TY  - JOUR
AU  - Bonda, David J.
AU  - Bajić, Vladan
AU  - Potparević, Biljana
AU  - Casadesus, G.
AU  - Zhu, Xiongwei
AU  - Smith, Mark A.
AU  - Lee, Hyoung-Gon
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1378
AB  - The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment.
PB  - Wiley, Hoboken
T2  - Neuropathology and Applied Neurobiology
T1  - Review: Cell cycle aberrations and neurodegeneration
VL  - 36
IS  - 2
SP  - 157
EP  - 163
DO  - 10.1111/j.1365-2990.2010.01064.x
ER  - 

@article{
author = "Bonda, David J. and Bajić, Vladan and Potparević, Biljana and Casadesus, G. and Zhu, Xiongwei and Smith, Mark A. and Lee, Hyoung-Gon",
year = "2010",
abstract = "The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment.",
publisher = "Wiley, Hoboken",
journal = "Neuropathology and Applied Neurobiology",
title = "Review: Cell cycle aberrations and neurodegeneration",
volume = "36",
number = "2",
pages = "157-163",
doi = "10.1111/j.1365-2990.2010.01064.x"
}

Bonda, D. J., Bajić, V., Potparević, B., Casadesus, G., Zhu, X., Smith, M. A.,& Lee, H.. (2010). Review: Cell cycle aberrations and neurodegeneration. in Neuropathology and Applied Neurobiology
Wiley, Hoboken., 36(2), 157-163.
https://doi.org/10.1111/j.1365-2990.2010.01064.x

Bonda DJ, Bajić V, Potparević B, Casadesus G, Zhu X, Smith MA, Lee H. Review: Cell cycle aberrations and neurodegeneration. in Neuropathology and Applied Neurobiology. 2010;36(2):157-163.
doi:10.1111/j.1365-2990.2010.01064.x .

Bonda, David J., Bajić, Vladan, Potparević, Biljana, Casadesus, G., Zhu, Xiongwei, Smith, Mark A., Lee, Hyoung-Gon, "Review: Cell cycle aberrations and neurodegeneration" in Neuropathology and Applied Neurobiology, 36, no. 2 (2010):157-163,
https://doi.org/10.1111/j.1365-2990.2010.01064.x . .