TY  - CONF
AU  - Marčetić, Mirjana
AU  - Vidović, Bojana
AU  - Samardžić, Stevan
AU  - Ilić, Tijana
AU  - Božić, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4610
AB  - The blackthorn is widespread across temperate Europe and also occurs in the Near East and Africa. The fruit is traditionally used in the treatment of digestive, respiratory and kidney disorders. The aim of the study was to investigate composition and the antibacterial activity of methanol extract of blackthorn fruit, and potential prebiotic effect on selected probiotic microorganisms. The blackthorn fruit is a rich source of vitamin C (5.3 mg/100 g, determinated by titration) as well as Ca, Mg and P (106.7; 42.0 and 43.2 mg/100 g, respectively, determinated by ICP-OES). The total phenolic content was 1,235 mg gallic acid/100 g (FC method). Hydroxycinnamic acid derivatives (caffeoylquinic and feruloylquinic acids), flavonoids (glycosides of quercetin, methylquercetin and kaempferol) and anthocyanins (glycosides of cyanidin and peonidin) were tentatively identified by LC-DAD-ESI-MS. The antimicrobial activity on eight laboratory control strains of bacteria was not pronounced (MIC 1.25->5 mg/ml). On the other hand the extract (0.3-5.0 mg/ml) exhibited significant prebiotic effect on investigated probiotic strains of Lactobacillus spp., Saccharomyces boulardii and their mixtures. The stimulation of growth was in the range 4.0-52.8% in concentration dependent manner. In conclusion, significant prebiotic activity of blackthorn fruit confers new insight in blackthorn health benefits.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia, Belgrade
C3  - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
T1  - Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae
SP  - 167
EP  - 167
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4610
ER  - 

@conference{
author = "Marčetić, Mirjana and Vidović, Bojana and Samardžić, Stevan and Ilić, Tijana and Božić, Dragana",
year = "2022",
abstract = "The blackthorn is widespread across temperate Europe and also occurs in the Near East and Africa. The fruit is traditionally used in the treatment of digestive, respiratory and kidney disorders. The aim of the study was to investigate composition and the antibacterial activity of methanol extract of blackthorn fruit, and potential prebiotic effect on selected probiotic microorganisms. The blackthorn fruit is a rich source of vitamin C (5.3 mg/100 g, determinated by titration) as well as Ca, Mg and P (106.7; 42.0 and 43.2 mg/100 g, respectively, determinated by ICP-OES). The total phenolic content was 1,235 mg gallic acid/100 g (FC method). Hydroxycinnamic acid derivatives (caffeoylquinic and feruloylquinic acids), flavonoids (glycosides of quercetin, methylquercetin and kaempferol) and anthocyanins (glycosides of cyanidin and peonidin) were tentatively identified by LC-DAD-ESI-MS. The antimicrobial activity on eight laboratory control strains of bacteria was not pronounced (MIC 1.25->5 mg/ml). On the other hand the extract (0.3-5.0 mg/ml) exhibited significant prebiotic effect on investigated probiotic strains of Lactobacillus spp., Saccharomyces boulardii and their mixtures. The stimulation of growth was in the range 4.0-52.8% in concentration dependent manner. In conclusion, significant prebiotic activity of blackthorn fruit confers new insight in blackthorn health benefits.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade",
journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts",
title = "Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae",
pages = "167-167",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4610"
}

Marčetić, M., Vidović, B., Samardžić, S., Ilić, T.,& Božić, D.. (2022). Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 167-167.
https://hdl.handle.net/21.15107/rcub_farfar_4610

Marčetić M, Vidović B, Samardžić S, Ilić T, Božić D. Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:167-167.
https://hdl.handle.net/21.15107/rcub_farfar_4610 .

Marčetić, Mirjana, Vidović, Bojana, Samardžić, Stevan, Ilić, Tijana, Božić, Dragana, "Chemical composition and prebiotic effect of the fruit of Prunus spinosa L., Rosaceae" in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):167-167,
https://hdl.handle.net/21.15107/rcub_farfar_4610 .

TY  - CONF
AU  - Zbiljić, Miloš
AU  - Stojanović, Danilo
AU  - Marčetić, Mirjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4611
AB  - Teucrium montanum L. is a semi-woody, evergreen small shrub, widely distributed in Europe occurring from the seacoast to the subalpine and alpine belts. The study aimed to investigate and compare the chemical composition of essential oil of aerial parts of T. montanum from 24 populations collected from West, Central, and South West Balkans. The essential oils were obtained by hydrodistillation and qualitative and quantitative analysis was performed by GC-FID and GC-MS. The dominant compounds were oxidized sesquiterpenes (24.83–85.75%), then sesquiterpene hydrocarbons (3.00–62.81%), and oxidized monoterpenes (0–27.78%). Cluster analysis revealed 10 clearly separated groups. First group (Žumberak) is completely separated and characterized by high germacrene-D-4-ol (63.17%), the second (Gjergjevice) by high shyobunol (51.23%), the third (Vratna) by high (dehydro)-sesquicineole-acetate (45.29%), the fourth (Ostrovice) by high epi-α-cadinol (36.80%), the fifth (Nera canyon) by high limonene (36.65%), sixth group (Orovica, Sićevo, Galičica) by high cis-sesquisabinene hydrate (18.73–29.05%), seventh group (Štrpce, Dobrilovina) by high γ-cadinene (13.43–23.06%), eighth group (Tara, Durmitor, Biokovo, Fužine) by moderate germacrene-D-4-ol (19.76–23.44%), and the ninth large group (Potoci, Lovćen, Orjen, Premantura, Vodice, Pletvar, Senj, Oštarije, Trebinje, Korita) by germacren D (6.15–33.87%). Such a high variability needs more research to define relationships among populations.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia, Belgrade
C3  - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
T1  - The new data on the variability of the essential oil of Teucrium montanum L. from Balkan Peninsula
SP  - 179
EP  - 179
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4611
ER  - 

@conference{
author = "Zbiljić, Miloš and Stojanović, Danilo and Marčetić, Mirjana",
year = "2022",
abstract = "Teucrium montanum L. is a semi-woody, evergreen small shrub, widely distributed in Europe occurring from the seacoast to the subalpine and alpine belts. The study aimed to investigate and compare the chemical composition of essential oil of aerial parts of T. montanum from 24 populations collected from West, Central, and South West Balkans. The essential oils were obtained by hydrodistillation and qualitative and quantitative analysis was performed by GC-FID and GC-MS. The dominant compounds were oxidized sesquiterpenes (24.83–85.75%), then sesquiterpene hydrocarbons (3.00–62.81%), and oxidized monoterpenes (0–27.78%). Cluster analysis revealed 10 clearly separated groups. First group (Žumberak) is completely separated and characterized by high germacrene-D-4-ol (63.17%), the second (Gjergjevice) by high shyobunol (51.23%), the third (Vratna) by high (dehydro)-sesquicineole-acetate (45.29%), the fourth (Ostrovice) by high epi-α-cadinol (36.80%), the fifth (Nera canyon) by high limonene (36.65%), sixth group (Orovica, Sićevo, Galičica) by high cis-sesquisabinene hydrate (18.73–29.05%), seventh group (Štrpce, Dobrilovina) by high γ-cadinene (13.43–23.06%), eighth group (Tara, Durmitor, Biokovo, Fužine) by moderate germacrene-D-4-ol (19.76–23.44%), and the ninth large group (Potoci, Lovćen, Orjen, Premantura, Vodice, Pletvar, Senj, Oštarije, Trebinje, Korita) by germacren D (6.15–33.87%). Such a high variability needs more research to define relationships among populations.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade",
journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts",
title = "The new data on the variability of the essential oil of Teucrium montanum L. from Balkan Peninsula",
pages = "179-179",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4611"
}

Zbiljić, M., Stojanović, D.,& Marčetić, M.. (2022). The new data on the variability of the essential oil of Teucrium montanum L. from Balkan Peninsula. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 179-179.
https://hdl.handle.net/21.15107/rcub_farfar_4611

Zbiljić M, Stojanović D, Marčetić M. The new data on the variability of the essential oil of Teucrium montanum L. from Balkan Peninsula. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:179-179.
https://hdl.handle.net/21.15107/rcub_farfar_4611 .

Zbiljić, Miloš, Stojanović, Danilo, Marčetić, Mirjana, "The new data on the variability of the essential oil of Teucrium montanum L. from Balkan Peninsula" in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):179-179,
https://hdl.handle.net/21.15107/rcub_farfar_4611 .

TY  - JOUR
AU  - Bon, Corentin
AU  - Barbachowska, Magdalena
AU  - Đoković, Nemanja
AU  - Ružić, Dušan
AU  - Si, Yang
AU  - Soresinetti, Laura
AU  - Jallet, Corinne
AU  - Tafit, Ambre
AU  - Halby, Ludovic
AU  - Nikolić, Katarina
AU  - Arimondo, Paola B
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4908
AB  - Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in various diseases, making it a very interesting target for drug discovery. DOT1L has two substrates, the SAM cofactor that gives the methyl group and the lysine H3K79 substrate. Results: Using molecular docking, the authors explored new bisubstrate analogs to enlarge the chemical landscape of DOT1L inhibitors. The authors showed that quinazoline can successfully replace the adenine in the design of bisubstrate inhibitors of DOT1L, showing similar activity compared with the adenine derivative but with diminished cytotoxicity. Conclusion: The docking model is validated together with the use of quinazoline in the design of bisubstrate inhibitors.
PB  - Newlands Press
T2  - Future Medicinal Chemistry
T1  - Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies
VL  - 14
VL  - 557
VL  - 570
IS  - 8
DO  - 10.4155/fmc-2021-0251
ER  - 

@article{
author = "Bon, Corentin and Barbachowska, Magdalena and Đoković, Nemanja and Ružić, Dušan and Si, Yang and Soresinetti, Laura and Jallet, Corinne and Tafit, Ambre and Halby, Ludovic and Nikolić, Katarina and Arimondo, Paola B",
year = "2022",
abstract = "Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in various diseases, making it a very interesting target for drug discovery. DOT1L has two substrates, the SAM cofactor that gives the methyl group and the lysine H3K79 substrate. Results: Using molecular docking, the authors explored new bisubstrate analogs to enlarge the chemical landscape of DOT1L inhibitors. The authors showed that quinazoline can successfully replace the adenine in the design of bisubstrate inhibitors of DOT1L, showing similar activity compared with the adenine derivative but with diminished cytotoxicity. Conclusion: The docking model is validated together with the use of quinazoline in the design of bisubstrate inhibitors.",
publisher = "Newlands Press",
journal = "Future Medicinal Chemistry",
title = "Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies",
volume = "14, 557, 570",
number = "8",
doi = "10.4155/fmc-2021-0251"
}

Bon, C., Barbachowska, M., Đoković, N., Ružić, D., Si, Y., Soresinetti, L., Jallet, C., Tafit, A., Halby, L., Nikolić, K.,& Arimondo, P. B.. (2022). Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies. in Future Medicinal Chemistry
Newlands Press., 14(8).
https://doi.org/10.4155/fmc-2021-0251

Bon C, Barbachowska M, Đoković N, Ružić D, Si Y, Soresinetti L, Jallet C, Tafit A, Halby L, Nikolić K, Arimondo PB. Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies. in Future Medicinal Chemistry. 2022;14(8).
doi:10.4155/fmc-2021-0251 .

Bon, Corentin, Barbachowska, Magdalena, Đoković, Nemanja, Ružić, Dušan, Si, Yang, Soresinetti, Laura, Jallet, Corinne, Tafit, Ambre, Halby, Ludovic, Nikolić, Katarina, Arimondo, Paola B, "Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies" in Future Medicinal Chemistry, 14, no. 8 (2022),
https://doi.org/10.4155/fmc-2021-0251 . .