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The examination of antinociceptive and toxic effects of oxcarbazepine and carbamazepine in mice
(Blackwell Publishing, Oxford, 2006)
Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study
(Wiley, Hoboken, 2009)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT center dot Moclobemide (MCB) undergoes extensive both presystemic and systemic metabolism that can be affected by concomitant drugs. center dot Valproic acid (VPA) and carbamazepine ...
Population pharmacokinetic model of carbamazepine derived from routine therapeutic drug monitoring data
(Lippincott Williams & Wilkins, Philadelphia, 2007)
The aim of the present study was to develop a population pharmacokinetic model of carbamazepine from routine therapeutic drug monitoring data. Steady-state carbamazepine plasma concentrations determined by homogenous enzyme ...
Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison
(ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf, 2007)
A growing concern for the biopharmaceutical characterization of pharmaceutical products increased the interest in the evaluation and identification of physicochemical properties of drugs and dosage forms that govern its ...
Justification of Biowaiver for Carbamazepine, a Low Soluble High Permeable Compound, in Solid Dosage Forms Based on IVIVC and Gastrointestinal Simulation
(Amer Chemical Soc, Washington, 2009)
The aim of the present study was to use gastrointestinal simulation technology and in vitro-in vivo correlation (IVIVC) as tools to investigate a possible extension of biowaiver criteria to BCS class II drugs using ...
Role of alpha 2-adrenoceptors in the local peripheral antinociception by carbamazepine in a rat model of inflammatory mechanical hyperalgesia
(Prous Science, Sa, Barcelona, 2007)
The anticonvulsant carbamazepine was recently shown to possess local peripheral antinociceptive properties. In this study, we investigated whether alpha 2-adrenergic receptors are involved in the local peripheral ...
Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine
(Prous Science, Sau-Thomson Reuters, Barcelona, 2007)
The mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, ...
GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia
(Karger, Basel, 2008)
Background/Aims: The purpose of this study was to investigate the involvement of GABAergic mechanisms in the antihyperalgesic effect of carbamazepine and oxcarbazepine by examining the effect of bicuculline ( GABA A receptor ...
The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists
(Lippincott Williams & Wilkins, Philadelphia, 2004)
The antinociceptive effects of carbamazepine and oxcarbazepine, and the influence of caffeine, were examined in a paw pressure test in rats. Carbamazepine (10-40 mg/kg; intraperitoneal, i.p.) and oxcarbazepine (40-160 ...