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Prikaz rezultata 21-30 od 115
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the gamma-Aminobutyric Acid Type A Receptor (GABA(A)R) alpha 6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability
(Amer Chemical Soc, Washington, 2018)
Recent reports indicate that alpha 6/beta 2/3 gamma 2 GABA(A)R selective ligands may be important for the treatment of trigeminal activation-related pain and neuropsychiatric disorders with sensori-motor gating deficits. ...
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
(Springer Heidelberg, Heidelberg, 2018)
Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our ...
Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on ...
Stability, bifurcations, and dynamics of global variables of a system of bursting neurons
(Amer Inst Physics, Melville, 2011)
An approximate mean field model of an ensemble of delayed coupled stochastic Hindmarsh-Rose bursting neurons is constructed and analyzed. Bifurcation analysis of the approximate system is performed using numerical continuation. ...
Sources of information and pharmacists' knowledge regarding rare diseases and orphan drugs: cross-sectional study in Serbia
(Elsevier, 2014)
Objectives: The lack of information and scientific knowledge of rare diseases (RDs)
and orphan drug (ODs) could affect the quality of health care delivered to patients suf-
fering from rare diseases. The aim of this study ...
Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach
(Elsevier Science Inc, 2014)
Objectives: Colistimethate sodium (Colistin) is an old, “forgotten” antibiotics
revived due to multidrug-resistant Gram-negative bacteria in nosocomial infec-
tions. In many countries, both – intravenous and inhalational ...
Correlation between oxidative stress and biomarkers of joint damage in patients with severe haemophilia treated by different prophylaxis regimens
(Ferrata Storti Foundation, Pavia, 2014)
Background: Haemophilic arthropathy is the main cause of morbidity in indi-
viduals with severe haemophilia and prevention of joint disease is the primary
goal of treatment. Recurrent bleeding into joints causes damage ...
Spontaneous Formation of Synchronization Clusters in Homogenous Neuronal Ensembles Induced by Noise and Interaction Delays
(Amer Physical Soc, College Pk, 2012)
The spontaneous formation of clusters of synchronized spiking in a structureless ensemble of equal stochastically perturbed excitable neurons with delayed coupling is demonstrated for the first time. The effect is a ...
The influence of an a5GABAA selective agonist XLi356 on rats' performance in morris water maze
(Oxford Univ Press, Oxford, 2012)
Objective : The impairing effects of diazepam in Morris water maze
(MWM) could be partially antagonized with co-administration of an
a5 subunit selective antagonist XLi093 (Savic ́ et al., 2009). In order
to further ...
Predictors of lipoprotein particle size and subclasses in patients with OSA
(European Respiratory Soc Journals Ltd, Sheffield, 2013)