđević A, Antonijević B. Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation. in Chemico-Biological Interactions. 2019;308:385-391.
doi:10.1016/j.cbi.2019.05.034 .

Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević, Biljana, "Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation" in Chemico-Biological Interactions, 308 (2019):385-391,
https://doi.org/10.1016/j.cbi.2019.05.034 . .

TY  - JOUR
AU  - Karaulov, A.V.
AU  - Renieri, E.A.
AU  - Smolyagin, A.I.
AU  - Mikhaylova, I.V.
AU  - Stadnikov, A.A.
AU  - Begun, D.N.
AU  - Tsarouhas, K.
AU  - Buha-Đorđević, Aleksandra
AU  - Hartung, T.
AU  - Tsatsakis, A.
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3451
AB  - AbstractHexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Long-term effects of chromium on morphological and immunological parameters of Wistar rats
VL  - 133
SP  - 1
EP  - 11
DO  - 10.1016/j.fct.2019.110748
ER  - 

@article{
author = "Karaulov, A.V. and Renieri, E.A. and Smolyagin, A.I. and Mikhaylova, I.V. and Stadnikov, A.A. and Begun, D.N. and Tsarouhas, K. and Buha-Đorđević, Aleksandra and Hartung, T. and Tsatsakis, A.",
year = "2019",
abstract = "AbstractHexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Long-term effects of chromium on morphological and immunological parameters of Wistar rats",
volume = "133",
pages = "1-11",
doi = "10.1016/j.fct.2019.110748"
}

Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, A., Hartung, T.,& Tsatsakis, A.. (2019). Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology
Elsevier., 133, 1-11.
https://doi.org/10.1016/j.fct.2019.110748

Karaulov A, Renieri E, Smolyagin A, Mikhaylova I, Stadnikov A, Begun D, Tsarouhas K, Buha-Đorđević A, Hartung T, Tsatsakis A. Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology. 2019;133:1-11.
doi:10.1016/j.fct.2019.110748 .

Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, Aleksandra, Hartung, T., Tsatsakis, A., "Long-term effects of chromium on morphological and immunological parameters of Wistar rats" in Food and Chemical Toxicology, 133 (2019):1-11,
https://doi.org/10.1016/j.fct.2019.110748 . .

TY  - JOUR
AU  - Bjørklund, Geir
AU  - Crisponi, Guido
AU  - Nurchi, Valeria Marina
AU  - Cappai, Rosita
AU  - Buha-Đorđević, Aleksandra
AU  - Aaseth, Jan
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3460
AB  - The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics.
PB  - MDPI
T2  - Molecules
T1  - A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead
VL  - 24
IS  - 3247
SP  - 1
EP  - 32
DO  - 10.3390/molecules24183247
ER  - 

@article{
author = "Bjørklund, Geir and Crisponi, Guido and Nurchi, Valeria Marina and Cappai, Rosita and Buha-Đorđević, Aleksandra and Aaseth, Jan",
year = "2019",
abstract = "The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics.",
publisher = "MDPI",
journal = "Molecules",
title = "A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead",
volume = "24",
number = "3247",
pages = "1-32",
doi = "10.3390/molecules24183247"
}

Bjørklund, G., Crisponi, G., Nurchi, V. M., Cappai, R., Buha-Đorđević, A.,& Aaseth, J.. (2019). A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead. in Molecules
MDPI., 24(3247), 1-32.
https://doi.org/10.3390/molecules24183247

Bjørklund G, Crisponi G, Nurchi VM, Cappai R, Buha-Đorđević A, Aaseth J. A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead. in Molecules. 2019;24(3247):1-32.
doi:10.3390/molecules24183247 .

Bjørklund, Geir, Crisponi, Guido, Nurchi, Valeria Marina, Cappai, Rosita, Buha-Đorđević, Aleksandra, Aaseth, Jan, "A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead" in Molecules, 24, no. 3247 (2019):1-32,
https://doi.org/10.3390/molecules24183247 . .

TY  - JOUR
AU  - Karaulov, A.V.
AU  - Renieri, E.A.
AU  - Smolyagin, A.I.
AU  - Mikhaylova, I.V.
AU  - Stadnikov, A.A.
AU  - Begun, D.N.
AU  - Tsarouhas, K.
AU  - Buha-Đorđević, Aleksandra
AU  - Hartung, T.
AU  - Tsatsakis, A.
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3450
AB  - Abstract
Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Long-term effects of chromium on morphological and immunological parameters of Wistar rats
VL  - 133
SP  - 1
EP  - 11
DO  - 10.1016/j.fct.2019.110748
ER  - 

@article{
author = "Karaulov, A.V. and Renieri, E.A. and Smolyagin, A.I. and Mikhaylova, I.V. and Stadnikov, A.A. and Begun, D.N. and Tsarouhas, K. and Buha-Đorđević, Aleksandra and Hartung, T. and Tsatsakis, A.",
year = "2019",
abstract = "Abstract
Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Long-term effects of chromium on morphological and immunological parameters of Wistar rats",
volume = "133",
pages = "1-11",
doi = "10.1016/j.fct.2019.110748"
}

Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, A., Hartung, T.,& Tsatsakis, A.. (2019). Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology
Elsevier., 133, 1-11.
https://doi.org/10.1016/j.fct.2019.110748

Karaulov A, Renieri E, Smolyagin A, Mikhaylova I, Stadnikov A, Begun D, Tsarouhas K, Buha-Đorđević A, Hartung T, Tsatsakis A. Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology. 2019;133:1-11.
doi:10.1016/j.fct.2019.110748 .

Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, Aleksandra, Hartung, T., Tsatsakis, A., "Long-term effects of chromium on morphological and immunological parameters of Wistar rats" in Food and Chemical Toxicology, 133 (2019):1-11,
https://doi.org/10.1016/j.fct.2019.110748 . .

TY  - JOUR
AU  - Hernandez, Antonio F.
AU  - Buha, Aleksandra
AU  - Constantin, Carolina
AU  - Wallace, David R.
AU  - Sarigiannis, Dimosthenis
AU  - Neagu, Monica
AU  - Antonijević, Biljana
AU  - Hayes, Wallace A.
AU  - Wilks, Martin F.
AU  - Tsatsakis, Aristidis
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3464
AB  - Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the organism. The need for adequate model systems (in vivo, in vitro, in silico and mathematical) is paramount for better understanding of chemical mixture toxicity. Currently, shortcomings plague each model system as investigators struggle to find the appropriate balance of rigor, reproducibility and appropriateness in mixture toxicity studies. Significant questions exist when comparing single-to mixture-chemical toxicity concerning additivity, synergism, potentiation, or antagonism. Dose/concentration relevance is a major consideration and should be subthreshold for better accuracy in toxicity assessment. Previous work was limited by the technology and methodology of the time, but recent advances have resulted in significant progress in the study of mixture toxicology. Novel technologies have added insight to data obtained from in vivo studies for predictive toxicity testing. These include new in vitro models: omics-related tools, organs-on-a-chip and 3D cell culture, and in silico methods. Taken together, all these modern methodologies improve the understanding of the multiple toxicity pathways associated with adverse outcomes (e.g., adverse outcome pathways), thus allowing investigators to better predict risks linked to exposure to chemical mixtures. As technology and knowledge advance, our ability to harness and integrate separate streams of evidence regarding outcomes associated with chemical mixture exposure improves. As many national and international organizations are currently stressing, studies on chemical mixture toxicity are of primary importance.
PB  - Springer Verlag
T2  - Archives of Toxicology
T1  - Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures
VL  - 93
IS  - 10
SP  - 2741
EP  - 2757
DO  - 10.1007/s00204-019-02547-x
ER  - 

@article{
author = "Hernandez, Antonio F. and Buha, Aleksandra and Constantin, Carolina and Wallace, David R. and Sarigiannis, Dimosthenis and Neagu, Monica and Antonijević, Biljana and Hayes, Wallace A. and Wilks, Martin F. and Tsatsakis, Aristidis",
year = "2019",
abstract = "Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the organism. The need for adequate model systems (in vivo, in vitro, in silico and mathematical) is paramount for better understanding of chemical mixture toxicity. Currently, shortcomings plague each model system as investigators struggle to find the appropriate balance of rigor, reproducibility and appropriateness in mixture toxicity studies. Significant questions exist when comparing single-to mixture-chemical toxicity concerning additivity, synergism, potentiation, or antagonism. Dose/concentration relevance is a major consideration and should be subthreshold for better accuracy in toxicity assessment. Previous work was limited by the technology and methodology of the time, but recent advances have resulted in significant progress in the study of mixture toxicology. Novel technologies have added insight to data obtained from in vivo studies for predictive toxicity testing. These include new in vitro models: omics-related tools, organs-on-a-chip and 3D cell culture, and in silico methods. Taken together, all these modern methodologies improve the understanding of the multiple toxicity pathways associated with adverse outcomes (e.g., adverse outcome pathways), thus allowing investigators to better predict risks linked to exposure to chemical mixtures. As technology and knowledge advance, our ability to harness and integrate separate streams of evidence regarding outcomes associated with chemical mixture exposure improves. As many national and international organizations are currently stressing, studies on chemical mixture toxicity are of primary importance.",
publisher = "Springer Verlag",
journal = "Archives of Toxicology",
title = "Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures",
volume = "93",
number = "10",
pages = "2741-2757",
doi = "10.1007/s00204-019-02547-x"
}

Hernandez, A. F., Buha, A., Constantin, C., Wallace, D. R., Sarigiannis, D., Neagu, M., Antonijević, B., Hayes, W. A., Wilks, M. F.,& Tsatsakis, A.. (2019). Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures. in Archives of Toxicology
Springer Verlag., 93(10), 2741-2757.
https://doi.org/10.1007/s00204-019-02547-x

Hernandez AF, Buha A, Constantin C, Wallace DR, Sarigiannis D, Neagu M, Antonijević B, Hayes WA, Wilks MF, Tsatsakis A. Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures. in Archives of Toxicology. 2019;93(10):2741-2757.
doi:10.1007/s00204-019-02547-x .

Hernandez, Antonio F., Buha, Aleksandra, Constantin, Carolina, Wallace, David R., Sarigiannis, Dimosthenis, Neagu, Monica, Antonijević, Biljana, Hayes, Wallace A., Wilks, Martin F., Tsatsakis, Aristidis, "Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures" in Archives of Toxicology, 93, no. 10 (2019):2741-2757,
https://doi.org/10.1007/s00204-019-02547-x . .

TY  - JOUR
AU  - Đorđević, Vladimir
AU  - Wallace, David
AU  - Schweitzer, Amie
AU  - Boricić, Novica
AU  - Knežević, Đorđe
AU  - Matić, Slavko
AU  - Grubor, Nikola
AU  - Kerkez, Mirko
AU  - Radenković, Dejan
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Matović, Vesna
AU  - Buha, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3346
AB  - Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Environment International
T1  - Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
VL  - 128
SP  - 353
EP  - 361
DO  - 10.1016/j.envint.2019.04.048
ER  - 

@article{
author = "Đorđević, Vladimir and Wallace, David and Schweitzer, Amie and Boricić, Novica and Knežević, Đorđe and Matić, Slavko and Grubor, Nikola and Kerkez, Mirko and Radenković, Dejan and Bulat, Zorica and Antonijević, Biljana and Matović, Vesna and Buha, Aleksandra",
year = "2019",
abstract = "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Environment International",
title = "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies",
volume = "128",
pages = "353-361",
doi = "10.1016/j.envint.2019.04.048"
}

Đorđević, V., Wallace, D., Schweitzer, A., Boricić, N., Knežević, Đ., Matić, S., Grubor, N., Kerkez, M., Radenković, D., Bulat, Z., Antonijević, B., Matović, V.,& Buha, A.. (2019). Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International
Pergamon-Elsevier Science Ltd, Oxford., 128, 353-361.
https://doi.org/10.1016/j.envint.2019.04.048

Đorđević V, Wallace D, Schweitzer A, Boricić N, Knežević Đ, Matić S, Grubor N, Kerkez M, Radenković D, Bulat Z, Antonijević B, Matović V, Buha A. Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies. in Environment International. 2019;128:353-361.
doi:10.1016/j.envint.2019.04.048 .

Đorđević, Vladimir, Wallace, David, Schweitzer, Amie, Boricić, Novica, Knežević, Đorđe, Matić, Slavko, Grubor, Nikola, Kerkez, Mirko, Radenković, Dejan, Bulat, Zorica, Antonijević, Biljana, Matović, Vesna, Buha, Aleksandra, "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies" in Environment International, 128 (2019):353-361,
https://doi.org/10.1016/j.envint.2019.04.048 . .

TY  - JOUR
AU  - Buha, Aleksandra
AU  - Jugdaohsingh, R
AU  - Matović, Vesna
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Kerns, J.G
AU  - Goodship, A
AU  - Hart, A
AU  - Powell, J.J
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3250
AB  - Exposure to cadmium (Cd) is recognised as one of the risk factors for osteoporosis, although critical exposure levels and exact mechanisms are still unknown. Here, we first confirmed that in male Wistar rats challenged orally with 6 different levels of Cd (0.3–10 mg/kg b.w.), over 28 days, there was a direct dose relationship to bone Cd concentration. Moreover, bone mineral content was significantly diminished by ∼15% (p  lt  0.0001) plateauing already at the lowest exposure level. For the other essential bone elements zinc (Zn) loss was most marked. Having established the sensitive metrics (measures of Cd exposure), we then applied them to 20 randomly selected human femoral head bone samples from 16 independent subjects. Bone Cd concentration was inversely proportional to trabecular bone mineral density and mineral (calcium) content and Zn content of bone, but not the donor's age. Our findings, through direct bone analyses, support the emerging epidemiological view that bone health, adjudged by mineral density, is extremely sensitive to even background levels of environmental Cd. Importantly, however, our data also suggest that Cd may play an even greater role in compromised bone health than prior indirect estimates of exposure could reveal. Environmental Cd may be a substantially determining factor in osteoporosis and large cohort studies with direct bone analyses are now merited.
PB  - Academic Press Inc.
T2  - Environmental Research
T1  - Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data
VL  - 176
DO  - 10.1016/j.envres.2019.108539
ER  - 

@article{
author = "Buha, Aleksandra and Jugdaohsingh, R and Matović, Vesna and Bulat, Zorica and Antonijević, Biljana and Kerns, J.G and Goodship, A and Hart, A and Powell, J.J",
year = "2019",
abstract = "Exposure to cadmium (Cd) is recognised as one of the risk factors for osteoporosis, although critical exposure levels and exact mechanisms are still unknown. Here, we first confirmed that in male Wistar rats challenged orally with 6 different levels of Cd (0.3–10 mg/kg b.w.), over 28 days, there was a direct dose relationship to bone Cd concentration. Moreover, bone mineral content was significantly diminished by ∼15% (p  lt  0.0001) plateauing already at the lowest exposure level. For the other essential bone elements zinc (Zn) loss was most marked. Having established the sensitive metrics (measures of Cd exposure), we then applied them to 20 randomly selected human femoral head bone samples from 16 independent subjects. Bone Cd concentration was inversely proportional to trabecular bone mineral density and mineral (calcium) content and Zn content of bone, but not the donor's age. Our findings, through direct bone analyses, support the emerging epidemiological view that bone health, adjudged by mineral density, is extremely sensitive to even background levels of environmental Cd. Importantly, however, our data also suggest that Cd may play an even greater role in compromised bone health than prior indirect estimates of exposure could reveal. Environmental Cd may be a substantially determining factor in osteoporosis and large cohort studies with direct bone analyses are now merited.",
publisher = "Academic Press Inc.",
journal = "Environmental Research",
title = "Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data",
volume = "176",
doi = "10.1016/j.envres.2019.108539"
}

Buha, A., Jugdaohsingh, R., Matović, V., Bulat, Z., Antonijević, B., Kerns, J.G, Goodship, A., Hart, A.,& Powell, J.J. (2019). Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data. in Environmental Research
Academic Press Inc.., 176.
https://doi.org/10.1016/j.envres.2019.108539

Buha A, Jugdaohsingh R, Matović V, Bulat Z, Antonijević B, Kerns J, Goodship A, Hart A, Powell J. Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data. in Environmental Research. 2019;176.
doi:10.1016/j.envres.2019.108539 .

Buha, Aleksandra, Jugdaohsingh, R, Matović, Vesna, Bulat, Zorica, Antonijević, Biljana, Kerns, J.G, Goodship, A, Hart, A, Powell, J.J, "Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data" in Environmental Research, 176 (2019),
https://doi.org/10.1016/j.envres.2019.108539 . .

TY  - JOUR
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Mandinić, Zoran
AU  - Ćurčić, Marijana
AU  - Ćupić-Miladinović, Dejana
AU  - Antonijević, Biljana
AU  - Matović, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3274
AB  - Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries.
AB  - Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia
T1  - Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija
VL  - 76
IS  - 6
SP  - 607
EP  - 614
DO  - 10.2298/VSP170721136D
ER  - 

@article{
author = "Đukić-Ćosić, Danijela and Antonijević, Evica and Mandinić, Zoran and Ćurčić, Marijana and Ćupić-Miladinović, Dejana and Antonijević, Biljana and Matović, Vesna",
year = "2019",
abstract = "Background/Aim. Fluoride has beneficial effect on dental caries prevention and enables high hardness of enamel. However, fluoride intake above optimal levels can have adverse effects on teeth and bones, especially in young children during the period of intense growth and teeth development. The aim of this study was to assess fluoride intake from water and toothpaste among 3-year-old children in Belgrade, Serbia, in the municipalities of Vračar and Novi Beograd. Methods. A questionnaire for the parents (n = 40) was used to provide information on the water consumption (tap and/or bottled water) and the brand of toothpaste used by children as well as the frequency of tooth brushing and the amount of toothpaste during brushing. Fluoride concentrations in water and toothpaste samples were determined electrochemically by using fluoride-selective electrode. Fluoride intake was estimated through a mathematical model commonly used by the U.S. Environmental Protection Agency. Results. The obtained results indicate no significant difference in daily fluoride intake through drinking water and toothpaste in 3-year-old children in Vračar (n = 19) compared to Novi Beograd (n = 21) (p > 0.05). However, all estimated fluoride levels (0.089-0.625 mg/day) are significantly lower than the optimal daily intake level for caries protection (0.7 mg/day for children up to 4 years, FNB-USA National Institute of Medicine) and two to six times lower than tolerable upper fluoride level for the children of same age (1.3 mg/day, FNB-USA National Institute of Medicine). Furthermore, calculated daily fluoride intake per kilogram body weight confirm very low fluoride intake by water and toothpaste in children of investigated municipalities in Belgrade, being significantly below the recommended an adequate intake (0.05 mg/kg/day, EFSA). Conclusion. This preliminary study has shown that daily fluoride intake in 3-year-olds is lower than tolerable upper fluoride level, even not sufficient for the prevention of dental caries., Uvod/Cilj. Fluoridi imaju pozitivan efekat na prevenciju karijesa zuba kao i povećanje čvrstine zubnog emajla. Međutim, njihov unos iznad optimalnog može imati štetne efekte na zube i kosti, posebno kod male dece tokom intenzivnog rasta i razvoja zuba. Cilj ovog rada bio je da se proceni unos fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine u Beogradu, na teritoriji dve opštine, Vračar i Novi Beograd. Metode. Anketnim upitnicima (n = 40) za roditelje dobijeni su podaci o vrsti vode koju deca piju (česmenska i/ili flaširana), proizvodima koje koriste za čišćenje i negu zuba, učestalosti pranja zuba kao i količini paste za zube koja se koristi po jednom pranju. Sadržaj fluorida u vodi za piće i pastama za zube određen je elektrohemijski sa fluoridnom jonselektivnom elektrodom. Unos fluorida procenjen je korišćenjem matematičkog modela datog od strane Američke agencije za zaštitu životne sredine. Rezultati. Dobijeni rezultati pokazuju da nema statistički značajne razlike u dnevnom unosu fluorida putem vode za piće i paste za zube između dece uzrasta od tri godine na Vračaru i Novom Beogradu (p > 0,05). Međutim, sve procenjene vrednosti unosa fluorida (0,089-0,625 mg/dan) značajno su niže od optimalnog dnevnog unosa za prevenciju karijesa (0,7 mg/dan za decu uzrasta do 4 godine, FNB-Nacionalnog instituta medicine, SAD) i dva do šest puta niže od tolerišućeg gornjeg nivoa unosa fluorida za decu istog uzrasta (1,3 mg/dan, FNBNacionalnog instituta medicine, SAD). Štaviše, izračunati dnevni unosi fluorida izraženi po kilogramu telesne mase potvrđuju veoma nizak unos fluorida kod dece ispitivanih opština u Beogradu, čak značajno niže od preporučenog optimalnog unosa (0,05 mg/kg/dan, EFSA). Zaključak. Ovim preliminarnim istraživanjem pokazano je da je dnevni unos fluorida kod trogodišnjaka u Beogradu značajno niži od tolerišućeg gornjeg nivoa unosa fluorida, čak niži od optimalnog unosa za prevenciju karijesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia, Procena unosa fluorida putem vode za piće i paste za zube kod dece uzrasta od tri godine - preliminarni rezultati u Beogradu, Republika Srbija",
volume = "76",
number = "6",
pages = "607-614",
doi = "10.2298/VSP170721136D"
}

Đukić-Ćosić, D., Antonijević, E., Mandinić, Z., Ćurčić, M., Ćupić-Miladinović, D., Antonijević, B.,& Matović, V.. (2019). Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(6), 607-614.
https://doi.org/10.2298/VSP170721136D

Đukić-Ćosić D, Antonijević E, Mandinić Z, Ćurčić M, Ćupić-Miladinović D, Antonijević B, Matović V. Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia. in Vojnosanitetski pregled. 2019;76(6):607-614.
doi:10.2298/VSP170721136D .

Đukić-Ćosić, Danijela, Antonijević, Evica, Mandinić, Zoran, Ćurčić, Marijana, Ćupić-Miladinović, Dejana, Antonijević, Biljana, Matović, Vesna, "Assessment of fluoride intake from drinking water and toothpaste in 3-year-olds: Preliminary results in Belgrade, Republic of Serbia" in Vojnosanitetski pregled, 76, no. 6 (2019):607-614,
https://doi.org/10.2298/VSP170721136D . .

TY  - JOUR
AU  - Tulić, Lidija
AU  - Vidaković, Snežana
AU  - Tulić, Ivan
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3359
AB  - The aim of this study was to investigate the association of trace element and toxic metal concentrations in blood and the outcome of in vitro fertilization (IVF). The study included 104 consecutive patients that underwent assisted reproductive technology (ART) procedures. The following parameters were determined: cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb); and copper (Cu), zinc (Zn), selenium (Se), and magnesium (Mg). Serum samples were obtained before commencing stimulation. Patients with smoking habit had significantly higher Pb concentrations (P=0.022), as well as higher concentrations of As and Hg but not significantly. All subjects were divided into groups of pregnant and nonpregnant patients. Pregnant patients had lower mean values of Mg (P=0.009), As (P lt 0.05), and Pb (P=0.034), compared to nonpregnant, and a significant correlation between pregnancy outcome and concentrations of Mg, Cd, and Pb was found. Women who had had delivered had lower Mg (P=0.009) and Cd (P=0.014) concentrations. There was a significant correlation of the negative outcome of IVF procedure with higher concentrations of Pb (P=0.046) and Cd (P=0.012). In conclusion, our results suggest that there is a difference in Mg, Pb, and Cd concentrations between pregnant and nonpregnant women. There was no association between toxic metals and number and quality of oocytes and embryos, while there was with fertilization rate. Concerning trace elements, we did not find the correlation of trace elements with oocyte number and quality, nor with a number of fertilized oocytes, except for Cu. Patients who were pregnant had lower concentrations of Mg.
PB  - Humana Press Inc, Totowa
T2  - Biological Trace Element Research
T1  - Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women
VL  - 188
IS  - 2
SP  - 284
EP  - 294
DO  - 10.1007/s12011-018-1421-z
ER  - 

@article{
author = "Tulić, Lidija and Vidaković, Snežana and Tulić, Ivan and Ćurčić, Marijana and Bulat, Zorica",
year = "2019",
abstract = "The aim of this study was to investigate the association of trace element and toxic metal concentrations in blood and the outcome of in vitro fertilization (IVF). The study included 104 consecutive patients that underwent assisted reproductive technology (ART) procedures. The following parameters were determined: cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb); and copper (Cu), zinc (Zn), selenium (Se), and magnesium (Mg). Serum samples were obtained before commencing stimulation. Patients with smoking habit had significantly higher Pb concentrations (P=0.022), as well as higher concentrations of As and Hg but not significantly. All subjects were divided into groups of pregnant and nonpregnant patients. Pregnant patients had lower mean values of Mg (P=0.009), As (P lt 0.05), and Pb (P=0.034), compared to nonpregnant, and a significant correlation between pregnancy outcome and concentrations of Mg, Cd, and Pb was found. Women who had had delivered had lower Mg (P=0.009) and Cd (P=0.014) concentrations. There was a significant correlation of the negative outcome of IVF procedure with higher concentrations of Pb (P=0.046) and Cd (P=0.012). In conclusion, our results suggest that there is a difference in Mg, Pb, and Cd concentrations between pregnant and nonpregnant women. There was no association between toxic metals and number and quality of oocytes and embryos, while there was with fertilization rate. Concerning trace elements, we did not find the correlation of trace elements with oocyte number and quality, nor with a number of fertilized oocytes, except for Cu. Patients who were pregnant had lower concentrations of Mg.",
publisher = "Humana Press Inc, Totowa",
journal = "Biological Trace Element Research",
title = "Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women",
volume = "188",
number = "2",
pages = "284-294",
doi = "10.1007/s12011-018-1421-z"
}

Tulić, L., Vidaković, S., Tulić, I., Ćurčić, M.,& Bulat, Z.. (2019). Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women. in Biological Trace Element Research
Humana Press Inc, Totowa., 188(2), 284-294.
https://doi.org/10.1007/s12011-018-1421-z

Tulić L, Vidaković S, Tulić I, Ćurčić M, Bulat Z. Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women. in Biological Trace Element Research. 2019;188(2):284-294.
doi:10.1007/s12011-018-1421-z .

Tulić, Lidija, Vidaković, Snežana, Tulić, Ivan, Ćurčić, Marijana, Bulat, Zorica, "Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women" in Biological Trace Element Research, 188, no. 2 (2019):284-294,
https://doi.org/10.1007/s12011-018-1421-z . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, V.
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Antonijević, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Matović, Vesna
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3126
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys
VL  - 295
IS  - Supplement 1
SP  - S235
EP  - S236
DO  - 10.1016/j.toxlet.2018.06.984
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Milovanović, V. and Janković, Saša and Vučinić, Slavica and Antonijević, Evica and Đukić-Ćosić, Danijela and Bulat, Zorica and Matović, Vesna and Antonijević, Biljana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys",
volume = "295",
number = "Supplement 1",
pages = "S235-S236",
doi = "10.1016/j.toxlet.2018.06.984"
}

Ćurčić, M., Buha-Đorđević, A., Milovanović, V., Janković, S., Vučinić, S., Antonijević, E., Đukić-Ćosić, D., Bulat, Z., Matović, V.,& Antonijević, B.. (2018). Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S235-S236.
https://doi.org/10.1016/j.toxlet.2018.06.984

Ćurčić M, Buha-Đorđević A, Milovanović V, Janković S, Vučinić S, Antonijević E, Đukić-Ćosić D, Bulat Z, Matović V, Antonijević B. Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters. 2018;295(Supplement 1):S235-S236.
doi:10.1016/j.toxlet.2018.06.984 .

Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Milovanović, V., Janković, Saša, Vučinić, Slavica, Antonijević, Evica, Đukić-Ćosić, Danijela, Bulat, Zorica, Matović, Vesna, Antonijević, Biljana, "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys" in Toxicology Letters, 295, no. Supplement 1 (2018):S235-S236,
https://doi.org/10.1016/j.toxlet.2018.06.984 . .

TY  - JOUR
AU  - Milovanović, Vesna
AU  - Buha, Aleksandra
AU  - Matović, Vesna
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Nakano, Takeshi
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3176
AB  - Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats
VL  - 25
IS  - 8
SP  - 7223
EP  - 7230
DO  - 10.1007/s11356-015-5921-5
ER  - 

@article{
author = "Milovanović, Vesna and Buha, Aleksandra and Matović, Vesna and Ćurčić, Marijana and Vučinić, Slavica and Nakano, Takeshi and Antonijević, Biljana",
year = "2018",
abstract = "Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats",
volume = "25",
number = "8",
pages = "7223-7230",
doi = "10.1007/s11356-015-5921-5"
}

Milovanović, V., Buha, A., Matović, V., Ćurčić, M., Vučinić, S., Nakano, T.,& Antonijević, B.. (2018). Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 25(8), 7223-7230.
https://doi.org/10.1007/s11356-015-5921-5

Milovanović V, Buha A, Matović V, Ćurčić M, Vučinić S, Nakano T, Antonijević B. Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research. 2018;25(8):7223-7230.
doi:10.1007/s11356-015-5921-5 .

Milovanović, Vesna, Buha, Aleksandra, Matović, Vesna, Ćurčić, Marijana, Vučinić, Slavica, Nakano, Takeshi, Antonijević, Biljana, "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats" in Environmental Science and Pollution Research, 25, no. 8 (2018):7223-7230,
https://doi.org/10.1007/s11356-015-5921-5 . .