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Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
(John Wiley and Sons Inc, 2024)
The European Cooperation in Science and Technology (COST) action ENOTTA (The European Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases) was launched in 2022. To pave the way for ...
Comparative spectrophotometric determination of 3-hydroxyflavone based on zinc and aluminium complexes and their antioxidative profiles / Uporedno spektrofotometrijsko određivanje 3-hidroksiflavona bazirano na kompleksima cinka i aluminijuma i njihovi antioksidatni profili
(Beograd : Savez farmaceutskih udruženja Srbije, 2024)
Abstract
Flavonoids, as plant-derived compounds, were essential active components in traditional
medicine for centuries. Their potential or confirmed effects include antiviral, antimutagenic, antiinflammatory, antibacterial, ...
Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions
(Taylor & Francis, 2024)
There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities ...
Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.)
(Taylor & Francis Ltd., 2024)
This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush (Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone (1), 2-carboxy-3 ...
Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds / Povećani oksidacijski stres u obućarskih radnika izloženih mješavini niskih razina hlapljivih organskih spojeva
(Sciendo, 2024)
This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic ...
Exploring pulmoprotection in COVID-19: Moving toward microRNA-based theranostics
(Molecular Therapy: Nucleic Acids, 2024)
The relentless struggle with the aftermath of COVID-19 has driven the medical community to seek innovative methods for predicting and managing the disease’s complications. Complications such as an overactive immune response, ...
Maternal deprivation causes CaMKII downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress
(Elsevier B.V., 2024)
Background: Early life stress is a major risk factor for later development of psychiatric disorders, including post-traumatic stress disorder (PTSD). An intricate relationship exists between various neurotransmitters (such ...
Clinical decision-making in benzodiazepine deprescribing by healthcare providers vs. AI-assisted approach
(John Wiley and Sons Inc, 2024)
Aims: The aim of this study was to compare the clinical decision-making for benzodiazepine deprescribing between a healthcare provider (HCP) and an artificial intelligence (AI) chatbot GPT4 (ChatGPT-4). Methods: We analysed ...
High-performance liquid chromatography evaluation of lipophilicity and QSRR modeling of a series of dual DNA gyrase and topoisomerase IV inhibitors
(Akadémiai Kiadó, 2024)
Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during replication
and represent important antibacterial drug targets. To be successful as drug candidates, newly synthesized compounds must ...
Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation
(2024)
The low aqueous and oil solubility of the novelpyrazoloquinolinone ligand (CW-02-79) with significantbinding affinity for sigma-2 receptors in the brain hindersthe development of conventional parenteral formulationsand ...