TY  - JOUR
AU  - Cvijić, Sandra
AU  - Langguth, Peter
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2108
AB  - The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Biopharmaceutics & Drug Disposition
T1  - Improvement of trospium-specific absorption models for fasted and fed states in humans
VL  - 35
IS  - 9
SP  - 553
EP  - 558
DO  - 10.1002/bdd.1911
ER  - 

@article{
author = "Cvijić, Sandra and Langguth, Peter",
year = "2014",
abstract = "The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Biopharmaceutics & Drug Disposition",
title = "Improvement of trospium-specific absorption models for fasted and fed states in humans",
volume = "35",
number = "9",
pages = "553-558",
doi = "10.1002/bdd.1911"
}

Cvijić, S.,& Langguth, P.. (2014). Improvement of trospium-specific absorption models for fasted and fed states in humans. in Biopharmaceutics & Drug Disposition
Wiley-Blackwell, Hoboken., 35(9), 553-558.
https://doi.org/10.1002/bdd.1911

Cvijić S, Langguth P. Improvement of trospium-specific absorption models for fasted and fed states in humans. in Biopharmaceutics & Drug Disposition. 2014;35(9):553-558.
doi:10.1002/bdd.1911 .

Cvijić, Sandra, Langguth, Peter, "Improvement of trospium-specific absorption models for fasted and fed states in humans" in Biopharmaceutics & Drug Disposition, 35, no. 9 (2014):553-558,
https://doi.org/10.1002/bdd.1911 . .