TY  - JOUR
AU  - Filipić, Brankica
AU  - Ušjak, Dušan
AU  - Hrast Rambaher, Martina
AU  - Oljačić, Slavica
AU  - Milenković, Marina
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5574
AB  - Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 million deaths per year could be associated with antimicrobial resistance, which would equal the annual number of cancer deaths worldwide. To overcome this emerging crisis, novel anti-bacterial compounds are urgently needed. There are two possible approaches in the fight against bacterial infections: a) targeting structures within bacterial cells, similar to existing antibiotics; and/or b) targeting virulence factors rather than bacterial growth. Here, for the first time, we provide a comprehensive overview of the key steps in the evaluation of potential new anti-bacterial and/or anti-virulence compounds. The methods described in this review include: a) in silico methods for the evaluation of novel compounds; b) anti-bacterial assays (MIC, MBC, Time-kill); b) anti-virulence assays (anti-biofilm, anti-quorum sensing, anti-adhesion); and c) evaluation of safety aspects (cytotoxicity assay and Ames test). Overall, we provide a detailed description of the methods that are an essential tool for chemists, computational chemists, microbiologists, and toxicologists in the evaluation of potential novel antimicrobial compounds. These methods are cost-effective and have high predictive value. They are widely used in preclinical studies to identify new molecular candidates, for further investigation in animal and human trials.
PB  - Frontiers Media SA
T2  - Frontiers in Cellular and Infection Microbiology
T1  - Evaluation of novel compounds as anti-bacterial or anti-virulence agents
VL  - 14
DO  - 10.3389/fcimb.2024.1370062
ER  - 

@article{
author = "Filipić, Brankica and Ušjak, Dušan and Hrast Rambaher, Martina and Oljačić, Slavica and Milenković, Marina",
abstract = "Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 million deaths per year could be associated with antimicrobial resistance, which would equal the annual number of cancer deaths worldwide. To overcome this emerging crisis, novel anti-bacterial compounds are urgently needed. There are two possible approaches in the fight against bacterial infections: a) targeting structures within bacterial cells, similar to existing antibiotics; and/or b) targeting virulence factors rather than bacterial growth. Here, for the first time, we provide a comprehensive overview of the key steps in the evaluation of potential new anti-bacterial and/or anti-virulence compounds. The methods described in this review include: a) in silico methods for the evaluation of novel compounds; b) anti-bacterial assays (MIC, MBC, Time-kill); b) anti-virulence assays (anti-biofilm, anti-quorum sensing, anti-adhesion); and c) evaluation of safety aspects (cytotoxicity assay and Ames test). Overall, we provide a detailed description of the methods that are an essential tool for chemists, computational chemists, microbiologists, and toxicologists in the evaluation of potential novel antimicrobial compounds. These methods are cost-effective and have high predictive value. They are widely used in preclinical studies to identify new molecular candidates, for further investigation in animal and human trials.",
publisher = "Frontiers Media SA",
journal = "Frontiers in Cellular and Infection Microbiology",
title = "Evaluation of novel compounds as anti-bacterial or anti-virulence agents",
volume = "14",
doi = "10.3389/fcimb.2024.1370062"
}

Filipić, B., Ušjak, D., Hrast Rambaher, M., Oljačić, S.,& Milenković, M..Evaluation of novel compounds as anti-bacterial or anti-virulence agents. in Frontiers in Cellular and Infection Microbiology
Frontiers Media SA., 14.
https://doi.org/10.3389/fcimb.2024.1370062

Filipić B, Ušjak D, Hrast Rambaher M, Oljačić S, Milenković M. Evaluation of novel compounds as anti-bacterial or anti-virulence agents. in Frontiers in Cellular and Infection Microbiology.14.
doi:10.3389/fcimb.2024.1370062 .

Filipić, Brankica, Ušjak, Dušan, Hrast Rambaher, Martina, Oljačić, Slavica, Milenković, Marina, "Evaluation of novel compounds as anti-bacterial or anti-virulence agents" in Frontiers in Cellular and Infection Microbiology, 14,
https://doi.org/10.3389/fcimb.2024.1370062 . .

TY  - JOUR
AU  - Petrović, Sanja
AU  - Kovačević, Milena
AU  - Vezmar-Kovačević, Sandra
AU  - Miljković, Branislava
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5597
AB  - Background: We aimed to characterize newer antiseizure medications (ASMs)-induced hepatotoxicity
in children and identify signals of disproportionate reporting of hepatotoxicity-related adverse drug
events (ADEs).
Research Design and Methods: Case reports reported to VigiBase were accessed using Empirica™
Signal software. To summarize characteristics of the retrieved cases, descriptive statistics were used.
A disproportionality analysis was conducted using the Multi-item Gamma Poisson Shrinker algorithm,
which calculates Empirical Bayesian Geometric Mean value and its lower and upper 95% confidence
limits (EB05 and EB95, respectively). EB05 > 2, N > 0 was considered a signal.
Results: Based on 870 analyzed cases, a higher proportion of cases was reported in girls than in boys
and in patients aged 2–11 years than in other age groups. Most cases were serious. In 25 cases,
hepatotoxicity resulted in death. A high proportion of patients (n = 275, 31.61%) experienced hyper-
sensitivity reactions, mostly due to lamotrigine. The disproportionality analysis yielded 17 signals
concerning felbamate, lamotrigine, levetiracetam, oxcarbazepine, stiripentol, and topiramate. Four
signals were for severe liver injury and concerned felbamate, lamotrigine, levetiracetam, and topira-
mate. Gender-biased reporting frequency was detected for four ASM-ADE combinations.
Conclusion: Our results should serve to raise clinicians’ awareness about the potential association
between several newer ASMs and drug-induced liver injury in children.
PB  - Taylor & Francis
T2  - Expert Opinion on Drug Metabolism & Toxicology
T1  - Hepatotoxicity of newer antiseizure medications in children: an overview and disproportionality analysis of VigiBase
VL  - 20
IS  - 3
SP  - 165
EP  - 173
DO  - 10.1080/17425255.2024.2322114
ER  - 

@article{
author = "Petrović, Sanja and Kovačević, Milena and Vezmar-Kovačević, Sandra and Miljković, Branislava",
year = "2024",
abstract = "Background: We aimed to characterize newer antiseizure medications (ASMs)-induced hepatotoxicity
in children and identify signals of disproportionate reporting of hepatotoxicity-related adverse drug
events (ADEs).
Research Design and Methods: Case reports reported to VigiBase were accessed using Empirica™
Signal software. To summarize characteristics of the retrieved cases, descriptive statistics were used.
A disproportionality analysis was conducted using the Multi-item Gamma Poisson Shrinker algorithm,
which calculates Empirical Bayesian Geometric Mean value and its lower and upper 95% confidence
limits (EB05 and EB95, respectively). EB05 > 2, N > 0 was considered a signal.
Results: Based on 870 analyzed cases, a higher proportion of cases was reported in girls than in boys
and in patients aged 2–11 years than in other age groups. Most cases were serious. In 25 cases,
hepatotoxicity resulted in death. A high proportion of patients (n = 275, 31.61%) experienced hyper-
sensitivity reactions, mostly due to lamotrigine. The disproportionality analysis yielded 17 signals
concerning felbamate, lamotrigine, levetiracetam, oxcarbazepine, stiripentol, and topiramate. Four
signals were for severe liver injury and concerned felbamate, lamotrigine, levetiracetam, and topira-
mate. Gender-biased reporting frequency was detected for four ASM-ADE combinations.
Conclusion: Our results should serve to raise clinicians’ awareness about the potential association
between several newer ASMs and drug-induced liver injury in children.",
publisher = "Taylor & Francis",
journal = "Expert Opinion on Drug Metabolism & Toxicology",
title = "Hepatotoxicity of newer antiseizure medications in children: an overview and disproportionality analysis of VigiBase",
volume = "20",
number = "3",
pages = "165-173",
doi = "10.1080/17425255.2024.2322114"
}

Petrović, S., Kovačević, M., Vezmar-Kovačević, S.,& Miljković, B.. (2024). Hepatotoxicity of newer antiseizure medications in children: an overview and disproportionality analysis of VigiBase. in Expert Opinion on Drug Metabolism & Toxicology
Taylor & Francis., 20(3), 165-173.
https://doi.org/10.1080/17425255.2024.2322114

Petrović S, Kovačević M, Vezmar-Kovačević S, Miljković B. Hepatotoxicity of newer antiseizure medications in children: an overview and disproportionality analysis of VigiBase. in Expert Opinion on Drug Metabolism & Toxicology. 2024;20(3):165-173.
doi:10.1080/17425255.2024.2322114 .

Petrović, Sanja, Kovačević, Milena, Vezmar-Kovačević, Sandra, Miljković, Branislava, "Hepatotoxicity of newer antiseizure medications in children: an overview and disproportionality analysis of VigiBase" in Expert Opinion on Drug Metabolism & Toxicology, 20, no. 3 (2024):165-173,
https://doi.org/10.1080/17425255.2024.2322114 . .

TY  - JOUR
AU  - Milosavljević, Filip
AU  - Molden, Espen
AU  - Ingelman-Sundberg, Magnus
AU  - Jukić, Marin
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5593
AB  - The aim of the study was to assess the clinical utility of currently available pharmacogenomic (PGx) tools compared with treatment as usual (TAU), using a meta-analysis of dichotomous and continuous antidepressant efficacy and tolerability data from previously published clinical trials. MEDLINE, clinicaltrial.gov, EU Clinical Trials Register, WHO ICTRP and CENTRAL were systematically searched; of the 962 results originally reviewed, 15 trials were included. Antidepressant efficacy was quantified by relative and absolute changes in symptom severity after eight weeks of treatment and by response and remission rates, while tolerability was estimated by the rate of study discontinuation for any reason. In the PGx-guided patients, symptom severity reduced by an average of 31.0% after eight weeks of treatment, compared to an average reduction of 26.8% in the TAU group. Accordingly, PGx-guided patients experienced a greater reduction in symptom severity of 3.4% (95%CI: 1.6-5.3%), which corresponded to a reduction in the Hamilton Depression score of 0.75 (0.30-1.21), a 37% (15-63%) higher remission rate, and an 18% (5-33%) higher response rate compared with TAU patients, while no difference was observed in discontinuation rate between groups. Notably, the majority of associations lost statistical significance when restricting the dataset to low risk of bias studies, while certain funnel plots suggested a potential publication bias favoring the reporting of statistically significant results. In summary, PGx tools marginally enhance antidepressant efficacy, but not antidepressant tolerability; thus, additional research and advancement of PGx tools are needed to improve integration of PGx in clinical pharmacotherapy of depression.
PB  - Elsevier B.V.
T2  - European Neuropsychopharmacology
T1  - Current level of evidence for improvement of antidepressant efficacy and
tolerability by pharmacogenomic-guided treatment: A Systematic review
and meta-analysis of randomized controlled clinical trials
VL  - 81
SP  - 43
EP  - 52
DO  - 10.1016/j.euroneuro.2024.01.005
ER  - 

@article{
author = "Milosavljević, Filip and Molden, Espen and Ingelman-Sundberg, Magnus and Jukić, Marin",
year = "2024",
abstract = "The aim of the study was to assess the clinical utility of currently available pharmacogenomic (PGx) tools compared with treatment as usual (TAU), using a meta-analysis of dichotomous and continuous antidepressant efficacy and tolerability data from previously published clinical trials. MEDLINE, clinicaltrial.gov, EU Clinical Trials Register, WHO ICTRP and CENTRAL were systematically searched; of the 962 results originally reviewed, 15 trials were included. Antidepressant efficacy was quantified by relative and absolute changes in symptom severity after eight weeks of treatment and by response and remission rates, while tolerability was estimated by the rate of study discontinuation for any reason. In the PGx-guided patients, symptom severity reduced by an average of 31.0% after eight weeks of treatment, compared to an average reduction of 26.8% in the TAU group. Accordingly, PGx-guided patients experienced a greater reduction in symptom severity of 3.4% (95%CI: 1.6-5.3%), which corresponded to a reduction in the Hamilton Depression score of 0.75 (0.30-1.21), a 37% (15-63%) higher remission rate, and an 18% (5-33%) higher response rate compared with TAU patients, while no difference was observed in discontinuation rate between groups. Notably, the majority of associations lost statistical significance when restricting the dataset to low risk of bias studies, while certain funnel plots suggested a potential publication bias favoring the reporting of statistically significant results. In summary, PGx tools marginally enhance antidepressant efficacy, but not antidepressant tolerability; thus, additional research and advancement of PGx tools are needed to improve integration of PGx in clinical pharmacotherapy of depression.",
publisher = "Elsevier B.V.",
journal = "European Neuropsychopharmacology",
title = "Current level of evidence for improvement of antidepressant efficacy and
tolerability by pharmacogenomic-guided treatment: A Systematic review
and meta-analysis of randomized controlled clinical trials",
volume = "81",
pages = "43-52",
doi = "10.1016/j.euroneuro.2024.01.005"
}

Milosavljević, F., Molden, E., Ingelman-Sundberg, M.,& Jukić, M.. (2024). Current level of evidence for improvement of antidepressant efficacy and
tolerability by pharmacogenomic-guided treatment: A Systematic review
and meta-analysis of randomized controlled clinical trials. in European Neuropsychopharmacology
Elsevier B.V.., 81, 43-52.
https://doi.org/10.1016/j.euroneuro.2024.01.005

Milosavljević F, Molden E, Ingelman-Sundberg M, Jukić M. Current level of evidence for improvement of antidepressant efficacy and
tolerability by pharmacogenomic-guided treatment: A Systematic review
and meta-analysis of randomized controlled clinical trials. in European Neuropsychopharmacology. 2024;81:43-52.
doi:10.1016/j.euroneuro.2024.01.005 .

Milosavljević, Filip, Molden, Espen, Ingelman-Sundberg, Magnus, Jukić, Marin, "Current level of evidence for improvement of antidepressant efficacy and
tolerability by pharmacogenomic-guided treatment: A Systematic review
and meta-analysis of randomized controlled clinical trials" in European Neuropsychopharmacology, 81 (2024):43-52,
https://doi.org/10.1016/j.euroneuro.2024.01.005 . .

TY  - JOUR
AU  - Božić, Dragana
AU  - Bufan, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5603
AB  - Antibacterial vaccines play a central role in modern medicine by providing an effective approach to
combating infectious diseases caused by bacteria. The importance of these vaccines lies in their ability to
stimulate the immune system to recognise and neutralise bacterial pathogens, or exotoxins produced by them,
thereby preventing, or mitigating the severity of bacterial infections. The development and widespread use of
antibacterial vaccines have contributed significantly to reducing the global burden of diseases such as pneumonia,
meningitis, and sepsis.
Today, the global increase in vaccine-preventable diseases is a worrying trend that is closely linked to the
emergence and advocacy of anti-vaccination policies. According to the latest World Health Organisation report,
vaccination coverage in Serbia has declined over the past decade, jeopardising the collective immunity and led to
recent outbreaks of vaccine-preventable diseases such as whooping cough and measles. Understanding the
significance of antibacterial vaccines underscores their importance in promoting individual and community immunity,
which ultimately leads to a healthier population and the prevention of antibiotic resistance.
This paper summarises the main characteristics of the different types of antibacterial vaccines, such as whole cell
vaccines, subunit vaccines and toxoid vaccines, and provides an overview of the types of bacterial antigens
contained in vaccines available for mandatory immunisation (vaccines against tuberculosis, diphtheria, tetanus,
pertussis, Haemophilus influenzae and pneumoccus) or for non-mandatory immunisation (meningococcal vaccine,
typhoid vaccine, cholera vaccine).
AB  - Antibakterijske vakcine igraju glavnu ulogu u savremenoj medicini obezbeđujući efikasan pristup u borbi protiv
zaraznih bolesti izazvanih bakterijama. Važnost ovih vakcina leži u njihovoj sposobnosti da stimulišu imunski sistem
da prepozna i neutrališe bakterijske patogene, ili egzotoksine koje oni proizvode, čime sprečavaju ili ublažavaju
ozbiljnost bakterijskih infekcija. Razvoj i široka upotreba antibakterijskih vakcina značajno su doprineli smanjenju
globalnog tereta bolesti kao što su pneumonija, meningitis i sepsa.
Danas je globalni porast bolesti koje se mogu sprečiti vakcinama zabrinjavajući trend koji je usko povezan sa
pojavom i zagovaranjem politike protiv vakcinacije. Prema poslednjem izveštaju Svetske zdravstvene organizacije,
pokrivenost vakcinacijom u Srbiji je opala tokom protekle decenije, što je ugrozilo kolektivni imunitet i dovelo do
nedavnih izbijanja bolesti koje se mogu sprečiti vakcinom, poput velikog kašlja i malih boginja. Razumevanje
značaja antibakterijskih vakcina naglašava njihov značaj u promovisanju imuniteta pojedinca i zajednice, što na
kraju dovodi do zdravije populacije i prevencije rezistencije na antibiotike.
Ovaj rad sumira glavne karakteristike različitih tipova antibakterijskih vakcina, kao što su celo ćelijske vakcine,
podjedinične vakcine i toksoidne vakcine, i daje pregled tipova bakterijskih antigena sadržanih u vakcinama
dostupnim za obaveznu imunizaciju (vakcine protiv tuberkuloze, difterije, tetanusa, pertusisa, Haemophilus
influenzae i pneumoka) ili za neobaveznu imunizaciju (vakcina protiv meningokoka, tifusa i kolere).
PB  - Udruženja za preventivnu pedijatriju Srbije
T2  - Preventive Paediatrics Journal of the Association for Preventive Pediatrics of Serbia / Preventivna pedijatrija Časopis Udruženja za preventivnu pedijatriju Srbije
T1  - An overview of current vacccines for the prophylaxis of bacterical infections Pres
T1  - Pregled aktuelnih vakcina za profilaksu bakterijskih infekcija
VL  - 10
IS  - 1-2
SP  - 19
EP  - 26
DO  - 10.46793/PP240214004B
DO  - 10.46793/PP240214004B
ER  - 

@article{
author = "Božić, Dragana and Bufan, Biljana",
year = "2024",
abstract = "Antibacterial vaccines play a central role in modern medicine by providing an effective approach to
combating infectious diseases caused by bacteria. The importance of these vaccines lies in their ability to
stimulate the immune system to recognise and neutralise bacterial pathogens, or exotoxins produced by them,
thereby preventing, or mitigating the severity of bacterial infections. The development and widespread use of
antibacterial vaccines have contributed significantly to reducing the global burden of diseases such as pneumonia,
meningitis, and sepsis.
Today, the global increase in vaccine-preventable diseases is a worrying trend that is closely linked to the
emergence and advocacy of anti-vaccination policies. According to the latest World Health Organisation report,
vaccination coverage in Serbia has declined over the past decade, jeopardising the collective immunity and led to
recent outbreaks of vaccine-preventable diseases such as whooping cough and measles. Understanding the
significance of antibacterial vaccines underscores their importance in promoting individual and community immunity,
which ultimately leads to a healthier population and the prevention of antibiotic resistance.
This paper summarises the main characteristics of the different types of antibacterial vaccines, such as whole cell
vaccines, subunit vaccines and toxoid vaccines, and provides an overview of the types of bacterial antigens
contained in vaccines available for mandatory immunisation (vaccines against tuberculosis, diphtheria, tetanus,
pertussis, Haemophilus influenzae and pneumoccus) or for non-mandatory immunisation (meningococcal vaccine,
typhoid vaccine, cholera vaccine)., Antibakterijske vakcine igraju glavnu ulogu u savremenoj medicini obezbeđujući efikasan pristup u borbi protiv
zaraznih bolesti izazvanih bakterijama. Važnost ovih vakcina leži u njihovoj sposobnosti da stimulišu imunski sistem
da prepozna i neutrališe bakterijske patogene, ili egzotoksine koje oni proizvode, čime sprečavaju ili ublažavaju
ozbiljnost bakterijskih infekcija. Razvoj i široka upotreba antibakterijskih vakcina značajno su doprineli smanjenju
globalnog tereta bolesti kao što su pneumonija, meningitis i sepsa.
Danas je globalni porast bolesti koje se mogu sprečiti vakcinama zabrinjavajući trend koji je usko povezan sa
pojavom i zagovaranjem politike protiv vakcinacije. Prema poslednjem izveštaju Svetske zdravstvene organizacije,
pokrivenost vakcinacijom u Srbiji je opala tokom protekle decenije, što je ugrozilo kolektivni imunitet i dovelo do
nedavnih izbijanja bolesti koje se mogu sprečiti vakcinom, poput velikog kašlja i malih boginja. Razumevanje
značaja antibakterijskih vakcina naglašava njihov značaj u promovisanju imuniteta pojedinca i zajednice, što na
kraju dovodi do zdravije populacije i prevencije rezistencije na antibiotike.
Ovaj rad sumira glavne karakteristike različitih tipova antibakterijskih vakcina, kao što su celo ćelijske vakcine,
podjedinične vakcine i toksoidne vakcine, i daje pregled tipova bakterijskih antigena sadržanih u vakcinama
dostupnim za obaveznu imunizaciju (vakcine protiv tuberkuloze, difterije, tetanusa, pertusisa, Haemophilus
influenzae i pneumoka) ili za neobaveznu imunizaciju (vakcina protiv meningokoka, tifusa i kolere).",
publisher = "Udruženja za preventivnu pedijatriju Srbije",
journal = "Preventive Paediatrics Journal of the Association for Preventive Pediatrics of Serbia / Preventivna pedijatrija Časopis Udruženja za preventivnu pedijatriju Srbije",
title = "An overview of current vacccines for the prophylaxis of bacterical infections Pres, Pregled aktuelnih vakcina za profilaksu bakterijskih infekcija",
volume = "10",
number = "1-2",
pages = "19-26",
doi = "10.46793/PP240214004B, 10.46793/PP240214004B"
}

Božić, D.,& Bufan, B.. (2024). An overview of current vacccines for the prophylaxis of bacterical infections Pres. in Preventive Paediatrics Journal of the Association for Preventive Pediatrics of Serbia / Preventivna pedijatrija Časopis Udruženja za preventivnu pedijatriju Srbije
Udruženja za preventivnu pedijatriju Srbije., 10(1-2), 19-26.
https://doi.org/10.46793/PP240214004B

Božić D, Bufan B. An overview of current vacccines for the prophylaxis of bacterical infections Pres. in Preventive Paediatrics Journal of the Association for Preventive Pediatrics of Serbia / Preventivna pedijatrija Časopis Udruženja za preventivnu pedijatriju Srbije. 2024;10(1-2):19-26.
doi:10.46793/PP240214004B .

Božić, Dragana, Bufan, Biljana, "An overview of current vacccines for the prophylaxis of bacterical infections Pres" in Preventive Paediatrics Journal of the Association for Preventive Pediatrics of Serbia / Preventivna pedijatrija Časopis Udruženja za preventivnu pedijatriju Srbije, 10, no. 1-2 (2024):19-26,
https://doi.org/10.46793/PP240214004B . .

TY  - JOUR
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Vukelić, Dragana
AU  - Marić, Đurđica
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Janković, Radmila
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5614
AB  - Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.
PB  - Elsevier Inc.
T2  - Environmental Research
T1  - Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
VL  - 252
IS  - 1
DO  - 10.1016/j.envres.2024.118680
ER  - 

@article{
author = "Živančević, Katarina and Baralić, Katarina and Vukelić, Dragana and Marić, Đurđica and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Savić, Miroslav and Batinić, Bojan and Janković, Radmila and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2024",
abstract = "Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately explored. The assessment of neurotoxic effects of lead, cadmium, mercury, and arsenic mixture (MIX) administered at low dose ranges, was conducted using an in vivo approach. A subacute study was conducted on a rat model consisting of a control and five treatment groups subjected to oral exposure with gradually increasing doses (from MIX 1 to MIX 5). The results indicated that behavioural patterns in an already developed nervous system displayed a reduced susceptibility to the metal mixture exposure with tendency of higher doses to alter short term memory. However, the vulnerability of the mature brain to even minimal amounts of the investigated metal mixture was evident, particularly in the context of oxidative stress. Moreover, the study highlights superoxide dismutase's sensitivity as an early-stage neurotoxicity marker, as indicated by dose-dependent induction of oxidative stress in the brain revealed through Benchmark analysis. The narrowest Benchmark Dose Interval (BMDI) for superoxide dismutase (SOD) activity (1e-06 - 3.18e-05 mg As/kg b.w./day) indicates that arsenic may dictate the alterations in SOD activity when co-exposed with the other examined metals. The predicted Benchmark doses for oxidative stress parameters were very low, supporting “no-threshold” concept. Histopathological alterations were most severe in the groups treated with higher doses of metal mixture. Similarly, the brain acetylcholinesterase (AChE) activity demonstrated a dose-dependent decrease significant in higher doses, while BMDI suggested Cd as the main contributor in the examined metal mixture. These findings imply varying susceptibility of neurotoxic endpoints to different doses of environmentally relevant metal mixtures, advocating for risk assessment and regulatory measures to address metal pollution and enhance remediation strategies.",
publisher = "Elsevier Inc.",
journal = "Environmental Research",
title = "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach",
volume = "252",
number = "1",
doi = "10.1016/j.envres.2024.118680"
}

Živančević, K., Baralić, K., Vukelić, D., Marić, Đ., Kotur-Stevuljević, J., Ivanišević, J., Savić, M., Batinić, B., Janković, R., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2024). Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research
Elsevier Inc.., 252(1).
https://doi.org/10.1016/j.envres.2024.118680

Živančević K, Baralić K, Vukelić D, Marić Đ, Kotur-Stevuljević J, Ivanišević J, Savić M, Batinić B, Janković R, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach. in Environmental Research. 2024;252(1).
doi:10.1016/j.envres.2024.118680 .

Živančević, Katarina, Baralić, Katarina, Vukelić, Dragana, Marić, Đurđica, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Savić, Miroslav, Batinić, Bojan, Janković, Radmila, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach" in Environmental Research, 252, no. 1 (2024),
https://doi.org/10.1016/j.envres.2024.118680 . .

TY  - JOUR
AU  - Bruić, Marija
AU  - Pirković, Andrea
AU  - Borozan, Sunčica
AU  - Nacka-Aleksić, Mirjana
AU  - Jovanović-Krivokuća, Milica
AU  - Spremo-Potparević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5613
AB  - Oxidative stress has been implicated in numerous pregnancy-related disorders. Biologically active plant sec-
ondary metabolites, which are present in everyday diet, could prove effective therapeutic agents in preventing
these disorders. This study evaluated effects of taxifolin (dihydroquercetin) on ROS production, markers of
oxidative damage to lipids and proteins, activity of antioxidant enzymes and production of pro-inflammatory
cytokines in H2O2-induced oxidative stress in trophoblast HTR-8/SVneo cells. Taxifolin in 10 μM and 100 μM
concentrations attenuated oxidative damage to lipids and proteins, as evidenced by a decrease in MDA content,
extracellular LDH activity, carbonyl groups and nitrite contents. A reduction in the activity of antioxidant en-
zymes SOD, CAT and GPx in cells pre-treated with taxifolin, prior to H2O2 exposure, was also observed, along
with a reduction in intracellular ROS production. Both evaluated concentrations of taxifolin showed anti-
inflammatory activity in trophoblast cells, by reducing production of pro-inflammatory cytokines IL-1β and IL-
6. In this model of H2O2-induced oxidative stress, taxifolin showed marked antioxidative and anti-
inflammatory activities in trophoblast cells, adding further evidence of its protective effects and showing po-
tential as a therapeutic agent in preventing adverse pregnancy outcomes.
PB  - Elsevier
T2  - Reproductive Toxicology
T1  - Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line
VL  - 126
SP  - 108585
DO  - 10.1016/j.reprotox.2024.108585
ER  - 

@article{
author = "Bruić, Marija and Pirković, Andrea and Borozan, Sunčica and Nacka-Aleksić, Mirjana and Jovanović-Krivokuća, Milica and Spremo-Potparević, Biljana",
year = "2024",
abstract = "Oxidative stress has been implicated in numerous pregnancy-related disorders. Biologically active plant sec-
ondary metabolites, which are present in everyday diet, could prove effective therapeutic agents in preventing
these disorders. This study evaluated effects of taxifolin (dihydroquercetin) on ROS production, markers of
oxidative damage to lipids and proteins, activity of antioxidant enzymes and production of pro-inflammatory
cytokines in H2O2-induced oxidative stress in trophoblast HTR-8/SVneo cells. Taxifolin in 10 μM and 100 μM
concentrations attenuated oxidative damage to lipids and proteins, as evidenced by a decrease in MDA content,
extracellular LDH activity, carbonyl groups and nitrite contents. A reduction in the activity of antioxidant en-
zymes SOD, CAT and GPx in cells pre-treated with taxifolin, prior to H2O2 exposure, was also observed, along
with a reduction in intracellular ROS production. Both evaluated concentrations of taxifolin showed anti-
inflammatory activity in trophoblast cells, by reducing production of pro-inflammatory cytokines IL-1β and IL-
6. In this model of H2O2-induced oxidative stress, taxifolin showed marked antioxidative and anti-
inflammatory activities in trophoblast cells, adding further evidence of its protective effects and showing po-
tential as a therapeutic agent in preventing adverse pregnancy outcomes.",
publisher = "Elsevier",
journal = "Reproductive Toxicology",
title = "Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line",
volume = "126",
pages = "108585",
doi = "10.1016/j.reprotox.2024.108585"
}

Bruić, M., Pirković, A., Borozan, S., Nacka-Aleksić, M., Jovanović-Krivokuća, M.,& Spremo-Potparević, B.. (2024). Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. in Reproductive Toxicology
Elsevier., 126, 108585.
https://doi.org/10.1016/j.reprotox.2024.108585

Bruić M, Pirković A, Borozan S, Nacka-Aleksić M, Jovanović-Krivokuća M, Spremo-Potparević B. Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. in Reproductive Toxicology. 2024;126:108585.
doi:10.1016/j.reprotox.2024.108585 .

Bruić, Marija, Pirković, Andrea, Borozan, Sunčica, Nacka-Aleksić, Mirjana, Jovanović-Krivokuća, Milica, Spremo-Potparević, Biljana, "Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line" in Reproductive Toxicology, 126 (2024):108585,
https://doi.org/10.1016/j.reprotox.2024.108585 . .

TY  - JOUR
AU  - Janošević-Ležaić, Aleksandra
AU  - Bajuk-Bogdanović, Danica
AU  - Ćirić-Marjanović, Gordana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5612
AB  - In situ Raman spectroscopy was used for the first time to study the reaction intermediates/products of the
oxidative polymerization of aniline to polyaniline (PANI) with peroxydisulfate in aqueous solutions of different
initial acidity. Raman spectra were recorded for the drops of reaction mixture taken at various reaction times.
Five reaction systems with different pH of the monomer solution (pHmon), leading to 1-D nanostructured PANIs
(pHmon =5.8, 4.6 and 4.5) and granular PANIs (pHmon= 3.4 and 1.0) were explored. Spectral characteristics of
different reaction phases - athermal, exothermic and post-propagation were identified and correlated with the
proposed mechanisms of aniline polymerization and nanostructures formation. For the nanostructured PANIs,
the athermal phase was characterized by pronounced strengthening of the δ(N H)/ν(C––N)Q band at
1510–1520 cm 1, while the characteristic of the second exothermic phase was the strengthening of the ν(C~C)B/
ν(C~C)Phz band at c.a. 1636 cm 1 which becomes stronger than the ν(C––C)Q/ν(C~C)SQ band at c.a. 1590 cm–1.
For granular PANIs, the band at 1590 cm–1 was stronger than that at 1630 cm–1 for all reaction phases. For all
reaction systems, characteristic feature of the post-propagation phase was strengthening of the ν(C~N+•) band at
1330–1340 cm 1 due to delocalized polarons. For granular PANIs, the band associated with phenazine-like units
at c.a. 1415 cm 1 disappeared after the exothermic phase, while for nanostructured PANIs it was seen until the
end of the reaction. The obtained results are expected to be useful in further investigations of the intermediates/
products and mechanisms of polymerizations of other aromatic amines.
PB  - Elsevier
T2  - Synthetic Metals  Synthetic Metals
T1  - In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity
VL  - 305
SP  - 117602
DO  - 10.1016/j.synthmet.2024.117602
ER  - 

@article{
author = "Janošević-Ležaić, Aleksandra and Bajuk-Bogdanović, Danica and Ćirić-Marjanović, Gordana",
year = "2024",
abstract = "In situ Raman spectroscopy was used for the first time to study the reaction intermediates/products of the
oxidative polymerization of aniline to polyaniline (PANI) with peroxydisulfate in aqueous solutions of different
initial acidity. Raman spectra were recorded for the drops of reaction mixture taken at various reaction times.
Five reaction systems with different pH of the monomer solution (pHmon), leading to 1-D nanostructured PANIs
(pHmon =5.8, 4.6 and 4.5) and granular PANIs (pHmon= 3.4 and 1.0) were explored. Spectral characteristics of
different reaction phases - athermal, exothermic and post-propagation were identified and correlated with the
proposed mechanisms of aniline polymerization and nanostructures formation. For the nanostructured PANIs,
the athermal phase was characterized by pronounced strengthening of the δ(N H)/ν(C––N)Q band at
1510–1520 cm 1, while the characteristic of the second exothermic phase was the strengthening of the ν(C~C)B/
ν(C~C)Phz band at c.a. 1636 cm 1 which becomes stronger than the ν(C––C)Q/ν(C~C)SQ band at c.a. 1590 cm–1.
For granular PANIs, the band at 1590 cm–1 was stronger than that at 1630 cm–1 for all reaction phases. For all
reaction systems, characteristic feature of the post-propagation phase was strengthening of the ν(C~N+•) band at
1330–1340 cm 1 due to delocalized polarons. For granular PANIs, the band associated with phenazine-like units
at c.a. 1415 cm 1 disappeared after the exothermic phase, while for nanostructured PANIs it was seen until the
end of the reaction. The obtained results are expected to be useful in further investigations of the intermediates/
products and mechanisms of polymerizations of other aromatic amines.",
publisher = "Elsevier",
journal = "Synthetic Metals  Synthetic Metals",
title = "In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity",
volume = "305",
pages = "117602",
doi = "10.1016/j.synthmet.2024.117602"
}

Janošević-Ležaić, A., Bajuk-Bogdanović, D.,& Ćirić-Marjanović, G.. (2024). In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity. in Synthetic Metals  Synthetic Metals
Elsevier., 305, 117602.
https://doi.org/10.1016/j.synthmet.2024.117602

Janošević-Ležaić A, Bajuk-Bogdanović D, Ćirić-Marjanović G. In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity. in Synthetic Metals  Synthetic Metals. 2024;305:117602.
doi:10.1016/j.synthmet.2024.117602 .

Janošević-Ležaić, Aleksandra, Bajuk-Bogdanović, Danica, Ćirić-Marjanović, Gordana, "In situ Raman spectroscopy study of the oxidative polymerization of aniline in media of different acidity" in Synthetic Metals  Synthetic Metals, 305 (2024):117602,
https://doi.org/10.1016/j.synthmet.2024.117602 . .

TY  - JOUR
AU  - Toljić, Mina
AU  - Nikolić, Nađa
AU  - Joksić, Ivana
AU  - Čarkić, Jelena
AU  - Munjas, Jelena
AU  - Karadžov Orlić, Nataša
AU  - Milašin, Jelena
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5615
AB  - Altered microRNAs (miRNAs1) and cytokines expression levels are associated with several pregnancy-induced complications. We evaluated the profile of circulating miRNAs (miR-17, miR-29a and miR-181a) and proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-17) in women with gestational diabetes mellitus (GDM2), as well as their potential use as GDM biomarkers. The case-control study included 65 pregnant women divided into 2 groups - GDM and control. Expression levels of miRNAs in plasma samples and cytokines mRNA isolated from peripheral blood buffy coat were analyzed by quantitative real-time PCR (qPCR3). Significant miR-29a downregulation was found in GDM compared to the control group, and was even more significant after adjustments for covariates. miR-17 and miR-181a expression levels did not differ between the examined groups. Expression levels of IL-1β were significantly higher in GDM group compared to controls, while TNF-α, IL-6 and IL-17 did not show significant changes in expression between the two groups. As jugded from the ROC curve analysis, miR-29a and IL-1β had a significant capacity to discriminate between CG and GDM. Additionally, a positive correlation was established between IL-1β and TNF-α in the GDM group. GDM appeared to be associated with altered levels of miR-29a and IL-1β making them markers of this condition.
PB  - Elsevier B.V.
T2  - Journal of Reproductive Immunology
T1  - Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus
VL  - 162
SP  - 104211
DO  - 10.1016/j.jri.2024.104211
ER  - 

@article{
author = "Toljić, Mina and Nikolić, Nađa and Joksić, Ivana and Čarkić, Jelena and Munjas, Jelena and Karadžov Orlić, Nataša and Milašin, Jelena",
year = "2024",
abstract = "Altered microRNAs (miRNAs1) and cytokines expression levels are associated with several pregnancy-induced complications. We evaluated the profile of circulating miRNAs (miR-17, miR-29a and miR-181a) and proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-17) in women with gestational diabetes mellitus (GDM2), as well as their potential use as GDM biomarkers. The case-control study included 65 pregnant women divided into 2 groups - GDM and control. Expression levels of miRNAs in plasma samples and cytokines mRNA isolated from peripheral blood buffy coat were analyzed by quantitative real-time PCR (qPCR3). Significant miR-29a downregulation was found in GDM compared to the control group, and was even more significant after adjustments for covariates. miR-17 and miR-181a expression levels did not differ between the examined groups. Expression levels of IL-1β were significantly higher in GDM group compared to controls, while TNF-α, IL-6 and IL-17 did not show significant changes in expression between the two groups. As jugded from the ROC curve analysis, miR-29a and IL-1β had a significant capacity to discriminate between CG and GDM. Additionally, a positive correlation was established between IL-1β and TNF-α in the GDM group. GDM appeared to be associated with altered levels of miR-29a and IL-1β making them markers of this condition.",
publisher = "Elsevier B.V.",
journal = "Journal of Reproductive Immunology",
title = "Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus",
volume = "162",
pages = "104211",
doi = "10.1016/j.jri.2024.104211"
}

Toljić, M., Nikolić, N., Joksić, I., Čarkić, J., Munjas, J., Karadžov Orlić, N.,& Milašin, J.. (2024). Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus. in Journal of Reproductive Immunology
Elsevier B.V.., 162, 104211.
https://doi.org/10.1016/j.jri.2024.104211

Toljić M, Nikolić N, Joksić I, Čarkić J, Munjas J, Karadžov Orlić N, Milašin J. Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus. in Journal of Reproductive Immunology. 2024;162:104211.
doi:10.1016/j.jri.2024.104211 .

Toljić, Mina, Nikolić, Nađa, Joksić, Ivana, Čarkić, Jelena, Munjas, Jelena, Karadžov Orlić, Nataša, Milašin, Jelena, "Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus" in Journal of Reproductive Immunology, 162 (2024):104211,
https://doi.org/10.1016/j.jri.2024.104211 . .

TY  - JOUR
AU  - Vasović, Dolika D.
AU  - Ivković, Sanja
AU  - Živanović, Ana
AU  - Major, Tamara
AU  - Milašin, Jelena M.
AU  - Nikolić, Nađa S.
AU  - Simonović, Jelena
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Stanojlović, Olivera
AU  - Vesković, Milena
AU  - Rašić, Dejan M.
AU  - Mladenović, Dušan
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5611
AB  - Diabetic retinopathy is not cured efficiently and changes of lifestyle measures may delay early retinal injury in
diabetes. The aim of our study was to investigate the effects of reduced daily light exposure on retinal vascular
changes in streptozotocin (STZ)-induced model of DM with emphasis on inflammation, Aqp4 expression, visual
cycle and cholesterol metabolism-related gene expression in rat retina and RPE. Male Wistar rats were divided
into the following groups: 1. control; 2. diabetic group (DM) treated with streptozotocin (100 mg/kg); 3. group
exposed to light/dark cycle 6/18 h (6/18); 4. diabetic group exposed to light/dark cycle 6/18 h (DM+6/18).
Retinal vascular abnormalities were estimated based on lectin staining, while the expression of genes involved in
the visual cycle, cholesterol metabolism, and inflammation was determined by qRT-PCR. Reduced light exposure
alleviated vasculopathy, gliosis and the expression of IL-1 and TNF-α in the retina with increased perivascular
Aqp4 expression. The expression of genes involved in visual cycle and cholesterol metabolism was significantly
up-regulated in RPE in DM+6/18 vs. DM group. In the retina only the expression of APOE was significantly
higher in DM+6/18 vs. DM group. Reduced light exposure mitigates vascular changes and gliosis in DM via its
anti-inflammatory effect, increased retinal cholesterol turnover and perivascular Aqp4 expression.
PB  - Elsevier
T2  - Chemico-Biological Interactions
T1  - Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover
VL  - 394
SP  - 110996
DO  - 10.1016/j.cbi.2024.110996
ER  - 

@article{
author = "Vasović, Dolika D. and Ivković, Sanja and Živanović, Ana and Major, Tamara and Milašin, Jelena M. and Nikolić, Nađa S. and Simonović, Jelena and Šutulović, Nikola and Hrnčić, Dragan and Stanojlović, Olivera and Vesković, Milena and Rašić, Dejan M. and Mladenović, Dušan",
year = "2024",
abstract = "Diabetic retinopathy is not cured efficiently and changes of lifestyle measures may delay early retinal injury in
diabetes. The aim of our study was to investigate the effects of reduced daily light exposure on retinal vascular
changes in streptozotocin (STZ)-induced model of DM with emphasis on inflammation, Aqp4 expression, visual
cycle and cholesterol metabolism-related gene expression in rat retina and RPE. Male Wistar rats were divided
into the following groups: 1. control; 2. diabetic group (DM) treated with streptozotocin (100 mg/kg); 3. group
exposed to light/dark cycle 6/18 h (6/18); 4. diabetic group exposed to light/dark cycle 6/18 h (DM+6/18).
Retinal vascular abnormalities were estimated based on lectin staining, while the expression of genes involved in
the visual cycle, cholesterol metabolism, and inflammation was determined by qRT-PCR. Reduced light exposure
alleviated vasculopathy, gliosis and the expression of IL-1 and TNF-α in the retina with increased perivascular
Aqp4 expression. The expression of genes involved in visual cycle and cholesterol metabolism was significantly
up-regulated in RPE in DM+6/18 vs. DM group. In the retina only the expression of APOE was significantly
higher in DM+6/18 vs. DM group. Reduced light exposure mitigates vascular changes and gliosis in DM via its
anti-inflammatory effect, increased retinal cholesterol turnover and perivascular Aqp4 expression.",
publisher = "Elsevier",
journal = "Chemico-Biological Interactions",
title = "Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover",
volume = "394",
pages = "110996",
doi = "10.1016/j.cbi.2024.110996"
}

Vasović, D. D., Ivković, S., Živanović, A., Major, T., Milašin, J. M., Nikolić, N. S., Simonović, J., Šutulović, N., Hrnčić, D., Stanojlović, O., Vesković, M., Rašić, D. M.,& Mladenović, D.. (2024). Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover. in Chemico-Biological Interactions
Elsevier., 394, 110996.
https://doi.org/10.1016/j.cbi.2024.110996

Vasović DD, Ivković S, Živanović A, Major T, Milašin JM, Nikolić NS, Simonović J, Šutulović N, Hrnčić D, Stanojlović O, Vesković M, Rašić DM, Mladenović D. Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover. in Chemico-Biological Interactions. 2024;394:110996.
doi:10.1016/j.cbi.2024.110996 .

Vasović, Dolika D., Ivković, Sanja, Živanović, Ana, Major, Tamara, Milašin, Jelena M., Nikolić, Nađa S., Simonović, Jelena, Šutulović, Nikola, Hrnčić, Dragan, Stanojlović, Olivera, Vesković, Milena, Rašić, Dejan M., Mladenović, Dušan, "Reduced light exposure mitigates streptozotocin-induced vascular changes and gliosis in diabetic retina by an anti-inflammatory effect and increased retinal cholesterol turnover" in Chemico-Biological Interactions, 394 (2024):110996,
https://doi.org/10.1016/j.cbi.2024.110996 . .

TY  - JOUR
AU  - Račić, Anđelka
AU  - Jurišić-Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Vučen, Sonja
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Pecikoza, Uroš
AU  - Bajac, Jelena
AU  - Krajišnik, Danina
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5610
AB  - The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the
residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The
main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient,
containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone
and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between
ketotifen and polymers. Physicochemical and rheological analysis at ambient and simulated physiological conditions, as well as the evaluation of mucoadhesive properties showed that vehicles containing combinations of
polymers have suitable physicochemical and functional properties with demonstrated synergism between
combined polymers (MCH and HPG i.e. SH and HPG). The drug permeability was successfully estimated in vitro
using HCE-T cell-based models. MTT cytotoxicity assay demonstrates that the tested formulations were non-toxic
and well tolerated. In vivo preclinical study on mice revealed that both vehicles containing mixed polymers
enhanced and prolonged the antipruritic/analgesic-like effect of ophthalmic ketotifen. Based on these results,
both combinations of polysaccharide polymers, especially SH-HPG, could be considered as potential new carriers
for ketotifen for ophthalmic use.
PB  - Elsevier
T2  - International Journal of Pharmaceutics
T1  - Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy
VL  - 655
SP  - 124033
DO  - 10.1016/j.ijpharm.2024.124033
ER  - 

@article{
author = "Račić, Anđelka and Jurišić-Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Vučen, Sonja and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Pecikoza, Uroš and Bajac, Jelena and Krajišnik, Danina",
year = "2024",
abstract = "The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the
residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The
main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient,
containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone
and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between
ketotifen and polymers. Physicochemical and rheological analysis at ambient and simulated physiological conditions, as well as the evaluation of mucoadhesive properties showed that vehicles containing combinations of
polymers have suitable physicochemical and functional properties with demonstrated synergism between
combined polymers (MCH and HPG i.e. SH and HPG). The drug permeability was successfully estimated in vitro
using HCE-T cell-based models. MTT cytotoxicity assay demonstrates that the tested formulations were non-toxic
and well tolerated. In vivo preclinical study on mice revealed that both vehicles containing mixed polymers
enhanced and prolonged the antipruritic/analgesic-like effect of ophthalmic ketotifen. Based on these results,
both combinations of polysaccharide polymers, especially SH-HPG, could be considered as potential new carriers
for ketotifen for ophthalmic use.",
publisher = "Elsevier",
journal = "International Journal of Pharmaceutics",
title = "Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy",
volume = "655",
pages = "124033",
doi = "10.1016/j.ijpharm.2024.124033"
}

Račić, A., Jurišić-Dukovski, B., Lovrić, J., Dobričić, V., Vučen, S., Micov, A., Stepanović-Petrović, R., Tomić, M., Pecikoza, U., Bajac, J.,& Krajišnik, D.. (2024). Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy. in International Journal of Pharmaceutics
Elsevier., 655, 124033.
https://doi.org/10.1016/j.ijpharm.2024.124033

Račić A, Jurišić-Dukovski B, Lovrić J, Dobričić V, Vučen S, Micov A, Stepanović-Petrović R, Tomić M, Pecikoza U, Bajac J, Krajišnik D. Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy. in International Journal of Pharmaceutics. 2024;655:124033.
doi:10.1016/j.ijpharm.2024.124033 .

Račić, Anđelka, Jurišić-Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Vučen, Sonja, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Pecikoza, Uroš, Bajac, Jelena, Krajišnik, Danina, "Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy" in International Journal of Pharmaceutics, 655 (2024):124033,
https://doi.org/10.1016/j.ijpharm.2024.124033 . .

TY  - CONF
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Bajić, Vladan
AU  - Brankov, Jovan
AU  - Zhou, Wei
AU  - Brey, Eric
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5608
AB  - INTRODUCTION: Imaging  techniques  based  on  X-ray  phase-contrast  (XPC)  have  shown  tremendous  promise  for applications involving biomaterials and soft tissue formation [1,2].XPC imaging can be applied at higher energy offering the  potential  for  lower  dose  imaging.  Essential  to  the  development  of  this  technique  and  its  routine  use  is  an understanding of the potential damage of X-ray dose on cells and tissues. EXPERIMENTAL: In this study the comet assay, a sensitive assay for DNA damage, was used to evaluate DNA damage on  mesenchymal  stem  cells  (MSCs) exposedto X-ray  irradiation.  We  examined  the  effects  of  early  (immediately following  irradiation)  and  delayed  (24h  post-irradiation) X-ray  effects  caused  by  low  (15mGy)  and  intermediate (150mGy  and  1.5  Gy)  exposure  on  MSCs  during  a  monitoring  period  of  4  weeks  (five  irradiations,  one  weekly).  Cells were submitted to apolychromatic X-ray source (Thermo Fisher PXS10 conditions: voltage 45 kV, source current 160A, source power 7.2 W, source spot size 9 um, photon flux on the sample 7.66106photonss-1mm-2irradiation).Statistical analysis was performedby using Two-way analysis of variance (ANOVA) with Tukey’s multiple comparisons posttest in GraphPad Prism 5.0.A difference at p< 0.05 was considered statistically significant.RESULTS AND DISCUSSION: Resultsof the DNA comet assay indicated that early effects of low-and intermediate-dose of XPC induced an increase in the number of cells with DNA damage after each irradiation, where intermediate-dose (150 mGy and 1.5 Gy) produced significantly higher damage relative to controls. DNA damage induced by low and intermediate doses returned to the control value 24h after the irradiation exposure, suggesting a strong protection of MSCs at the tested doses of XPC irradiation. CONCLUSIONS: The data presented in this studyshows that 24 h after the last of five weekly low and intermediate doses XPC irradiation, the harmful effects on DNA in MSCs were notdetected. The current study reinforces the need of investigating consequences of low and intermediate doses of X-ray PC irradiation in the field of tissue engineering and provide new basis for MSCs using in the clinics.
PB  - Savez hemijskih inženjera, Beograd
C3  - Hemijska industrija
T1  - Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay: Abstract
VL  - 78
IS  - 1S
SP  - 14
EP  - 14
DO  - 10.1016/j.reprotox.2024.108585
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5608
ER  - 

@conference{
author = "Živković, Lada and Spremo-Potparević, Biljana and Bajić, Vladan and Brankov, Jovan and Zhou, Wei and Brey, Eric",
year = "2024",
abstract = "INTRODUCTION: Imaging  techniques  based  on  X-ray  phase-contrast  (XPC)  have  shown  tremendous  promise  for applications involving biomaterials and soft tissue formation [1,2].XPC imaging can be applied at higher energy offering the  potential  for  lower  dose  imaging.  Essential  to  the  development  of  this  technique  and  its  routine  use  is  an understanding of the potential damage of X-ray dose on cells and tissues. EXPERIMENTAL: In this study the comet assay, a sensitive assay for DNA damage, was used to evaluate DNA damage on  mesenchymal  stem  cells  (MSCs) exposedto X-ray  irradiation.  We  examined  the  effects  of  early  (immediately following  irradiation)  and  delayed  (24h  post-irradiation) X-ray  effects  caused  by  low  (15mGy)  and  intermediate (150mGy  and  1.5  Gy)  exposure  on  MSCs  during  a  monitoring  period  of  4  weeks  (five  irradiations,  one  weekly).  Cells were submitted to apolychromatic X-ray source (Thermo Fisher PXS10 conditions: voltage 45 kV, source current 160A, source power 7.2 W, source spot size 9 um, photon flux on the sample 7.66106photonss-1mm-2irradiation).Statistical analysis was performedby using Two-way analysis of variance (ANOVA) with Tukey’s multiple comparisons posttest in GraphPad Prism 5.0.A difference at p< 0.05 was considered statistically significant.RESULTS AND DISCUSSION: Resultsof the DNA comet assay indicated that early effects of low-and intermediate-dose of XPC induced an increase in the number of cells with DNA damage after each irradiation, where intermediate-dose (150 mGy and 1.5 Gy) produced significantly higher damage relative to controls. DNA damage induced by low and intermediate doses returned to the control value 24h after the irradiation exposure, suggesting a strong protection of MSCs at the tested doses of XPC irradiation. CONCLUSIONS: The data presented in this studyshows that 24 h after the last of five weekly low and intermediate doses XPC irradiation, the harmful effects on DNA in MSCs were notdetected. The current study reinforces the need of investigating consequences of low and intermediate doses of X-ray PC irradiation in the field of tissue engineering and provide new basis for MSCs using in the clinics.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay: Abstract",
volume = "78",
number = "1S",
pages = "14-14",
doi = "10.1016/j.reprotox.2024.108585",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5608"
}

Živković, L., Spremo-Potparević, B., Bajić, V., Brankov, J., Zhou, W.,& Brey, E.. (2024). Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay: Abstract. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 78(1S), 14-14.
https://doi.org/10.1016/j.reprotox.2024.108585
https://hdl.handle.net/21.15107/rcub_farfar_5608

Živković L, Spremo-Potparević B, Bajić V, Brankov J, Zhou W, Brey E. Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay: Abstract. in Hemijska industrija. 2024;78(1S):14-14.
doi:10.1016/j.reprotox.2024.108585
https://hdl.handle.net/21.15107/rcub_farfar_5608 .

Živković, Lada, Spremo-Potparević, Biljana, Bajić, Vladan, Brankov, Jovan, Zhou, Wei, Brey, Eric, "Examination of the effects of X-ray phase contrast imaging dose on DNA in mesenchymal stem cells by comet assay: Abstract" in Hemijska industrija, 78, no. 1S (2024):14-14,
https://doi.org/10.1016/j.reprotox.2024.108585 .,
https://hdl.handle.net/21.15107/rcub_farfar_5608 .

TY  - JOUR
AU  - Varga, Filip
AU  - Liber, Zlatko
AU  - Turudić, Ante
AU  - Jakše, Jernej
AU  - Juzbašić, Lea
AU  - Jeran, Nina
AU  - Grdiša, Martina
AU  - Zbiljić, Miloš
AU  - Šatović, Zlatko
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5609
AB  - Teucrium montanum L. and T. capitatum L. are two plant species with overlapping distribution
in the Balkan Peninsula, especially in Croatia, where several occurrences of their putative hybrid
species T. × rohlenae have been recorded. Next-generation sequencing of both species and de novo
assembly was carried out resulting in 120 contigs for T. montanum and 1685 contigs for T. capitatum
assembled. The Dig-up primers pipeline was used for SSR mining of both assemblies, applying
different criteria that resulted in 112 SSR candidates for testing. A subset of 41 SSRs was selected and
after two rounds of testing, twelve SSRs were developed and characterized. A total of 232 alleles
were detected with 5 to 29 alleles per locus, based on the test sample. The genetic diversity analysis
of three Teucrium taxa from a single location revealed a higher level of diversity in T. montanum
than in T. capitatum with intermediate values for the hybrid species. The NeighborNet diagram and
genetic structure analysis grouped the taxa into two separate clusters, the first of which consisted
exclusively of T. montanum, while the other was composed of intermixed T. capitatum and T. × rohlenae
individuals. The availability of SSR markers for two Teucrium taxa will allow in-depth analysis
of genetic diversity and structure, as well as molecular identification of their putative hybrids in
the future.
PB  - MDPI
T2  - Diversity
T1  - Joint Identification and Application of Microsatellite Markers in Genetic Diversity Study of Closely Related Species Teucrium montanum, T. capitatum and Their Natural Hybrid
VL  - 16
IS  - 4
SP  - 204
DO  - 10.3390/d16040206
ER  - 

@article{
author = "Varga, Filip and Liber, Zlatko and Turudić, Ante and Jakše, Jernej and Juzbašić, Lea and Jeran, Nina and Grdiša, Martina and Zbiljić, Miloš and Šatović, Zlatko",
year = "2024",
abstract = "Teucrium montanum L. and T. capitatum L. are two plant species with overlapping distribution
in the Balkan Peninsula, especially in Croatia, where several occurrences of their putative hybrid
species T. × rohlenae have been recorded. Next-generation sequencing of both species and de novo
assembly was carried out resulting in 120 contigs for T. montanum and 1685 contigs for T. capitatum
assembled. The Dig-up primers pipeline was used for SSR mining of both assemblies, applying
different criteria that resulted in 112 SSR candidates for testing. A subset of 41 SSRs was selected and
after two rounds of testing, twelve SSRs were developed and characterized. A total of 232 alleles
were detected with 5 to 29 alleles per locus, based on the test sample. The genetic diversity analysis
of three Teucrium taxa from a single location revealed a higher level of diversity in T. montanum
than in T. capitatum with intermediate values for the hybrid species. The NeighborNet diagram and
genetic structure analysis grouped the taxa into two separate clusters, the first of which consisted
exclusively of T. montanum, while the other was composed of intermixed T. capitatum and T. × rohlenae
individuals. The availability of SSR markers for two Teucrium taxa will allow in-depth analysis
of genetic diversity and structure, as well as molecular identification of their putative hybrids in
the future.",
publisher = "MDPI",
journal = "Diversity",
title = "Joint Identification and Application of Microsatellite Markers in Genetic Diversity Study of Closely Related Species Teucrium montanum, T. capitatum and Their Natural Hybrid",
volume = "16",
number = "4",
pages = "204",
doi = "10.3390/d16040206"
}

Varga, F., Liber, Z., Turudić, A., Jakše, J., Juzbašić, L., Jeran, N., Grdiša, M., Zbiljić, M.,& Šatović, Z.. (2024). Joint Identification and Application of Microsatellite Markers in Genetic Diversity Study of Closely Related Species Teucrium montanum, T. capitatum and Their Natural Hybrid. in Diversity
MDPI., 16(4), 204.
https://doi.org/10.3390/d16040206

Varga F, Liber Z, Turudić A, Jakše J, Juzbašić L, Jeran N, Grdiša M, Zbiljić M, Šatović Z. Joint Identification and Application of Microsatellite Markers in Genetic Diversity Study of Closely Related Species Teucrium montanum, T. capitatum and Their Natural Hybrid. in Diversity. 2024;16(4):204.
doi:10.3390/d16040206 .

Varga, Filip, Liber, Zlatko, Turudić, Ante, Jakše, Jernej, Juzbašić, Lea, Jeran, Nina, Grdiša, Martina, Zbiljić, Miloš, Šatović, Zlatko, "Joint Identification and Application of Microsatellite Markers in Genetic Diversity Study of Closely Related Species Teucrium montanum, T. capitatum and Their Natural Hybrid" in Diversity, 16, no. 4 (2024):204,
https://doi.org/10.3390/d16040206 . .

TY  - JOUR
AU  - Kovačević, Milena
AU  - Ivanović, Nevena
AU  - Protić, Ana
AU  - Milenković, Danijela
AU  - Mandinić, Zoran
AU  - Puzović, Dragana
AU  - Bajčetić, Miloš
AU  - Popadić, Dušan
AU  - Parojčić, Jelena
AU  - Malenović, Anđelija
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5596
AB  - Digital transformation in education and relevant calls for action are recognised global priorities aimed to support education and training in the digital age. The experiences from the emergency remote teaching during the COVID-19 pandemic and recent research findings reveal relevant advantages, challenges, as well as different students and teaching staff perspectives which should be carefully considered and integrated into institutional strategies and policies to improve and enrich students’ learning experience. The present study aimed to explore health sciences students' perspectives on online teaching and learning (T&L) in four domains—Satisfaction, Motivation, Interaction and Challenges, and to identify the preferred T&L models or tools. A total of 1,041 responses were collected, including 476 dental medicine (45.7%), 399 pharmacy (38.3%), and 166 medical students (15.9%). Overall Satisfaction was quite high (4.0 ± 1.2; out of 5), followed by satisfactory Interaction (3.4 ± 1.4), whereas Motivation was quite low on average (3.0 ± 1.5). Challenges in online T&L were not markedly expressed (3.0 ± 1.6). The majority of students (46.6%) opted for the blended model as the preferred T&L model. Moodle lessons were perceived as the most useful online T&L tool (45.5% of students), followed by video materials (32.2%). Other T&L tools which require more active student's role, such as short test/quiz, and group or team assignment were declared as less favourable. The findings from the current study may contribute to raising the awareness of academic staff and higher institutions management about the student attitudes and needs related to online T&L and inform institutional planning, decision-making and policy development.
PB  - John Wiley & Sons Ltd
T2  - European Journal of Education
T1  - Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID-19 pandemic
DO  - 10.1111/ejed.12660
ER  - 

@article{
author = "Kovačević, Milena and Ivanović, Nevena and Protić, Ana and Milenković, Danijela and Mandinić, Zoran and Puzović, Dragana and Bajčetić, Miloš and Popadić, Dušan and Parojčić, Jelena and Malenović, Anđelija",
year = "2024",
abstract = "Digital transformation in education and relevant calls for action are recognised global priorities aimed to support education and training in the digital age. The experiences from the emergency remote teaching during the COVID-19 pandemic and recent research findings reveal relevant advantages, challenges, as well as different students and teaching staff perspectives which should be carefully considered and integrated into institutional strategies and policies to improve and enrich students’ learning experience. The present study aimed to explore health sciences students' perspectives on online teaching and learning (T&L) in four domains—Satisfaction, Motivation, Interaction and Challenges, and to identify the preferred T&L models or tools. A total of 1,041 responses were collected, including 476 dental medicine (45.7%), 399 pharmacy (38.3%), and 166 medical students (15.9%). Overall Satisfaction was quite high (4.0 ± 1.2; out of 5), followed by satisfactory Interaction (3.4 ± 1.4), whereas Motivation was quite low on average (3.0 ± 1.5). Challenges in online T&L were not markedly expressed (3.0 ± 1.6). The majority of students (46.6%) opted for the blended model as the preferred T&L model. Moodle lessons were perceived as the most useful online T&L tool (45.5% of students), followed by video materials (32.2%). Other T&L tools which require more active student's role, such as short test/quiz, and group or team assignment were declared as less favourable. The findings from the current study may contribute to raising the awareness of academic staff and higher institutions management about the student attitudes and needs related to online T&L and inform institutional planning, decision-making and policy development.",
publisher = "John Wiley & Sons Ltd",
journal = "European Journal of Education",
title = "Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID-19 pandemic",
doi = "10.1111/ejed.12660"
}

Kovačević, M., Ivanović, N., Protić, A., Milenković, D., Mandinić, Z., Puzović, D., Bajčetić, M., Popadić, D., Parojčić, J.,& Malenović, A.. (2024). Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID-19 pandemic. in European Journal of Education
John Wiley & Sons Ltd..
https://doi.org/10.1111/ejed.12660

Kovačević M, Ivanović N, Protić A, Milenković D, Mandinić Z, Puzović D, Bajčetić M, Popadić D, Parojčić J, Malenović A. Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID-19 pandemic. in European Journal of Education. 2024;.
doi:10.1111/ejed.12660 .

Kovačević, Milena, Ivanović, Nevena, Protić, Ana, Milenković, Danijela, Mandinić, Zoran, Puzović, Dragana, Bajčetić, Miloš, Popadić, Dušan, Parojčić, Jelena, Malenović, Anđelija, "Health sciences students' perspectives on online teaching and learning: Extending the implications beyond the COVID-19 pandemic" in European Journal of Education (2024),
https://doi.org/10.1111/ejed.12660 . .

TY  - JOUR
AU  - Popović-Nikolić, Marija
AU  - Čakar, Mira
AU  - Todorović, Nina
AU  - Nikolić, Katarina
AU  - Popović, Gordana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5589
AB  - The acid–base equilibria of raloxifene and the mutual influence of pH and solubility enhancers on the solubility of raloxifene
hydrochloride were studied. The apparent ionization constants (pKa*) of raloxifene were determined potentiometrically in
methanol–water mixtures (45%-55% w/w), and the pKa values (pKa1 = 7.21 ± 0.02, pKa2 = 7.86 ± 0.02, pKa3 = 9.97 ± 0.04)
defining ionization in aqueous media were obtained by extrapolating the pKa* values to 0% of methanol. The obtained pKa
values were assigned to the corresponding ionization centers. Based on the ionization constants obtained in this study, the
distribution of the equilibrium forms of raloxifene was calculated. The solubility of raloxifene hydrochloride in 0.01 M
HCl, acetate buffer pH 4.5 and phosphate buffer pH 6.8 was studied with and without the presence of β-CD, HP-β-CD and
polysorbate 80. The most effective solubility enhancer of raloxifene hydrochloride in 0.01 M HCl was polysorbate 80 at a
concentration of 0.5%, while the influence of this enhancer in phosphate buffer pH 6.8 was negligible. The highest solubility
of raloxifene hydrochloride in acetate and phosphate buffer was achieved in the presence of 10–
3 M HP–β-CD which
was 1.3-fold higher in both 0.01 M HCl and acetate buffer and 2.3-fold higher in phosphate buffer than in the presence of
10–
3 M β-CD.
PB  - Springer Nature
T2  - Chemical Papers
T1  - Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride
DO  - 10.1007/s11696-024-03399-1
ER  - 

@article{
author = "Popović-Nikolić, Marija and Čakar, Mira and Todorović, Nina and Nikolić, Katarina and Popović, Gordana",
year = "2024",
abstract = "The acid–base equilibria of raloxifene and the mutual influence of pH and solubility enhancers on the solubility of raloxifene
hydrochloride were studied. The apparent ionization constants (pKa*) of raloxifene were determined potentiometrically in
methanol–water mixtures (45%-55% w/w), and the pKa values (pKa1 = 7.21 ± 0.02, pKa2 = 7.86 ± 0.02, pKa3 = 9.97 ± 0.04)
defining ionization in aqueous media were obtained by extrapolating the pKa* values to 0% of methanol. The obtained pKa
values were assigned to the corresponding ionization centers. Based on the ionization constants obtained in this study, the
distribution of the equilibrium forms of raloxifene was calculated. The solubility of raloxifene hydrochloride in 0.01 M
HCl, acetate buffer pH 4.5 and phosphate buffer pH 6.8 was studied with and without the presence of β-CD, HP-β-CD and
polysorbate 80. The most effective solubility enhancer of raloxifene hydrochloride in 0.01 M HCl was polysorbate 80 at a
concentration of 0.5%, while the influence of this enhancer in phosphate buffer pH 6.8 was negligible. The highest solubility
of raloxifene hydrochloride in acetate and phosphate buffer was achieved in the presence of 10–
3 M HP–β-CD which
was 1.3-fold higher in both 0.01 M HCl and acetate buffer and 2.3-fold higher in phosphate buffer than in the presence of
10–
3 M β-CD.",
publisher = "Springer Nature",
journal = "Chemical Papers",
title = "Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride",
doi = "10.1007/s11696-024-03399-1"
}

Popović-Nikolić, M., Čakar, M., Todorović, N., Nikolić, K.,& Popović, G.. (2024). Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride. in Chemical Papers
Springer Nature..
https://doi.org/10.1007/s11696-024-03399-1

Popović-Nikolić M, Čakar M, Todorović N, Nikolić K, Popović G. Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride. in Chemical Papers. 2024;.
doi:10.1007/s11696-024-03399-1 .

Popović-Nikolić, Marija, Čakar, Mira, Todorović, Nina, Nikolić, Katarina, Popović, Gordana, "Study on protolytic equilibria and the effects of pH, cyclodextrins and polysorbate 80 on solubility of raloxifene hydrochloride" in Chemical Papers (2024),
https://doi.org/10.1007/s11696-024-03399-1 . .

TY  - JOUR
AU  - Kováčiková, Lucia
AU  - Gaikwad, Sunil
AU  - Almášiová, Kristína
AU  - Almássy, Ambroz
AU  - Addová, Gabriela
AU  - Májeková, Magdaléna
AU  - Hanquet, Gilles
AU  - Dobričić, Vladimir
AU  - Boháč, Andrej
AU  - Štefek, Milan
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5545
AB  - Novel oxotriazinoindoles (OTIs) were recently reported as highly efficient and selective aldose reductase inhibitors. Here, a series of novel N(2)-substituted oxotriazinoindoles was developed with the aim to investigate molecular interactions within the aldose reductase (ALR2) inhibitor binding site. About twice increased inhibition efficacy of the most efficient derivative 14 (N(2)-CH2CH2COOH) compared to the unsubstituted lead OTI was obtained, yet at the expense of selectivity relative to anti-target aldehyde reductase (ALR1). To explain the major drop in selectivity, observed also in other N(2)-substituted derivatives, in silico molecular modeling approach revealed the role of extra interactions with the residues of Arg309, Arg312 and Met302 located in the additional C-terminal loop of ALR1 missing in ALR2, which can prevent or enhance binding in ALR1. These key findings will be used for development of the next generation of selective OTI inhibitors. (Figure presented.).
PB  - Springer
T2  - Medicinal Chemistry Research
T1  - Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase
VL  - 33
SP  - 492
EP  - 503
DO  - 10.1007/s00044-024-03194-3
ER  - 

@article{
author = "Kováčiková, Lucia and Gaikwad, Sunil and Almášiová, Kristína and Almássy, Ambroz and Addová, Gabriela and Májeková, Magdaléna and Hanquet, Gilles and Dobričić, Vladimir and Boháč, Andrej and Štefek, Milan",
year = "2024",
abstract = "Novel oxotriazinoindoles (OTIs) were recently reported as highly efficient and selective aldose reductase inhibitors. Here, a series of novel N(2)-substituted oxotriazinoindoles was developed with the aim to investigate molecular interactions within the aldose reductase (ALR2) inhibitor binding site. About twice increased inhibition efficacy of the most efficient derivative 14 (N(2)-CH2CH2COOH) compared to the unsubstituted lead OTI was obtained, yet at the expense of selectivity relative to anti-target aldehyde reductase (ALR1). To explain the major drop in selectivity, observed also in other N(2)-substituted derivatives, in silico molecular modeling approach revealed the role of extra interactions with the residues of Arg309, Arg312 and Met302 located in the additional C-terminal loop of ALR1 missing in ALR2, which can prevent or enhance binding in ALR1. These key findings will be used for development of the next generation of selective OTI inhibitors. (Figure presented.).",
publisher = "Springer",
journal = "Medicinal Chemistry Research",
title = "Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase",
volume = "33",
pages = "492-503",
doi = "10.1007/s00044-024-03194-3"
}

Kováčiková, L., Gaikwad, S., Almášiová, K., Almássy, A., Addová, G., Májeková, M., Hanquet, G., Dobričić, V., Boháč, A.,& Štefek, M.. (2024). Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase. in Medicinal Chemistry Research
Springer., 33, 492-503.
https://doi.org/10.1007/s00044-024-03194-3

Kováčiková L, Gaikwad S, Almášiová K, Almássy A, Addová G, Májeková M, Hanquet G, Dobričić V, Boháč A, Štefek M. Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase. in Medicinal Chemistry Research. 2024;33:492-503.
doi:10.1007/s00044-024-03194-3 .

Kováčiková, Lucia, Gaikwad, Sunil, Almášiová, Kristína, Almássy, Ambroz, Addová, Gabriela, Májeková, Magdaléna, Hanquet, Gilles, Dobričić, Vladimir, Boháč, Andrej, Štefek, Milan, "Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase" in Medicinal Chemistry Research, 33 (2024):492-503,
https://doi.org/10.1007/s00044-024-03194-3 . .

TY  - JOUR
AU  - Pelgrim, Teuntje A. D.
AU  - Philipsen, Alexandra
AU  - Young, Allan H.
AU  - Juruena, Mario
AU  - Jimenez, Ester
AU  - Vieta, Eduard
AU  - Jukić, Marin
AU  - Van der Eycken, Erik
AU  - Heilbronner, Urs
AU  - Moldovan, Ramona
AU  - Kas, Martien J. H.
AU  - Jagesar, Raj R.
AU  - Nöthen, Markus M.
AU  - Hoffmann, Per
AU  - Shomron, Noam
AU  - Kilarski, Laura L
AU  - van Amelsvoort, Thérèse
AU  - Campforts, Bea
AU  - van Westrhenen, Roos
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5548
AB  - (1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent treatment failure, often because of side effects, and a long process of trial-and-error pharmacotherapy until an effective and tolerable treatment is found. This notion emphasizes the urgency for a personalized medicine approach in psychiatry. (2) Methods This prospective patient- and rater-blinded, randomized, controlled study will investigate the effect of dose-adjustment of antidepressants escitalopram and sertraline or antipsychotics risperidone and aripiprazole according to the latest state-of-the-art international dosing recommendations for CYP2C19 and CYP2D6 metabolizer status in patients with mood, anxiety, and psychotic disorders. A total sample of N = 2500 will be recruited at nine sites in seven countries (expected drop-out rate of 30%). Patients will be randomized to a pharmacogenetic group or a dosing-as-usual group and treated over a 24-week period with four study visits. The primary outcome is personal recovery using the Recovery Assessment Scale as assessed by the patient (RAS-DS), with secondary outcomes including clinical effects (response or symptomatic remission), side effects, general well-being, digital phenotyping, and psychosocial functioning. (3) Conclusions This is, to our knowledge, the first international, multi-center, non-industry-sponsored randomized controlled trial (RCT) that may provide insights into the effectiveness and utility of implementing pharmacogenetic-guided treatment of psychiatric disorders, and as such, results will be incorporated in already available dosing guidelines.
PB  - MDPI
T2  - Pharmaceuticals
T1  - A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study
VL  - 17
IS  - 2
DO  - 10.3390/ph17020151
ER  - 

@article{
author = "Pelgrim, Teuntje A. D. and Philipsen, Alexandra and Young, Allan H. and Juruena, Mario and Jimenez, Ester and Vieta, Eduard and Jukić, Marin and Van der Eycken, Erik and Heilbronner, Urs and Moldovan, Ramona and Kas, Martien J. H. and Jagesar, Raj R. and Nöthen, Markus M. and Hoffmann, Per and Shomron, Noam and Kilarski, Laura L and van Amelsvoort, Thérèse and Campforts, Bea and van Westrhenen, Roos",
year = "2024",
abstract = "(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent treatment failure, often because of side effects, and a long process of trial-and-error pharmacotherapy until an effective and tolerable treatment is found. This notion emphasizes the urgency for a personalized medicine approach in psychiatry. (2) Methods This prospective patient- and rater-blinded, randomized, controlled study will investigate the effect of dose-adjustment of antidepressants escitalopram and sertraline or antipsychotics risperidone and aripiprazole according to the latest state-of-the-art international dosing recommendations for CYP2C19 and CYP2D6 metabolizer status in patients with mood, anxiety, and psychotic disorders. A total sample of N = 2500 will be recruited at nine sites in seven countries (expected drop-out rate of 30%). Patients will be randomized to a pharmacogenetic group or a dosing-as-usual group and treated over a 24-week period with four study visits. The primary outcome is personal recovery using the Recovery Assessment Scale as assessed by the patient (RAS-DS), with secondary outcomes including clinical effects (response or symptomatic remission), side effects, general well-being, digital phenotyping, and psychosocial functioning. (3) Conclusions This is, to our knowledge, the first international, multi-center, non-industry-sponsored randomized controlled trial (RCT) that may provide insights into the effectiveness and utility of implementing pharmacogenetic-guided treatment of psychiatric disorders, and as such, results will be incorporated in already available dosing guidelines.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study",
volume = "17",
number = "2",
doi = "10.3390/ph17020151"
}

Pelgrim, T. A. D., Philipsen, A., Young, A. H., Juruena, M., Jimenez, E., Vieta, E., Jukić, M., Van der Eycken, E., Heilbronner, U., Moldovan, R., Kas, M. J. H., Jagesar, R. R., Nöthen, M. M., Hoffmann, P., Shomron, N., Kilarski, L. L., van Amelsvoort, T., Campforts, B.,& van Westrhenen, R.. (2024). A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study. in Pharmaceuticals
MDPI., 17(2).
https://doi.org/10.3390/ph17020151

Pelgrim TAD, Philipsen A, Young AH, Juruena M, Jimenez E, Vieta E, Jukić M, Van der Eycken E, Heilbronner U, Moldovan R, Kas MJH, Jagesar RR, Nöthen MM, Hoffmann P, Shomron N, Kilarski LL, van Amelsvoort T, Campforts B, van Westrhenen R. A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study. in Pharmaceuticals. 2024;17(2).
doi:10.3390/ph17020151 .

Pelgrim, Teuntje A. D., Philipsen, Alexandra, Young, Allan H., Juruena, Mario, Jimenez, Ester, Vieta, Eduard, Jukić, Marin, Van der Eycken, Erik, Heilbronner, Urs, Moldovan, Ramona, Kas, Martien J. H., Jagesar, Raj R., Nöthen, Markus M., Hoffmann, Per, Shomron, Noam, Kilarski, Laura L, van Amelsvoort, Thérèse, Campforts, Bea, van Westrhenen, Roos, "A New Intervention for Implementation of Pharmacogenetics in Psychiatry: A Description of the PSY-PGx Clinical Study" in Pharmaceuticals, 17, no. 2 (2024),
https://doi.org/10.3390/ph17020151 . .

TY  - JOUR
AU  - Obradović, Darija
AU  - Savić, Jelena
AU  - Joksimović, Jovana
AU  - Marković, Bojan
AU  - Vujić, Zorica
AU  - Lazović, Saša
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5549
AB  - Abstract: The retention profile of six serotonin receptor ligands such as arylpiperazines (aripiprazole, ziprasidone, risperidone), and benzothiazepine derivatives (olanzapine, mianserin, quetiapine), was investigated on C8 alkyl and pentafluorophenylpropyl stationary phases. The experimental design methodology was used to define their retention behavior and achieve acceptable separation results. Both phases showed satisfactory selectivity for all compounds. The optimal separation among the structurally related arylpiperazines and benzothiazepines was found with the C8 phase at 25°C, using acetonitrile (40%, v/v) and 20 mM ammonium acetate as a mobile phase modifier. The selectivity and sensitivity performances of the selected C8 system were discussed considering the separation of aripiprazole and its related compounds. In addition, the specified conditions were validated for determining aripiprazole in pharmaceutical dosage forms. The developed reversed-phase high-performance liquid chromatography method can be successfully used for the rapid chromatographic profiling of serotonin receptor ligands and related analogs, providing increased selectivity during pharmaceutical analysis.
PB  - Pleiades Publishing
T2  - Journal of Analytical Chemistry
T1  - Rapid Reversed-Phase High-Performance Liquid Chromatography Profiling of Serotonin Receptor Ligands and their Related Compounds
VL  - 79
IS  - 1
SP  - 95
EP  - 104
DO  - 10.1134/S1061934824010076
ER  - 

@article{
author = "Obradović, Darija and Savić, Jelena and Joksimović, Jovana and Marković, Bojan and Vujić, Zorica and Lazović, Saša",
year = "2024",
abstract = "Abstract: The retention profile of six serotonin receptor ligands such as arylpiperazines (aripiprazole, ziprasidone, risperidone), and benzothiazepine derivatives (olanzapine, mianserin, quetiapine), was investigated on C8 alkyl and pentafluorophenylpropyl stationary phases. The experimental design methodology was used to define their retention behavior and achieve acceptable separation results. Both phases showed satisfactory selectivity for all compounds. The optimal separation among the structurally related arylpiperazines and benzothiazepines was found with the C8 phase at 25°C, using acetonitrile (40%, v/v) and 20 mM ammonium acetate as a mobile phase modifier. The selectivity and sensitivity performances of the selected C8 system were discussed considering the separation of aripiprazole and its related compounds. In addition, the specified conditions were validated for determining aripiprazole in pharmaceutical dosage forms. The developed reversed-phase high-performance liquid chromatography method can be successfully used for the rapid chromatographic profiling of serotonin receptor ligands and related analogs, providing increased selectivity during pharmaceutical analysis.",
publisher = "Pleiades Publishing",
journal = "Journal of Analytical Chemistry",
title = "Rapid Reversed-Phase High-Performance Liquid Chromatography Profiling of Serotonin Receptor Ligands and their Related Compounds",
volume = "79",
number = "1",
pages = "95-104",
doi = "10.1134/S1061934824010076"
}

Obradović, D., Savić, J., Joksimović, J., Marković, B., Vujić, Z.,& Lazović, S.. (2024). Rapid Reversed-Phase High-Performance Liquid Chromatography Profiling of Serotonin Receptor Ligands and their Related Compounds. in Journal of Analytical Chemistry
Pleiades Publishing., 79(1), 95-104.
https://doi.org/10.1134/S1061934824010076

Obradović D, Savić J, Joksimović J, Marković B, Vujić Z, Lazović S. Rapid Reversed-Phase High-Performance Liquid Chromatography Profiling of Serotonin Receptor Ligands and their Related Compounds. in Journal of Analytical Chemistry. 2024;79(1):95-104.
doi:10.1134/S1061934824010076 .

Obradović, Darija, Savić, Jelena, Joksimović, Jovana, Marković, Bojan, Vujić, Zorica, Lazović, Saša, "Rapid Reversed-Phase High-Performance Liquid Chromatography Profiling of Serotonin Receptor Ligands and their Related Compounds" in Journal of Analytical Chemistry, 79, no. 1 (2024):95-104,
https://doi.org/10.1134/S1061934824010076 . .

TY  - JOUR
AU  - Senćanski, Dejan
AU  - Marinković, Valentina
AU  - Milošević-Georgiev, Andrijana
AU  - Tadić, Ivana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5550
AB  - Background: Emotional Intelligence (EI) has been recognized by the International Pharmaceutical Federation as a required competency for a pharmacist. This study aimed to compare EI and Perceived Stress (PS) levels in pharmacists who completed the post-graduate specialization program (the Case), and pharmacists who started the program (the Control group). Materials and Methods: Validated instruments measuring EI and PS were distributed online to participating postgraduates or alumni. All complete responses were analyzed; data from participants who had undergone previous EI training were excluded. Comparing the groups, additional EI domains’ subanalysis and their correlations with PS were made. Results: The overall response rate was 67.8%. There was no expected difference between the groups either in EI or in the PS levels, and the overall population reached means of 119.30±12.92 and 17.25±6.46, respectively. The highest EI levels were found in sales and marketing professionals in the pharmaceutical industry and the lowest in clinical pharmacy practitioners. EI and PS were highly negatively correlated (r=-0,543), thus indicating that developing EI may have protective effects against stress. Subanalysis revealed the highest potential for stress-protective effects in the Emotional Self-Management and Emotional Self-Control subdomains (r=-0,528, r=-0,457, respectively). Conclusion: Given the expanded importance of EI development in pharmacy practice, the results of the study could be a basis for the specialization and continuing pharmacist education program creators to evaluate the curricula and propose changes in the methodologies, contents, and approaches in work to meet development needs of post-graduate pharmacists better. Further research should confirm the findings of the EI subanalysis.
PB  - Association of Pharmaceutical Teachers of India
T2  - Indian Journal of Pharmaceutical Education and Research
T1  - Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study
VL  - 58
IS  - 2
SP  - 671
EP  - 678
DO  - 10.5530/ijper.58.2.75
ER  - 

@article{
author = "Senćanski, Dejan and Marinković, Valentina and Milošević-Georgiev, Andrijana and Tadić, Ivana",
year = "2024",
abstract = "Background: Emotional Intelligence (EI) has been recognized by the International Pharmaceutical Federation as a required competency for a pharmacist. This study aimed to compare EI and Perceived Stress (PS) levels in pharmacists who completed the post-graduate specialization program (the Case), and pharmacists who started the program (the Control group). Materials and Methods: Validated instruments measuring EI and PS were distributed online to participating postgraduates or alumni. All complete responses were analyzed; data from participants who had undergone previous EI training were excluded. Comparing the groups, additional EI domains’ subanalysis and their correlations with PS were made. Results: The overall response rate was 67.8%. There was no expected difference between the groups either in EI or in the PS levels, and the overall population reached means of 119.30±12.92 and 17.25±6.46, respectively. The highest EI levels were found in sales and marketing professionals in the pharmaceutical industry and the lowest in clinical pharmacy practitioners. EI and PS were highly negatively correlated (r=-0,543), thus indicating that developing EI may have protective effects against stress. Subanalysis revealed the highest potential for stress-protective effects in the Emotional Self-Management and Emotional Self-Control subdomains (r=-0,528, r=-0,457, respectively). Conclusion: Given the expanded importance of EI development in pharmacy practice, the results of the study could be a basis for the specialization and continuing pharmacist education program creators to evaluate the curricula and propose changes in the methodologies, contents, and approaches in work to meet development needs of post-graduate pharmacists better. Further research should confirm the findings of the EI subanalysis.",
publisher = "Association of Pharmaceutical Teachers of India",
journal = "Indian Journal of Pharmaceutical Education and Research",
title = "Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study",
volume = "58",
number = "2",
pages = "671-678",
doi = "10.5530/ijper.58.2.75"
}

Senćanski, D., Marinković, V., Milošević-Georgiev, A.,& Tadić, I.. (2024). Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study. in Indian Journal of Pharmaceutical Education and Research
Association of Pharmaceutical Teachers of India., 58(2), 671-678.
https://doi.org/10.5530/ijper.58.2.75

Senćanski D, Marinković V, Milošević-Georgiev A, Tadić I. Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study. in Indian Journal of Pharmaceutical Education and Research. 2024;58(2):671-678.
doi:10.5530/ijper.58.2.75 .

Senćanski, Dejan, Marinković, Valentina, Milošević-Georgiev, Andrijana, Tadić, Ivana, "Emotional Intelligence and Perceived Stress in Pharmacists Completing Post-Graduate Specialization Programs: A Cross-Sectional Study" in Indian Journal of Pharmaceutical Education and Research, 58, no. 2 (2024):671-678,
https://doi.org/10.5530/ijper.58.2.75 . .

TY  - JOUR
AU  - Sopić, Miron
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5555
AB  - The relentless struggle with the aftermath of COVID-19 has driven the medical community to seek innovative methods for predicting and managing the disease’s complications. Complications such as an overactive immune response, manifesting as cytokine storms, and shifts toward a procoagulant state not only exacerbate symptoms but also elevate the risk of mortality and long-term health issues. Consequently, there is a pressing need for novel diagnostic tools and therapeutic strategies that not only track disease progression and complications but also serve as potential drug targets or can be influenced by pharmacological interventions. In the presented study by Perez-Pons et al.1 titled “MicroRNA-centered theranostics for pulmoprotection in critical COVID-19,” the authors shed light on the promising role of microRNAs (miRNAs) as dual-purpose theranostic agents. By focusing on a multicenter cohort of intensive care unit (ICU) survivors, the research elucidates the potential of miRNAs in mitigating diffusion impairment—a common but debilitating consequence of severe infection. This commentary aims to contextualize these findings within the broader spectrum of molecular and cellular therapies, underlining their significance and implications they pose for the field.

Since the outbreak of the COVID-19 pandemic, a significant number of survivors, particularly those who experienced severe illness, have continued to face post-acute pulmonary sequelae. COVID-19 survivors often experience a spectrum of long-term lung issues, with dyspnea being a common symptom reported by 42%–66% of individuals within 60–100 days post-infection.2 Individuals who experienced severe forms of COVID-19, particularly those in need of intensive respiratory support, are more likely to suffer from long-lasting lung issues.2 This includes diffusion impairment, which refers to a decreased ability of the lungs to transfer oxygen from the air into the bloodstream, as well as observable lung damage like pulmonary fibrosis on medical imaging.2 The persistence of these health issues among survivors indicates a substantial impact on their quality of life and the healthcare system, stressing the urgency in identifying effective interventions and support mechanisms for those affected.
T2  - Molecular Therapy: Nucleic Acids
T1  - Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics
VL  - 35
IS  - 1
SP  - 102152
DO  - 10.1016/j.omtn.2024.102152
ER  - 

@article{
author = "Sopić, Miron",
year = "2024",
abstract = "The relentless struggle with the aftermath of COVID-19 has driven the medical community to seek innovative methods for predicting and managing the disease’s complications. Complications such as an overactive immune response, manifesting as cytokine storms, and shifts toward a procoagulant state not only exacerbate symptoms but also elevate the risk of mortality and long-term health issues. Consequently, there is a pressing need for novel diagnostic tools and therapeutic strategies that not only track disease progression and complications but also serve as potential drug targets or can be influenced by pharmacological interventions. In the presented study by Perez-Pons et al.1 titled “MicroRNA-centered theranostics for pulmoprotection in critical COVID-19,” the authors shed light on the promising role of microRNAs (miRNAs) as dual-purpose theranostic agents. By focusing on a multicenter cohort of intensive care unit (ICU) survivors, the research elucidates the potential of miRNAs in mitigating diffusion impairment—a common but debilitating consequence of severe infection. This commentary aims to contextualize these findings within the broader spectrum of molecular and cellular therapies, underlining their significance and implications they pose for the field.

Since the outbreak of the COVID-19 pandemic, a significant number of survivors, particularly those who experienced severe illness, have continued to face post-acute pulmonary sequelae. COVID-19 survivors often experience a spectrum of long-term lung issues, with dyspnea being a common symptom reported by 42%–66% of individuals within 60–100 days post-infection.2 Individuals who experienced severe forms of COVID-19, particularly those in need of intensive respiratory support, are more likely to suffer from long-lasting lung issues.2 This includes diffusion impairment, which refers to a decreased ability of the lungs to transfer oxygen from the air into the bloodstream, as well as observable lung damage like pulmonary fibrosis on medical imaging.2 The persistence of these health issues among survivors indicates a substantial impact on their quality of life and the healthcare system, stressing the urgency in identifying effective interventions and support mechanisms for those affected.",
journal = "Molecular Therapy: Nucleic Acids",
title = "Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics",
volume = "35",
number = "1",
pages = "102152",
doi = "10.1016/j.omtn.2024.102152"
}

Sopić, M.. (2024). Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics. in Molecular Therapy: Nucleic Acids, 35(1), 102152.
https://doi.org/10.1016/j.omtn.2024.102152

Sopić M. Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics. in Molecular Therapy: Nucleic Acids. 2024;35(1):102152.
doi:10.1016/j.omtn.2024.102152 .

Sopić, Miron, "Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics" in Molecular Therapy: Nucleic Acids, 35, no. 1 (2024):102152,
https://doi.org/10.1016/j.omtn.2024.102152 . .

TY  - JOUR
AU  - Milaković, Dragana
AU  - Kovačević, Tijana
AU  - Kovačević, Peđa
AU  - Barišić, Vedrana
AU  - Avram, Sanja
AU  - Dragić, Saša
AU  - Zlojutro, Biljana
AU  - Momčičević, Danica
AU  - Miljković, Branislava
AU  - Vučićević, Katarina
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5557
AB  - During veno-venous extracorporeal membrane oxygenation (vv ECMO) therapy, antimicrobial drugs are frequently used, and appropriate dosing is challenging due to there being limited data to support the dosage. Linezolid is effective against multidrug-resistant Gram-positive pathogens frequently isolated in ECMO patients. In total, 53 steady-state linezolid levels were obtained following 600 mg intravenous (IV) injections every 8 h, and these were used to develop a population pharmacokinetic (PopPK) model in patients with COVID-19-associated acute respiratory distress syndrome (CARDS) on vv ECMO. The data were analyzed using a nonlinear mixed-effects modelling approach. Monte Carlo simulation generated 5000 patients’ individual PK parameters and corresponding concentration–time profiles using the PopPK model, following the administration of 600 mg/8 h (a higher-than-standard dosing) and 600 mg/12 h (standard). The probabilities of pharmacokinetic/pharmacodynamic (PK/PD) target attainment (PTA) and the cumulative fraction of responses (CFR) for three pathogens were calculated and compared between the two dosing scenarios. Linezolid 600 mg/8 h was predicted to achieve greater than or equal to 85%Tf>MIC in at least 90% of the patients with CARDS on vv ECMO compared to only approximately two thirds of the patients after dosing every 12 h at a minimal inhibitory concentration (MIC) of 2 mg/L. In addition, for the same MIC, fAUC24/MIC ≥ 80 was achieved in almost three times the number of patients following an 8-h versus a 12-h interval. PopPK simulation predicted that a significantly higher proportion of the patients with CARDS on vv ECMO would achieve the PK/PD targets following the 8-h dosing interval compared to standard linezolid dosing. Nevertheless, the safety concern, in particular, for thrombocytopenia, with higher-than-standard linezolid dosage is reasonable, and consequently, monitoring is essential.
PB  - MDPI
T2  - Pharmaceutics
T1  - Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing
VL  - 16
IS  - 2
DO  - 10.3390/pharmaceutics16020253
ER  - 

@article{
author = "Milaković, Dragana and Kovačević, Tijana and Kovačević, Peđa and Barišić, Vedrana and Avram, Sanja and Dragić, Saša and Zlojutro, Biljana and Momčičević, Danica and Miljković, Branislava and Vučićević, Katarina",
year = "2024",
abstract = "During veno-venous extracorporeal membrane oxygenation (vv ECMO) therapy, antimicrobial drugs are frequently used, and appropriate dosing is challenging due to there being limited data to support the dosage. Linezolid is effective against multidrug-resistant Gram-positive pathogens frequently isolated in ECMO patients. In total, 53 steady-state linezolid levels were obtained following 600 mg intravenous (IV) injections every 8 h, and these were used to develop a population pharmacokinetic (PopPK) model in patients with COVID-19-associated acute respiratory distress syndrome (CARDS) on vv ECMO. The data were analyzed using a nonlinear mixed-effects modelling approach. Monte Carlo simulation generated 5000 patients’ individual PK parameters and corresponding concentration–time profiles using the PopPK model, following the administration of 600 mg/8 h (a higher-than-standard dosing) and 600 mg/12 h (standard). The probabilities of pharmacokinetic/pharmacodynamic (PK/PD) target attainment (PTA) and the cumulative fraction of responses (CFR) for three pathogens were calculated and compared between the two dosing scenarios. Linezolid 600 mg/8 h was predicted to achieve greater than or equal to 85%Tf>MIC in at least 90% of the patients with CARDS on vv ECMO compared to only approximately two thirds of the patients after dosing every 12 h at a minimal inhibitory concentration (MIC) of 2 mg/L. In addition, for the same MIC, fAUC24/MIC ≥ 80 was achieved in almost three times the number of patients following an 8-h versus a 12-h interval. PopPK simulation predicted that a significantly higher proportion of the patients with CARDS on vv ECMO would achieve the PK/PD targets following the 8-h dosing interval compared to standard linezolid dosing. Nevertheless, the safety concern, in particular, for thrombocytopenia, with higher-than-standard linezolid dosage is reasonable, and consequently, monitoring is essential.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing",
volume = "16",
number = "2",
doi = "10.3390/pharmaceutics16020253"
}

Milaković, D., Kovačević, T., Kovačević, P., Barišić, V., Avram, S., Dragić, S., Zlojutro, B., Momčičević, D., Miljković, B.,& Vučićević, K.. (2024). Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing. in Pharmaceutics
MDPI., 16(2).
https://doi.org/10.3390/pharmaceutics16020253

Milaković D, Kovačević T, Kovačević P, Barišić V, Avram S, Dragić S, Zlojutro B, Momčičević D, Miljković B, Vučićević K. Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing. in Pharmaceutics. 2024;16(2).
doi:10.3390/pharmaceutics16020253 .

Milaković, Dragana, Kovačević, Tijana, Kovačević, Peđa, Barišić, Vedrana, Avram, Sanja, Dragić, Saša, Zlojutro, Biljana, Momčičević, Danica, Miljković, Branislava, Vučićević, Katarina, "Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing" in Pharmaceutics, 16, no. 2 (2024),
https://doi.org/10.3390/pharmaceutics16020253 . .

TY  - JOUR
AU  - Lukačišinová, Anna
AU  - Reissigová, Jindra
AU  - Ortner-Hadžiabdić, Maja
AU  - Brkić, Jovana
AU  - Okuyan, Betul
AU  - Volmer, Daisy
AU  - Tadić, Ivana
AU  - Modamio, Pilar
AU  - Mariño, Eduardo
AU  - Tachkov, Konstantine
AU  - Liperotti, Rosa
AU  - Onder, Graziano
AU  - Finne-Soveri, Harriet
AU  - van Hout, Hein
AU  - Howard, Elizabeth P.
AU  - Fialová, Daniela
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5563
AB  - Background: The use of benzodiazepines (BZDs) in older population is often accompanied by drug-related complications. Inappropriate BZD use significantly alters older adults’ clinical and functional status. This study compares the prevalence, prescribing patterns and factors associated with BZD use in community-dwelling older patients in 7 European countries. Methods: International, cross-sectional study was conducted in community-dwelling older adults (65 +) in the Czech Republic, Serbia, Estonia, Bulgaria, Croatia, Turkey, and Spain between Feb2019 and Mar2020. Structured and standardized questionnaire based on interRAI assessment scales was applied. Logistic regression was used to evaluate factors associated with BZD use. Results: Out of 2,865 older patients (mean age 73.2 years ± 6.8, 61.2% women) 14.9% were BZD users. The highest prevalence of BZD use was identified in Croatia (35.5%), Spain (33.5%) and Serbia (31.3%). The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). In comparison to Croatia, residing in other countries was associated with lower odds of BZD use (ORs varied from 0.49 (95%CI 0.32–0.75) in Spain to 0.01 (95%CI 0.00–0.03) in Turkey), excluding Serbia (OR 1.11, 95%CI 0.79–1.56). Conclusions: Despite well-known negative effects, BZDs are still frequently prescribed in older outpatient population in European countries. Principles of safer geriatric prescribing and effective deprescribing strategies should be individually applied in older BZD users.
PB  - BioMed Central Ltd
T2  - BMC Geriatrics
T1  - Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries
VL  - 24
IS  - 1
DO  - 10.1186/s12877-024-04742-7
ER  - 

@article{
author = "Lukačišinová, Anna and Reissigová, Jindra and Ortner-Hadžiabdić, Maja and Brkić, Jovana and Okuyan, Betul and Volmer, Daisy and Tadić, Ivana and Modamio, Pilar and Mariño, Eduardo and Tachkov, Konstantine and Liperotti, Rosa and Onder, Graziano and Finne-Soveri, Harriet and van Hout, Hein and Howard, Elizabeth P. and Fialová, Daniela",
year = "2024",
abstract = "Background: The use of benzodiazepines (BZDs) in older population is often accompanied by drug-related complications. Inappropriate BZD use significantly alters older adults’ clinical and functional status. This study compares the prevalence, prescribing patterns and factors associated with BZD use in community-dwelling older patients in 7 European countries. Methods: International, cross-sectional study was conducted in community-dwelling older adults (65 +) in the Czech Republic, Serbia, Estonia, Bulgaria, Croatia, Turkey, and Spain between Feb2019 and Mar2020. Structured and standardized questionnaire based on interRAI assessment scales was applied. Logistic regression was used to evaluate factors associated with BZD use. Results: Out of 2,865 older patients (mean age 73.2 years ± 6.8, 61.2% women) 14.9% were BZD users. The highest prevalence of BZD use was identified in Croatia (35.5%), Spain (33.5%) and Serbia (31.3%). The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). In comparison to Croatia, residing in other countries was associated with lower odds of BZD use (ORs varied from 0.49 (95%CI 0.32–0.75) in Spain to 0.01 (95%CI 0.00–0.03) in Turkey), excluding Serbia (OR 1.11, 95%CI 0.79–1.56). Conclusions: Despite well-known negative effects, BZDs are still frequently prescribed in older outpatient population in European countries. Principles of safer geriatric prescribing and effective deprescribing strategies should be individually applied in older BZD users.",
publisher = "BioMed Central Ltd",
journal = "BMC Geriatrics",
title = "Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries",
volume = "24",
number = "1",
doi = "10.1186/s12877-024-04742-7"
}

Lukačišinová, A., Reissigová, J., Ortner-Hadžiabdić, M., Brkić, J., Okuyan, B., Volmer, D., Tadić, I., Modamio, P., Mariño, E., Tachkov, K., Liperotti, R., Onder, G., Finne-Soveri, H., van Hout, H., Howard, E. P.,& Fialová, D.. (2024). Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries. in BMC Geriatrics
BioMed Central Ltd., 24(1).
https://doi.org/10.1186/s12877-024-04742-7

Lukačišinová A, Reissigová J, Ortner-Hadžiabdić M, Brkić J, Okuyan B, Volmer D, Tadić I, Modamio P, Mariño E, Tachkov K, Liperotti R, Onder G, Finne-Soveri H, van Hout H, Howard EP, Fialová D. Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries. in BMC Geriatrics. 2024;24(1).
doi:10.1186/s12877-024-04742-7 .

Lukačišinová, Anna, Reissigová, Jindra, Ortner-Hadžiabdić, Maja, Brkić, Jovana, Okuyan, Betul, Volmer, Daisy, Tadić, Ivana, Modamio, Pilar, Mariño, Eduardo, Tachkov, Konstantine, Liperotti, Rosa, Onder, Graziano, Finne-Soveri, Harriet, van Hout, Hein, Howard, Elizabeth P., Fialová, Daniela, "Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries" in BMC Geriatrics, 24, no. 1 (2024),
https://doi.org/10.1186/s12877-024-04742-7 . .

TY  - CHAP
AU  - Medarević, Đorđe
AU  - Krstić, Mirjana
AU  - Ibrić, Svetlana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5607
AB  - With the progress in medicine during the last several decades, it became clear
that the course of the disease and response to applied therapy differ to a great
extent between patients due to differences in genetic, anatomical, and physiological
characteristics of the patients. This brought into question the current
concept of therapy, so-called one size fits all, where similar drug doses have
been prescribed to a huge number of patients, with neglect of interindividual
differences between patients.
PB  - Elsevier Inc.
T2  - From Current to Future Trends in Pharmaceutical Technology
T1  - Fundamentals of 3D printing of pharmaceuticals
SP  - 1
EP  - 65
DO  - 10.1016/B978-0-323-91111-5.00001-9
ER  - 

@inbook{
author = "Medarević, Đorđe and Krstić, Mirjana and Ibrić, Svetlana",
year = "2024",
abstract = "With the progress in medicine during the last several decades, it became clear
that the course of the disease and response to applied therapy differ to a great
extent between patients due to differences in genetic, anatomical, and physiological
characteristics of the patients. This brought into question the current
concept of therapy, so-called one size fits all, where similar drug doses have
been prescribed to a huge number of patients, with neglect of interindividual
differences between patients.",
publisher = "Elsevier Inc.",
journal = "From Current to Future Trends in Pharmaceutical Technology",
booktitle = "Fundamentals of 3D printing of pharmaceuticals",
pages = "1-65",
doi = "10.1016/B978-0-323-91111-5.00001-9"
}

Medarević, Đ., Krstić, M.,& Ibrić, S.. (2024). Fundamentals of 3D printing of pharmaceuticals. in From Current to Future Trends in Pharmaceutical Technology
Elsevier Inc.., 1-65.
https://doi.org/10.1016/B978-0-323-91111-5.00001-9

Medarević Đ, Krstić M, Ibrić S. Fundamentals of 3D printing of pharmaceuticals. in From Current to Future Trends in Pharmaceutical Technology. 2024;:1-65.
doi:10.1016/B978-0-323-91111-5.00001-9 .

Medarević, Đorđe, Krstić, Mirjana, Ibrić, Svetlana, "Fundamentals of 3D printing of pharmaceuticals" in From Current to Future Trends in Pharmaceutical Technology (2024):1-65,
https://doi.org/10.1016/B978-0-323-91111-5.00001-9 . .

TY  - CONF
AU  - Medarević, Đorđe
AU  - Turković, Erna
AU  - Čežek, Maša
AU  - Ibrić, Svetlana
AU  - Maksimović, Zoran
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5606
AB  - INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...
PB  - International Association for Pharmaceutical Technology (APV), Mainz, Germany
PB  - International Society of Drug Delivery Sciences and Technology (APGI), Lille, France
PB  - Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy
C3  - 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
T1  - Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5606
ER  - 

@conference{
author = "Medarević, Đorđe and Turković, Erna and Čežek, Maša and Ibrić, Svetlana and Maksimović, Zoran",
year = "2024",
abstract = "INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...",
publisher = "International Association for Pharmaceutical Technology (APV), Mainz, Germany, International Society of Drug Delivery Sciences and Technology (APGI), Lille, France, Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy",
journal = "14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria",
title = "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5606"
}

Medarević, Đ., Turković, E., Čežek, M., Ibrić, S.,& Maksimović, Z.. (2024). Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
International Association for Pharmaceutical Technology (APV), Mainz, Germany..
https://hdl.handle.net/21.15107/rcub_farfar_5606

Medarević Đ, Turković E, Čežek M, Ibrić S, Maksimović Z. Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria. 2024;.
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

Medarević, Đorđe, Turković, Erna, Čežek, Maša, Ibrić, Svetlana, Maksimović, Zoran, "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues" in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria (2024),
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

TY  - JOUR
AU  - Draganov, Ivana
AU  - Drndarević, Aneta
AU  - Kovačević, Milena
AU  - Miljković, Branislava
AU  - Vuksanović, Miljanka
AU  - Janković, Aleksandar
AU  - Kalaba, Ana
AU  - Vezmar-Kovačević, Sandra
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5604
AB  - Drug-related hospitalizations pose a significant burden to the health-care system. The aim
was to investigate the prevalence of drug-related problems (DRPs) and their association with hospital
admissions in five internal medicine wards. The study included patients admitted to the nephrology,
cardiology, gastroenterology, endocrinology, and geriatric wards. The Pharmaceutical Care Network
Europe classification V9.1 was used for identifying DRPs. In total, 535 patients participated in the study.
We identified 954 DRPs (range 1-7) in 80.7% of patients. Most DRPs were identified on the endocrinology,
cardiology, and geriatric wards, and they were associated with the efficacy of treatment (71.4%), adverse
drug events (10.2%), and unnecessary drug treatment (18.4%). DRPs were associated with the cause of
hospitalization in 74.4% of patients on the nephrology ward, 60.1% and 60.6% of patients on the cardiology
and endocrinology wards, respectively, whereas this number was lower on the geriatric and gastroenterology
wards (26.9% and 8.9%, respectively). Suboptimal drug treatment due to medication omissions was often
associated with the potential cause of hospital admission. Focusing on patients with specific diseases and
DRPs, rather than reducing the number of medications in primary care, may be potentially rational in an
attempt to reduce drug-related hospitalizations.
PB  - Polish Pharmaceutical Society
T2  - Acta Poloniae Pharmaceutica - Drug Research
T1  - Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards
VL  - 81
IS  - 1
SP  - 145
EP  - 154
DO  - 10.32383/appdr/182840
ER  - 

@article{
author = "Draganov, Ivana and Drndarević, Aneta and Kovačević, Milena and Miljković, Branislava and Vuksanović, Miljanka and Janković, Aleksandar and Kalaba, Ana and Vezmar-Kovačević, Sandra",
year = "2024",
abstract = "Drug-related hospitalizations pose a significant burden to the health-care system. The aim
was to investigate the prevalence of drug-related problems (DRPs) and their association with hospital
admissions in five internal medicine wards. The study included patients admitted to the nephrology,
cardiology, gastroenterology, endocrinology, and geriatric wards. The Pharmaceutical Care Network
Europe classification V9.1 was used for identifying DRPs. In total, 535 patients participated in the study.
We identified 954 DRPs (range 1-7) in 80.7% of patients. Most DRPs were identified on the endocrinology,
cardiology, and geriatric wards, and they were associated with the efficacy of treatment (71.4%), adverse
drug events (10.2%), and unnecessary drug treatment (18.4%). DRPs were associated with the cause of
hospitalization in 74.4% of patients on the nephrology ward, 60.1% and 60.6% of patients on the cardiology
and endocrinology wards, respectively, whereas this number was lower on the geriatric and gastroenterology
wards (26.9% and 8.9%, respectively). Suboptimal drug treatment due to medication omissions was often
associated with the potential cause of hospital admission. Focusing on patients with specific diseases and
DRPs, rather than reducing the number of medications in primary care, may be potentially rational in an
attempt to reduce drug-related hospitalizations.",
publisher = "Polish Pharmaceutical Society",
journal = "Acta Poloniae Pharmaceutica - Drug Research",
title = "Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards",
volume = "81",
number = "1",
pages = "145-154",
doi = "10.32383/appdr/182840"
}

Draganov, I., Drndarević, A., Kovačević, M., Miljković, B., Vuksanović, M., Janković, A., Kalaba, A.,& Vezmar-Kovačević, S.. (2024). Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards. in Acta Poloniae Pharmaceutica - Drug Research
Polish Pharmaceutical Society., 81(1), 145-154.
https://doi.org/10.32383/appdr/182840

Draganov I, Drndarević A, Kovačević M, Miljković B, Vuksanović M, Janković A, Kalaba A, Vezmar-Kovačević S. Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards. in Acta Poloniae Pharmaceutica - Drug Research. 2024;81(1):145-154.
doi:10.32383/appdr/182840 .

Draganov, Ivana, Drndarević, Aneta, Kovačević, Milena, Miljković, Branislava, Vuksanović, Miljanka, Janković, Aleksandar, Kalaba, Ana, Vezmar-Kovačević, Sandra, "Drug-Related Problems Prior to Hospitalization on Internal Medicine Wards" in Acta Poloniae Pharmaceutica - Drug Research, 81, no. 1 (2024):145-154,
https://doi.org/10.32383/appdr/182840 . .

TY  - JOUR
AU  - Tasić, Gordana
AU  - Mitrović, Nikola
AU  - Simić, Milena
AU  - Koravović, Mladen
AU  - Jovanović, Predrag
AU  - Petković, Miloš
AU  - Jovanović, Miloš
AU  - Ivković, Branka
AU  - Savić, Vladimir
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5556
AB  - Hydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%).
PB  - Wiley Periodicals LLC.
T2  - Journal Heterocyclic Chemistry
T1  - Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent
DO  - 10.1002/jhet.4802
ER  - 

@article{
author = "Tasić, Gordana and Mitrović, Nikola and Simić, Milena and Koravović, Mladen and Jovanović, Predrag and Petković, Miloš and Jovanović, Miloš and Ivković, Branka and Savić, Vladimir",
year = "2024",
abstract = "Hydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%).",
publisher = "Wiley Periodicals LLC.",
journal = "Journal Heterocyclic Chemistry",
title = "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent",
doi = "10.1002/jhet.4802"
}

Tasić, G., Mitrović, N., Simić, M., Koravović, M., Jovanović, P., Petković, M., Jovanović, M., Ivković, B.,& Savić, V.. (2024). Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry
Wiley Periodicals LLC...
https://doi.org/10.1002/jhet.4802

Tasić G, Mitrović N, Simić M, Koravović M, Jovanović P, Petković M, Jovanović M, Ivković B, Savić V. Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry. 2024;.
doi:10.1002/jhet.4802 .

Tasić, Gordana, Mitrović, Nikola, Simić, Milena, Koravović, Mladen, Jovanović, Predrag, Petković, Miloš, Jovanović, Miloš, Ivković, Branka, Savić, Vladimir, "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent" in Journal Heterocyclic Chemistry (2024),
https://doi.org/10.1002/jhet.4802 . .