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Polymorphism of alpha-1-antitrypsin in hematological malignancies
(Soc Brasil Genetica, Ribeirao Pret, 2009)
Alpha-1-antitrypsin (AAT) or serine protease inhibitor A1 (SERPINA1) is an important serine protease inhibitor in humans. The main physiological role of AAT is to inhibit neutrophil elastase (NE) released from triggered ...
Identification of a rare p.G320R alpha-1-antitrypsin variant in emphysema and lung cancer patients
(Soc Brasil Genetica, Ribeirao Pret, 2010)
The alpha-1-antitrypsin (A1AT) gene is highly polymorphic, with more than 100 genetic variants identified of which some can affect A1AT protein concentration and/or function and lead to pulmonary and/or liver disease. This ...
Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes
(Soc Brasil Genetica, Ribeirao Pret, 2007)
Thyroid hormones stimulate aerobic metabolism which may lead to oxidative stress accompanied by damage to various cellular macromolecules, including DNA. Previous comet assay studies have shown that thyroid hormones cause ...