TY  - JOUR
AU  - Marinko, Marija
AU  - Hou, Hai-Tao
AU  - Stojanović, Ivan
AU  - Milojević, Predrag
AU  - Nenezić, Dragoslav
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
AU  - Novaković, Aleksandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3901
AB  - Hydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S-induced relaxation in human vessels remains unclear, the present study aimed to investigate the effects of H2S donor, sodium hydrosulfide (NaHS), on isolated human saphenous vein (HSV) and to determine the mechanism of action. Our results showed that NaHS (1 µM–3 mM) induced a concentration-dependent relaxation of endothelium-intact HSV rings pre-contracted by phenylephrine. Pre-treatment with L-NAME, ODQ and KT5823 significantly inhibited NaHS-induced relaxation, while indomethacin induced partial inhibition. Among K+ channel blockers, the combination of apamin and TRAM-34 significantly affected the relaxation produced by NaHS, while iberiotoxin and glibenclamide only reduced maximal relaxation of HSV. NaHS partially relaxed endothelium-intact rings pre-contracted by high K+, as well as phenylephrine-contracted rings in the presence of nifedipine. Additionally, the incubation of HSV rings with NaHS increased NO production. These results demonstrate that NaHS produces the concentration- and endothelium-dependent relaxation of isolated HSV. Vasorelaxation to NaHS probably involves activation of NO/cGMP/PKG pathway and partially prostacyclin. In addition, different K+ channels subtypes, especially SKCa and IKCa, as well as BKCa and KATP channels in high concentrations of NaHS, probably participate in the NaHS-induced vasorelaxation.
PB  - Blackwell Publishing Ltd
T2  - Fundamental and Clinical Pharmacology
T1  - Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein
VL  - 35
IS  - 5
SP  - 906
EP  - 918
DO  - 10.1111/fcp.12658
ER  - 

@article{
author = "Marinko, Marija and Hou, Hai-Tao and Stojanović, Ivan and Milojević, Predrag and Nenezić, Dragoslav and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei and Novaković, Aleksandra",
year = "2021",
abstract = "Hydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S-induced relaxation in human vessels remains unclear, the present study aimed to investigate the effects of H2S donor, sodium hydrosulfide (NaHS), on isolated human saphenous vein (HSV) and to determine the mechanism of action. Our results showed that NaHS (1 µM–3 mM) induced a concentration-dependent relaxation of endothelium-intact HSV rings pre-contracted by phenylephrine. Pre-treatment with L-NAME, ODQ and KT5823 significantly inhibited NaHS-induced relaxation, while indomethacin induced partial inhibition. Among K+ channel blockers, the combination of apamin and TRAM-34 significantly affected the relaxation produced by NaHS, while iberiotoxin and glibenclamide only reduced maximal relaxation of HSV. NaHS partially relaxed endothelium-intact rings pre-contracted by high K+, as well as phenylephrine-contracted rings in the presence of nifedipine. Additionally, the incubation of HSV rings with NaHS increased NO production. These results demonstrate that NaHS produces the concentration- and endothelium-dependent relaxation of isolated HSV. Vasorelaxation to NaHS probably involves activation of NO/cGMP/PKG pathway and partially prostacyclin. In addition, different K+ channels subtypes, especially SKCa and IKCa, as well as BKCa and KATP channels in high concentrations of NaHS, probably participate in the NaHS-induced vasorelaxation.",
publisher = "Blackwell Publishing Ltd",
journal = "Fundamental and Clinical Pharmacology",
title = "Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein",
volume = "35",
number = "5",
pages = "906-918",
doi = "10.1111/fcp.12658"
}

Marinko, M., Hou, H., Stojanović, I., Milojević, P., Nenezić, D., Kanjuh, V., Yang, Q., He, G.,& Novaković, A.. (2021). Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein. in Fundamental and Clinical Pharmacology
Blackwell Publishing Ltd., 35(5), 906-918.
https://doi.org/10.1111/fcp.12658

Marinko M, Hou H, Stojanović I, Milojević P, Nenezić D, Kanjuh V, Yang Q, He G, Novaković A. Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein. in Fundamental and Clinical Pharmacology. 2021;35(5):906-918.
doi:10.1111/fcp.12658 .

Marinko, Marija, Hou, Hai-Tao, Stojanović, Ivan, Milojević, Predrag, Nenezić, Dragoslav, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, Novaković, Aleksandra, "Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein" in Fundamental and Clinical Pharmacology, 35, no. 5 (2021):906-918,
https://doi.org/10.1111/fcp.12658 . .

TY  - THES
AU  - Marinko, Marija
PY  - 2020
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7753
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:22987/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=23129865
UR  - https://nardus.mpn.gov.rs/handle/123456789/17654
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3755
AB  - Gasotransmiteri ostvaruju deo svojih uticaja na organizam regulacijom jonskih kanala, posebno kalijumovih (K+) kanala. Promenjena struktura/funkcija jonskih kanala, ali i poremećaji metabolizma i/ili nivoa gasotransmitera, povezani su sa nekoliko patofizioloških stanja, uključujući kardiovaskularne bolesti.Glavni cilj našeg istraživanja bio je ispitivanje mehanizama vazodilatatornog dejstva nikorandila, donora azot monoksida (NO), i natrijum-hidrogensulfida, donora vodonik-sulfida (H2S), na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka.Neiskorišćeni segmenti unutrašnje torakalne arterije i vene safene uzimani su od pacijenata tokom bajpas operacija. Ispitivanje je rađeno u in vitro uslovima u sistemu za izolovane organe. Koncentracijski-zavisne krive relaksacije konstruisane su na prekontrahovanim preparatima sa i bez endotela u prisustvu/odsustvu blokatora K+ kanala i/ili inhibitora signalnog puta cikličnog gvanozin-monofosfata (cGMP).Naši rezultati su pokazali da nikorandil i natrijum-hidrogensulfid prouzrokuju koncentracijski-zavisnu relaksaciju izolovane humane vene safene i unutrašnje torakalne arterije prekontrahovane fenilefrinom. Nikorandil izaziva endotel-nezavisnu, a natrijum-hidrogensulfid endotel-zavisnu relaksaciju oba krvna suda. Signalni put cGMP-a ima značajnu ulogu u vazorelaksantnom efektu nikorandila. Takođe, mehanizam dejstva natrijum-hidrogensulfida uključuje pojačanje NO/cGMP signalnog puta na oba krvna suda. Kalijumovi kanali doprinose relaksantnom dejstvu oba ispitivana agensa, s tim da postoje razlike u tipovima K+ kanala i njihovom relativnom značaju.S obzirom da se spazam vene safene i unutrašnje torakalne arterije i dalje javlja u kliničkim uslovima, a njegova prevencija i reverzija još uvek predstavljaju izazov, rezultati naše studije mogu ukazati na nove tarapijske ciljeve u lečenju spazma bajpas graftova i potencijalno dati farmakološku osnovu za razvoj novih vazodilatatornih lekova.
AB  - Gasotransmitters exert part of their impact on the organism via regulation of ion channels, especially potassium (K+) channels. Altered structure/function of ion channels, as well disorders of the metabolism and/or levels of the gasotransmitters are associated with several pathophysiological conditions, including cardiovascular diseases.The principal aim of our study was to investigate the mechanisms of vasodilator action of nicorandil, a nitric oxide (NO) donor, and of sodium hydrosulfide, a hydrogen sulfide (H2S) donor, on the isolated human internal thoracic artery and saphenous vein.Discarded segments of the internal thoracic artery and saphenous vein were collected from patients undergoing coronary artery bypass grafting. The investigation was performed in vitro in an isolated organs system. Concentration-response curves were constructed on pre-contracted preparations with and without endothelium in the presence/absence of K+ channel blockers and/or cyclic guanosine monophosphate (cGMP) pathway inhibitors.Our results showed that nicorandil and sodium hydrosulfide cause a concentration-dependent relaxation of the isolated human saphenous vein and internal thoracic artery pre-contracted by phenylephrine. Nicorandil exerts endothelium-independent and sodium hydrosulfide endothelium-dependent relaxation of both blood vessels. cGMP signalling pathway plays a significant role in the vasorelaxant effect of nicorandil. Also, sodium hydrosulfide mechanism of action involves enhancement of the NO/cGMP signalling pathway in both vessels. Potassium channels contribute to the relaxant effect of both investigated agents, although differences exist in K+ channel subtypes and their relative importance.Since the spasm of saphenous vein and internal thoracic artery still occurs in clinical settings, and its prevention and reversion is still challenging, the results of our study may indicate new targets in the treatment of bypass grafts spasm, and potentially provide a pharmacological basis for the development of new vasodilator drugs.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Vazodilatatorno delovanje donora azot monoksida i vodonik-sulfida na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka: uloga kalijumovih kanala
UR  - https://hdl.handle.net/21.15107/rcub_nardus_17654
ER  - 

@phdthesis{
author = "Marinko, Marija",
year = "2020",
abstract = "Gasotransmiteri ostvaruju deo svojih uticaja na organizam regulacijom jonskih kanala, posebno kalijumovih (K+) kanala. Promenjena struktura/funkcija jonskih kanala, ali i poremećaji metabolizma i/ili nivoa gasotransmitera, povezani su sa nekoliko patofizioloških stanja, uključujući kardiovaskularne bolesti.Glavni cilj našeg istraživanja bio je ispitivanje mehanizama vazodilatatornog dejstva nikorandila, donora azot monoksida (NO), i natrijum-hidrogensulfida, donora vodonik-sulfida (H2S), na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka.Neiskorišćeni segmenti unutrašnje torakalne arterije i vene safene uzimani su od pacijenata tokom bajpas operacija. Ispitivanje je rađeno u in vitro uslovima u sistemu za izolovane organe. Koncentracijski-zavisne krive relaksacije konstruisane su na prekontrahovanim preparatima sa i bez endotela u prisustvu/odsustvu blokatora K+ kanala i/ili inhibitora signalnog puta cikličnog gvanozin-monofosfata (cGMP).Naši rezultati su pokazali da nikorandil i natrijum-hidrogensulfid prouzrokuju koncentracijski-zavisnu relaksaciju izolovane humane vene safene i unutrašnje torakalne arterije prekontrahovane fenilefrinom. Nikorandil izaziva endotel-nezavisnu, a natrijum-hidrogensulfid endotel-zavisnu relaksaciju oba krvna suda. Signalni put cGMP-a ima značajnu ulogu u vazorelaksantnom efektu nikorandila. Takođe, mehanizam dejstva natrijum-hidrogensulfida uključuje pojačanje NO/cGMP signalnog puta na oba krvna suda. Kalijumovi kanali doprinose relaksantnom dejstvu oba ispitivana agensa, s tim da postoje razlike u tipovima K+ kanala i njihovom relativnom značaju.S obzirom da se spazam vene safene i unutrašnje torakalne arterije i dalje javlja u kliničkim uslovima, a njegova prevencija i reverzija još uvek predstavljaju izazov, rezultati naše studije mogu ukazati na nove tarapijske ciljeve u lečenju spazma bajpas graftova i potencijalno dati farmakološku osnovu za razvoj novih vazodilatatornih lekova., Gasotransmitters exert part of their impact on the organism via regulation of ion channels, especially potassium (K+) channels. Altered structure/function of ion channels, as well disorders of the metabolism and/or levels of the gasotransmitters are associated with several pathophysiological conditions, including cardiovascular diseases.The principal aim of our study was to investigate the mechanisms of vasodilator action of nicorandil, a nitric oxide (NO) donor, and of sodium hydrosulfide, a hydrogen sulfide (H2S) donor, on the isolated human internal thoracic artery and saphenous vein.Discarded segments of the internal thoracic artery and saphenous vein were collected from patients undergoing coronary artery bypass grafting. The investigation was performed in vitro in an isolated organs system. Concentration-response curves were constructed on pre-contracted preparations with and without endothelium in the presence/absence of K+ channel blockers and/or cyclic guanosine monophosphate (cGMP) pathway inhibitors.Our results showed that nicorandil and sodium hydrosulfide cause a concentration-dependent relaxation of the isolated human saphenous vein and internal thoracic artery pre-contracted by phenylephrine. Nicorandil exerts endothelium-independent and sodium hydrosulfide endothelium-dependent relaxation of both blood vessels. cGMP signalling pathway plays a significant role in the vasorelaxant effect of nicorandil. Also, sodium hydrosulfide mechanism of action involves enhancement of the NO/cGMP signalling pathway in both vessels. Potassium channels contribute to the relaxant effect of both investigated agents, although differences exist in K+ channel subtypes and their relative importance.Since the spasm of saphenous vein and internal thoracic artery still occurs in clinical settings, and its prevention and reversion is still challenging, the results of our study may indicate new targets in the treatment of bypass grafts spasm, and potentially provide a pharmacological basis for the development of new vasodilator drugs.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Vazodilatatorno delovanje donora azot monoksida i vodonik-sulfida na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka: uloga kalijumovih kanala",
url = "https://hdl.handle.net/21.15107/rcub_nardus_17654"
}

Marinko, M.. (2020). Vazodilatatorno delovanje donora azot monoksida i vodonik-sulfida na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka: uloga kalijumovih kanala. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_17654

Marinko M. Vazodilatatorno delovanje donora azot monoksida i vodonik-sulfida na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka: uloga kalijumovih kanala. in Универзитет у Београду. 2020;.
https://hdl.handle.net/21.15107/rcub_nardus_17654 .

Marinko, Marija, "Vazodilatatorno delovanje donora azot monoksida i vodonik-sulfida na izolovanoj unutrašnjoj torakalnoj arteriji i veni safeni čoveka: uloga kalijumovih kanala" in Универзитет у Београду (2020),
https://hdl.handle.net/21.15107/rcub_nardus_17654 .

TY  - JOUR
AU  - Janković, Goran
AU  - Marinko, Marija
AU  - Milojević, Predrag
AU  - Stojanović, Ivan
AU  - Nenezić, Dragoslav
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
AU  - Novaković, Aleksandra
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3515
AB  - Cardioprotective abilities of procyanidins, might, at least in part, attribute to their vasodilator properties. The present study was undertaken to assess the vasorelaxant effect of procyanidin B2 on isolated human saphenous vein (HSV) and its underlying mechanisms. Procyanidin B2 relaxed phenylephrine-induced contraction of HSV rings in concentration-dependent manner. The relaxation was dependent on the presence of endothelium and was strongly affected by l-NAME, hydroxocobalamin or ODQ, the inhibitors of NO/cGMP pathway. Indomethacin significantly affected only the relaxation produced by the highest concentrations of procyanidin B2. Apamin and TRAM-34 combination, in the presence of l-NAME and indomethacin, did not additionally decreased procyanidin B2-induced relaxation. In the presence of K+ channel blockers, relaxation induced by procyanidin B2 was partially attenuated by 4-aminopyridine, significantly inhibited by glibenclamide and almost abolished by iberiotoxin. Procyanidin B2 also relaxed the contractions induced by phenylephrine or caffeine in Ca2+-free solution. Finally, nifedipine slightly, while thapsigargin strongly antagonized HSV relaxation. Our results indicate that procyanidin B2 induces endothelium-dependent relaxation of HSV, which results primarily from stimulation of NO production, as well K+ channels opening, especially BKCa, and partially KATP and KV. Regulation of the intracellular Ca2+ release and inhibition of Ca2+ influx probably contr
PB  - Elsevier B.V.
T2  - Journal of Pharmacological Sciences
T1  - Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft
VL  - 142
IS  - 3
SP  - 101
EP  - 108
DO  - 10.1016/j.jphs.2019.11.006
ER  - 

@article{
author = "Janković, Goran and Marinko, Marija and Milojević, Predrag and Stojanović, Ivan and Nenezić, Dragoslav and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei and Novaković, Aleksandra",
year = "2019",
abstract = "Cardioprotective abilities of procyanidins, might, at least in part, attribute to their vasodilator properties. The present study was undertaken to assess the vasorelaxant effect of procyanidin B2 on isolated human saphenous vein (HSV) and its underlying mechanisms. Procyanidin B2 relaxed phenylephrine-induced contraction of HSV rings in concentration-dependent manner. The relaxation was dependent on the presence of endothelium and was strongly affected by l-NAME, hydroxocobalamin or ODQ, the inhibitors of NO/cGMP pathway. Indomethacin significantly affected only the relaxation produced by the highest concentrations of procyanidin B2. Apamin and TRAM-34 combination, in the presence of l-NAME and indomethacin, did not additionally decreased procyanidin B2-induced relaxation. In the presence of K+ channel blockers, relaxation induced by procyanidin B2 was partially attenuated by 4-aminopyridine, significantly inhibited by glibenclamide and almost abolished by iberiotoxin. Procyanidin B2 also relaxed the contractions induced by phenylephrine or caffeine in Ca2+-free solution. Finally, nifedipine slightly, while thapsigargin strongly antagonized HSV relaxation. Our results indicate that procyanidin B2 induces endothelium-dependent relaxation of HSV, which results primarily from stimulation of NO production, as well K+ channels opening, especially BKCa, and partially KATP and KV. Regulation of the intracellular Ca2+ release and inhibition of Ca2+ influx probably contr",
publisher = "Elsevier B.V.",
journal = "Journal of Pharmacological Sciences",
title = "Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft",
volume = "142",
number = "3",
pages = "101-108",
doi = "10.1016/j.jphs.2019.11.006"
}

Janković, G., Marinko, M., Milojević, P., Stojanović, I., Nenezić, D., Kanjuh, V., Yang, Q., He, G.,& Novaković, A.. (2019). Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft. in Journal of Pharmacological Sciences
Elsevier B.V.., 142(3), 101-108.
https://doi.org/10.1016/j.jphs.2019.11.006

Janković G, Marinko M, Milojević P, Stojanović I, Nenezić D, Kanjuh V, Yang Q, He G, Novaković A. Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft. in Journal of Pharmacological Sciences. 2019;142(3):101-108.
doi:10.1016/j.jphs.2019.11.006 .

Janković, Goran, Marinko, Marija, Milojević, Predrag, Stojanović, Ivan, Nenezić, Dragoslav, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, Novaković, Aleksandra, "Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft" in Journal of Pharmacological Sciences, 142, no. 3 (2019):101-108,
https://doi.org/10.1016/j.jphs.2019.11.006 . .

TY  - JOUR
AU  - Marinko, Marija
AU  - Janković, Goran
AU  - Nenezić, Dragoslav
AU  - Milojević, Predrag
AU  - Stojanović, Ivan
AU  - Kanjuh, Vladimir
AU  - Novaković, Aleksandra
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3191
AB  - In this study, we aimed to investigate relaxant effect of flavanol (-)-epicatechin on the isolated human saphenous vein (HSV), as a part of its cardioprotective action, and to define the mechanisms underlying this vasorelaxation. (-)-Epicatechin induced a concentration-dependent relaxation of HSV pre-contracted by phenylephrine. Among K+ channel blockers, 4-aminopyridine, margatoxin, and iberiotoxin significantly inhibited relaxation of HSV, while glibenclamide considerably reduced effects of the high concentrations of (-)-epicatechin. Additionally, (-)-epicatechin relaxed contraction induced by 80 mM K+, whereas in the presence of nifedipine produced partial relaxation of HSV rings pre-contracted by phenylephrine. In Ca2+-free solution, (-)-epicatechin relaxed contraction induced by phenylephrine, but had no effect on contraction induced by caffeine. A sarcoplasmic reticulum Ca2+-ATPase inhibitor, thapsigargin, significantly reduced relaxation of HSV produced by (-)-epicatechin. These results demonstrate that (-)-epicatechin produces endothelium-independent relaxation of isolated HSV rings. Vasorelaxation to (-)-epicatechin probably involves activation of 4-aminopyridine- and margatoxin-sensitive K-V channels, BKCa channels, and at least partly, K-ATP channels. In addition, not only the inhibition of extracellular Ca2+ influx, but regulation of the intracellular Ca2+ release, via inositol-trisphosphate receptors and reuptake into sarcoplasmic reticulum, via stimulation of Ca2+-ATPase, as well, most likely participate in (-)-epicatechin-induced relaxation of HSV.
PB  - Wiley, Hoboken
T2  - Phytotherapy Research
T1  - (-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels
VL  - 32
IS  - 2
SP  - 267
EP  - 275
DO  - 10.1002/ptr.5969
ER  - 

@article{
author = "Marinko, Marija and Janković, Goran and Nenezić, Dragoslav and Milojević, Predrag and Stojanović, Ivan and Kanjuh, Vladimir and Novaković, Aleksandra",
year = "2018",
abstract = "In this study, we aimed to investigate relaxant effect of flavanol (-)-epicatechin on the isolated human saphenous vein (HSV), as a part of its cardioprotective action, and to define the mechanisms underlying this vasorelaxation. (-)-Epicatechin induced a concentration-dependent relaxation of HSV pre-contracted by phenylephrine. Among K+ channel blockers, 4-aminopyridine, margatoxin, and iberiotoxin significantly inhibited relaxation of HSV, while glibenclamide considerably reduced effects of the high concentrations of (-)-epicatechin. Additionally, (-)-epicatechin relaxed contraction induced by 80 mM K+, whereas in the presence of nifedipine produced partial relaxation of HSV rings pre-contracted by phenylephrine. In Ca2+-free solution, (-)-epicatechin relaxed contraction induced by phenylephrine, but had no effect on contraction induced by caffeine. A sarcoplasmic reticulum Ca2+-ATPase inhibitor, thapsigargin, significantly reduced relaxation of HSV produced by (-)-epicatechin. These results demonstrate that (-)-epicatechin produces endothelium-independent relaxation of isolated HSV rings. Vasorelaxation to (-)-epicatechin probably involves activation of 4-aminopyridine- and margatoxin-sensitive K-V channels, BKCa channels, and at least partly, K-ATP channels. In addition, not only the inhibition of extracellular Ca2+ influx, but regulation of the intracellular Ca2+ release, via inositol-trisphosphate receptors and reuptake into sarcoplasmic reticulum, via stimulation of Ca2+-ATPase, as well, most likely participate in (-)-epicatechin-induced relaxation of HSV.",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "(-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels",
volume = "32",
number = "2",
pages = "267-275",
doi = "10.1002/ptr.5969"
}

Marinko, M., Janković, G., Nenezić, D., Milojević, P., Stojanović, I., Kanjuh, V.,& Novaković, A.. (2018). (-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels. in Phytotherapy Research
Wiley, Hoboken., 32(2), 267-275.
https://doi.org/10.1002/ptr.5969

Marinko M, Janković G, Nenezić D, Milojević P, Stojanović I, Kanjuh V, Novaković A. (-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels. in Phytotherapy Research. 2018;32(2):267-275.
doi:10.1002/ptr.5969 .

Marinko, Marija, Janković, Goran, Nenezić, Dragoslav, Milojević, Predrag, Stojanović, Ivan, Kanjuh, Vladimir, Novaković, Aleksandra, "(-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels" in Phytotherapy Research, 32, no. 2 (2018):267-275,
https://doi.org/10.1002/ptr.5969 . .

TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Marinko, Marija
AU  - Janković, Goran
AU  - Stojanović, Ivan
AU  - Milojević, Predrag
AU  - Nenezić, Dragoslav
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2972
AB  - The aim of the present study was to investigate and characterize vasorelaxant effect of procyanidin B2 on human internal mammary artery (HIMA) as one of the mechanisms of its protective effect against vascular risk. Procyanidin B2 induced strong concentration-dependent relaxation of HIMA rings pre-contracted by phenylephrine. Pretreatment with L-NAME, a NO synthase inhibitor, hydroxocobalamin, a NO scavenger, and ODQ, an inhibitor of soluble guanylate cyclase, significantly inhibited procyanidin B2-induced relaxation of HIMA, while indomethacin, a cyclooxygenase inhibitor, considerably reduced effects of low concentrations. Among K+ channel blockers, iberiotoxin, a selective blocker of large conductance Ca2+-activated K+ channels (BKCa), abolished procyanidin B2-induced relaxation, glibenclamide, a selective ATP-sensitive K+(K-ATP) channels blocker, induced partial inhibition, while 4-aminopyridine, a blocker of voltage-gated K+(K-V) channels, and TRAM-34, an inhibitor of intermediate-conductance Ca2+-activated K+(IKCa) channels, slightly reduced maximal relaxation of HIMA. Further, procyanidin B2 relaxed contraction induced by phenylephrine in Ca2+-free Krebs solution, but had no effect on contraction induced by caffeine. Finally, thapsigargin, a sarcoplasmic reticulum Ca2+-ATPase inhibitor, significantly reduced relaxation of HIMA produced by procyanidin B2. These results demonstrate that procyanidin B2 produces endothelium-dependent relaxation of HIMA pre-contracted by phenylephrine. This effect is primarily the result of an increased NO synthesis and secretion by endothelial cells and partially of prostacyclin, although it involves activation of BKCa and K-ATP, as well as K-V and IKCa channels in high concentrations of procyanidin B2.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmacology
T1  - Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery
VL  - 807
SP  - 75
EP  - 81
DO  - 10.1016/j.ejphar.2017.04.015
ER  - 

@article{
author = "Novaković, Aleksandra and Marinko, Marija and Janković, Goran and Stojanović, Ivan and Milojević, Predrag and Nenezić, Dragoslav and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei",
year = "2017",
abstract = "The aim of the present study was to investigate and characterize vasorelaxant effect of procyanidin B2 on human internal mammary artery (HIMA) as one of the mechanisms of its protective effect against vascular risk. Procyanidin B2 induced strong concentration-dependent relaxation of HIMA rings pre-contracted by phenylephrine. Pretreatment with L-NAME, a NO synthase inhibitor, hydroxocobalamin, a NO scavenger, and ODQ, an inhibitor of soluble guanylate cyclase, significantly inhibited procyanidin B2-induced relaxation of HIMA, while indomethacin, a cyclooxygenase inhibitor, considerably reduced effects of low concentrations. Among K+ channel blockers, iberiotoxin, a selective blocker of large conductance Ca2+-activated K+ channels (BKCa), abolished procyanidin B2-induced relaxation, glibenclamide, a selective ATP-sensitive K+(K-ATP) channels blocker, induced partial inhibition, while 4-aminopyridine, a blocker of voltage-gated K+(K-V) channels, and TRAM-34, an inhibitor of intermediate-conductance Ca2+-activated K+(IKCa) channels, slightly reduced maximal relaxation of HIMA. Further, procyanidin B2 relaxed contraction induced by phenylephrine in Ca2+-free Krebs solution, but had no effect on contraction induced by caffeine. Finally, thapsigargin, a sarcoplasmic reticulum Ca2+-ATPase inhibitor, significantly reduced relaxation of HIMA produced by procyanidin B2. These results demonstrate that procyanidin B2 produces endothelium-dependent relaxation of HIMA pre-contracted by phenylephrine. This effect is primarily the result of an increased NO synthesis and secretion by endothelial cells and partially of prostacyclin, although it involves activation of BKCa and K-ATP, as well as K-V and IKCa channels in high concentrations of procyanidin B2.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmacology",
title = "Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery",
volume = "807",
pages = "75-81",
doi = "10.1016/j.ejphar.2017.04.015"
}

Novaković, A., Marinko, M., Janković, G., Stojanović, I., Milojević, P., Nenezić, D., Kanjuh, V., Yang, Q.,& He, G.. (2017). Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. in European Journal of Pharmacology
Elsevier Science BV, Amsterdam., 807, 75-81.
https://doi.org/10.1016/j.ejphar.2017.04.015

Novaković A, Marinko M, Janković G, Stojanović I, Milojević P, Nenezić D, Kanjuh V, Yang Q, He G. Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. in European Journal of Pharmacology. 2017;807:75-81.
doi:10.1016/j.ejphar.2017.04.015 .

Novaković, Aleksandra, Marinko, Marija, Janković, Goran, Stojanović, Ivan, Milojević, Predrag, Nenezić, Dragoslav, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, "Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery" in European Journal of Pharmacology, 807 (2017):75-81,
https://doi.org/10.1016/j.ejphar.2017.04.015 . .

TY  - JOUR
AU  - Marinko, Marija
AU  - Novaković, Aleksandra
AU  - Nenezić, Dragoslav
AU  - Stojanović, Ivan
AU  - Milojević, Predrag
AU  - Jović, Miomir
AU  - Ugrešić, Nenad
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2461
AB  - As we previously demonstrated the role of different K+ channels in the action of nicorandil on human saphenous vein (HSV) and human internal mammary artery (HIMA), this study aimed to analyse the contribution of the cGMP pathway in nicorandil-induced vasorelaxation and to determine the involvement of cGMP in the K+ channel-activating effect of nicorandil. An inhibitor of soluble guanylate cyclase (GC), ODQ, significantly inhibited nicorandil-induced relaxation, while ODQ plus glibenclamide, a selective ATP-sensitive K+ (KATP) channel inhibitor, produced a further inhibition of both vessels. In HSV, ODQ in combination with 4-aminopyridine, a blocker of voltage-gated K+ (K-V) channels, did not modify the concentration-response to nicorandil compared with ODQ, whereas in HIMA, ODQ plus iberiotoxin, a selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, produced greater inhibition than ODQ alone. We showed that the cGMP pathway plays a significant role in the vasorelaxant effect of nicorandil on HSV and HIMA. It seems that nicorandil directly opens KATP channels in both vessels and BKCa channels in HIMA, although it is possible that stimulation of GC contributes to KATP channels activation in HIMA. Contrary, the activation of K-V channels in HSV is probably due to GC activation and increased levels of cGMP.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts
VL  - 128
IS  - 2
SP  - 59
EP  - 64
DO  - 10.1016/j.jphs.2015.03.003
ER  - 

@article{
author = "Marinko, Marija and Novaković, Aleksandra and Nenezić, Dragoslav and Stojanović, Ivan and Milojević, Predrag and Jović, Miomir and Ugrešić, Nenad and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei",
year = "2015",
abstract = "As we previously demonstrated the role of different K+ channels in the action of nicorandil on human saphenous vein (HSV) and human internal mammary artery (HIMA), this study aimed to analyse the contribution of the cGMP pathway in nicorandil-induced vasorelaxation and to determine the involvement of cGMP in the K+ channel-activating effect of nicorandil. An inhibitor of soluble guanylate cyclase (GC), ODQ, significantly inhibited nicorandil-induced relaxation, while ODQ plus glibenclamide, a selective ATP-sensitive K+ (KATP) channel inhibitor, produced a further inhibition of both vessels. In HSV, ODQ in combination with 4-aminopyridine, a blocker of voltage-gated K+ (K-V) channels, did not modify the concentration-response to nicorandil compared with ODQ, whereas in HIMA, ODQ plus iberiotoxin, a selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, produced greater inhibition than ODQ alone. We showed that the cGMP pathway plays a significant role in the vasorelaxant effect of nicorandil on HSV and HIMA. It seems that nicorandil directly opens KATP channels in both vessels and BKCa channels in HIMA, although it is possible that stimulation of GC contributes to KATP channels activation in HIMA. Contrary, the activation of K-V channels in HSV is probably due to GC activation and increased levels of cGMP.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts",
volume = "128",
number = "2",
pages = "59-64",
doi = "10.1016/j.jphs.2015.03.003"
}

Marinko, M., Novaković, A., Nenezić, D., Stojanović, I., Milojević, P., Jović, M., Ugrešić, N., Kanjuh, V., Yang, Q.,& He, G.. (2015). Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 128(2), 59-64.
https://doi.org/10.1016/j.jphs.2015.03.003

Marinko M, Novaković A, Nenezić D, Stojanović I, Milojević P, Jović M, Ugrešić N, Kanjuh V, Yang Q, He G. Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts. in Journal of Pharmacological Sciences. 2015;128(2):59-64.
doi:10.1016/j.jphs.2015.03.003 .

Marinko, Marija, Novaković, Aleksandra, Nenezić, Dragoslav, Stojanović, Ivan, Milojević, Predrag, Jović, Miomir, Ugrešić, Nenad, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, "Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts" in Journal of Pharmacological Sciences, 128, no. 2 (2015):59-64,
https://doi.org/10.1016/j.jphs.2015.03.003 . .

TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Marinko, Marija
AU  - Vranić, Aleksandra
AU  - Janković, Goran
AU  - Milojević, Predrag
AU  - Stojanović, Ivan
AU  - Nenezić, Dragoslav
AU  - Ugrešić, Nenad
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2439
AB  - Evidences have suggested that flavanol compound (-)-epicatechin is associated with reduced risk of cardiovascular diseases. One of the mechanisms of its cardioprotective effect is vasodilation. However, the exact mechanisms by which (-)-epicatechin causes vasodilation are not yet clearly defined. The aims of the present study were to investigate relaxant effect of flavanol (-)-epicatechin on the isolated human internal mammary artery (HIMA) and to determine the mechanisms underlying its vasorelaxation. Our results showed that (-)-epicatechin induced a concentration-dependent relaxation of RNA rings pre-contracted by phenylephrine. Among the K+ channel blockers, 4-aminopyricline (4-AP) and margatoxin, blockers of voltage gated K+ (K-V) channels, and glibenclamide, a selective ATP sensitive K+ (K-ATP,) channels blocker, partly inhibited the (-)-epicatechin-induced relaxation of HIMA, while iberiotoxin, a most selective blocker of large conductance Ca2+-activated K+ channels (BKCa), almost completely inhibited the relaxation. In rings pre-contracted by 80 mM K+, (-)-epicatechin induced partial relaxation of HIMA, whereas in Ca2+-free medium, (-)-epicatechin completely relaxed HIMA rings pre-contracted by phenylephrine and caffeine. Finally, thapsigargin, a sarcoplasmic reticulum Ca2+-ATPase inhibitor, slightly antagonized (-)-epicatechin-induced relaxation of HIMA pre-contracted by phenylephrine. These results suggest that (-)-epicatechin induces strong endothelium independent relaxation of HIMA pre-contracted by phenylephrine whilst 4-AP- and rnargatoxin-sensitive K-V channels, as well as BKCa and K-ATP channels, located in vascular smooth muscle, mediate this relaxation. In addition, it seems that (-)-epicatechin could inhibit influx of extracellular Ca2+, interfere with intracellular Ca2+ release and re uptake by the sarcoplasmic reticulum.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmacology
T1  - Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin
VL  - 762
SP  - 306
EP  - 312
DO  - 10.1016/j.ejphar.2015.05.066
ER  - 

@article{
author = "Novaković, Aleksandra and Marinko, Marija and Vranić, Aleksandra and Janković, Goran and Milojević, Predrag and Stojanović, Ivan and Nenezić, Dragoslav and Ugrešić, Nenad and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei",
year = "2015",
abstract = "Evidences have suggested that flavanol compound (-)-epicatechin is associated with reduced risk of cardiovascular diseases. One of the mechanisms of its cardioprotective effect is vasodilation. However, the exact mechanisms by which (-)-epicatechin causes vasodilation are not yet clearly defined. The aims of the present study were to investigate relaxant effect of flavanol (-)-epicatechin on the isolated human internal mammary artery (HIMA) and to determine the mechanisms underlying its vasorelaxation. Our results showed that (-)-epicatechin induced a concentration-dependent relaxation of RNA rings pre-contracted by phenylephrine. Among the K+ channel blockers, 4-aminopyricline (4-AP) and margatoxin, blockers of voltage gated K+ (K-V) channels, and glibenclamide, a selective ATP sensitive K+ (K-ATP,) channels blocker, partly inhibited the (-)-epicatechin-induced relaxation of HIMA, while iberiotoxin, a most selective blocker of large conductance Ca2+-activated K+ channels (BKCa), almost completely inhibited the relaxation. In rings pre-contracted by 80 mM K+, (-)-epicatechin induced partial relaxation of HIMA, whereas in Ca2+-free medium, (-)-epicatechin completely relaxed HIMA rings pre-contracted by phenylephrine and caffeine. Finally, thapsigargin, a sarcoplasmic reticulum Ca2+-ATPase inhibitor, slightly antagonized (-)-epicatechin-induced relaxation of HIMA pre-contracted by phenylephrine. These results suggest that (-)-epicatechin induces strong endothelium independent relaxation of HIMA pre-contracted by phenylephrine whilst 4-AP- and rnargatoxin-sensitive K-V channels, as well as BKCa and K-ATP channels, located in vascular smooth muscle, mediate this relaxation. In addition, it seems that (-)-epicatechin could inhibit influx of extracellular Ca2+, interfere with intracellular Ca2+ release and re uptake by the sarcoplasmic reticulum.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmacology",
title = "Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin",
volume = "762",
pages = "306-312",
doi = "10.1016/j.ejphar.2015.05.066"
}

Novaković, A., Marinko, M., Vranić, A., Janković, G., Milojević, P., Stojanović, I., Nenezić, D., Ugrešić, N., Kanjuh, V., Yang, Q.,& He, G.. (2015). Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin. in European Journal of Pharmacology
Elsevier Science BV, Amsterdam., 762, 306-312.
https://doi.org/10.1016/j.ejphar.2015.05.066

Novaković A, Marinko M, Vranić A, Janković G, Milojević P, Stojanović I, Nenezić D, Ugrešić N, Kanjuh V, Yang Q, He G. Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin. in European Journal of Pharmacology. 2015;762:306-312.
doi:10.1016/j.ejphar.2015.05.066 .

Novaković, Aleksandra, Marinko, Marija, Vranić, Aleksandra, Janković, Goran, Milojević, Predrag, Stojanović, Ivan, Nenezić, Dragoslav, Ugrešić, Nenad, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, "Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin" in European Journal of Pharmacology, 762 (2015):306-312,
https://doi.org/10.1016/j.ejphar.2015.05.066 . .

TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Pavlović, Marija
AU  - Milojević, Predrag
AU  - Stojanović, Ivan
AU  - Nenezić, Dragoslav
AU  - Jović, Miomir
AU  - Ugrešić, Nenad
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1731
AB  - The ATP-sensitive K+ channels opener (KATPCO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N?-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K+ (KATP) channels. In addition to the well-known effect on the opening of KATP channels, it has been reported that vasorelaxation induced by some of the KATPCOs includes some other K+ channel subtypes. Given that there is still no information on other types of K+ channels possibly involved in the mechanism of relaxation induced by P1075, this study was designed to examine the effects of P1075 on the rat renal artery with endothelium and with denuded endothelium and to define the contribution of different K+ channel subtypes in the P1075 action on this blood vessel. Our results show that P1075 induced a concentration-dependent relaxation of rat renal artery rings pre-contracted by phenylephrine. Glibenclamide, a selective KATP channels inhibitor, partly antagonized the relaxation of rat renal artery induced by P1075. Tetraethylammonium (TEA), a non-selective inhibitor of Ca2+-activated K+ channels, as well as iberiotoxin, a most selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, did not abolish the effect of P1075 on rat renal artery. In contrast, a non-selective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP), as well as margatoxin, a potent inhibitor of KV1.3 channels, caused partial inhibition of the P1075-induced relaxation of rat renal artery. In addition, in this study, P1075 relaxed contractions induced by 20 similar to mM K+, but had no effect on contractions induced by 80 similar to mM K+. Our results showed that P1075 induced strong endothelium-independent relaxation of rat renal artery. It seems that KATP, 4-AP- and margatoxin-sensitive K+ channels located in vascular smooth muscle mediated the relaxation of rat renal artery induced by P1075.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075
VL  - 111
IS  - 1
SP  - 24
EP  - 30
DO  - 10.1111/j.1742-7843.2011.00855.x
ER  - 

@article{
author = "Novaković, Aleksandra and Pavlović, Marija and Milojević, Predrag and Stojanović, Ivan and Nenezić, Dragoslav and Jović, Miomir and Ugrešić, Nenad and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei",
year = "2012",
abstract = "The ATP-sensitive K+ channels opener (KATPCO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N?-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K+ (KATP) channels. In addition to the well-known effect on the opening of KATP channels, it has been reported that vasorelaxation induced by some of the KATPCOs includes some other K+ channel subtypes. Given that there is still no information on other types of K+ channels possibly involved in the mechanism of relaxation induced by P1075, this study was designed to examine the effects of P1075 on the rat renal artery with endothelium and with denuded endothelium and to define the contribution of different K+ channel subtypes in the P1075 action on this blood vessel. Our results show that P1075 induced a concentration-dependent relaxation of rat renal artery rings pre-contracted by phenylephrine. Glibenclamide, a selective KATP channels inhibitor, partly antagonized the relaxation of rat renal artery induced by P1075. Tetraethylammonium (TEA), a non-selective inhibitor of Ca2+-activated K+ channels, as well as iberiotoxin, a most selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, did not abolish the effect of P1075 on rat renal artery. In contrast, a non-selective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP), as well as margatoxin, a potent inhibitor of KV1.3 channels, caused partial inhibition of the P1075-induced relaxation of rat renal artery. In addition, in this study, P1075 relaxed contractions induced by 20 similar to mM K+, but had no effect on contractions induced by 80 similar to mM K+. Our results showed that P1075 induced strong endothelium-independent relaxation of rat renal artery. It seems that KATP, 4-AP- and margatoxin-sensitive K+ channels located in vascular smooth muscle mediated the relaxation of rat renal artery induced by P1075.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075",
volume = "111",
number = "1",
pages = "24-30",
doi = "10.1111/j.1742-7843.2011.00855.x"
}

Novaković, A., Pavlović, M., Milojević, P., Stojanović, I., Nenezić, D., Jović, M., Ugrešić, N., Kanjuh, V., Yang, Q.,& He, G.. (2012). Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 111(1), 24-30.
https://doi.org/10.1111/j.1742-7843.2011.00855.x

Novaković A, Pavlović M, Milojević P, Stojanović I, Nenezić D, Jović M, Ugrešić N, Kanjuh V, Yang Q, He G. Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075. in Basic & Clinical Pharmacology & Toxicology. 2012;111(1):24-30.
doi:10.1111/j.1742-7843.2011.00855.x .

Novaković, Aleksandra, Pavlović, Marija, Milojević, Predrag, Stojanović, Ivan, Nenezić, Dragoslav, Jović, Miomir, Ugrešić, Nenad, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, "Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075" in Basic & Clinical Pharmacology & Toxicology, 111, no. 1 (2012):24-30,
https://doi.org/10.1111/j.1742-7843.2011.00855.x . .