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Application of miscibility analysis and determination of Soluplus solubility map for development of carvedilol-loaded nanofibers
(Elsevier Science BV, Amsterdam, 2017)
Electrospinning was used to produce carvedilol-loaded Soluplus polymer nanofibers using a systematic approach. Miscibility between drug and polymer was determined through calculation of the interaction parameter, chi, and ...
Evaluation of critical formulation parameters in design and differentiation of self-microemulsifying drug delivery systems (SMEDDSs) for oral delivery of aciclovir
(Elsevier Science BV, Amsterdam, 2016)
The study investigated the influence of formulation parameters for design of self-microemulsifying drug delivery systems (SMEDDSs) comprising oil (medium chain triglycerides) (10%), surfactant (Labrasol (R), polysorbate ...
Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
(Elsevier Science BV, Amsterdam, 2016)
In silico modeling of in situ fluidized bed melt granulation
(Elsevier Science BV, Amsterdam, 2014)
Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response ...
Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions
(Elsevier Science BV, Amsterdam, 2019)
Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages ...
Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol
(Elsevier B.V., 2021)
In this study, four low molecular weight (LMW) excipients, tryptophan (TRY), phenylalanine (PHE), lysine (LYS) and saccharin (SAC) were evaluated as co-formers to generate co-amorphous systems (CAMS) by ball milling with ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
Predicting drug release from diazepam FDM printed tablets using deep learning approach: Influence of process parameters and tablet surface/volume ratio
(Elsevier B.V., 2021)
The aim of this study was to apply artificial neural networks as deep learning tools in establishing a model for understanding and prediction of diazepam release from fused deposition modeling (FDM) printed tablets. Diazepam ...
Application of miscibility analysis and determination of Soluplus solubility map for development of carvedilol-loaded nanofibers
(Elsevier, 2017)
Electrospinning was used to produce carvedilol-loaded Soluplus polymer nanofibers using a systematic approach. Miscibility between drug and polymer was determined through calculation of the interaction parameter, chi, and ...
Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug
(Elsevier Science BV, Amsterdam, 2004)
Microemulsion systems composed of water, isopropyl myristate, PEG-8 caprylic/captzc glycerides (Labrasol((R))), and polyglyceryl-6 dioleate (Plurol Oleique((R))), were investigated as potential drug delivery vehicles for ...