TY  - JOUR
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Milašinović, Nikola
AU  - Daković, Aleksandra
AU  - Trifković, Kata
AU  - Stojanović, Jovica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3478
AB  - This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics
PB  - Wiley Periodicals, Inc.
T2  - Journal of Applied Polymer Science
T1  - Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
VL  - 137
IS  - 8
DO  - 10.1002/app.48406
ER  - 

@article{
author = "Čalija, Bojan and Milić, Jela and Milašinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica",
year = "2020",
abstract = "This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics",
publisher = "Wiley Periodicals, Inc.",
journal = "Journal of Applied Polymer Science",
title = "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass",
volume = "137",
number = "8",
doi = "10.1002/app.48406"
}

Čalija, B., Milić, J., Milašinović, N., Daković, A., Trifković, K.,& Stojanović, J.. (2020). Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science
Wiley Periodicals, Inc.., 137(8).
https://doi.org/10.1002/app.48406

Čalija B, Milić J, Milašinović N, Daković A, Trifković K, Stojanović J. Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8).
doi:10.1002/app.48406 .

Čalija, Bojan, Milić, Jela, Milašinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020),
https://doi.org/10.1002/app.48406 . .

TY  - JOUR
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Milašinović, Nikola
AU  - Daković, Aleksandra
AU  - Trifković, Kata
AU  - Stojanović, Jovica
AU  - Krajišnik, Danina
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3476
AB  - This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics.
PB  - Wiley Periodicals, Inc.
T2  - Journal of Applied Polymer Science
T1  - Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
VL  - 137
IS  - 8
DO  - 10.1002/app.48406
ER  - 

@article{
author = "Čalija, Bojan and Milić, Jela and Milašinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica and Krajišnik, Danina",
year = "2020",
abstract = "This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics.",
publisher = "Wiley Periodicals, Inc.",
journal = "Journal of Applied Polymer Science",
title = "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass",
volume = "137",
number = "8",
doi = "10.1002/app.48406"
}

Čalija, B., Milić, J., Milašinović, N., Daković, A., Trifković, K., Stojanović, J.,& Krajišnik, D.. (2020). Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science
Wiley Periodicals, Inc.., 137(8).
https://doi.org/10.1002/app.48406

Čalija B, Milić J, Milašinović N, Daković A, Trifković K, Stojanović J, Krajišnik D. Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8).
doi:10.1002/app.48406 .

Čalija, Bojan, Milić, Jela, Milašinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, Krajišnik, Danina, "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020),
https://doi.org/10.1002/app.48406 . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3490
AB  - Parenteralnim  putem  se  primenjuju  različiti  tipovi  farmaceutskih  preparata  čiji  sastav može  biti  jednostavan  (vodeni  rastvori)  i  manje  ili  više  kompleksan  (emulzije,  suspenzije, liposomi kao nosači lekovitih supstanci, čestični sistemi, čvrsti implanti/implantati). Napredak u bio-  i  nanotehnologiji  omogućio  je  razvoj  nove  klase  kompleksnih  lekova,  bioloških  i  tzv. nebioloških  kompleksnih  lekova  (i  njihovih  „similara”-  sličnih lekova),  čiji  dalji  razvoj  se očekuje u bliskoj budućnosti, a  koji se, u velikom broju slučajeva, primenjuju parenteralnim putem.  Parenteralni preparati koji u svom sastavu sadrže lekovite supstance koje su inkapsulirane u nosače tipa liposoma predstavljaju nebiološke kompleksne lekove koji su do sada najduže u upotrebi i čije su osobine i definisana svojstva kvaliteta najviše ispitivana. U radu je dat pregled obaveznih  i  dodatnih  (specifičnih) in  vitro  ispitivanja  liposomskih  nosača  lekovitih supstanci za primenu parenteralnim putem. Činjenica da postupci izvođenja ovih ispitivanja u  osnovi  nisu  propisani  u  relevantnim  farmakopejama  (Ph.  Eur., USP  i  JP)  i  da  se  mogu značajno razlikovati između laboratorija, doprinosi velikoj varijabilnosti dobijenih rezultata i ograničenjima u njihovom međusobnom poređenju. Regulatorna tela EMA i FDA učestvovala su u pripremi određenih dokumenata i razvoju odgovarajućih standarda i smernica u pogledu ispitivanja  kvaliteta  farmaceutskih  oblika  sa  liposomskim  nosačima  lekovitih  supstanci  za parenteralnu primenu.
AB  - A greater variety of pharmaceutical preparations can be administered by the parenteral route, the composition of which can be simple (aqueous solutions) and more or less complex (emulsions,  suspensions,  liposomes  as  carriers  of  active  pharmaceutical  ingredients,  particle systems,  solid  implants/implants).  In  addition,  advances  in  bio-  and  nano-  technology  have enabled the development of new classes of complex drugs, so-called non-biological complex drugs (and their similars) whose further development is expected in the near future, and which are in many cases applied by parenteral route.  Parenteral preparations containing active substances encapsulated in the liposome-type carriers represent a class of non-biological complex drugs which have the longest use so far and whose properties and defined quality characteristics are being most examined. In this paper, an overview  of  mandatory  and  additional  (specific) in  vitro  tests  for  parenteral  liposomal  drug carriers is presented. The fact that standard testing procedures are often not available in relevant pharmacopoeias  (Ph.  Eur.,  USP  and  JP),  so  that  they  can  vary  significantly  between laboratories, contributes to the great variability of the results obtained and constraints in their mutual  comparison.  EMA  and  FDA,  as  regulatory  agencies,  have  also  participated  in  the preparation of certain documents and development of appropriate standards and guidelines for quality control of liposomal drug carriers for parenteral application.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci
T1  - Challenges of in vitro characterization of non-biological complex drugs - example of parenteral preparations with liposomal drug carriers
VL  - 69
IS  - 3
SP  - 176
EP  - 198
DO  - 10.5937/arhfarm1903176K
ER  - 

@article{
author = "Krajišnik, Danina and Milić, Jela and Savić, Snežana",
year = "2019",
abstract = "Parenteralnim  putem  se  primenjuju  različiti  tipovi  farmaceutskih  preparata  čiji  sastav može  biti  jednostavan  (vodeni  rastvori)  i  manje  ili  više  kompleksan  (emulzije,  suspenzije, liposomi kao nosači lekovitih supstanci, čestični sistemi, čvrsti implanti/implantati). Napredak u bio-  i  nanotehnologiji  omogućio  je  razvoj  nove  klase  kompleksnih  lekova,  bioloških  i  tzv. nebioloških  kompleksnih  lekova  (i  njihovih  „similara”-  sličnih lekova),  čiji  dalji  razvoj  se očekuje u bliskoj budućnosti, a  koji se, u velikom broju slučajeva, primenjuju parenteralnim putem.  Parenteralni preparati koji u svom sastavu sadrže lekovite supstance koje su inkapsulirane u nosače tipa liposoma predstavljaju nebiološke kompleksne lekove koji su do sada najduže u upotrebi i čije su osobine i definisana svojstva kvaliteta najviše ispitivana. U radu je dat pregled obaveznih  i  dodatnih  (specifičnih) in  vitro  ispitivanja  liposomskih  nosača  lekovitih supstanci za primenu parenteralnim putem. Činjenica da postupci izvođenja ovih ispitivanja u  osnovi  nisu  propisani  u  relevantnim  farmakopejama  (Ph.  Eur., USP  i  JP)  i  da  se  mogu značajno razlikovati između laboratorija, doprinosi velikoj varijabilnosti dobijenih rezultata i ograničenjima u njihovom međusobnom poređenju. Regulatorna tela EMA i FDA učestvovala su u pripremi određenih dokumenata i razvoju odgovarajućih standarda i smernica u pogledu ispitivanja  kvaliteta  farmaceutskih  oblika  sa  liposomskim  nosačima  lekovitih  supstanci  za parenteralnu primenu., A greater variety of pharmaceutical preparations can be administered by the parenteral route, the composition of which can be simple (aqueous solutions) and more or less complex (emulsions,  suspensions,  liposomes  as  carriers  of  active  pharmaceutical  ingredients,  particle systems,  solid  implants/implants).  In  addition,  advances  in  bio-  and  nano-  technology  have enabled the development of new classes of complex drugs, so-called non-biological complex drugs (and their similars) whose further development is expected in the near future, and which are in many cases applied by parenteral route.  Parenteral preparations containing active substances encapsulated in the liposome-type carriers represent a class of non-biological complex drugs which have the longest use so far and whose properties and defined quality characteristics are being most examined. In this paper, an overview  of  mandatory  and  additional  (specific) in  vitro  tests  for  parenteral  liposomal  drug carriers is presented. The fact that standard testing procedures are often not available in relevant pharmacopoeias  (Ph.  Eur.,  USP  and  JP),  so  that  they  can  vary  significantly  between laboratories, contributes to the great variability of the results obtained and constraints in their mutual  comparison.  EMA  and  FDA,  as  regulatory  agencies,  have  also  participated  in  the preparation of certain documents and development of appropriate standards and guidelines for quality control of liposomal drug carriers for parenteral application.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci, Challenges of in vitro characterization of non-biological complex drugs - example of parenteral preparations with liposomal drug carriers",
volume = "69",
number = "3",
pages = "176-198",
doi = "10.5937/arhfarm1903176K"
}

Krajišnik, D., Milić, J.,& Savić, S.. (2019). Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(3), 176-198.
https://doi.org/10.5937/arhfarm1903176K

Krajišnik D, Milić J, Savić S. Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci. in Arhiv za farmaciju. 2019;69(3):176-198.
doi:10.5937/arhfarm1903176K .

Krajišnik, Danina, Milić, Jela, Savić, Snežana, "Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci" in Arhiv za farmaciju, 69, no. 3 (2019):176-198,
https://doi.org/10.5937/arhfarm1903176K . .

TY  - JOUR
AU  - Jevremović, Anka
AU  - Bober, Patrycja
AU  - Mičušík, Matej
AU  - Kuliček, Jaroslav
AU  - Acharya, Udit
AU  - Pfleger, Jiří
AU  - Milojević-Rakić, Maja
AU  - Krajišnik, Danina
AU  - Trchova, Miroslava
AU  - Stejskal, Jaroslav
AU  - Ćirić-Marjanović, Gordana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3248
AB  - Composite materials of BEA zeolite and polyaniline (PANI) were prepared by the chemical oxidative polymerization of aniline in the presence of zeolite in water (without added acid) and in an aqueous solution of sulfuric acid, using ammonium peroxydisulfate as an oxidant. Protonated (as-synthesized) and deprotonated forms of the composites and pristine PANIs were characterized by scanning electron microscopy, conductivity and zeta potential measurements, FTIR, Raman and XPS spectroscopies, and thermogravimetric analysis. Adsorption properties of synthesized materials for removal of nicosulfuron pesticide from aqueous solutions were studied, using HPLC technique. The obtained adsorption isotherms were analyzed using Freundlich and Langmuir-Freundlich equations. Protonated PANI/BEA composites showed excellent adsorption capacity (18.4–25.4 mg g−1), that was higher than the adsorption capacity of pristine BEA zeolite (18.2 mg g−1) but slightly less than neat PANI. Among PANIs, the highest adsorption capacity of 29.8 mg g−1 of adsorbent was found for protonated PANI prepared in sulfuric acid solution. Analysis of adsorption isotherms revealed high degree of surface homogeneity for all prepared composite materials and PANIs. Proposed mechanism for enhanced adsorption of nicosulfuron on protonated composites is based on hydrogen bonding of nicosulfuron O- and N-containing groups with bridging hydroxyls of BEA zeolite and –NH/ = NH+/−NH•+ groups in protonated emeraldine salt form of PANI chains (PANI-ES), accompanied with electrostatic attractive interaction between anionic nicosulfuron species and positive = NH+/−NH•+ groups in bipolaron/polaron containing structures of PANI-ES. Presence of protons in bridging hydroxyls in BEA zeolite and in protonated PANI-ES chains is essential for excellent adsorption of nicosulfuron via hydrogen bonding on all protonated composite samples. In support of this interpretation, deprotonated PANI/BEA composites and deprotonated PANIs showed significantly lower adsorption capacities (in the range 5.5–13.0 mg g−1) compared to those of their protonated counterparts.
PB  - Elsevier B.V.
T2  - Microporous and Mesoporous Materials
T1  - Synthesis and characterization of polyaniline/BEA zeolite composites and their application in nicosulfuron adsorption
SP  - 234
EP  - 245
DO  - 10.1016/j.micromeso.2019.06.006
ER  - 

@article{
author = "Jevremović, Anka and Bober, Patrycja and Mičušík, Matej and Kuliček, Jaroslav and Acharya, Udit and Pfleger, Jiří and Milojević-Rakić, Maja and Krajišnik, Danina and Trchova, Miroslava and Stejskal, Jaroslav and Ćirić-Marjanović, Gordana",
year = "2019",
abstract = "Composite materials of BEA zeolite and polyaniline (PANI) were prepared by the chemical oxidative polymerization of aniline in the presence of zeolite in water (without added acid) and in an aqueous solution of sulfuric acid, using ammonium peroxydisulfate as an oxidant. Protonated (as-synthesized) and deprotonated forms of the composites and pristine PANIs were characterized by scanning electron microscopy, conductivity and zeta potential measurements, FTIR, Raman and XPS spectroscopies, and thermogravimetric analysis. Adsorption properties of synthesized materials for removal of nicosulfuron pesticide from aqueous solutions were studied, using HPLC technique. The obtained adsorption isotherms were analyzed using Freundlich and Langmuir-Freundlich equations. Protonated PANI/BEA composites showed excellent adsorption capacity (18.4–25.4 mg g−1), that was higher than the adsorption capacity of pristine BEA zeolite (18.2 mg g−1) but slightly less than neat PANI. Among PANIs, the highest adsorption capacity of 29.8 mg g−1 of adsorbent was found for protonated PANI prepared in sulfuric acid solution. Analysis of adsorption isotherms revealed high degree of surface homogeneity for all prepared composite materials and PANIs. Proposed mechanism for enhanced adsorption of nicosulfuron on protonated composites is based on hydrogen bonding of nicosulfuron O- and N-containing groups with bridging hydroxyls of BEA zeolite and –NH/ = NH+/−NH•+ groups in protonated emeraldine salt form of PANI chains (PANI-ES), accompanied with electrostatic attractive interaction between anionic nicosulfuron species and positive = NH+/−NH•+ groups in bipolaron/polaron containing structures of PANI-ES. Presence of protons in bridging hydroxyls in BEA zeolite and in protonated PANI-ES chains is essential for excellent adsorption of nicosulfuron via hydrogen bonding on all protonated composite samples. In support of this interpretation, deprotonated PANI/BEA composites and deprotonated PANIs showed significantly lower adsorption capacities (in the range 5.5–13.0 mg g−1) compared to those of their protonated counterparts.",
publisher = "Elsevier B.V.",
journal = "Microporous and Mesoporous Materials",
title = "Synthesis and characterization of polyaniline/BEA zeolite composites and their application in nicosulfuron adsorption",
pages = "234-245",
doi = "10.1016/j.micromeso.2019.06.006"
}

Jevremović, A., Bober, P., Mičušík, M., Kuliček, J., Acharya, U., Pfleger, J., Milojević-Rakić, M., Krajišnik, D., Trchova, M., Stejskal, J.,& Ćirić-Marjanović, G.. (2019). Synthesis and characterization of polyaniline/BEA zeolite composites and their application in nicosulfuron adsorption. in Microporous and Mesoporous Materials
Elsevier B.V.., 234-245.
https://doi.org/10.1016/j.micromeso.2019.06.006

Jevremović A, Bober P, Mičušík M, Kuliček J, Acharya U, Pfleger J, Milojević-Rakić M, Krajišnik D, Trchova M, Stejskal J, Ćirić-Marjanović G. Synthesis and characterization of polyaniline/BEA zeolite composites and their application in nicosulfuron adsorption. in Microporous and Mesoporous Materials. 2019;:234-245.
doi:10.1016/j.micromeso.2019.06.006 .

Jevremović, Anka, Bober, Patrycja, Mičušík, Matej, Kuliček, Jaroslav, Acharya, Udit, Pfleger, Jiří, Milojević-Rakić, Maja, Krajišnik, Danina, Trchova, Miroslava, Stejskal, Jaroslav, Ćirić-Marjanović, Gordana, "Synthesis and characterization of polyaniline/BEA zeolite composites and their application in nicosulfuron adsorption" in Microporous and Mesoporous Materials (2019):234-245,
https://doi.org/10.1016/j.micromeso.2019.06.006 . .

TY  - JOUR
AU  - Jović, A.
AU  - Bajuk-Bogdanović, Danica
AU  - Nedić-Vasiljević, Bojana
AU  - Milojević-Rakić, Maja
AU  - Krajišnik, Danina
AU  - Dondur, Vera
AU  - Popa, Alexandru
AU  - Uskoković-Marković, Snežana
AU  - Holclajtner-Antunović, Ivanka
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2932
AB  - An optimized synthetic route for obtaining heteropoly acid (HPA) species supported on BEA zeolite was applied, and different samples, comprising 20 to 50 wt% of 12-phosphotungstic acid (HPW) were prepared. The as-synthesized supported HPW were subjected to different post-synthesis routes, which involved calcination and ultrasound treatment. Characterization of these materials was performed by means of Scanning Electron Microscopy, zeta potential measurements, Infrared Spectroscopy and X-ray Powder Diffraction analysis. Results suggest strong interaction of HPW with the support and revealed that ultrasound treatment resulted in better dispersion of active phase and thus homogeneous morphology of the samples. The zeta potential was found to be dependent on the preparation procedure and HPW content in these materials, while higher HPW loadings induced its agglomeration. Catalytic activity of the synthesized materials was investigated in an ethanol dehydration reaction, where lower HPW loadings induced higher ethanol conversion. Acid sites distribution and accessibility for ethanol molecules were found to be more essential for catalytic activity than HPW loadings, i.e., amount of active sites present in these hybrid materials.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry and Physics
T1  - Synthesis and characterization of 12-phosphotungstic acid supported on BEA zeolite
VL  - 186
SP  - 430
EP  - 437
DO  - 10.1016/j.matchemphys.2016.11.015
ER  - 

@article{
author = "Jović, A. and Bajuk-Bogdanović, Danica and Nedić-Vasiljević, Bojana and Milojević-Rakić, Maja and Krajišnik, Danina and Dondur, Vera and Popa, Alexandru and Uskoković-Marković, Snežana and Holclajtner-Antunović, Ivanka",
year = "2017",
abstract = "An optimized synthetic route for obtaining heteropoly acid (HPA) species supported on BEA zeolite was applied, and different samples, comprising 20 to 50 wt% of 12-phosphotungstic acid (HPW) were prepared. The as-synthesized supported HPW were subjected to different post-synthesis routes, which involved calcination and ultrasound treatment. Characterization of these materials was performed by means of Scanning Electron Microscopy, zeta potential measurements, Infrared Spectroscopy and X-ray Powder Diffraction analysis. Results suggest strong interaction of HPW with the support and revealed that ultrasound treatment resulted in better dispersion of active phase and thus homogeneous morphology of the samples. The zeta potential was found to be dependent on the preparation procedure and HPW content in these materials, while higher HPW loadings induced its agglomeration. Catalytic activity of the synthesized materials was investigated in an ethanol dehydration reaction, where lower HPW loadings induced higher ethanol conversion. Acid sites distribution and accessibility for ethanol molecules were found to be more essential for catalytic activity than HPW loadings, i.e., amount of active sites present in these hybrid materials.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry and Physics",
title = "Synthesis and characterization of 12-phosphotungstic acid supported on BEA zeolite",
volume = "186",
pages = "430-437",
doi = "10.1016/j.matchemphys.2016.11.015"
}

Jović, A., Bajuk-Bogdanović, D., Nedić-Vasiljević, B., Milojević-Rakić, M., Krajišnik, D., Dondur, V., Popa, A., Uskoković-Marković, S.,& Holclajtner-Antunović, I.. (2017). Synthesis and characterization of 12-phosphotungstic acid supported on BEA zeolite. in Materials Chemistry and Physics
Elsevier Science Sa, Lausanne., 186, 430-437.
https://doi.org/10.1016/j.matchemphys.2016.11.015

Jović A, Bajuk-Bogdanović D, Nedić-Vasiljević B, Milojević-Rakić M, Krajišnik D, Dondur V, Popa A, Uskoković-Marković S, Holclajtner-Antunović I. Synthesis and characterization of 12-phosphotungstic acid supported on BEA zeolite. in Materials Chemistry and Physics. 2017;186:430-437.
doi:10.1016/j.matchemphys.2016.11.015 .

Jović, A., Bajuk-Bogdanović, Danica, Nedić-Vasiljević, Bojana, Milojević-Rakić, Maja, Krajišnik, Danina, Dondur, Vera, Popa, Alexandru, Uskoković-Marković, Snežana, Holclajtner-Antunović, Ivanka, "Synthesis and characterization of 12-phosphotungstic acid supported on BEA zeolite" in Materials Chemistry and Physics, 186 (2017):430-437,
https://doi.org/10.1016/j.matchemphys.2016.11.015 . .

TY  - JOUR
AU  - Bajuk-Bogdanović, Danica
AU  - Jović, Aleksandar
AU  - Nedić-Vasiljević, Bojana
AU  - Milojević-Rakić, Maja
AU  - Kragović, Milan
AU  - Krajišnik, Danina
AU  - Holclajtner-Antunović, Ivanka
AU  - Dondur, Vera
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2873
AB  - Tungstophosphoric acid and BEA zeolite composites were synthesized by wetness impregnation, followed by ultrasonication and calcination. Composites were characterized using Raman spectroscopy, thermal analysis and pH-dependent zeta potential. Spectroscopic measurements indicated the interaction of acid and the support by binding of polyanion terminal oxygens and BEA extra framework H+ via hydrogen bonds. Evaluation of prepared composites revealed their higher efficiency in nicosulfuron adsorption, in comparison to parent zeolite. All prepared composites showed excellent adsorption properties for pesticide removal in the range 12.1-25.8 mg of nicosulfuron per gram of investigated sample. Better adsorption capacity was found for sonicated samples in comparison to as-synthesized and calcined ones. It was found that the amount of polyanion in the composites and the extent of the particles surface charge are not crucial for the adsorption application, it is rather the uniformity of the zeolite surface coverage with the polyanion that is was more important.
PB  - Elsevier Science BV, Amsterdam
T2  - Materials Science and Engineering B: Advanced Functional Solid-State Materials
T1  - 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal
VL  - 225
SP  - 60
EP  - 67
DO  - 10.1016/j.mseb.2017.08.011
ER  - 

@article{
author = "Bajuk-Bogdanović, Danica and Jović, Aleksandar and Nedić-Vasiljević, Bojana and Milojević-Rakić, Maja and Kragović, Milan and Krajišnik, Danina and Holclajtner-Antunović, Ivanka and Dondur, Vera",
year = "2017",
abstract = "Tungstophosphoric acid and BEA zeolite composites were synthesized by wetness impregnation, followed by ultrasonication and calcination. Composites were characterized using Raman spectroscopy, thermal analysis and pH-dependent zeta potential. Spectroscopic measurements indicated the interaction of acid and the support by binding of polyanion terminal oxygens and BEA extra framework H+ via hydrogen bonds. Evaluation of prepared composites revealed their higher efficiency in nicosulfuron adsorption, in comparison to parent zeolite. All prepared composites showed excellent adsorption properties for pesticide removal in the range 12.1-25.8 mg of nicosulfuron per gram of investigated sample. Better adsorption capacity was found for sonicated samples in comparison to as-synthesized and calcined ones. It was found that the amount of polyanion in the composites and the extent of the particles surface charge are not crucial for the adsorption application, it is rather the uniformity of the zeolite surface coverage with the polyanion that is was more important.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Materials Science and Engineering B: Advanced Functional Solid-State Materials",
title = "12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal",
volume = "225",
pages = "60-67",
doi = "10.1016/j.mseb.2017.08.011"
}

Bajuk-Bogdanović, D., Jović, A., Nedić-Vasiljević, B., Milojević-Rakić, M., Kragović, M., Krajišnik, D., Holclajtner-Antunović, I.,& Dondur, V.. (2017). 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal. in Materials Science and Engineering B: Advanced Functional Solid-State Materials
Elsevier Science BV, Amsterdam., 225, 60-67.
https://doi.org/10.1016/j.mseb.2017.08.011

Bajuk-Bogdanović D, Jović A, Nedić-Vasiljević B, Milojević-Rakić M, Kragović M, Krajišnik D, Holclajtner-Antunović I, Dondur V. 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal. in Materials Science and Engineering B: Advanced Functional Solid-State Materials. 2017;225:60-67.
doi:10.1016/j.mseb.2017.08.011 .

Bajuk-Bogdanović, Danica, Jović, Aleksandar, Nedić-Vasiljević, Bojana, Milojević-Rakić, Maja, Kragović, Milan, Krajišnik, Danina, Holclajtner-Antunović, Ivanka, Dondur, Vera, "12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal" in Materials Science and Engineering B: Advanced Functional Solid-State Materials, 225 (2017):60-67,
https://doi.org/10.1016/j.mseb.2017.08.011 . .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Čalija, Bojan
AU  - Cekić, Nebojša
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2785
AB  - Recent expansion of innovative micro- and nanosized drug carriers has been driven by utilization of materials with improved functional properties, along with employment of innovative preparation techniques. Various materials of both natural and synthetic origin, with diverse physicochemical properties, ranging from polymers to structured porous inorganic materials have been investigated as starting materials for preparation of these carriers.This chapter focuses on characteristics, methods of preparation/functionalization of micro- and nanosized carriers consisting of these two distinct groups of materials. In addition, their potential application in up-to-date drug delivery is discussed.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application
SP  - 33
EP  - 67
DO  - 10.1016/B978-0-12-804017-1.00002-9
ER  - 

@inbook{
author = "Krajišnik, Danina and Čalija, Bojan and Cekić, Nebojša",
year = "2017",
abstract = "Recent expansion of innovative micro- and nanosized drug carriers has been driven by utilization of materials with improved functional properties, along with employment of innovative preparation techniques. Various materials of both natural and synthetic origin, with diverse physicochemical properties, ranging from polymers to structured porous inorganic materials have been investigated as starting materials for preparation of these carriers.This chapter focuses on characteristics, methods of preparation/functionalization of micro- and nanosized carriers consisting of these two distinct groups of materials. In addition, their potential application in up-to-date drug delivery is discussed.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application",
pages = "33-67",
doi = "10.1016/B978-0-12-804017-1.00002-9"
}

Krajišnik, D., Čalija, B.,& Cekić, N.. (2017). Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 33-67.
https://doi.org/10.1016/B978-0-12-804017-1.00002-9

Krajišnik D, Čalija B, Cekić N. Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:33-67.
doi:10.1016/B978-0-12-804017-1.00002-9 .

Krajišnik, Danina, Čalija, Bojan, Cekić, Nebojša, "Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):33-67,
https://doi.org/10.1016/B978-0-12-804017-1.00002-9 . .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Janićijević, Jelena
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2819
AB  - In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Natural and Modified Silica-Based Materials as Carriers for NSAIDs
SP  - 219
EP  - 258
DO  - 10.1016/B978-0-12-804017-1.00008-X
ER  - 

@inbook{
author = "Krajišnik, Danina and Daković, Aleksandra and Janićijević, Jelena and Milić, Jela",
year = "2017",
abstract = "In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Natural and Modified Silica-Based Materials as Carriers for NSAIDs",
pages = "219-258",
doi = "10.1016/B978-0-12-804017-1.00008-X"
}

Krajišnik, D., Daković, A., Janićijević, J.,& Milić, J.. (2017). Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 219-258.
https://doi.org/10.1016/B978-0-12-804017-1.00008-X

Krajišnik D, Daković A, Janićijević J, Milić J. Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:219-258.
doi:10.1016/B978-0-12-804017-1.00008-X .

Krajišnik, Danina, Daković, Aleksandra, Janićijević, Jelena, Milić, Jela, "Natural and Modified Silica-Based Materials as Carriers for NSAIDs" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):219-258,
https://doi.org/10.1016/B978-0-12-804017-1.00008-X . .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
AU  - Kragović, Milan
AU  - Milić, Jela
AU  - Langella, Alessio
AU  - de Gennaro, Bruno
AU  - Cappelletti, Piergiulio
AU  - Mercurio, Mariano
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2696
AB  - Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Molecular Liquids
T1  - Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium
VL  - 222
SP  - 711
EP  - 716
DO  - 10.1016/j.molliq.2016.07.127
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Krajišnik, Danina and Kragović, Milan and Milić, Jela and Langella, Alessio and de Gennaro, Bruno and Cappelletti, Piergiulio and Mercurio, Mariano",
year = "2016",
abstract = "Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Molecular Liquids",
title = "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium",
volume = "222",
pages = "711-716",
doi = "10.1016/j.molliq.2016.07.127"
}

Marković, M., Daković, A., Krajišnik, D., Kragović, M., Milić, J., Langella, A., de Gennaro, B., Cappelletti, P.,& Mercurio, M.. (2016). Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids
Elsevier Science BV, Amsterdam., 222, 711-716.
https://doi.org/10.1016/j.molliq.2016.07.127

Marković M, Daković A, Krajišnik D, Kragović M, Milić J, Langella A, de Gennaro B, Cappelletti P, Mercurio M. Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids. 2016;222:711-716.
doi:10.1016/j.molliq.2016.07.127 .

Marković, Marija, Daković, Aleksandra, Krajišnik, Danina, Kragović, Milan, Milić, Jela, Langella, Alessio, de Gennaro, Bruno, Cappelletti, Piergiulio, Mercurio, Mariano, "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium" in Journal of Molecular Liquids, 222 (2016):711-716,
https://doi.org/10.1016/j.molliq.2016.07.127 . .

TY  - CHAP
AU  - Milić, Jela
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
AU  - Rottinghaus, George E.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2259
AB  - Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.
PB  - Wiley Blackwell
T2  - Advanced Healthcare Materials
T1  - Modified Natural Zeolites-Functional Characterization and Biomedical Application
SP  - 359
EP  - 403
DO  - 10.1002/9781118774205.ch10
ER  - 

@inbook{
author = "Milić, Jela and Daković, Aleksandra and Krajišnik, Danina and Rottinghaus, George E.",
year = "2014",
abstract = "Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.",
publisher = "Wiley Blackwell",
journal = "Advanced Healthcare Materials",
booktitle = "Modified Natural Zeolites-Functional Characterization and Biomedical Application",
pages = "359-403",
doi = "10.1002/9781118774205.ch10"
}

Milić, J., Daković, A., Krajišnik, D.,& Rottinghaus, G. E.. (2014). Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials
Wiley Blackwell., 359-403.
https://doi.org/10.1002/9781118774205.ch10

Milić J, Daković A, Krajišnik D, Rottinghaus GE. Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials. 2014;:359-403.
doi:10.1002/9781118774205.ch10 .

Milić, Jela, Daković, Aleksandra, Krajišnik, Danina, Rottinghaus, George E., "Modified Natural Zeolites-Functional Characterization and Biomedical Application" in Advanced Healthcare Materials (2014):359-403,
https://doi.org/10.1002/9781118774205.ch10 . .