TY  - JOUR
AU  - Dragičević-Curić, Nina
AU  - Winter, Sven
AU  - Krajišnik, Danina
AU  - Stupar, Mirjana
AU  - Milić, Jela
AU  - Graefe, Susanna
AU  - Fahr, Alfred
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1386
AB  - Temoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Liposome Research
T1  - Stability evaluation of temoporfin-loaded liposomal gels for topical application
VL  - 20
IS  - 1
SP  - 38
EP  - 48
DO  - 10.3109/08982100903030263
ER  - 

@article{
author = "Dragičević-Curić, Nina and Winter, Sven and Krajišnik, Danina and Stupar, Mirjana and Milić, Jela and Graefe, Susanna and Fahr, Alfred",
year = "2010",
abstract = "Temoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Liposome Research",
title = "Stability evaluation of temoporfin-loaded liposomal gels for topical application",
volume = "20",
number = "1",
pages = "38-48",
doi = "10.3109/08982100903030263"
}

Dragičević-Curić, N., Winter, S., Krajišnik, D., Stupar, M., Milić, J., Graefe, S.,& Fahr, A.. (2010). Stability evaluation of temoporfin-loaded liposomal gels for topical application. in Journal of Liposome Research
Taylor & Francis Ltd, Abingdon., 20(1), 38-48.
https://doi.org/10.3109/08982100903030263

Dragičević-Curić N, Winter S, Krajišnik D, Stupar M, Milić J, Graefe S, Fahr A. Stability evaluation of temoporfin-loaded liposomal gels for topical application. in Journal of Liposome Research. 2010;20(1):38-48.
doi:10.3109/08982100903030263 .

Dragičević-Curić, Nina, Winter, Sven, Krajišnik, Danina, Stupar, Mirjana, Milić, Jela, Graefe, Susanna, Fahr, Alfred, "Stability evaluation of temoporfin-loaded liposomal gels for topical application" in Journal of Liposome Research, 20, no. 1 (2010):38-48,
https://doi.org/10.3109/08982100903030263 . .