TY  - THES
AU  - Milutinović, Violeta
PY  - 2021
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=8442
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:24744/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49042953
UR  - https://nardus.mpn.gov.rs/handle/123456789/18845
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4039
AB  - hibridogenih).Semipreparativnim LC-MS metodama, iz MeOH ekstrakta cvasti H. calophyllum izolovana sučetiri seskviterpenska laktona (krepizid E i tri nova jedinjenja: 8-epi-ikserisamin A, kalofilamin A ikalofilamin B), a iz MeOH ekstrakta podzemnih organa H. scheppigianum pet fenolkarboksilnih(mono- ili di-O-kafeoilhina) kiselina (identifikacija na osnovu NMR i MS spektara).Ukupno četiri seskviterpenska laktona, sedam mono- ili di-O-kafeoilhina kiselina i 19flavonoida (luteolin, apigenin, diosmetin, 15 njihovih heterozida i heterozid kvercetina)kvantifikovani su u suvim MeOH ekstraktima ispitivanih podzemnih organa dve vrste i herbi 28vrsta LC-MS metodama, i pet triterpena (derivata ursana, oleana i lupana) u suvim CH2Cl2ekstraktima herbi 28 vrsta GC-FID-MS metodom (identifikacija pomoću standarda, NMR, MS i/iliUV spektara). Hemosistematski značaj jedinjenja identifikovanih u herbama 28 vrsta utvrđen jemultivarijantnim statističkim metodama (PCA, nMDS i UPGMA).Suvi MeOH ekstrakti herbi su in vitro pokazali značajan ukupni antioksidantni potencijal isposobnost neutralizacije slobodnih DPPH•, ABTS•+ i OH• radikala (28 vrsta) i inhibicijeacetilholinesteraze (27 vrsta) i butirilholinesteraze (7 vrsta). Među testiranih 12 jedinjenja, najboljuantiholinesteraznu aktivnost ispoljila su tri flavonoidna aglikona i 8-epi-ikserisamin A. Odabranisuvi MeOH i CH2Cl2 ekstrakti herbi šest vrsta pokazali su antimikrobnu aktivnost prema 18, a 8-epi-ikserisamin A i krepizid E prema 4 mikroorganizma. Isti odabrani izolati ispoljili sucitotoksični efekat prema tri, odnosno jednoj tumorskoj ćelijskoj liniji, uz zanemarljivu inhibicijurasta zdravih ćelija. Tri odabrana MeOH i CH2Cl2 ekstrakta su u modelu inflamacije šape pacovaizazvane karageninom pokazala antihiperalgezijsku, ali ne i antiedematoznu aktivnost; bezbednostprimene dva ekstrakta koji su ispoljili značajnu antihiperalgezijsku aktivnost pokazana je in vivorotarod i testom akutne toksičnosti.Ključne reči:
AB  - nonhybridogenousand 16 hybridogenous).Using semipreparative LC-MS methods, four sesquiterpene lactones (crepiside E and three newcompounds: 8-epiixerisamine A, calophyllamine A and calophyllamine B) were isolated from theMeOH extract of H. calophyllum flowering heads, and five phenolic (mono- or di-Ocaffeoylquinic)acids from the MeOH extract of H. scheppigianum underground parts(identification based on NMR and MS spectra).Total of four sesquiterpene lactones, seven mono- or di-O-caffeoylquinic acids and 19flavonoids (luteolin, apigenin, diosmetin, their 15 glycosides and one quercetin glycoside) werequantified in the dried MeOH extracts of the investigated underground parts of two species andherbs of 28 species, using LC-MS methods, and five triterpenes (ursane, oleane and lupanederivatives) in the dried CH2Cl2 extracts of the herbs of 28 species, using GC-FID-MS method(identification using standards, NMR, MS and/or UV spectra). Chemosystematic significance ofthe compounds identified in the herbs of 28 species was determined using multivariate statistics(PCA, nMDS and UPGMA).Dried MeOH herb extracts in vitro exhibited significant total antioxidant activity andscavenging of DPPH•, ABTS•+ and OH• radicals (28 species), as well as the ability to inhibitacetylcholinesterase (27 species) and butyrylcholinesterase (7 species). Among 12 testedcompounds, three flavonoid aglycones and 8-epiixerisamine A exhibited the highestanticholinesterase activity. Selected dried MeOH and CH2Cl2 herb extracts of six species showedantimicrobial activity against 18, whereas 8-epiixerisamine A and crepiside E against fourmicroorganisms. The same selected isolates exhibited cytotoxic activity against three and onecancer cell lines, respectively, with negligible inhibition of the normal cells growth. In thecarrageenan-induced localized inflammation model in rats, three selected MeOH and CH2Cl2extracts exhibited antihyperalgesic, but not antiedematous activity; safety of the oral administrationof two extracts that exhibited significant antihyperalgesic activity was demonstrated in vivo inrotarod test and acute oral toxicity study.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Ispitivanje sekundarnih metabolita i farmakološke aktivnosti odabranih vrsta roda Hieracium L. (Asteraceae) sa Balkanskog poluostrva
UR  - https://hdl.handle.net/21.15107/rcub_nardus_18845
ER  - 

@phdthesis{
author = "Milutinović, Violeta",
year = "2021",
abstract = "hibridogenih).Semipreparativnim LC-MS metodama, iz MeOH ekstrakta cvasti H. calophyllum izolovana sučetiri seskviterpenska laktona (krepizid E i tri nova jedinjenja: 8-epi-ikserisamin A, kalofilamin A ikalofilamin B), a iz MeOH ekstrakta podzemnih organa H. scheppigianum pet fenolkarboksilnih(mono- ili di-O-kafeoilhina) kiselina (identifikacija na osnovu NMR i MS spektara).Ukupno četiri seskviterpenska laktona, sedam mono- ili di-O-kafeoilhina kiselina i 19flavonoida (luteolin, apigenin, diosmetin, 15 njihovih heterozida i heterozid kvercetina)kvantifikovani su u suvim MeOH ekstraktima ispitivanih podzemnih organa dve vrste i herbi 28vrsta LC-MS metodama, i pet triterpena (derivata ursana, oleana i lupana) u suvim CH2Cl2ekstraktima herbi 28 vrsta GC-FID-MS metodom (identifikacija pomoću standarda, NMR, MS i/iliUV spektara). Hemosistematski značaj jedinjenja identifikovanih u herbama 28 vrsta utvrđen jemultivarijantnim statističkim metodama (PCA, nMDS i UPGMA).Suvi MeOH ekstrakti herbi su in vitro pokazali značajan ukupni antioksidantni potencijal isposobnost neutralizacije slobodnih DPPH•, ABTS•+ i OH• radikala (28 vrsta) i inhibicijeacetilholinesteraze (27 vrsta) i butirilholinesteraze (7 vrsta). Među testiranih 12 jedinjenja, najboljuantiholinesteraznu aktivnost ispoljila su tri flavonoidna aglikona i 8-epi-ikserisamin A. Odabranisuvi MeOH i CH2Cl2 ekstrakti herbi šest vrsta pokazali su antimikrobnu aktivnost prema 18, a 8-epi-ikserisamin A i krepizid E prema 4 mikroorganizma. Isti odabrani izolati ispoljili sucitotoksični efekat prema tri, odnosno jednoj tumorskoj ćelijskoj liniji, uz zanemarljivu inhibicijurasta zdravih ćelija. Tri odabrana MeOH i CH2Cl2 ekstrakta su u modelu inflamacije šape pacovaizazvane karageninom pokazala antihiperalgezijsku, ali ne i antiedematoznu aktivnost; bezbednostprimene dva ekstrakta koji su ispoljili značajnu antihiperalgezijsku aktivnost pokazana je in vivorotarod i testom akutne toksičnosti.Ključne reči:, nonhybridogenousand 16 hybridogenous).Using semipreparative LC-MS methods, four sesquiterpene lactones (crepiside E and three newcompounds: 8-epiixerisamine A, calophyllamine A and calophyllamine B) were isolated from theMeOH extract of H. calophyllum flowering heads, and five phenolic (mono- or di-Ocaffeoylquinic)acids from the MeOH extract of H. scheppigianum underground parts(identification based on NMR and MS spectra).Total of four sesquiterpene lactones, seven mono- or di-O-caffeoylquinic acids and 19flavonoids (luteolin, apigenin, diosmetin, their 15 glycosides and one quercetin glycoside) werequantified in the dried MeOH extracts of the investigated underground parts of two species andherbs of 28 species, using LC-MS methods, and five triterpenes (ursane, oleane and lupanederivatives) in the dried CH2Cl2 extracts of the herbs of 28 species, using GC-FID-MS method(identification using standards, NMR, MS and/or UV spectra). Chemosystematic significance ofthe compounds identified in the herbs of 28 species was determined using multivariate statistics(PCA, nMDS and UPGMA).Dried MeOH herb extracts in vitro exhibited significant total antioxidant activity andscavenging of DPPH•, ABTS•+ and OH• radicals (28 species), as well as the ability to inhibitacetylcholinesterase (27 species) and butyrylcholinesterase (7 species). Among 12 testedcompounds, three flavonoid aglycones and 8-epiixerisamine A exhibited the highestanticholinesterase activity. Selected dried MeOH and CH2Cl2 herb extracts of six species showedantimicrobial activity against 18, whereas 8-epiixerisamine A and crepiside E against fourmicroorganisms. The same selected isolates exhibited cytotoxic activity against three and onecancer cell lines, respectively, with negligible inhibition of the normal cells growth. In thecarrageenan-induced localized inflammation model in rats, three selected MeOH and CH2Cl2extracts exhibited antihyperalgesic, but not antiedematous activity; safety of the oral administrationof two extracts that exhibited significant antihyperalgesic activity was demonstrated in vivo inrotarod test and acute oral toxicity study.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Ispitivanje sekundarnih metabolita i farmakološke aktivnosti odabranih vrsta roda Hieracium L. (Asteraceae) sa Balkanskog poluostrva",
url = "https://hdl.handle.net/21.15107/rcub_nardus_18845"
}

Milutinović, V.. (2021). Ispitivanje sekundarnih metabolita i farmakološke aktivnosti odabranih vrsta roda Hieracium L. (Asteraceae) sa Balkanskog poluostrva. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_18845

Milutinović V. Ispitivanje sekundarnih metabolita i farmakološke aktivnosti odabranih vrsta roda Hieracium L. (Asteraceae) sa Balkanskog poluostrva. in Универзитет у Београду. 2021;.
https://hdl.handle.net/21.15107/rcub_nardus_18845 .

Milutinović, Violeta, "Ispitivanje sekundarnih metabolita i farmakološke aktivnosti odabranih vrsta roda Hieracium L. (Asteraceae) sa Balkanskog poluostrva" in Универзитет у Београду (2021),
https://hdl.handle.net/21.15107/rcub_nardus_18845 .

TY  - THES
AU  - Ušjak, Ljuboš
PY  - 2019
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6810
UR  - http://nardus.mpn.gov.rs/handle/123456789/11249
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19901/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=2048355682
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3696
AB  - Predmet istraņivanja doktorske disertacije je devet taksona roda Heracleum (Apiaceae): H. sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicum subsp. pollinianum, H. pyrenaicum subsp. orsinii i H. verticillatum iz grupe H. sphondylium, i H. orphanidis, svi iz (tipske) sect. Heracleum, kao i H. austriacum subsp. siifolium iz sect. Wendia.Gasnom hromatografijom sa FID i MS detekcijom analiziran je sastav etarskih ulja izolovanih destilacijom vodenom parom iz podzemnih organa, listova, cvasti i plodova. U uljima podzemnih organa dominirali su monoterpeni i/ili fenilpropani (taksoni grupe H. sphondylium), ili (Z)-falkarinol (H. orphanidis i H. austriacum); u uljima plodova alifatiĉni estri oktilacetat (sect. Heracleum) ili oktilheksanoat (H. austriacum), a u uljima listova i cvasti alifatiĉni estri (H. orphanidis) ili seskviterpeni i/ili fenilpropani. S obzirom da je u pojedinim uljima utvrĊeno prisustvo furanokumarina koji mogu delovati fototoksiĉno, definisan je bezbednosni profil ulja, tj. utvrĊen njihov maksimalni dozvoljeni dnevni unos.U dihlormetanskim ekstraktima podzemnih organa i plodova svih taksona identifikovano je ukupno 12 furanokumarina (LC-MS metodom pomoću standardnih supstanci ili na osnovu UV, MS, 1H i ROESY NMR spektara), od kojih su dominantni bili pimpinelin, bergapten, biakangelikol, heraklenin i/ili imperatorin.Hemosistematski znaĉaj komponenti etarskih ulja (u sluĉaju podzemnih organa i plodova i komponenti njihovih headspace frakcija) i furanokumarina utvrĊen je multivarijantnom statistiĉkom analizom (PCA, nMDS i UPGMA).U uljastim supernatantima dihlormetanskih ekstrakata plodova gasnom hromatografijom (GC-FID i GC-MS) analizirane su masne kiseline (dominantna je bila petroselinska), steroli (najzastupljeniji je bio β-sitosterol) i triterpeni.Antimikrobna aktivnost etarskih ulja pokazana je mikrodilucionom metodom na po osam sojeva bakterija i mikromiceta (u nekim sluĉajevima MIK su bile niņe ili bliske 0,1 mg/mL); selektivna citotoksiĉnost MTT testom na tumorske HeLa, LS174 i A549 ćelije (u nekim sluĉajevima IC50 su bile niņe ili bliske 30 μg/mL; ulja uglavnom nisuinhibirala rast normalnih MRC-5 ćelija)...
AB  - This    doctoral    dissertation focuses    on    nineHeracleumtaxa (Apiaceae): H.  sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicumsubsp. pollinianum, H. pyrenaicumsubsp. orsiniiandH. verticillatum,  belonging  togroupH.  sphondylium, andH. orphanidis, all  from  the (type)sect. Heracleum, as  well  asH.austriacum subsp.siifoliumfromsect. Wendia. By   GC-FID   and   GC-MS,   the   composition   of   essential   oils isolated by hydrodistillation fromunderground  parts,  leaves,  flowers  and  fruits  was  analysed. Underground  parts  oils  were  dominated  bymonoterpenesand/orphenylpropanoids (H. sphondyliumgroup), or(Z)-falcarinol (H. orphanidisandH. austriacum); fruit oils byaliphatic  estersoctylacetate(sect. Heracleum) oroctylhexanoate(H.  austriacum), andleaf  and  flower  oilsby  aliphatic  esters(H.  orphanidis) or  sesquiterpenesand/orphenylpropanoids. Considering   that   in   some   of   these   oils   potentially   phototoxic furanocoumarins  were  detected, safety  profileof  the  oils,  i.e.  their  maximum  daily intake wasestimated.In dichloromethane extracts of underground parts and fruits of investigated taxa,atotal  of 12  furanocoumarins  were  identified(by LC-MS using standard  compoundsorbased onUV, MS, 1H andROESY NMR spectra), among which pimpinellin, bergapten, byakangelicol, heraclenin and/orimperatorinwere dominant. Chemosystematicsignificance   ofessential   oil   components(in   the   case   ofunderground  parts  and  fruits,  of  their headspacefractioncomponents as  well) and furanocoumarinswas demonstrated  usingmultivariatestatistics  (PCA,  nMDS  andUPGMA).In  oily  supernatants  of  fruit dichloromethaneextracts,  by GC-FID and  GC-MS,fatty acids (petroselinic acid was dominant), sterols (β-sitosterolwas the most abundant) and triterpeneswere analysed. Antimicrobialactivity of the essential oilswas showedbymicrodilutionmethodoneightbacteria and eightfungi(in some cases MICs werelower or around0.1 mg/mL); selective cytotoxicityby  MTT  teston cancerHeLa,  LS174 andA549 cells(in  some 
cases IC50werelower or around 30 μg/mL; oils mostly did not inhibit growth ofnormalMRC-5 cells). Essential  oils  showed  weakanti-DPPH  potential. The  composition  of their active zones in TLC-DPPH test was analysed byGC-FID and GC-MS(oxygenated terpenes and phenylpropanoidswere dominant).
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Hemijska i farmakološka karakterizacija odabranih taksona roda Heracleum L. (Apiaceae), autohtonih za jugoistočnu Evropu
UR  - https://hdl.handle.net/21.15107/rcub_nardus_11249
ER  - 

@phdthesis{
author = "Ušjak, Ljuboš",
year = "2019",
abstract = "Predmet istraņivanja doktorske disertacije je devet taksona roda Heracleum (Apiaceae): H. sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicum subsp. pollinianum, H. pyrenaicum subsp. orsinii i H. verticillatum iz grupe H. sphondylium, i H. orphanidis, svi iz (tipske) sect. Heracleum, kao i H. austriacum subsp. siifolium iz sect. Wendia.Gasnom hromatografijom sa FID i MS detekcijom analiziran je sastav etarskih ulja izolovanih destilacijom vodenom parom iz podzemnih organa, listova, cvasti i plodova. U uljima podzemnih organa dominirali su monoterpeni i/ili fenilpropani (taksoni grupe H. sphondylium), ili (Z)-falkarinol (H. orphanidis i H. austriacum); u uljima plodova alifatiĉni estri oktilacetat (sect. Heracleum) ili oktilheksanoat (H. austriacum), a u uljima listova i cvasti alifatiĉni estri (H. orphanidis) ili seskviterpeni i/ili fenilpropani. S obzirom da je u pojedinim uljima utvrĊeno prisustvo furanokumarina koji mogu delovati fototoksiĉno, definisan je bezbednosni profil ulja, tj. utvrĊen njihov maksimalni dozvoljeni dnevni unos.U dihlormetanskim ekstraktima podzemnih organa i plodova svih taksona identifikovano je ukupno 12 furanokumarina (LC-MS metodom pomoću standardnih supstanci ili na osnovu UV, MS, 1H i ROESY NMR spektara), od kojih su dominantni bili pimpinelin, bergapten, biakangelikol, heraklenin i/ili imperatorin.Hemosistematski znaĉaj komponenti etarskih ulja (u sluĉaju podzemnih organa i plodova i komponenti njihovih headspace frakcija) i furanokumarina utvrĊen je multivarijantnom statistiĉkom analizom (PCA, nMDS i UPGMA).U uljastim supernatantima dihlormetanskih ekstrakata plodova gasnom hromatografijom (GC-FID i GC-MS) analizirane su masne kiseline (dominantna je bila petroselinska), steroli (najzastupljeniji je bio β-sitosterol) i triterpeni.Antimikrobna aktivnost etarskih ulja pokazana je mikrodilucionom metodom na po osam sojeva bakterija i mikromiceta (u nekim sluĉajevima MIK su bile niņe ili bliske 0,1 mg/mL); selektivna citotoksiĉnost MTT testom na tumorske HeLa, LS174 i A549 ćelije (u nekim sluĉajevima IC50 su bile niņe ili bliske 30 μg/mL; ulja uglavnom nisuinhibirala rast normalnih MRC-5 ćelija)..., This    doctoral    dissertation focuses    on    nineHeracleumtaxa (Apiaceae): H.  sphondylium, H. sibiricum, H. montanum, H. ternatum, H. pyrenaicumsubsp. pollinianum, H. pyrenaicumsubsp. orsiniiandH. verticillatum,  belonging  togroupH.  sphondylium, andH. orphanidis, all  from  the (type)sect. Heracleum, as  well  asH.austriacum subsp.siifoliumfromsect. Wendia. By   GC-FID   and   GC-MS,   the   composition   of   essential   oils isolated by hydrodistillation fromunderground  parts,  leaves,  flowers  and  fruits  was  analysed. Underground  parts  oils  were  dominated  bymonoterpenesand/orphenylpropanoids (H. sphondyliumgroup), or(Z)-falcarinol (H. orphanidisandH. austriacum); fruit oils byaliphatic  estersoctylacetate(sect. Heracleum) oroctylhexanoate(H.  austriacum), andleaf  and  flower  oilsby  aliphatic  esters(H.  orphanidis) or  sesquiterpenesand/orphenylpropanoids. Considering   that   in   some   of   these   oils   potentially   phototoxic furanocoumarins  were  detected, safety  profileof  the  oils,  i.e.  their  maximum  daily intake wasestimated.In dichloromethane extracts of underground parts and fruits of investigated taxa,atotal  of 12  furanocoumarins  were  identified(by LC-MS using standard  compoundsorbased onUV, MS, 1H andROESY NMR spectra), among which pimpinellin, bergapten, byakangelicol, heraclenin and/orimperatorinwere dominant. Chemosystematicsignificance   ofessential   oil   components(in   the   case   ofunderground  parts  and  fruits,  of  their headspacefractioncomponents as  well) and furanocoumarinswas demonstrated  usingmultivariatestatistics  (PCA,  nMDS  andUPGMA).In  oily  supernatants  of  fruit dichloromethaneextracts,  by GC-FID and  GC-MS,fatty acids (petroselinic acid was dominant), sterols (β-sitosterolwas the most abundant) and triterpeneswere analysed. Antimicrobialactivity of the essential oilswas showedbymicrodilutionmethodoneightbacteria and eightfungi(in some cases MICs werelower or around0.1 mg/mL); selective cytotoxicityby  MTT  teston cancerHeLa,  LS174 andA549 cells(in  some 
cases IC50werelower or around 30 μg/mL; oils mostly did not inhibit growth ofnormalMRC-5 cells). Essential  oils  showed  weakanti-DPPH  potential. The  composition  of their active zones in TLC-DPPH test was analysed byGC-FID and GC-MS(oxygenated terpenes and phenylpropanoidswere dominant).",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Hemijska i farmakološka karakterizacija odabranih taksona roda Heracleum L. (Apiaceae), autohtonih za jugoistočnu Evropu",
url = "https://hdl.handle.net/21.15107/rcub_nardus_11249"
}

Ušjak, L.. (2019). Hemijska i farmakološka karakterizacija odabranih taksona roda Heracleum L. (Apiaceae), autohtonih za jugoistočnu Evropu. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_11249

Ušjak L. Hemijska i farmakološka karakterizacija odabranih taksona roda Heracleum L. (Apiaceae), autohtonih za jugoistočnu Evropu. in Универзитет у Београду. 2019;.
https://hdl.handle.net/21.15107/rcub_nardus_11249 .

Ušjak, Ljuboš, "Hemijska i farmakološka karakterizacija odabranih taksona roda Heracleum L. (Apiaceae), autohtonih za jugoistočnu Evropu" in Универзитет у Београду (2019),
https://hdl.handle.net/21.15107/rcub_nardus_11249 .

TY  - JOUR
AU  - Maksimović, Zoran
AU  - Nedić, Nebojša
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1923
AB  - Antioxidant properties of fifteen multifloral and honeydew types of honey from Serbia were assessed by determination of ferric-reducing antioxidant power (FRAP assay) and 2,2- diphenyl-1-picrylhydrazyl free radical scavenging ability (DPPH assay), with respect to their total polyphenol content and colour intensity. The results of this study showed that total polyphenol content, antioxidant activity and colour intensity varied widely among different samples, even within the same type of honey. All investigated parameters were strongly dependent on geographic origin of samples, further emphasizing the importance of their detailed chemical characterisation. In general, polyphenolic content in investigated samples of honey, expressed as catechin equivalents, ranged from 480.2 to 1861.1 mg/kg. The ferric-reducing antioxidant power of honey tended to be lower in brighter and higher in darker samples, varying between 489.6 and 3089.8 μmol Fe(II) per 100 g of honey. The correlation between the colour and antioxidant activity never reached statistical significance in the case of honeydew type of honey, which was opposed to a trend observed in the case of multifloral honey.
AB  - U ovom radu, ispitivana su antioksidantna svojstva petnaest uzoraka livadskog i šumskog meda, primenom Ferric-Reducing/Antioxidant Power i DPPH-free radical scavenging ability testa, u odnosu na sadržaj ukupnih polifenolnih sastojaka i intenzitet boje meda. Rezultati ovog ispitivanja su pokazali da su sadržaj ukupnih polifenola, antioksidantna aktivnost i intenzitet boje izrazito varirali od jednog uzorka do drugog, čak i u okviru svake vrste meda ponaosob. Svi ispitivani parametri su bili vrlo zavisni od geografskog porekla uzoraka, naglašavajući važnost detaljne hemijske karakterizacije meda. Generalno, sadržaj ukupnih polifenola u ispitivanim uzorcima meda, izražen u ekvivalentima katehina, kretao se u intervalu od 480,2 mg/kg do 1861,1 mg/kg. Sposobnost redukcije gvožđa bila je niža u svetlijim vrstama meda, a viša u tamnijim, varirajući između 489,6 i 3089,8 μmol Fe(II) na 100 g meda. Korelacija između intenziteta boje i antioksidantne aktivnosti nije imala statističku značajnost kod uzoraka šumskog meda, nasuprot trendu koji je uočen u slučaju livadskog meda.
PB  - Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad
T2  - Acta periodica technologica
T1  - In vitro antioxidant activity of honeydew and multifloral types of honey from Serbia
T1  - In vitro antioksidantna aktivnost šumskog i livadskog meda iz Srbije
IS  - 44
SP  - 269
EP  - 277
DO  - 10.2298/APT1344269M
ER  - 

@article{
author = "Maksimović, Zoran and Nedić, Nebojša",
year = "2013",
abstract = "Antioxidant properties of fifteen multifloral and honeydew types of honey from Serbia were assessed by determination of ferric-reducing antioxidant power (FRAP assay) and 2,2- diphenyl-1-picrylhydrazyl free radical scavenging ability (DPPH assay), with respect to their total polyphenol content and colour intensity. The results of this study showed that total polyphenol content, antioxidant activity and colour intensity varied widely among different samples, even within the same type of honey. All investigated parameters were strongly dependent on geographic origin of samples, further emphasizing the importance of their detailed chemical characterisation. In general, polyphenolic content in investigated samples of honey, expressed as catechin equivalents, ranged from 480.2 to 1861.1 mg/kg. The ferric-reducing antioxidant power of honey tended to be lower in brighter and higher in darker samples, varying between 489.6 and 3089.8 μmol Fe(II) per 100 g of honey. The correlation between the colour and antioxidant activity never reached statistical significance in the case of honeydew type of honey, which was opposed to a trend observed in the case of multifloral honey., U ovom radu, ispitivana su antioksidantna svojstva petnaest uzoraka livadskog i šumskog meda, primenom Ferric-Reducing/Antioxidant Power i DPPH-free radical scavenging ability testa, u odnosu na sadržaj ukupnih polifenolnih sastojaka i intenzitet boje meda. Rezultati ovog ispitivanja su pokazali da su sadržaj ukupnih polifenola, antioksidantna aktivnost i intenzitet boje izrazito varirali od jednog uzorka do drugog, čak i u okviru svake vrste meda ponaosob. Svi ispitivani parametri su bili vrlo zavisni od geografskog porekla uzoraka, naglašavajući važnost detaljne hemijske karakterizacije meda. Generalno, sadržaj ukupnih polifenola u ispitivanim uzorcima meda, izražen u ekvivalentima katehina, kretao se u intervalu od 480,2 mg/kg do 1861,1 mg/kg. Sposobnost redukcije gvožđa bila je niža u svetlijim vrstama meda, a viša u tamnijim, varirajući između 489,6 i 3089,8 μmol Fe(II) na 100 g meda. Korelacija između intenziteta boje i antioksidantne aktivnosti nije imala statističku značajnost kod uzoraka šumskog meda, nasuprot trendu koji je uočen u slučaju livadskog meda.",
publisher = "Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad",
journal = "Acta periodica technologica",
title = "In vitro antioxidant activity of honeydew and multifloral types of honey from Serbia, In vitro antioksidantna aktivnost šumskog i livadskog meda iz Srbije",
number = "44",
pages = "269-277",
doi = "10.2298/APT1344269M"
}

Maksimović, Z.,& Nedić, N.. (2013). In vitro antioxidant activity of honeydew and multifloral types of honey from Serbia. in Acta periodica technologica
Univerzitet u Novom Sadu - Tehnološki fakultet, Novi Sad.(44), 269-277.
https://doi.org/10.2298/APT1344269M

Maksimović Z, Nedić N. In vitro antioxidant activity of honeydew and multifloral types of honey from Serbia. in Acta periodica technologica. 2013;(44):269-277.
doi:10.2298/APT1344269M .

Maksimović, Zoran, Nedić, Nebojša, "In vitro antioxidant activity of honeydew and multifloral types of honey from Serbia" in Acta periodica technologica, no. 44 (2013):269-277,
https://doi.org/10.2298/APT1344269M . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Ražić, Slavica
AU  - Arsenijević, Jelena
AU  - Maksimović, Zoran
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1833
AB  - This paper describes the relationships between the concentrations of selected trace elements in soil and their bioaccumulation in the aerial parts of three Veronica species (Plantaginaceae). Plant and soil samples were collected from three mountainous areas in Serbia, prepared by microwave-assisted acid digestion and analyzed by flame and flameless atomic absorption spectrometry. The total concentrations of Cu, Zn, Mn, Fe and Cr in the soil varied from 12.38 to 47.77, 62.78 to 138.00, 517.58 to 1675.78, 13574.22 to 35920.00 and 36.18 to 115.15 mg kg-1, respectively, while those in the plants ranged from 6.04 to 12.8, 27.66 to 58.01, 25.38 to 89.25, 35.53 to 563.26 and 0.44 to 18.96 mg kg-1, respectively. There were no significant differences in heavy metal concentrations between the tested Veronica species from the same location, indicating that their heavy metal uptake pattern was not species specific. In the case of Mn, despite its wide variation in the soil, the concentrations in the plant samples were uniform, which suggests the potential ability of the tested species to control Mn uptake and/or its translocation to the upper plant parts. Additionally, the lowest concentrations of Cu were obtained in plant samples collected from soil with the highest Fe concentrations, indicating that Cu availability to plants might be reduced due to high Fe contents in soil solution.
AB  - U ovom radu prikazan je odnos sadržaja odabranih elemenata u tragovima u zemljištu i njihove bioakumulacije u nadzemnim delovima tri Veronica vrste (Plantaginaceae). Biljni i uzorci zemljišta sakupljeni su sa tri planinska lokaliteta u Srbiji, podvrgnuti su mikrotalasnoj digestiji u kiseloj sredini i analizirani primenom plamene i elektrotermalne atomske apsorpcione spektroskopije. Ukupna koncentracija Cu, Zn, Mn, Fe i Cr u uzorcima zemljišta varira od 12,38 do 47,77, 62,78 do 138,00, 517,58 do 1675,78, 13574,22 do 35920,00 i 36,18 do 115,15 mg kg-1, dok se u biljnim uzorcima kreće u opsegu od 6,04 do 12,8, 27,66 do 58,01, 25,38 do 89,25, 35,53 do 563,26 i 0,44 do 18,96 mg kg-1, redom. Nisu pokazane značajne razlike u koncentraciji teških metala između testiranih Veronica vrsta sa istih lokaliteta, što pokazuje da model usvajanja teških metala nije karakteristika vrste. Uprkos velikih variranja koncentracije Mn u zemljištu, koncentracija u biljnim uzorcima je uniformna, što ukazuje na potencijalnu mogućnost testiranih vrsta da kontrolišu preuzimanje Mn ili njegov transport do nadzemnih delova biljke. Najniža koncentracija Cu dobijena je u biljnim uzorcima sakupljenim na zemljištu sa najvećom Fe koncentracijom, sugerišući da je dostupnost Cu biljkama redukovana usled visokog sadržaja Fe u zemljišnom rastvoru.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Heavy metal contents in Veronica species and soil from mountainous areas in Serbia
T1  - Sposobnost akumulacije teških metala Veronica vrsta sa planinskih lokaliteta u Srbiji
VL  - 77
IS  - 7
SP  - 959
EP  - 970
DO  - 10.2298/JSC111225221Z
ER  - 

@article{
author = "Živković, Jelena and Ražić, Slavica and Arsenijević, Jelena and Maksimović, Zoran",
year = "2012",
abstract = "This paper describes the relationships between the concentrations of selected trace elements in soil and their bioaccumulation in the aerial parts of three Veronica species (Plantaginaceae). Plant and soil samples were collected from three mountainous areas in Serbia, prepared by microwave-assisted acid digestion and analyzed by flame and flameless atomic absorption spectrometry. The total concentrations of Cu, Zn, Mn, Fe and Cr in the soil varied from 12.38 to 47.77, 62.78 to 138.00, 517.58 to 1675.78, 13574.22 to 35920.00 and 36.18 to 115.15 mg kg-1, respectively, while those in the plants ranged from 6.04 to 12.8, 27.66 to 58.01, 25.38 to 89.25, 35.53 to 563.26 and 0.44 to 18.96 mg kg-1, respectively. There were no significant differences in heavy metal concentrations between the tested Veronica species from the same location, indicating that their heavy metal uptake pattern was not species specific. In the case of Mn, despite its wide variation in the soil, the concentrations in the plant samples were uniform, which suggests the potential ability of the tested species to control Mn uptake and/or its translocation to the upper plant parts. Additionally, the lowest concentrations of Cu were obtained in plant samples collected from soil with the highest Fe concentrations, indicating that Cu availability to plants might be reduced due to high Fe contents in soil solution., U ovom radu prikazan je odnos sadržaja odabranih elemenata u tragovima u zemljištu i njihove bioakumulacije u nadzemnim delovima tri Veronica vrste (Plantaginaceae). Biljni i uzorci zemljišta sakupljeni su sa tri planinska lokaliteta u Srbiji, podvrgnuti su mikrotalasnoj digestiji u kiseloj sredini i analizirani primenom plamene i elektrotermalne atomske apsorpcione spektroskopije. Ukupna koncentracija Cu, Zn, Mn, Fe i Cr u uzorcima zemljišta varira od 12,38 do 47,77, 62,78 do 138,00, 517,58 do 1675,78, 13574,22 do 35920,00 i 36,18 do 115,15 mg kg-1, dok se u biljnim uzorcima kreće u opsegu od 6,04 do 12,8, 27,66 do 58,01, 25,38 do 89,25, 35,53 do 563,26 i 0,44 do 18,96 mg kg-1, redom. Nisu pokazane značajne razlike u koncentraciji teških metala između testiranih Veronica vrsta sa istih lokaliteta, što pokazuje da model usvajanja teških metala nije karakteristika vrste. Uprkos velikih variranja koncentracije Mn u zemljištu, koncentracija u biljnim uzorcima je uniformna, što ukazuje na potencijalnu mogućnost testiranih vrsta da kontrolišu preuzimanje Mn ili njegov transport do nadzemnih delova biljke. Najniža koncentracija Cu dobijena je u biljnim uzorcima sakupljenim na zemljištu sa najvećom Fe koncentracijom, sugerišući da je dostupnost Cu biljkama redukovana usled visokog sadržaja Fe u zemljišnom rastvoru.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Heavy metal contents in Veronica species and soil from mountainous areas in Serbia, Sposobnost akumulacije teških metala Veronica vrsta sa planinskih lokaliteta u Srbiji",
volume = "77",
number = "7",
pages = "959-970",
doi = "10.2298/JSC111225221Z"
}

Živković, J., Ražić, S., Arsenijević, J.,& Maksimović, Z.. (2012). Heavy metal contents in Veronica species and soil from mountainous areas in Serbia. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 77(7), 959-970.
https://doi.org/10.2298/JSC111225221Z

Živković J, Ražić S, Arsenijević J, Maksimović Z. Heavy metal contents in Veronica species and soil from mountainous areas in Serbia. in Journal of the Serbian Chemical Society. 2012;77(7):959-970.
doi:10.2298/JSC111225221Z .

Živković, Jelena, Ražić, Slavica, Arsenijević, Jelena, Maksimović, Zoran, "Heavy metal contents in Veronica species and soil from mountainous areas in Serbia" in Journal of the Serbian Chemical Society, 77, no. 7 (2012):959-970,
https://doi.org/10.2298/JSC111225221Z . .

TY  - JOUR
AU  - Maksimović, Zoran
AU  - Arsenijević, Jelena
AU  - Novaković, Jelena
AU  - Agbaba, Danica
AU  - Janković, Saša
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1789
AB  - This study deals with the examination of total aescin content in flowers and seeds of Aesculus hippocastanum L. and Aesculus x carnea Hayne (Hippocastanaceae), collected in urban areas, as well as the content of Pb, Cd and Hg as an indicator of potential aerial pollution. Aescin identification was performed by TLC. Total aescin content was determined by UV-VIS spectrophotometry and HPTLC densitometry. The contents of Pb, Cd and Hg was determined by AAS. The concentration of aescin varied in a wide range between 0.17% (A. hippocastanum hulls) and 2.95% (A. hippocastanum cotyledons), as determined by spectrophotometric assay. Slightly lower results were recorded in HPTLC densitometry assay, ranging from 0,10% (the hulls of both plant species) to 2.39% (A. x carnea cotyledons). The extractable matter yield was between 5% and 26%, with a high share of total aescin (5% - 13%, depending on the source). The levels of Pb, Cd and Hg both in the plant material and the extracts remained low, indicating that the health safety of the plant specimens was not compromised. Our results suggest that the seeds and flowers of Chestnut trees in urban areas could be considered as a raw material for chemical and pharmaceutical industry in Serbia.
AB  - Osnovni cilj ovog rada je bio da se utvrdi ukupni sadržaj escina u cvetu i plodu Aesculus hippocastanum L. i Aesculus x carnea Hayne (Hippocastanaceae), sakupljenim u gradskom području, kao i sadržaj Pb, Cd i Hg kao indikatora potencijalnog gradskog aerozagađenja. Identifikacija escina u ispitivanom materijalu je izvršena primenom TLC. Ukupni sadržaj escina je određen primenom UV-VIS spektrofotometrije i HPTLC denzitometrije, kako u biljnom materijalu, tako i u ekstraktima dobijenim ekstrakcijom pomoću 60% etanola. Sadržaj Pb, Cd i Hg je određen primenom AAS. Rezultati spektrofotometrijskog određivanja pokazuju da se koncentracija escina nalazi u širokom rasponu između 0,17% (semenjača ploda A. hippocastanum) i 2,95% (kotiledoni semena A. hippocastanum). Nešto niži rezultati su dobijeni primenom HPTLC denzitometrije, između 0,10% (semenjača ploda obe biljne vrste) i 2,39% (kotiledoni semena A. x carnea). Biljni materijal sadrži između 5% i 26% ekstraktibilnih materija, sa visokim udelom ukupnog escina (5% - 13%, u zavisnosti od izvora). Koncentracija Pb, Cd i Hg, kako u biljnom materijalu, tako i u ekstraktima, bila je niska, što implicira da zdravstvena ispravnost uzoraka biljnog materijala nije ugrožena činjenicom da je biljni materijal sakupljen u gradskoj sredini. Naši rezultati ukazuju na to da seme i cvet obe vrste kestena, koji se gaje u urbanim sredinama radi svojih dekorativnih svojstava, ali proizvode značajnu količinu komunalnog otpada, mogu da se koriste kao sirovina za proizvodnju vrednih proizvoda za upotrebu u hemijskoj i farmaceutskoj industriji.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Seeds and flowers of chestnut trees in urban areas: A municipal waste or a raw material?
T1  - Seme i cvet kestena u gradskim područjima - komunalni otpad ili sirovina?
IS  - 32
SP  - 47
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1789
ER  - 

@article{
author = "Maksimović, Zoran and Arsenijević, Jelena and Novaković, Jelena and Agbaba, Danica and Janković, Saša and Ćurčić, Marijana and Antonijević, Biljana",
year = "2012",
abstract = "This study deals with the examination of total aescin content in flowers and seeds of Aesculus hippocastanum L. and Aesculus x carnea Hayne (Hippocastanaceae), collected in urban areas, as well as the content of Pb, Cd and Hg as an indicator of potential aerial pollution. Aescin identification was performed by TLC. Total aescin content was determined by UV-VIS spectrophotometry and HPTLC densitometry. The contents of Pb, Cd and Hg was determined by AAS. The concentration of aescin varied in a wide range between 0.17% (A. hippocastanum hulls) and 2.95% (A. hippocastanum cotyledons), as determined by spectrophotometric assay. Slightly lower results were recorded in HPTLC densitometry assay, ranging from 0,10% (the hulls of both plant species) to 2.39% (A. x carnea cotyledons). The extractable matter yield was between 5% and 26%, with a high share of total aescin (5% - 13%, depending on the source). The levels of Pb, Cd and Hg both in the plant material and the extracts remained low, indicating that the health safety of the plant specimens was not compromised. Our results suggest that the seeds and flowers of Chestnut trees in urban areas could be considered as a raw material for chemical and pharmaceutical industry in Serbia., Osnovni cilj ovog rada je bio da se utvrdi ukupni sadržaj escina u cvetu i plodu Aesculus hippocastanum L. i Aesculus x carnea Hayne (Hippocastanaceae), sakupljenim u gradskom području, kao i sadržaj Pb, Cd i Hg kao indikatora potencijalnog gradskog aerozagađenja. Identifikacija escina u ispitivanom materijalu je izvršena primenom TLC. Ukupni sadržaj escina je određen primenom UV-VIS spektrofotometrije i HPTLC denzitometrije, kako u biljnom materijalu, tako i u ekstraktima dobijenim ekstrakcijom pomoću 60% etanola. Sadržaj Pb, Cd i Hg je određen primenom AAS. Rezultati spektrofotometrijskog određivanja pokazuju da se koncentracija escina nalazi u širokom rasponu između 0,17% (semenjača ploda A. hippocastanum) i 2,95% (kotiledoni semena A. hippocastanum). Nešto niži rezultati su dobijeni primenom HPTLC denzitometrije, između 0,10% (semenjača ploda obe biljne vrste) i 2,39% (kotiledoni semena A. x carnea). Biljni materijal sadrži između 5% i 26% ekstraktibilnih materija, sa visokim udelom ukupnog escina (5% - 13%, u zavisnosti od izvora). Koncentracija Pb, Cd i Hg, kako u biljnom materijalu, tako i u ekstraktima, bila je niska, što implicira da zdravstvena ispravnost uzoraka biljnog materijala nije ugrožena činjenicom da je biljni materijal sakupljen u gradskoj sredini. Naši rezultati ukazuju na to da seme i cvet obe vrste kestena, koji se gaje u urbanim sredinama radi svojih dekorativnih svojstava, ali proizvode značajnu količinu komunalnog otpada, mogu da se koriste kao sirovina za proizvodnju vrednih proizvoda za upotrebu u hemijskoj i farmaceutskoj industriji.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Seeds and flowers of chestnut trees in urban areas: A municipal waste or a raw material?, Seme i cvet kestena u gradskim područjima - komunalni otpad ili sirovina?",
number = "32",
pages = "47-58",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1789"
}

Maksimović, Z., Arsenijević, J., Novaković, J., Agbaba, D., Janković, S., Ćurčić, M.,& Antonijević, B.. (2012). Seeds and flowers of chestnut trees in urban areas: A municipal waste or a raw material?. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(32), 47-58.
https://hdl.handle.net/21.15107/rcub_farfar_1789

Maksimović Z, Arsenijević J, Novaković J, Agbaba D, Janković S, Ćurčić M, Antonijević B. Seeds and flowers of chestnut trees in urban areas: A municipal waste or a raw material?. in Lekovite sirovine. 2012;(32):47-58.
https://hdl.handle.net/21.15107/rcub_farfar_1789 .

Maksimović, Zoran, Arsenijević, Jelena, Novaković, Jelena, Agbaba, Danica, Janković, Saša, Ćurčić, Marijana, Antonijević, Biljana, "Seeds and flowers of chestnut trees in urban areas: A municipal waste or a raw material?" in Lekovite sirovine, no. 32 (2012):47-58,
https://hdl.handle.net/21.15107/rcub_farfar_1789 .

TY  - JOUR
AU  - Živković, Jelena
AU  - Cebović, Tatjana
AU  - Maksimović, Zoran
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1707
AB  - The aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 A mu g/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 A mu g/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.
PB  - Versita, Warsaw
T2  - Central European Journal of Biology
T1  - In vivo and in vitro antioxidant effects of three Veronica species
VL  - 7
IS  - 3
SP  - 559
EP  - 568
DO  - 10.2478/s11535-012-0041-4
ER  - 

@article{
author = "Živković, Jelena and Cebović, Tatjana and Maksimović, Zoran",
year = "2012",
abstract = "The aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 A mu g/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 A mu g/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Biology",
title = "In vivo and in vitro antioxidant effects of three Veronica species",
volume = "7",
number = "3",
pages = "559-568",
doi = "10.2478/s11535-012-0041-4"
}

Živković, J., Cebović, T.,& Maksimović, Z.. (2012). In vivo and in vitro antioxidant effects of three Veronica species. in Central European Journal of Biology
Versita, Warsaw., 7(3), 559-568.
https://doi.org/10.2478/s11535-012-0041-4

Živković J, Cebović T, Maksimović Z. In vivo and in vitro antioxidant effects of three Veronica species. in Central European Journal of Biology. 2012;7(3):559-568.
doi:10.2478/s11535-012-0041-4 .

Živković, Jelena, Cebović, Tatjana, Maksimović, Zoran, "In vivo and in vitro antioxidant effects of three Veronica species" in Central European Journal of Biology, 7, no. 3 (2012):559-568,
https://doi.org/10.2478/s11535-012-0041-4 . .

TY  - JOUR
AU  - Lakušić, Branislava
AU  - Ristić, Mihailo
AU  - Slavkovska, Violeta
AU  - Milenković, Marina
AU  - Lakušić, Dmitar
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1526
AB  - The chemical composition of the essential oils of Satureja horvatii SILIC from two natural habitats (Mt. Orjen and Mt. Lovcen in Montenegro) and from cultivated plants (Belgrade, Serbia) were characterized. For the latter, plants from the locus classicus, i.e., Orjenske Lokve (Mt. Orjen), were transferred to Belgrade and, after three years of cultivation, the chemical composition of their essential oils at different phenological stages was analyzed. The essential oils were obtained from the aerial parts of the plants by hydrodistillation and analyzed by GC and GC/MS. The yields and chemical compositions of the S. horvatii oils showed significant differences between the plants collected in the natural habitats and those from cultivation, as well as between the plants at different phenological stages. In the populations from the natural habitats, growing in Mediterranean conditions, the most abundant oil constituents were the phenols thymol (63.7% in the samples from Mt. Orjen) or carvacrol (68.1% in the samples from Mt. Lovcen), while the oils from the cultivated plants (Belgrade), growing in continental conditions, were dominated by linalool (up to 65.8 and 55.9% in average). The basic characteristics of the essential oil from plants at the early phenological stage (before flowering) were high percentages of linalool (37.4%), thymol (27.3%), and carvacrol (12.2%). At the stage of flowering, the percentage of linalool (56.6-57.5%) increased, while those of thymol (15.5-15.8%) and carvacrol (1.4-1.5%) significantly decreased. The essential oil of plants in the full stage of fruiting was characterized by the domination of linalool (58.4 and 65.8%) and lower percentages of thymol (7.6 and 1.3%) and carvacrol (0.7 and 0.1%). In conclusion, the oil composition of S. horvatii was found to depend on the pedoclimatic conditions of the habitat and the phenological stage of the plants.
PB  - Wiley-Blackwell, Malden
T2  - Chemistry & Biodiversity
T1  - Environmental and Seasonal Impacts on the Chemical Composition of Satureja horvatii Šilić (Lamiaceae) Essential Oils
VL  - 8
IS  - 3
SP  - 483
EP  - 493
DO  - 10.1002/cbdv.201000169
ER  - 

@article{
author = "Lakušić, Branislava and Ristić, Mihailo and Slavkovska, Violeta and Milenković, Marina and Lakušić, Dmitar",
year = "2011",
abstract = "The chemical composition of the essential oils of Satureja horvatii SILIC from two natural habitats (Mt. Orjen and Mt. Lovcen in Montenegro) and from cultivated plants (Belgrade, Serbia) were characterized. For the latter, plants from the locus classicus, i.e., Orjenske Lokve (Mt. Orjen), were transferred to Belgrade and, after three years of cultivation, the chemical composition of their essential oils at different phenological stages was analyzed. The essential oils were obtained from the aerial parts of the plants by hydrodistillation and analyzed by GC and GC/MS. The yields and chemical compositions of the S. horvatii oils showed significant differences between the plants collected in the natural habitats and those from cultivation, as well as between the plants at different phenological stages. In the populations from the natural habitats, growing in Mediterranean conditions, the most abundant oil constituents were the phenols thymol (63.7% in the samples from Mt. Orjen) or carvacrol (68.1% in the samples from Mt. Lovcen), while the oils from the cultivated plants (Belgrade), growing in continental conditions, were dominated by linalool (up to 65.8 and 55.9% in average). The basic characteristics of the essential oil from plants at the early phenological stage (before flowering) were high percentages of linalool (37.4%), thymol (27.3%), and carvacrol (12.2%). At the stage of flowering, the percentage of linalool (56.6-57.5%) increased, while those of thymol (15.5-15.8%) and carvacrol (1.4-1.5%) significantly decreased. The essential oil of plants in the full stage of fruiting was characterized by the domination of linalool (58.4 and 65.8%) and lower percentages of thymol (7.6 and 1.3%) and carvacrol (0.7 and 0.1%). In conclusion, the oil composition of S. horvatii was found to depend on the pedoclimatic conditions of the habitat and the phenological stage of the plants.",
publisher = "Wiley-Blackwell, Malden",
journal = "Chemistry & Biodiversity",
title = "Environmental and Seasonal Impacts on the Chemical Composition of Satureja horvatii Šilić (Lamiaceae) Essential Oils",
volume = "8",
number = "3",
pages = "483-493",
doi = "10.1002/cbdv.201000169"
}

Lakušić, B., Ristić, M., Slavkovska, V., Milenković, M.,& Lakušić, D.. (2011). Environmental and Seasonal Impacts on the Chemical Composition of Satureja horvatii Šilić (Lamiaceae) Essential Oils. in Chemistry & Biodiversity
Wiley-Blackwell, Malden., 8(3), 483-493.
https://doi.org/10.1002/cbdv.201000169

Lakušić B, Ristić M, Slavkovska V, Milenković M, Lakušić D. Environmental and Seasonal Impacts on the Chemical Composition of Satureja horvatii Šilić (Lamiaceae) Essential Oils. in Chemistry & Biodiversity. 2011;8(3):483-493.
doi:10.1002/cbdv.201000169 .

Lakušić, Branislava, Ristić, Mihailo, Slavkovska, Violeta, Milenković, Marina, Lakušić, Dmitar, "Environmental and Seasonal Impacts on the Chemical Composition of Satureja horvatii Šilić (Lamiaceae) Essential Oils" in Chemistry & Biodiversity, 8, no. 3 (2011):483-493,
https://doi.org/10.1002/cbdv.201000169 . .

TY  - JOUR
AU  - Arsenijević, Jelena
AU  - Ražić, Slavica
AU  - Maksimović, Zoran
AU  - Đogo-Mračević, Svetlana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1566
AB  - This paper brings out the results of the study on the levels of selected trace elements (Cu, Fe, Mn, Zn and Cr) in aerial parts of Thymus pannonicus All. (Lamiaceae) and rhizosphere soil from twelve locations in Serbia. Prior to assays by flame and flameless atomic absorption spectrometry, samples were subjected to microwave-assisted acid digestion. Real and potential acidity of soil samples were also measured. Obtained results for soil samples, although slightly higher for some elements (Cu: 12.38-45.18 mg/kg; Fe: 22102-46193 mg/kg; Mn: 776.95-4901.27 mg/kg; Zn: 62.27-214.02 mg/kg; Cr: 48.86-69.13 mg/kg), were found to fit into biogeochemical background. Element contents in plant samples differed depending on collecting site (Cu: 5.26-14.07 mg/kg; Fe: 25.92-1454.07 mg/kg; Mn: 89.29-278.25 mg/kg; Zn: 1.81-10.64 mg/kg; Cr: 1.11-3.51 mg/kg), which can be partly explainable by different nutrient availability influenced by soil acidity. Zinc levels in T. pannonicus were below expected and seem to be strongly influenced by plant physiological properties.
PB  - Versita, Warsaw
T2  - Central European Journal of Biology
T1  - Trace elements in aerial parts and rhizosphere of Thymus pannonicus All.
VL  - 6
IS  - 4
SP  - 616
EP  - 623
DO  - 10.2478/s11535-011-0013-0
ER  - 

@article{
author = "Arsenijević, Jelena and Ražić, Slavica and Maksimović, Zoran and Đogo-Mračević, Svetlana",
year = "2011",
abstract = "This paper brings out the results of the study on the levels of selected trace elements (Cu, Fe, Mn, Zn and Cr) in aerial parts of Thymus pannonicus All. (Lamiaceae) and rhizosphere soil from twelve locations in Serbia. Prior to assays by flame and flameless atomic absorption spectrometry, samples were subjected to microwave-assisted acid digestion. Real and potential acidity of soil samples were also measured. Obtained results for soil samples, although slightly higher for some elements (Cu: 12.38-45.18 mg/kg; Fe: 22102-46193 mg/kg; Mn: 776.95-4901.27 mg/kg; Zn: 62.27-214.02 mg/kg; Cr: 48.86-69.13 mg/kg), were found to fit into biogeochemical background. Element contents in plant samples differed depending on collecting site (Cu: 5.26-14.07 mg/kg; Fe: 25.92-1454.07 mg/kg; Mn: 89.29-278.25 mg/kg; Zn: 1.81-10.64 mg/kg; Cr: 1.11-3.51 mg/kg), which can be partly explainable by different nutrient availability influenced by soil acidity. Zinc levels in T. pannonicus were below expected and seem to be strongly influenced by plant physiological properties.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Biology",
title = "Trace elements in aerial parts and rhizosphere of Thymus pannonicus All.",
volume = "6",
number = "4",
pages = "616-623",
doi = "10.2478/s11535-011-0013-0"
}

Arsenijević, J., Ražić, S., Maksimović, Z.,& Đogo-Mračević, S.. (2011). Trace elements in aerial parts and rhizosphere of Thymus pannonicus All.. in Central European Journal of Biology
Versita, Warsaw., 6(4), 616-623.
https://doi.org/10.2478/s11535-011-0013-0

Arsenijević J, Ražić S, Maksimović Z, Đogo-Mračević S. Trace elements in aerial parts and rhizosphere of Thymus pannonicus All.. in Central European Journal of Biology. 2011;6(4):616-623.
doi:10.2478/s11535-011-0013-0 .

Arsenijević, Jelena, Ražić, Slavica, Maksimović, Zoran, Đogo-Mračević, Svetlana, "Trace elements in aerial parts and rhizosphere of Thymus pannonicus All." in Central European Journal of Biology, 6, no. 4 (2011):616-623,
https://doi.org/10.2478/s11535-011-0013-0 . .

TY  - JOUR
AU  - Maksimović, Zoran
AU  - Petrović, Silvana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1556
PB  - Springer, New York
T2  - Chemistry of Natural Compounds
T1  - A rare flavonoid from Maydis stigma with the ability to influence lipid peroxidation in liposomes
VL  - 47
IS  - 1
SP  - 109
EP  - 109
DO  - 10.1007/s10600-011-9845-0
ER  - 

@article{
author = "Maksimović, Zoran and Petrović, Silvana",
year = "2011",
publisher = "Springer, New York",
journal = "Chemistry of Natural Compounds",
title = "A rare flavonoid from Maydis stigma with the ability to influence lipid peroxidation in liposomes",
volume = "47",
number = "1",
pages = "109-109",
doi = "10.1007/s10600-011-9845-0"
}

Maksimović, Z.,& Petrović, S.. (2011). A rare flavonoid from Maydis stigma with the ability to influence lipid peroxidation in liposomes. in Chemistry of Natural Compounds
Springer, New York., 47(1), 109-109.
https://doi.org/10.1007/s10600-011-9845-0

Maksimović Z, Petrović S. A rare flavonoid from Maydis stigma with the ability to influence lipid peroxidation in liposomes. in Chemistry of Natural Compounds. 2011;47(1):109-109.
doi:10.1007/s10600-011-9845-0 .

Maksimović, Zoran, Petrović, Silvana, "A rare flavonoid from Maydis stigma with the ability to influence lipid peroxidation in liposomes" in Chemistry of Natural Compounds, 47, no. 1 (2011):109-109,
https://doi.org/10.1007/s10600-011-9845-0 . .

TY  - JOUR
AU  - Maksimović, Zoran
AU  - Kovačević, Nada
AU  - Lakušić, Branislava
AU  - Cebović, Tatjana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1535
AB  - The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright
PB  - Wiley, Hoboken
T2  - Phytotherapy Research
T1  - Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract
VL  - 25
IS  - 1
SP  - 101
EP  - 105
DO  - 10.1002/ptr.3234
ER  - 

@article{
author = "Maksimović, Zoran and Kovačević, Nada and Lakušić, Branislava and Cebović, Tatjana",
year = "2011",
abstract = "The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract",
volume = "25",
number = "1",
pages = "101-105",
doi = "10.1002/ptr.3234"
}

Maksimović, Z., Kovačević, N., Lakušić, B.,& Cebović, T.. (2011). Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract. in Phytotherapy Research
Wiley, Hoboken., 25(1), 101-105.
https://doi.org/10.1002/ptr.3234

Maksimović Z, Kovačević N, Lakušić B, Cebović T. Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract. in Phytotherapy Research. 2011;25(1):101-105.
doi:10.1002/ptr.3234 .

Maksimović, Zoran, Kovačević, Nada, Lakušić, Branislava, Cebović, Tatjana, "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract" in Phytotherapy Research, 25, no. 1 (2011):101-105,
https://doi.org/10.1002/ptr.3234 . .

TY  - JOUR
AU  - Drobac, Milica
AU  - Petrović, Silvana
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Tzakou, Olga
AU  - Niketić, Marjan
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1545
AB  - The essential oil obtained by hydrodistillation from the roots of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae) was analyzed by GC and GC-MS. Among sixty-two compounds identified (representing 89.0% of the total oil), the main components were: n-nonane (12.1%), n-hexadecanol (6.9%), delta-cadinene (6.4%), beta-pinene (6.0%) and germacrene D (5.4%). Furthermore, the antimicrobial activity of the oil was evaluated against the Gram-positive bacteria Staphylococcus epidermidis (ATCC 12228) and Bacillus subtilis (ATCC 6633), the Gram-negative bacterium Escherichia coli (ATCC 25922), and a yeast Candida albicans (ATCC 10259 and ATCC 24433) using the broth microdilution method.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Chemical Composition and Antimicrobial Activity of Anthriscus nemorosa Root Essential Oil
VL  - 6
IS  - 2
SP  - 271
EP  - 273
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1545
ER  - 

@article{
author = "Drobac, Milica and Petrović, Silvana and Milenković, Marina and Couladis, Maria and Tzakou, Olga and Niketić, Marjan",
year = "2011",
abstract = "The essential oil obtained by hydrodistillation from the roots of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae) was analyzed by GC and GC-MS. Among sixty-two compounds identified (representing 89.0% of the total oil), the main components were: n-nonane (12.1%), n-hexadecanol (6.9%), delta-cadinene (6.4%), beta-pinene (6.0%) and germacrene D (5.4%). Furthermore, the antimicrobial activity of the oil was evaluated against the Gram-positive bacteria Staphylococcus epidermidis (ATCC 12228) and Bacillus subtilis (ATCC 6633), the Gram-negative bacterium Escherichia coli (ATCC 25922), and a yeast Candida albicans (ATCC 10259 and ATCC 24433) using the broth microdilution method.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Chemical Composition and Antimicrobial Activity of Anthriscus nemorosa Root Essential Oil",
volume = "6",
number = "2",
pages = "271-273",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1545"
}

Drobac, M., Petrović, S., Milenković, M., Couladis, M., Tzakou, O.,& Niketić, M.. (2011). Chemical Composition and Antimicrobial Activity of Anthriscus nemorosa Root Essential Oil. in Natural Product Communications
Natural Products Inc, Westerville., 6(2), 271-273.
https://hdl.handle.net/21.15107/rcub_farfar_1545

Drobac M, Petrović S, Milenković M, Couladis M, Tzakou O, Niketić M. Chemical Composition and Antimicrobial Activity of Anthriscus nemorosa Root Essential Oil. in Natural Product Communications. 2011;6(2):271-273.
https://hdl.handle.net/21.15107/rcub_farfar_1545 .

Drobac, Milica, Petrović, Silvana, Milenković, Marina, Couladis, Maria, Tzakou, Olga, Niketić, Marjan, "Chemical Composition and Antimicrobial Activity of Anthriscus nemorosa Root Essential Oil" in Natural Product Communications, 6, no. 2 (2011):271-273,
https://hdl.handle.net/21.15107/rcub_farfar_1545 .

TY  - JOUR
AU  - Popović, Višnja
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Tzakou, Olga
AU  - Duraki, Semija
AU  - Niketić, Marjan
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1385
AB  - The composition and antimicrobial activity of the essential oil from the underground parts (roots and rhizomes) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The pale blue essential oil, obtained by hydrodistillation, was analyzed by GC and GC-MS. Forty-three compounds were identified (94.3% of total oil). The main constituent, beside alpha-pinene (31.6%) was alpha-bisabolol (30.9%), so this oil may be a novel potential natural source of this sesquiterpene alcohol. The antimicrobial activity was tested using the microdilution method against Grain (+) bacteria (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis), Gram (-) bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli), and two strains of yeast (Candida albicans). L. zernyi oil showed significant antibacterial activity against S. epidermidis, S. aureus and M. luteus, but lower activities against the other tested strains.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of alpha-Bisabolol and its Antimicrobial Activity
VL  - 5
IS  - 2
SP  - 307
EP  - 310
DO  - 10.1177/1934578X1000500228
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1385
ER  - 

@article{
author = "Popović, Višnja and Petrović, Silvana and Drobac, Milica and Milenković, Marina and Couladis, Maria and Tzakou, Olga and Duraki, Semija and Niketić, Marjan",
year = "2010",
abstract = "The composition and antimicrobial activity of the essential oil from the underground parts (roots and rhizomes) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The pale blue essential oil, obtained by hydrodistillation, was analyzed by GC and GC-MS. Forty-three compounds were identified (94.3% of total oil). The main constituent, beside alpha-pinene (31.6%) was alpha-bisabolol (30.9%), so this oil may be a novel potential natural source of this sesquiterpene alcohol. The antimicrobial activity was tested using the microdilution method against Grain (+) bacteria (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis), Gram (-) bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli), and two strains of yeast (Candida albicans). L. zernyi oil showed significant antibacterial activity against S. epidermidis, S. aureus and M. luteus, but lower activities against the other tested strains.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of alpha-Bisabolol and its Antimicrobial Activity",
volume = "5",
number = "2",
pages = "307-310",
doi = "10.1177/1934578X1000500228",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1385"
}

Popović, V., Petrović, S., Drobac, M., Milenković, M., Couladis, M., Tzakou, O., Duraki, S.,& Niketić, M.. (2010). Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of alpha-Bisabolol and its Antimicrobial Activity. in Natural Product Communications
Natural Products Inc, Westerville., 5(2), 307-310.
https://doi.org/10.1177/1934578X1000500228
https://hdl.handle.net/21.15107/rcub_farfar_1385

Popović V, Petrović S, Drobac M, Milenković M, Couladis M, Tzakou O, Duraki S, Niketić M. Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of alpha-Bisabolol and its Antimicrobial Activity. in Natural Product Communications. 2010;5(2):307-310.
doi:10.1177/1934578X1000500228
https://hdl.handle.net/21.15107/rcub_farfar_1385 .

Popović, Višnja, Petrović, Silvana, Drobac, Milica, Milenković, Marina, Couladis, Maria, Tzakou, Olga, Duraki, Semija, Niketić, Marjan, "Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of alpha-Bisabolol and its Antimicrobial Activity" in Natural Product Communications, 5, no. 2 (2010):307-310,
https://doi.org/10.1177/1934578X1000500228 .,
https://hdl.handle.net/21.15107/rcub_farfar_1385 .

TY  - JOUR
AU  - Drobac, Milica
AU  - Lakušić, Dmitar
AU  - Kovačević, Nada
AU  - Tzakou, Olga
AU  - Couladis, Maria
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1414
AB  - The essential-oil composition of six Anthemis taxa from several populations in Serbia and Montenegro, Anthemis triumfetti (L.) DC., A. tinctoria L.. A. austriaca JACQ., A. ruthenica BIER., A. COMM L., and A. cretica ssp. carpatica (WILLD.) GRIERSON were analyzed by GC and GC/MS. The main constituents have been identified as follows: camphor (13.8-15.4%), alpha-pinene (5.2-9.3%). beta-pinene (4.9-7.8%), and (E)-caryophyllene (7.3-9.8%) in three populations, and cis-chrysanthenol (27.0%) and 1,8-cineole (8.4%) in one population of A. triumfetti; 1,8-cineole (9.0-25.8%) in the oils of five populations, and borneol (16.0%) and spatulenol (16.0%) in the oil of one population of A. tinctoria: cis-chrysanthenyl acetate (17.5-22.0%). beta-pinene (8.6-13.2%), and 1,8-cineole (7.2-10.4%) in the oils of A. austriaca: germacrene D (8.3-11.3%) and terpinen-4-ol (6.3-7.3%) in A. ruthenica oils; beta-cedrene (10.3-19.0%), (E)-beta-farnesene (78-13.5%), and germacrene D (5.2-9.1%) in the oils of A. cotula; cis-thujone (39.0%), trans-thujone (13.5%), and yomogi alcohol (7.1%) in the oil of A. cretica ssp. carpatica. The essential oil of A. austriaca was studied for the first time. A cluster analysis based on the relative percentages of all components of the essential oils was used to determine the distances between taxa and populations.
PB  - Wiley-Blackwell, Malden
T2  - Chemistry & Biodiversity
T1  - Comparative Analysis of Essential Oils of Six Anthemis Taxa from Serbia and Montenegro
VL  - 7
IS  - 5
SP  - 1231
EP  - 1244
DO  - 10.1002/cbdv.200900156
ER  - 

@article{
author = "Drobac, Milica and Lakušić, Dmitar and Kovačević, Nada and Tzakou, Olga and Couladis, Maria",
year = "2010",
abstract = "The essential-oil composition of six Anthemis taxa from several populations in Serbia and Montenegro, Anthemis triumfetti (L.) DC., A. tinctoria L.. A. austriaca JACQ., A. ruthenica BIER., A. COMM L., and A. cretica ssp. carpatica (WILLD.) GRIERSON were analyzed by GC and GC/MS. The main constituents have been identified as follows: camphor (13.8-15.4%), alpha-pinene (5.2-9.3%). beta-pinene (4.9-7.8%), and (E)-caryophyllene (7.3-9.8%) in three populations, and cis-chrysanthenol (27.0%) and 1,8-cineole (8.4%) in one population of A. triumfetti; 1,8-cineole (9.0-25.8%) in the oils of five populations, and borneol (16.0%) and spatulenol (16.0%) in the oil of one population of A. tinctoria: cis-chrysanthenyl acetate (17.5-22.0%). beta-pinene (8.6-13.2%), and 1,8-cineole (7.2-10.4%) in the oils of A. austriaca: germacrene D (8.3-11.3%) and terpinen-4-ol (6.3-7.3%) in A. ruthenica oils; beta-cedrene (10.3-19.0%), (E)-beta-farnesene (78-13.5%), and germacrene D (5.2-9.1%) in the oils of A. cotula; cis-thujone (39.0%), trans-thujone (13.5%), and yomogi alcohol (7.1%) in the oil of A. cretica ssp. carpatica. The essential oil of A. austriaca was studied for the first time. A cluster analysis based on the relative percentages of all components of the essential oils was used to determine the distances between taxa and populations.",
publisher = "Wiley-Blackwell, Malden",
journal = "Chemistry & Biodiversity",
title = "Comparative Analysis of Essential Oils of Six Anthemis Taxa from Serbia and Montenegro",
volume = "7",
number = "5",
pages = "1231-1244",
doi = "10.1002/cbdv.200900156"
}

Drobac, M., Lakušić, D., Kovačević, N., Tzakou, O.,& Couladis, M.. (2010). Comparative Analysis of Essential Oils of Six Anthemis Taxa from Serbia and Montenegro. in Chemistry & Biodiversity
Wiley-Blackwell, Malden., 7(5), 1231-1244.
https://doi.org/10.1002/cbdv.200900156

Drobac M, Lakušić D, Kovačević N, Tzakou O, Couladis M. Comparative Analysis of Essential Oils of Six Anthemis Taxa from Serbia and Montenegro. in Chemistry & Biodiversity. 2010;7(5):1231-1244.
doi:10.1002/cbdv.200900156 .

Drobac, Milica, Lakušić, Dmitar, Kovačević, Nada, Tzakou, Olga, Couladis, Maria, "Comparative Analysis of Essential Oils of Six Anthemis Taxa from Serbia and Montenegro" in Chemistry & Biodiversity, 7, no. 5 (2010):1231-1244,
https://doi.org/10.1002/cbdv.200900156 . .

TY  - JOUR
AU  - Lakušić, Branislava
AU  - Stevanović, Branka
AU  - Jančić, Radiša
AU  - Lakušić, Dmitar
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1355
AB  - In this paper adaptive morpho-anatomical traits are described of the species Teucrium fruticans, T. arduini, T. scordium, T. botrys,T. chamaedrys, T.flavum, T. montanum and T. polium in Serbia and Montenegro (Balkan peninsula). These characters of leaves and stems were related with chorology and ecology of the species. The research is based on 63 populations sampled across the region, from Eu-Mediterranean coastal areas up to the mountains and to temperate deciduous forest regions of Serbia. Descriptive statistics were calculated for 22 quantitative characters and multivariate analyses were performed to describe the structure of variability (PCA), to identify the significance of differences between the species studied (MANOVA), and to measure distances between them (CDA). In contrast to the widely distributed species Teucrium chamaedrys, T. montanum and T. polium, the species T. fruticans, T. arduini, T. scordium, T. botrys and T. flavum have narrow ecological ranges. Morpho-anatomical analysis gives evidence that all species except T. scordium are xerophytes with distinctly xeromorphic structures. But each of them is characterized by specific structural adaptations to the more or less arid environmental conditions. The perennial herbaceous T. scordium, from the humid habitats, belongs to the mesophytic plant type. The results show that structures of the analyzed species are only partially related with the phylogenetic position of the respective taxa. Multivariate analysis indicates that the morpho-anatomical similarity of some species with each other can be characterized as convergently developed rather in adaptation to xeric ecological conditions that as based on phylogenetic relations.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Flora
T1  - Habitat-related adaptations in morphology and anatomy of Teucrium (Lamiaceae) species from the Balkan peninsula (Serbia and Montenegro)
VL  - 205
IS  - 10
SP  - 633
EP  - 646
DO  - 10.1016/j.flora.2010.04.018
ER  - 

@article{
author = "Lakušić, Branislava and Stevanović, Branka and Jančić, Radiša and Lakušić, Dmitar",
year = "2010",
abstract = "In this paper adaptive morpho-anatomical traits are described of the species Teucrium fruticans, T. arduini, T. scordium, T. botrys,T. chamaedrys, T.flavum, T. montanum and T. polium in Serbia and Montenegro (Balkan peninsula). These characters of leaves and stems were related with chorology and ecology of the species. The research is based on 63 populations sampled across the region, from Eu-Mediterranean coastal areas up to the mountains and to temperate deciduous forest regions of Serbia. Descriptive statistics were calculated for 22 quantitative characters and multivariate analyses were performed to describe the structure of variability (PCA), to identify the significance of differences between the species studied (MANOVA), and to measure distances between them (CDA). In contrast to the widely distributed species Teucrium chamaedrys, T. montanum and T. polium, the species T. fruticans, T. arduini, T. scordium, T. botrys and T. flavum have narrow ecological ranges. Morpho-anatomical analysis gives evidence that all species except T. scordium are xerophytes with distinctly xeromorphic structures. But each of them is characterized by specific structural adaptations to the more or less arid environmental conditions. The perennial herbaceous T. scordium, from the humid habitats, belongs to the mesophytic plant type. The results show that structures of the analyzed species are only partially related with the phylogenetic position of the respective taxa. Multivariate analysis indicates that the morpho-anatomical similarity of some species with each other can be characterized as convergently developed rather in adaptation to xeric ecological conditions that as based on phylogenetic relations.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Flora",
title = "Habitat-related adaptations in morphology and anatomy of Teucrium (Lamiaceae) species from the Balkan peninsula (Serbia and Montenegro)",
volume = "205",
number = "10",
pages = "633-646",
doi = "10.1016/j.flora.2010.04.018"
}

Lakušić, B., Stevanović, B., Jančić, R.,& Lakušić, D.. (2010). Habitat-related adaptations in morphology and anatomy of Teucrium (Lamiaceae) species from the Balkan peninsula (Serbia and Montenegro). in Flora
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 205(10), 633-646.
https://doi.org/10.1016/j.flora.2010.04.018

Lakušić B, Stevanović B, Jančić R, Lakušić D. Habitat-related adaptations in morphology and anatomy of Teucrium (Lamiaceae) species from the Balkan peninsula (Serbia and Montenegro). in Flora. 2010;205(10):633-646.
doi:10.1016/j.flora.2010.04.018 .

Lakušić, Branislava, Stevanović, Branka, Jančić, Radiša, Lakušić, Dmitar, "Habitat-related adaptations in morphology and anatomy of Teucrium (Lamiaceae) species from the Balkan peninsula (Serbia and Montenegro)" in Flora, 205, no. 10 (2010):633-646,
https://doi.org/10.1016/j.flora.2010.04.018 . .

TY  - JOUR
AU  - Tomić, Ana
AU  - Božin, Biljana
AU  - Samojlik, Isidora
AU  - Milenković, Marina
AU  - Mimica-Dukić, Neda
AU  - Petrović, Silvana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5235
AB  - The effects of essential oils isolated from mature fruits of Athamanta turbith ssp. hungarica (Borbás) Tutin
and A. turbith ssp. haynaldii (Borbás & Uechtr.) Tutin (Umbelliferae) on some liver biochemical parameters
in mice intoxicated with carbon tetrachloride were investigated. Pretreatment with both essential oils extenuated
the effects caused by carbon tetrachloride. In order to investigate in vitro antioxidant properties of the
oils, three methods were applied: scavenging of both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals,
as well as a test of inhibition of Fe2+/ascorbic-induced lipid peroxidation. Investigated essential oils exhibited
modest antioxidant capacity. Therefore, their infl uence on biochemical parameters in intoxicated animals might
be linked to the inhibition of enzymes (cytochrome P450 2E1) involved in metabolic activation of halomethanes.
PB  - John Wiley & Sons, Ltd.
T2  - Phytotherapy Research
T1  - Effects of Athamanta turbith Fruit Essential Oils on CCl4-induced Hepatic Failure in Mice and Their Antioxidant Properties
VL  - 24
IS  - 5
SP  - 787
EP  - 790
DO  - 10.1002/ptr.3036
ER  - 

@article{
author = "Tomić, Ana and Božin, Biljana and Samojlik, Isidora and Milenković, Marina and Mimica-Dukić, Neda and Petrović, Silvana",
year = "2010",
abstract = "The effects of essential oils isolated from mature fruits of Athamanta turbith ssp. hungarica (Borbás) Tutin
and A. turbith ssp. haynaldii (Borbás & Uechtr.) Tutin (Umbelliferae) on some liver biochemical parameters
in mice intoxicated with carbon tetrachloride were investigated. Pretreatment with both essential oils extenuated
the effects caused by carbon tetrachloride. In order to investigate in vitro antioxidant properties of the
oils, three methods were applied: scavenging of both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals,
as well as a test of inhibition of Fe2+/ascorbic-induced lipid peroxidation. Investigated essential oils exhibited
modest antioxidant capacity. Therefore, their infl uence on biochemical parameters in intoxicated animals might
be linked to the inhibition of enzymes (cytochrome P450 2E1) involved in metabolic activation of halomethanes.",
publisher = "John Wiley & Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Effects of Athamanta turbith Fruit Essential Oils on CCl4-induced Hepatic Failure in Mice and Their Antioxidant Properties",
volume = "24",
number = "5",
pages = "787-790",
doi = "10.1002/ptr.3036"
}

Tomić, A., Božin, B., Samojlik, I., Milenković, M., Mimica-Dukić, N.,& Petrović, S.. (2010). Effects of Athamanta turbith Fruit Essential Oils on CCl4-induced Hepatic Failure in Mice and Their Antioxidant Properties. in Phytotherapy Research
John Wiley & Sons, Ltd.., 24(5), 787-790.
https://doi.org/10.1002/ptr.3036

Tomić A, Božin B, Samojlik I, Milenković M, Mimica-Dukić N, Petrović S. Effects of Athamanta turbith Fruit Essential Oils on CCl4-induced Hepatic Failure in Mice and Their Antioxidant Properties. in Phytotherapy Research. 2010;24(5):787-790.
doi:10.1002/ptr.3036 .

Tomić, Ana, Božin, Biljana, Samojlik, Isidora, Milenković, Marina, Mimica-Dukić, Neda, Petrović, Silvana, "Effects of Athamanta turbith Fruit Essential Oils on CCl4-induced Hepatic Failure in Mice and Their Antioxidant Properties" in Phytotherapy Research, 24, no. 5 (2010):787-790,
https://doi.org/10.1002/ptr.3036 . .

TY  - JOUR
AU  - Ražić, Slavica
AU  - Kuntić, Vesna
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1445
AB  - The metal contents of Fe, Cu, Mn, Zn, As, Cd, Sn, Hg and Pb in the five herbal tea mixtures containing a variety of different plants were determined. Microwave-assisted acid digestion was used for all of the samples, and the element contents were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). A matched calibration curve method was used for the quantification of the analytes. For accuracy assay, SRM 2977, NIST, Mussel Tissue (Organic Contaminants and Trace Elements) was used. The obtained results agreed with the certified values. The concentration of all elements varied among examined herbal tea mixtures and are in the expected intervals. The contents of all investigated toxic elements were below the maximum permissible levels.
AB  - U ovom radu određen je sadržaj metala u pet izabranih mešavina biljnih čajeva. Devet elemenata: Fe, Cu, Mn, Zn, As, Cd, Sn, Hg i Pb su analizirani metodom induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Uzorci su pripremani mikrotalasnom digestijom, sadržaj metala određen je primenom eksterne kalibracije, a tačnost metode proverena je pomoću standardnog referentnog materijala (SRM 2977, NIST) i internog standarda. Dobijeni rezultati su u dobroj saglasnosti sa sertifikovanim vrednostima. U zavisnosti od ispitivane mešavine, koncentracije analiziranih elemenata su različite i nalaze se u očekivanim intervalima. Koncentracije svih teških metala su ispod dozvoljene granice.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Determination of metal contents in herbal tea mixtures consumed in Belgrade using Inductively Coupled Plasma Mass Spectrometry
T1  - Određivanje sadržaja metala u mešavinama biljnih čajeva sa tržišta u Beogradu primenom induktivno spregnute plazme sa masenom spektrometrijom
VL  - 60
IS  - 4
SP  - 391
EP  - 398
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1445
ER  - 

@article{
author = "Ražić, Slavica and Kuntić, Vesna",
year = "2010",
abstract = "The metal contents of Fe, Cu, Mn, Zn, As, Cd, Sn, Hg and Pb in the five herbal tea mixtures containing a variety of different plants were determined. Microwave-assisted acid digestion was used for all of the samples, and the element contents were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). A matched calibration curve method was used for the quantification of the analytes. For accuracy assay, SRM 2977, NIST, Mussel Tissue (Organic Contaminants and Trace Elements) was used. The obtained results agreed with the certified values. The concentration of all elements varied among examined herbal tea mixtures and are in the expected intervals. The contents of all investigated toxic elements were below the maximum permissible levels., U ovom radu određen je sadržaj metala u pet izabranih mešavina biljnih čajeva. Devet elemenata: Fe, Cu, Mn, Zn, As, Cd, Sn, Hg i Pb su analizirani metodom induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Uzorci su pripremani mikrotalasnom digestijom, sadržaj metala određen je primenom eksterne kalibracije, a tačnost metode proverena je pomoću standardnog referentnog materijala (SRM 2977, NIST) i internog standarda. Dobijeni rezultati su u dobroj saglasnosti sa sertifikovanim vrednostima. U zavisnosti od ispitivane mešavine, koncentracije analiziranih elemenata su različite i nalaze se u očekivanim intervalima. Koncentracije svih teških metala su ispod dozvoljene granice.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Determination of metal contents in herbal tea mixtures consumed in Belgrade using Inductively Coupled Plasma Mass Spectrometry, Određivanje sadržaja metala u mešavinama biljnih čajeva sa tržišta u Beogradu primenom induktivno spregnute plazme sa masenom spektrometrijom",
volume = "60",
number = "4",
pages = "391-398",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1445"
}

Ražić, S.,& Kuntić, V.. (2010). Determination of metal contents in herbal tea mixtures consumed in Belgrade using Inductively Coupled Plasma Mass Spectrometry. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 60(4), 391-398.
https://hdl.handle.net/21.15107/rcub_farfar_1445

Ražić S, Kuntić V. Determination of metal contents in herbal tea mixtures consumed in Belgrade using Inductively Coupled Plasma Mass Spectrometry. in Arhiv za farmaciju. 2010;60(4):391-398.
https://hdl.handle.net/21.15107/rcub_farfar_1445 .

Ražić, Slavica, Kuntić, Vesna, "Determination of metal contents in herbal tea mixtures consumed in Belgrade using Inductively Coupled Plasma Mass Spectrometry" in Arhiv za farmaciju, 60, no. 4 (2010):391-398,
https://hdl.handle.net/21.15107/rcub_farfar_1445 .

TY  - CONF
AU  - Lakušić, Branislava
AU  - Stojčev, Vladimir
AU  - Pavlović, Milica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5163
AB  - The aim of this work was to study anatomy of vegetative and reproductive organs of Freyera cynapioides and Meum athamanticum (Apiaceae), to determine secretory structures as well as to investigate chemical composition of essential oils from aerial parts of those plants.
Plant material was collected at mountain Bjelasica, Montenegro, in July 2008. Anatornical analyses of root, stem, leaf, and fruit were done on permanent slides, prepared by the standard method for light
microscopy. The essential oils were obtained by hydrodistillation and analyzed by GC and GC-MS.
Freyera cynapioides is a perennial herbaceous plant with a globose tuber. There are secretory canals
in tuber under the peridermis. Stem has primary structure with vascular bundles. Secretory canals are in the parenchyma of cortex and in the central cylinder parenchyma, above and below vascular bundles. Petiole is ribbed, every rib containing a vascular bundle and a secretory canal. Fruit is a schizocarp that splits up into two nuts. Each nut has five ribs with one secretory canal, and in mesocarp there are six more. The aerial parts of F. cynapioides yielded 0.1% v/v of light yellow oil. The main compounds of the oil were caryophyllene oxide (24.4%), humulene epoxide II (23.0%) and α-humulene (7.0%).
Meum athamanticum is a perennial herbaceous plant with spindle rhizome. In cortex parenchyma of rhizome there are many scattered secretory canals. Stern is ribbed, there is a central cavity, and there are
one to two secretory canals in cortex parenchyma above each vascular bundle. There is also central cavity within the petiole, ribs are less obvious, and above every vascular bundle phloem there is a secretory canal. The essential oil content in aerial parts of M. athamanticum was 0.6% v/v. The most dominant constituents of the essential oil were β-pinene (29.l%), p-cymene (12.1%) and myrcene (8.0%).
PB  - Faculty o f Biology, University of Belgrade
C3  - 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
T1  - Anatomy of Freyera cynapioides Griseb. and Meum athamanticum Jacq. (Apiaceae)
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5163
ER  - 

@conference{
author = "Lakušić, Branislava and Stojčev, Vladimir and Pavlović, Milica",
year = "2009",
abstract = "The aim of this work was to study anatomy of vegetative and reproductive organs of Freyera cynapioides and Meum athamanticum (Apiaceae), to determine secretory structures as well as to investigate chemical composition of essential oils from aerial parts of those plants.
Plant material was collected at mountain Bjelasica, Montenegro, in July 2008. Anatornical analyses of root, stem, leaf, and fruit were done on permanent slides, prepared by the standard method for light
microscopy. The essential oils were obtained by hydrodistillation and analyzed by GC and GC-MS.
Freyera cynapioides is a perennial herbaceous plant with a globose tuber. There are secretory canals
in tuber under the peridermis. Stem has primary structure with vascular bundles. Secretory canals are in the parenchyma of cortex and in the central cylinder parenchyma, above and below vascular bundles. Petiole is ribbed, every rib containing a vascular bundle and a secretory canal. Fruit is a schizocarp that splits up into two nuts. Each nut has five ribs with one secretory canal, and in mesocarp there are six more. The aerial parts of F. cynapioides yielded 0.1% v/v of light yellow oil. The main compounds of the oil were caryophyllene oxide (24.4%), humulene epoxide II (23.0%) and α-humulene (7.0%).
Meum athamanticum is a perennial herbaceous plant with spindle rhizome. In cortex parenchyma of rhizome there are many scattered secretory canals. Stern is ribbed, there is a central cavity, and there are
one to two secretory canals in cortex parenchyma above each vascular bundle. There is also central cavity within the petiole, ribs are less obvious, and above every vascular bundle phloem there is a secretory canal. The essential oil content in aerial parts of M. athamanticum was 0.6% v/v. The most dominant constituents of the essential oil were β-pinene (29.l%), p-cymene (12.1%) and myrcene (8.0%).",
publisher = "Faculty o f Biology, University of Belgrade",
journal = "5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts",
title = "Anatomy of Freyera cynapioides Griseb. and Meum athamanticum Jacq. (Apiaceae)",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5163"
}

Lakušić, B., Stojčev, V.,& Pavlović, M.. (2009). Anatomy of Freyera cynapioides Griseb. and Meum athamanticum Jacq. (Apiaceae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
Faculty o f Biology, University of Belgrade., 112.
https://hdl.handle.net/21.15107/rcub_farfar_5163

Lakušić B, Stojčev V, Pavlović M. Anatomy of Freyera cynapioides Griseb. and Meum athamanticum Jacq. (Apiaceae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts. 2009;:112.
https://hdl.handle.net/21.15107/rcub_farfar_5163 .

Lakušić, Branislava, Stojčev, Vladimir, Pavlović, Milica, "Anatomy of Freyera cynapioides Griseb. and Meum athamanticum Jacq. (Apiaceae)" in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts (2009):112,
https://hdl.handle.net/21.15107/rcub_farfar_5163 .

TY  - JOUR
AU  - Lakušić, Branislava
AU  - Slavkovska, Violeta
AU  - Drobac, Milica
AU  - Milenković, Marina
AU  - Antić-Stanković, Jelena
AU  - Couladis, Maria
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1246
AB  - The essential oils of the aerial parts and fruits of Chaerophyllum aureum L., collected from two Mountains in Serbia, were analyzed by GC and GUMS. Sabinene (18.5-31.6%), p-cymene (7.9-25.4%) and limonene (1.9-10.9%) were characterized as the main constituents. The oils were tested against six bacterial strains and one strain of yeast, Candida albicans. The highest antimicrobial activity was observed against the Gram-positive bacteria Staphylococcus aureus, S. epidermidis and Micrococcus luteus, while of the Gram-negative strains, Escherichia coli was the most sensitive.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Chemical Composition and Antimicrobial Activity of the Essential Oil from Chaerophyllum aureum L. (Apiaceae)
VL  - 4
IS  - 1
SP  - 115
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1246
ER  - 

@article{
author = "Lakušić, Branislava and Slavkovska, Violeta and Drobac, Milica and Milenković, Marina and Antić-Stanković, Jelena and Couladis, Maria",
year = "2009",
abstract = "The essential oils of the aerial parts and fruits of Chaerophyllum aureum L., collected from two Mountains in Serbia, were analyzed by GC and GUMS. Sabinene (18.5-31.6%), p-cymene (7.9-25.4%) and limonene (1.9-10.9%) were characterized as the main constituents. The oils were tested against six bacterial strains and one strain of yeast, Candida albicans. The highest antimicrobial activity was observed against the Gram-positive bacteria Staphylococcus aureus, S. epidermidis and Micrococcus luteus, while of the Gram-negative strains, Escherichia coli was the most sensitive.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Chemical Composition and Antimicrobial Activity of the Essential Oil from Chaerophyllum aureum L. (Apiaceae)",
volume = "4",
number = "1",
pages = "115-118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1246"
}

Lakušić, B., Slavkovska, V., Drobac, M., Milenković, M., Antić-Stanković, J.,& Couladis, M.. (2009). Chemical Composition and Antimicrobial Activity of the Essential Oil from Chaerophyllum aureum L. (Apiaceae). in Natural Product Communications
Natural Products Inc, Westerville., 4(1), 115-118.
https://hdl.handle.net/21.15107/rcub_farfar_1246

Lakušić B, Slavkovska V, Drobac M, Milenković M, Antić-Stanković J, Couladis M. Chemical Composition and Antimicrobial Activity of the Essential Oil from Chaerophyllum aureum L. (Apiaceae). in Natural Product Communications. 2009;4(1):115-118.
https://hdl.handle.net/21.15107/rcub_farfar_1246 .

Lakušić, Branislava, Slavkovska, Violeta, Drobac, Milica, Milenković, Marina, Antić-Stanković, Jelena, Couladis, Maria, "Chemical Composition and Antimicrobial Activity of the Essential Oil from Chaerophyllum aureum L. (Apiaceae)" in Natural Product Communications, 4, no. 1 (2009):115-118,
https://hdl.handle.net/21.15107/rcub_farfar_1246 .

TY  - CONF
AU  - Pavlović, Milica
AU  - Petrović, Silvana
AU  - Couladis, Maria
AU  - Tzakou, Olga
AU  - Milenković, Marina
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5162
AB  - Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae) is a nitrophile pererurial with a long, stout root. This plant occurs in the temperate area of Eurasia [l], from ltaly on the west to Japan on the East. The species is a member of A. sylvestris (L.) Hoffm. complex [2]. In Serbia, it usually inhabits the shady herbaceous layer in thermophilous forests and underbrush vegetation at the lower altitudes. It prefers moderately wet, steep, stony and eroded slopes. From methanol extract of the roots of A. nemorosa two lignan lactones (savinin, and nemerosin) were isolated [3].
We investigated composition and antimicrobial activity of essential oil from the roots of this plant.
Plant material was collected in Sićevača gorge (E. Serbia), in July 2007. The essential oil was isolated by hydrodistillation and analyzed by GC and GC-MS. The roots yielded 0.2% w/w of light yellow oil with aromatic smell. The main constituents of the oil were: n-nonane (12.1%), n-hexadecanol (6.9%), δ-cadinene (6.4%), β-pinene (6.0%) and germacrene D (5.4%). The essential oil from roots of A. nemorosa differed from the root oil of the closely related species A. sylvestris (L.) Hoffm. which was dominated by β-phellandrene (45.4%), Z-β-ocimene (16.9%), and α-pinene (4.6%) [4].
The microbial growth inhibitory properties of isolated essential oil were determined using the broth microdilution method [5] against Gram-positive bacteria Staphylococcus epidermidis (ATCC 12228), Bacillus subtilis (ATCC 6633), Gram-negative bacteria Escherichia coli (ATCC 25922) and a yeast
Candida albicans (ATCC 10259 and ATCC 24433). The best inhibitory effect was detected against B. subtilis (MIC 6.25 µg/ml) and C. albicans (ATCC 10259) (MIC 50 µg/ml).
References: [1] Nikolić, V. (1973): Anthriscus Pers. In: Josifović, M. (ed.): Flora SR Srbije 5: 334-338. Srpska akademija nauka i umetnosti, Beograd.; [2] Cannon, J.F.M. (1968): Anthriscus Pers. In: Tutin, T.G., Heywood, V.H., Burges, N.A., Moore, D.M., Valentine, D.H., Walters, S.M., Webb, D.A. (eds): Flora Europaea 2: 326. University Press, Cambridge.; [3] Turabelidze, D.G., Mikaya, G.A., Kemertelidze, Vul"fson, N.S. (1982) Bioorg. Khim. 8: 695-701.; [4] Bos, R., Koulman, A., Woerdenbag, H.J., Quax, W.J., Pras, N. (2002) J. Chromatogr. A 966: 233-238.; [5] Candan, F., Unlq M., Tepe, 8., Daferera, D., Polissiou, M., Sdkmen, A., Akpulat, A. (2003) J. Ethnopharmacol. 87: 215-220.
PB  - Faculty o f Biology, University of Belgrade
C3  - 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
T1  - Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae)
SP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5162
ER  - 

@conference{
author = "Pavlović, Milica and Petrović, Silvana and Couladis, Maria and Tzakou, Olga and Milenković, Marina and Niketić, Marjan",
year = "2009",
abstract = "Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae) is a nitrophile pererurial with a long, stout root. This plant occurs in the temperate area of Eurasia [l], from ltaly on the west to Japan on the East. The species is a member of A. sylvestris (L.) Hoffm. complex [2]. In Serbia, it usually inhabits the shady herbaceous layer in thermophilous forests and underbrush vegetation at the lower altitudes. It prefers moderately wet, steep, stony and eroded slopes. From methanol extract of the roots of A. nemorosa two lignan lactones (savinin, and nemerosin) were isolated [3].
We investigated composition and antimicrobial activity of essential oil from the roots of this plant.
Plant material was collected in Sićevača gorge (E. Serbia), in July 2007. The essential oil was isolated by hydrodistillation and analyzed by GC and GC-MS. The roots yielded 0.2% w/w of light yellow oil with aromatic smell. The main constituents of the oil were: n-nonane (12.1%), n-hexadecanol (6.9%), δ-cadinene (6.4%), β-pinene (6.0%) and germacrene D (5.4%). The essential oil from roots of A. nemorosa differed from the root oil of the closely related species A. sylvestris (L.) Hoffm. which was dominated by β-phellandrene (45.4%), Z-β-ocimene (16.9%), and α-pinene (4.6%) [4].
The microbial growth inhibitory properties of isolated essential oil were determined using the broth microdilution method [5] against Gram-positive bacteria Staphylococcus epidermidis (ATCC 12228), Bacillus subtilis (ATCC 6633), Gram-negative bacteria Escherichia coli (ATCC 25922) and a yeast
Candida albicans (ATCC 10259 and ATCC 24433). The best inhibitory effect was detected against B. subtilis (MIC 6.25 µg/ml) and C. albicans (ATCC 10259) (MIC 50 µg/ml).
References: [1] Nikolić, V. (1973): Anthriscus Pers. In: Josifović, M. (ed.): Flora SR Srbije 5: 334-338. Srpska akademija nauka i umetnosti, Beograd.; [2] Cannon, J.F.M. (1968): Anthriscus Pers. In: Tutin, T.G., Heywood, V.H., Burges, N.A., Moore, D.M., Valentine, D.H., Walters, S.M., Webb, D.A. (eds): Flora Europaea 2: 326. University Press, Cambridge.; [3] Turabelidze, D.G., Mikaya, G.A., Kemertelidze, Vul"fson, N.S. (1982) Bioorg. Khim. 8: 695-701.; [4] Bos, R., Koulman, A., Woerdenbag, H.J., Quax, W.J., Pras, N. (2002) J. Chromatogr. A 966: 233-238.; [5] Candan, F., Unlq M., Tepe, 8., Daferera, D., Polissiou, M., Sdkmen, A., Akpulat, A. (2003) J. Ethnopharmacol. 87: 215-220.",
publisher = "Faculty o f Biology, University of Belgrade",
journal = "5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts",
title = "Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae)",
pages = "147",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5162"
}

Pavlović, M., Petrović, S., Couladis, M., Tzakou, O., Milenković, M.,& Niketić, M.. (2009). Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
Faculty o f Biology, University of Belgrade., 147.
https://hdl.handle.net/21.15107/rcub_farfar_5162

Pavlović M, Petrović S, Couladis M, Tzakou O, Milenković M, Niketić M. Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts. 2009;:147.
https://hdl.handle.net/21.15107/rcub_farfar_5162 .

Pavlović, Milica, Petrović, Silvana, Couladis, Maria, Tzakou, Olga, Milenković, Marina, Niketić, Marjan, "Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae)" in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts (2009):147,
https://hdl.handle.net/21.15107/rcub_farfar_5162 .

TY  - CONF
AU  - Niketić, Marjan
AU  - Petrović, Silvana
AU  - Pavlović, Milica
AU  - Stevanović, Vladimir
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5164
AB  - The genus Cerastium L., with ca. 200 species primarily distributed in the Palaearctic, is one of the
largest genus in the family Caryophyllaceae. The type subsection of the genus (subsect. Cerastium) encompasses between 55 and 60 perennial species. The chorological analyses had shown that the present
centres of diversity and endemism both of genus (34 species) and the type subsection (19 species) are
located in the area of Balkan countries.
Giving that subsect. Cerastium represents an intricate and highly variable taxonomic group, we performed a HPLC analysis of phenolic compounds (flavonoids and phenolic acids) in methanol extracts of the flowering herbs of 15 taxa (including 9 species) from 17 Balkan localities in order to elucidate their chemotaxonomic differentiation. The HPLC chromatograms of 17 samples showed presence of 43 compounds grouped into 5 classes: O-glycosides of apigenin, C-glycosides of apigenin and luteolin, flavonoid aglycones and phenolic acids. Among the mentioned phenolic compounds we have identified: apigenin 7-O-glucoside, apigenin 7-O-rutinoside, vitexin, vitexin 2"-O-ramnoside, homoorientine and free apigenin. Apigenin O- and C-glycosides were detected in all samples. None of the compounds or compound groups has a statistically important impact on subspecies differentiation.
Among the studied taxa, C. dinaricum G. Beck & Szysz. particularly stands out, as it differs by a significantly smaller number of compounds and the lack of C-glycosides of luteolin. The second isolated
group includes C. banaticum (Rochel) Steudel and C. arvense L., characterized by presence of phenolic acids, which were not registered in other samples. The third (C. alpinum L., C. malyi (Georgiev) Niketić
and C. eriophorum Kit.) and the fourth group (C. decalvans Schlosser & Vuk. , C. grandiflorum Waldst. & Kit. and C. candidissimum Correns) do not show great differences in composition of compounds.
C3  - 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
T1  - Chemosystematic investigations on phenolic compounds of some Cerastium taxa (Caryophyllaceae) from Balkan Peninsula
SP  - 29
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5164
ER  - 

@conference{
author = "Niketić, Marjan and Petrović, Silvana and Pavlović, Milica and Stevanović, Vladimir",
year = "2009",
abstract = "The genus Cerastium L., with ca. 200 species primarily distributed in the Palaearctic, is one of the
largest genus in the family Caryophyllaceae. The type subsection of the genus (subsect. Cerastium) encompasses between 55 and 60 perennial species. The chorological analyses had shown that the present
centres of diversity and endemism both of genus (34 species) and the type subsection (19 species) are
located in the area of Balkan countries.
Giving that subsect. Cerastium represents an intricate and highly variable taxonomic group, we performed a HPLC analysis of phenolic compounds (flavonoids and phenolic acids) in methanol extracts of the flowering herbs of 15 taxa (including 9 species) from 17 Balkan localities in order to elucidate their chemotaxonomic differentiation. The HPLC chromatograms of 17 samples showed presence of 43 compounds grouped into 5 classes: O-glycosides of apigenin, C-glycosides of apigenin and luteolin, flavonoid aglycones and phenolic acids. Among the mentioned phenolic compounds we have identified: apigenin 7-O-glucoside, apigenin 7-O-rutinoside, vitexin, vitexin 2"-O-ramnoside, homoorientine and free apigenin. Apigenin O- and C-glycosides were detected in all samples. None of the compounds or compound groups has a statistically important impact on subspecies differentiation.
Among the studied taxa, C. dinaricum G. Beck & Szysz. particularly stands out, as it differs by a significantly smaller number of compounds and the lack of C-glycosides of luteolin. The second isolated
group includes C. banaticum (Rochel) Steudel and C. arvense L., characterized by presence of phenolic acids, which were not registered in other samples. The third (C. alpinum L., C. malyi (Georgiev) Niketić
and C. eriophorum Kit.) and the fourth group (C. decalvans Schlosser & Vuk. , C. grandiflorum Waldst. & Kit. and C. candidissimum Correns) do not show great differences in composition of compounds.",
journal = "5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts",
title = "Chemosystematic investigations on phenolic compounds of some Cerastium taxa (Caryophyllaceae) from Balkan Peninsula",
pages = "29",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5164"
}

Niketić, M., Petrović, S., Pavlović, M.,& Stevanović, V.. (2009). Chemosystematic investigations on phenolic compounds of some Cerastium taxa (Caryophyllaceae) from Balkan Peninsula. in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts, 29.
https://hdl.handle.net/21.15107/rcub_farfar_5164

Niketić M, Petrović S, Pavlović M, Stevanović V. Chemosystematic investigations on phenolic compounds of some Cerastium taxa (Caryophyllaceae) from Balkan Peninsula. in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts. 2009;:29.
https://hdl.handle.net/21.15107/rcub_farfar_5164 .

Niketić, Marjan, Petrović, Silvana, Pavlović, Milica, Stevanović, Vladimir, "Chemosystematic investigations on phenolic compounds of some Cerastium taxa (Caryophyllaceae) from Balkan Peninsula" in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts (2009):29,
https://hdl.handle.net/21.15107/rcub_farfar_5164 .

TY  - CONF
AU  - Popović, Višnja
AU  - Petrović, Silvana
AU  - Pavlović, Milica
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Tzakou, Olga
AU  - Duraki, Šemija
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5160
AB  - Laserpitium zernyi Hayek is Scardo-Pindic endemic plant distributed in the mountain regions of
C. Balkans. It was treated earlier as a subspecies, L. siler L. subsp. zernyi (Hayek) Tutin [1,2]. Root of L.
siler is traditionally used as tonic, diuretic, emenagogue, in gynecology and externally for toothache treatments [3].
Composition and antimicrobial activity of essential oil from the underground parts (roots and rhizomes)
of L. zernyi were investigated. Air-dried and powdered plant material was hydrodistilled using n-hexane
as a collecting solvent. Pale blue oil yielded 1.2l% (w/w).
The essential oil was analyzed by GC/FID and GC/MS. Forty-three compounds were identified (94.3% of total oil). Oil was characterised by similar content of monoterpenes and sesquiterpenes (52.9% and 41.4%, respectively). The main constituents were α-pinene (3 1.6%) and α-bisabolol (30.9%).
The antimicrobial activity was tested using the microdillution method [4] against Gram(+) bacteria Staphylococcus aureus ATCC 25923, S. epidermidis ATCC 12228, Micrococcus luteus ATCC 9341, Enterococcus faecalis ATCC 29212, Gram(-) bacteria Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae NCIMB 9111, Escherichia coli ATCC 25922, and two strains of yeast Candida albicans (ATCC 10259 and 24433).
Laserpitium zernyi oil showed significant antibacterial activity against Staphylococcus epidermidis (MIC 31.83 µg/ml), S. aureus and Micrococcus luteus (MICs 63.67 µg/ml). For all other tested microorganisms MIC values were higher than 100.00 µg /ml.
The studied essential oil isolated from the underground parts of L. zernyi had a remarkably different composition than the previously tested oils from flower and herb of this plant, and also showed a much higher antimicrobial activity [5].
PB  - Faculty o f Biology, University of Belgrade
C3  - 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
T1  - Composition and antimicrobial activity of essential oil from the underground parts of Laserpitium zernyi Hayek (Apiaceae)
SP  - 149
EP  - 149
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5160
ER  - 

@conference{
author = "Popović, Višnja and Petrović, Silvana and Pavlović, Milica and Milenković, Marina and Couladis, Maria and Tzakou, Olga and Duraki, Šemija and Niketić, Marjan",
year = "2009",
abstract = "Laserpitium zernyi Hayek is Scardo-Pindic endemic plant distributed in the mountain regions of
C. Balkans. It was treated earlier as a subspecies, L. siler L. subsp. zernyi (Hayek) Tutin [1,2]. Root of L.
siler is traditionally used as tonic, diuretic, emenagogue, in gynecology and externally for toothache treatments [3].
Composition and antimicrobial activity of essential oil from the underground parts (roots and rhizomes)
of L. zernyi were investigated. Air-dried and powdered plant material was hydrodistilled using n-hexane
as a collecting solvent. Pale blue oil yielded 1.2l% (w/w).
The essential oil was analyzed by GC/FID and GC/MS. Forty-three compounds were identified (94.3% of total oil). Oil was characterised by similar content of monoterpenes and sesquiterpenes (52.9% and 41.4%, respectively). The main constituents were α-pinene (3 1.6%) and α-bisabolol (30.9%).
The antimicrobial activity was tested using the microdillution method [4] against Gram(+) bacteria Staphylococcus aureus ATCC 25923, S. epidermidis ATCC 12228, Micrococcus luteus ATCC 9341, Enterococcus faecalis ATCC 29212, Gram(-) bacteria Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae NCIMB 9111, Escherichia coli ATCC 25922, and two strains of yeast Candida albicans (ATCC 10259 and 24433).
Laserpitium zernyi oil showed significant antibacterial activity against Staphylococcus epidermidis (MIC 31.83 µg/ml), S. aureus and Micrococcus luteus (MICs 63.67 µg/ml). For all other tested microorganisms MIC values were higher than 100.00 µg /ml.
The studied essential oil isolated from the underground parts of L. zernyi had a remarkably different composition than the previously tested oils from flower and herb of this plant, and also showed a much higher antimicrobial activity [5].",
publisher = "Faculty o f Biology, University of Belgrade",
journal = "5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts",
title = "Composition and antimicrobial activity of essential oil from the underground parts of Laserpitium zernyi Hayek (Apiaceae)",
pages = "149-149",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5160"
}

Popović, V., Petrović, S., Pavlović, M., Milenković, M., Couladis, M., Tzakou, O., Duraki, Š.,& Niketić, M.. (2009). Composition and antimicrobial activity of essential oil from the underground parts of Laserpitium zernyi Hayek (Apiaceae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts
Faculty o f Biology, University of Belgrade., 149-149.
https://hdl.handle.net/21.15107/rcub_farfar_5160

Popović V, Petrović S, Pavlović M, Milenković M, Couladis M, Tzakou O, Duraki Š, Niketić M. Composition and antimicrobial activity of essential oil from the underground parts of Laserpitium zernyi Hayek (Apiaceae). in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts. 2009;:149-149.
https://hdl.handle.net/21.15107/rcub_farfar_5160 .

Popović, Višnja, Petrović, Silvana, Pavlović, Milica, Milenković, Marina, Couladis, Maria, Tzakou, Olga, Duraki, Šemija, Niketić, Marjan, "Composition and antimicrobial activity of essential oil from the underground parts of Laserpitium zernyi Hayek (Apiaceae)" in 5th Balkan Botanical Congress, 07-11 September 2009, Belgrade, Serbia, Book of Abstracts (2009):149-149,
https://hdl.handle.net/21.15107/rcub_farfar_5160 .

TY  - JOUR
AU  - Tomić, Ana
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Trajkovski, Bojana
AU  - Milenković, Marina
AU  - Božić, Dragana
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1273
AB  - The methanol extracts of fruits and leaves of Athamanta turbith subsp. hungarica (Borbas) Tutin (Umbelliferae) and A. turbith subsp. haynaldii (Borbas & Uechtr.) Tutin were analyzed for their antimicrobial and antioxidant properties. Phenolic compounds (flavonoids and phenolic acids) of the extracts were examined using HPLC. All the extracts were characterized by the presence of caffeic acid derivates, luteolin and its glycosides, with luteolin 7-O-glucoside as one of the main compounds. Luteolin 7-O-rutinoside was detected only in A. turbith subsp. haynaldii extracts. Investigation of antimicrobial activity was performed against six bacteria and two fungal strains, using the agar diffusion technique and broth microdilution assay. The extracts of investigated A. turbith subspecies exerted similar antimicrobial activity, whereas the best activity was detected against Candida albicans. In order to investigate antioxidant properties, ferric ion reducing antioxidant power (FRAP), radical scavenging capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical (HO.), and the effect on lipid peroxidation (LP) were examined. All the examined extracts showed moderate antioxidant capacity, whereas the fruit extracts were more active than the extracts of leaves. Also, the extracts of A. turbith subsp. hungarica exerted higher antioxidant capacity than corresponding A. turbith subsp. haynaldii extracts. The relationship between estimated activity and chemical composition of the extracts is discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Pharmaceutical Biology
T1  - Antimicrobial and antioxidant properties of methanol extracts of two Athamanta turbith subspecies
VL  - 47
IS  - 4
SP  - 314
EP  - 319
DO  - 10.1080/13880200902748452
ER  - 

@article{
author = "Tomić, Ana and Petrović, Silvana and Drobac, Milica and Trajkovski, Bojana and Milenković, Marina and Božić, Dragana and Niketić, Marjan",
year = "2009",
abstract = "The methanol extracts of fruits and leaves of Athamanta turbith subsp. hungarica (Borbas) Tutin (Umbelliferae) and A. turbith subsp. haynaldii (Borbas & Uechtr.) Tutin were analyzed for their antimicrobial and antioxidant properties. Phenolic compounds (flavonoids and phenolic acids) of the extracts were examined using HPLC. All the extracts were characterized by the presence of caffeic acid derivates, luteolin and its glycosides, with luteolin 7-O-glucoside as one of the main compounds. Luteolin 7-O-rutinoside was detected only in A. turbith subsp. haynaldii extracts. Investigation of antimicrobial activity was performed against six bacteria and two fungal strains, using the agar diffusion technique and broth microdilution assay. The extracts of investigated A. turbith subspecies exerted similar antimicrobial activity, whereas the best activity was detected against Candida albicans. In order to investigate antioxidant properties, ferric ion reducing antioxidant power (FRAP), radical scavenging capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical (HO.), and the effect on lipid peroxidation (LP) were examined. All the examined extracts showed moderate antioxidant capacity, whereas the fruit extracts were more active than the extracts of leaves. Also, the extracts of A. turbith subsp. hungarica exerted higher antioxidant capacity than corresponding A. turbith subsp. haynaldii extracts. The relationship between estimated activity and chemical composition of the extracts is discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Pharmaceutical Biology",
title = "Antimicrobial and antioxidant properties of methanol extracts of two Athamanta turbith subspecies",
volume = "47",
number = "4",
pages = "314-319",
doi = "10.1080/13880200902748452"
}

Tomić, A., Petrović, S., Drobac, M., Trajkovski, B., Milenković, M., Božić, D.,& Niketić, M.. (2009). Antimicrobial and antioxidant properties of methanol extracts of two Athamanta turbith subspecies. in Pharmaceutical Biology
Taylor & Francis Ltd, Abingdon., 47(4), 314-319.
https://doi.org/10.1080/13880200902748452

Tomić A, Petrović S, Drobac M, Trajkovski B, Milenković M, Božić D, Niketić M. Antimicrobial and antioxidant properties of methanol extracts of two Athamanta turbith subspecies. in Pharmaceutical Biology. 2009;47(4):314-319.
doi:10.1080/13880200902748452 .

Tomić, Ana, Petrović, Silvana, Drobac, Milica, Trajkovski, Bojana, Milenković, Marina, Božić, Dragana, Niketić, Marjan, "Antimicrobial and antioxidant properties of methanol extracts of two Athamanta turbith subspecies" in Pharmaceutical Biology, 47, no. 4 (2009):314-319,
https://doi.org/10.1080/13880200902748452 . .

TY  - JOUR
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Popović, Višnja
AU  - Couladis, Maria
AU  - Tzakou, Olga
AU  - Milenković, Marina
AU  - Božić, Dragana
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1256
AB  - The hydrodistilled essential oils of the flowers and leaves of Laserpitium zernyi by GC-FID and GC/MS. Fifty-five compounds were identified in the flower oil (96.8% of total oil) and 58 in the leaf oil (89.4% of total oil). Both oils were characterised by the high amount of monoterpenes (59.1-75.6%), whereas sesquiterpenes were present in smaller quantity (21.2-29.2%). The main compounds in the flower oil were sabinene (18.5%), limonene (12.0%), beta-phellandrene (12.0%) and terpinen-4-ol (10.6%), while in the leaf oil the most dominant were beta-pinene (20.0%) and terpinen-4-ol (12.0%). The antimicrobial activity of the oils was determined using the agar diffusion and broth microdilution method against bacteria Staphylococcus aureus, St. epidermidis, Micrococcus luteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and a yeast Candida albicans. The best inhibitory effect (MIC 0.6 mg/mL) was exhibited by the flower oil against St. epidermidis, K pneumoniae and C. albicans, the leaf oil against M. luteus, and both oils against E. coli.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Essential Oil Research
T1  - Composition and Antimicrobial Activity of Essential Oils From Flower and Leaf of Laserpitium zernyi Hayek
VL  - 21
IS  - 5
SP  - 467
EP  - 470
DO  - 10.1080/10412905.2009.9700220
ER  - 

@article{
author = "Petrović, Silvana and Drobac, Milica and Popović, Višnja and Couladis, Maria and Tzakou, Olga and Milenković, Marina and Božić, Dragana and Niketić, Marjan",
year = "2009",
abstract = "The hydrodistilled essential oils of the flowers and leaves of Laserpitium zernyi by GC-FID and GC/MS. Fifty-five compounds were identified in the flower oil (96.8% of total oil) and 58 in the leaf oil (89.4% of total oil). Both oils were characterised by the high amount of monoterpenes (59.1-75.6%), whereas sesquiterpenes were present in smaller quantity (21.2-29.2%). The main compounds in the flower oil were sabinene (18.5%), limonene (12.0%), beta-phellandrene (12.0%) and terpinen-4-ol (10.6%), while in the leaf oil the most dominant were beta-pinene (20.0%) and terpinen-4-ol (12.0%). The antimicrobial activity of the oils was determined using the agar diffusion and broth microdilution method against bacteria Staphylococcus aureus, St. epidermidis, Micrococcus luteus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and a yeast Candida albicans. The best inhibitory effect (MIC 0.6 mg/mL) was exhibited by the flower oil against St. epidermidis, K pneumoniae and C. albicans, the leaf oil against M. luteus, and both oils against E. coli.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Essential Oil Research",
title = "Composition and Antimicrobial Activity of Essential Oils From Flower and Leaf of Laserpitium zernyi Hayek",
volume = "21",
number = "5",
pages = "467-470",
doi = "10.1080/10412905.2009.9700220"
}

Petrović, S., Drobac, M., Popović, V., Couladis, M., Tzakou, O., Milenković, M., Božić, D.,& Niketić, M.. (2009). Composition and Antimicrobial Activity of Essential Oils From Flower and Leaf of Laserpitium zernyi Hayek. in Journal of Essential Oil Research
Taylor & Francis Inc, Philadelphia., 21(5), 467-470.
https://doi.org/10.1080/10412905.2009.9700220

Petrović S, Drobac M, Popović V, Couladis M, Tzakou O, Milenković M, Božić D, Niketić M. Composition and Antimicrobial Activity of Essential Oils From Flower and Leaf of Laserpitium zernyi Hayek. in Journal of Essential Oil Research. 2009;21(5):467-470.
doi:10.1080/10412905.2009.9700220 .

Petrović, Silvana, Drobac, Milica, Popović, Višnja, Couladis, Maria, Tzakou, Olga, Milenković, Marina, Božić, Dragana, Niketić, Marjan, "Composition and Antimicrobial Activity of Essential Oils From Flower and Leaf of Laserpitium zernyi Hayek" in Journal of Essential Oil Research, 21, no. 5 (2009):467-470,
https://doi.org/10.1080/10412905.2009.9700220 . .

TY  - JOUR
AU  - Tomić, Ana
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Tzakou, Olga
AU  - Couladis, Maria
AU  - Milenković, Marina
AU  - Božić, Dragana
AU  - Lakušić, Branislava
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1227
AB  - The hydrodistilled essential oils of the rhizomes of Athamanta turbith subsp. hungarica and A. turbith subsp. haynaldii were analyzed by GC-FID and GC/MS. Twenty-one compounds (99.8% of total oil) were identified in the oil from A. turbith subsp. hungarica, mid 33 components (99.9% of total oil) were identified in the oil from A. turbith subsp. haynaldii. Both oils were characterized by high amounts of phenylpropanes, with myristicin (54.2% and 22.3%, respectively) and apiole (32.6% and 48.5%, respectively) being the main components. The antimicrobial activity of the oils was determined using the agar diffusion and broth microdilution method. Investigated essential oils were the most effective against Micrococcus luteus and Klebsiella pneumoniae, and had no effect against Pseudomonas aeruginosa. As for antifungal activity, essential oils exerted similar and significant activity, but only in higher concentrations.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Essential Oil Research
T1  - Composition and Antimicrobial Activity of the Rhizome Essential Oils of Two Athamanta turbith Subspecies
VL  - 21
IS  - 3
SP  - 276
EP  - 279
DO  - 10.1080/10412905.2009.9700169
ER  - 

@article{
author = "Tomić, Ana and Petrović, Silvana and Drobac, Milica and Tzakou, Olga and Couladis, Maria and Milenković, Marina and Božić, Dragana and Lakušić, Branislava",
year = "2009",
abstract = "The hydrodistilled essential oils of the rhizomes of Athamanta turbith subsp. hungarica and A. turbith subsp. haynaldii were analyzed by GC-FID and GC/MS. Twenty-one compounds (99.8% of total oil) were identified in the oil from A. turbith subsp. hungarica, mid 33 components (99.9% of total oil) were identified in the oil from A. turbith subsp. haynaldii. Both oils were characterized by high amounts of phenylpropanes, with myristicin (54.2% and 22.3%, respectively) and apiole (32.6% and 48.5%, respectively) being the main components. The antimicrobial activity of the oils was determined using the agar diffusion and broth microdilution method. Investigated essential oils were the most effective against Micrococcus luteus and Klebsiella pneumoniae, and had no effect against Pseudomonas aeruginosa. As for antifungal activity, essential oils exerted similar and significant activity, but only in higher concentrations.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Essential Oil Research",
title = "Composition and Antimicrobial Activity of the Rhizome Essential Oils of Two Athamanta turbith Subspecies",
volume = "21",
number = "3",
pages = "276-279",
doi = "10.1080/10412905.2009.9700169"
}

Tomić, A., Petrović, S., Drobac, M., Tzakou, O., Couladis, M., Milenković, M., Božić, D.,& Lakušić, B.. (2009). Composition and Antimicrobial Activity of the Rhizome Essential Oils of Two Athamanta turbith Subspecies. in Journal of Essential Oil Research
Taylor & Francis Inc, Philadelphia., 21(3), 276-279.
https://doi.org/10.1080/10412905.2009.9700169

Tomić A, Petrović S, Drobac M, Tzakou O, Couladis M, Milenković M, Božić D, Lakušić B. Composition and Antimicrobial Activity of the Rhizome Essential Oils of Two Athamanta turbith Subspecies. in Journal of Essential Oil Research. 2009;21(3):276-279.
doi:10.1080/10412905.2009.9700169 .

Tomić, Ana, Petrović, Silvana, Drobac, Milica, Tzakou, Olga, Couladis, Maria, Milenković, Marina, Božić, Dragana, Lakušić, Branislava, "Composition and Antimicrobial Activity of the Rhizome Essential Oils of Two Athamanta turbith Subspecies" in Journal of Essential Oil Research, 21, no. 3 (2009):276-279,
https://doi.org/10.1080/10412905.2009.9700169 . .

TY  - JOUR
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Tzakou, Olga
AU  - Couladis, Maria
AU  - Milenković, Marina
AU  - Božić, Dragana
AU  - Niketić, Marjan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1203
AB  - The chemical analysis of the Salvia amplexicaulis Lam. herb essential oil was performed using GC-FID and GC/ MS. Fifty-one compounds (90.2% of the total oil) were identified. The oil was characterized by a high amount of sesquiterpenes (81.1%), with germacrene D (14.8%), viridiflorol (10.6%), caryophyllene oxide (10.5%), and beta-caryophyllene (9.4%) being the main components. The microbial growth inhibitory properties of the oil was determined against Gram-positive bacteria Staphylococcus aureus, St. epidermidis, Micrococcus luteus, Grain-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli,and a yeast Candida albicans. The best inhibitory effectwas detected against M. luteus, followed by the effects against St. epidermidis, St. aureus and C. albicans. Tested Gram-negative bacteria were more resistant than Gram-positive bacteria and C. albicans.
PB  - Allured Publ Corp, Carol Stream
T2  - Journal of Essential Oil Research
T1  - Composition and Antimicrobial Activity of Salvia amplexicaulis Lam. Essential Oil
VL  - 21
IS  - 6
SP  - 563
EP  - 566
DO  - 10.1080/10412905.2009.9700246
ER  - 

@article{
author = "Petrović, Silvana and Drobac, Milica and Tzakou, Olga and Couladis, Maria and Milenković, Marina and Božić, Dragana and Niketić, Marjan",
year = "2009",
abstract = "The chemical analysis of the Salvia amplexicaulis Lam. herb essential oil was performed using GC-FID and GC/ MS. Fifty-one compounds (90.2% of the total oil) were identified. The oil was characterized by a high amount of sesquiterpenes (81.1%), with germacrene D (14.8%), viridiflorol (10.6%), caryophyllene oxide (10.5%), and beta-caryophyllene (9.4%) being the main components. The microbial growth inhibitory properties of the oil was determined against Gram-positive bacteria Staphylococcus aureus, St. epidermidis, Micrococcus luteus, Grain-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli,and a yeast Candida albicans. The best inhibitory effectwas detected against M. luteus, followed by the effects against St. epidermidis, St. aureus and C. albicans. Tested Gram-negative bacteria were more resistant than Gram-positive bacteria and C. albicans.",
publisher = "Allured Publ Corp, Carol Stream",
journal = "Journal of Essential Oil Research",
title = "Composition and Antimicrobial Activity of Salvia amplexicaulis Lam. Essential Oil",
volume = "21",
number = "6",
pages = "563-566",
doi = "10.1080/10412905.2009.9700246"
}

Petrović, S., Drobac, M., Tzakou, O., Couladis, M., Milenković, M., Božić, D.,& Niketić, M.. (2009). Composition and Antimicrobial Activity of Salvia amplexicaulis Lam. Essential Oil. in Journal of Essential Oil Research
Allured Publ Corp, Carol Stream., 21(6), 563-566.
https://doi.org/10.1080/10412905.2009.9700246

Petrović S, Drobac M, Tzakou O, Couladis M, Milenković M, Božić D, Niketić M. Composition and Antimicrobial Activity of Salvia amplexicaulis Lam. Essential Oil. in Journal of Essential Oil Research. 2009;21(6):563-566.
doi:10.1080/10412905.2009.9700246 .

Petrović, Silvana, Drobac, Milica, Tzakou, Olga, Couladis, Maria, Milenković, Marina, Božić, Dragana, Niketić, Marjan, "Composition and Antimicrobial Activity of Salvia amplexicaulis Lam. Essential Oil" in Journal of Essential Oil Research, 21, no. 6 (2009):563-566,
https://doi.org/10.1080/10412905.2009.9700246 . .